-
1
-
-
0035415493
-
Prodrug strategies in cancer therapy
-
W.A. Denny Prodrug strategies in cancer therapy Eur. J. Med. Chem. 36 2001 577 595
-
(2001)
Eur. J. Med. Chem.
, vol.36
, pp. 577-595
-
-
Denny, W.A.1
-
2
-
-
0029588221
-
The choice of prodrugs for gene directed enzyme prodrug therapy of cancer
-
T.A. Connors The choice of prodrugs for gene directed enzyme prodrug therapy of cancer Gene Ther. 2 1995 702 709
-
(1995)
Gene Ther.
, vol.2
, pp. 702-709
-
-
Connors, T.A.1
-
3
-
-
73349090587
-
Bystander or no bystander for gene directed enzyme prodrug therapy
-
G.U. Dachs, M.A. Hunt, S. Syddall, D.C. Singleton, and A.V. Patterson Bystander or no bystander for gene directed enzyme prodrug therapy Molecules 14 2009 4517 4545
-
(2009)
Molecules
, vol.14
, pp. 4517-4545
-
-
Dachs, G.U.1
Hunt, M.A.2
Syddall, S.3
Singleton, D.C.4
Patterson, A.V.5
-
4
-
-
0034660014
-
Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of Escherichia coli nitroreductase
-
S.J. Weedon, N.K. Green, I.A. McNeish, M.G. Gilligan, V. Mautner, C.J. Wrighton, A. Mountain, L.S. Young, D.J. Kerr, and P.F. Searle Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of Escherichia coli nitroreductase Int. J. Cancer 86 2000 848 854
-
(2000)
Int. J. Cancer
, vol.86
, pp. 848-854
-
-
Weedon, S.J.1
Green, N.K.2
McNeish, I.A.3
Gilligan, M.G.4
Mautner, V.5
Wrighton, C.J.6
Mountain, A.7
Young, L.S.8
Kerr, D.J.9
Searle, P.F.10
-
5
-
-
80054729738
-
Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo
-
T.J. Harvey, I.M. Hennig, S.D. Shnyder, P.A. Cooper, N. Ingram, G.D. Hall, P.J. Selby, and J.D. Chester Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo Cancer Gene Ther. 18 2011 773 784
-
(2011)
Cancer Gene Ther.
, vol.18
, pp. 773-784
-
-
Harvey, T.J.1
Hennig, I.M.2
Shnyder, S.D.3
Cooper, P.A.4
Ingram, N.5
Hall, G.D.6
Selby, P.J.7
Chester, J.D.8
-
6
-
-
29244455327
-
Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954
-
A.N. Lukashev, C. Fuerer, M.J. Chen, P. Searle, and R. Iggo Late expression of nitroreductase in an oncolytic adenovirus sensitizes colon cancer cells to the prodrug CB1954 Hum. Gene Ther. 16 2005 1473 1483
-
(2005)
Hum. Gene Ther.
, vol.16
, pp. 1473-1483
-
-
Lukashev, A.N.1
Fuerer, C.2
Chen, M.J.3
Searle, P.4
Iggo, R.5
-
7
-
-
70449111294
-
Antivector and tumor immune responses following adenovirus-directed enzyme prodrug therapy for the treatment of prostate cancer
-
D. Onion, P. Patel, R.G. Pineda, N. James, and V. Mautner Antivector and tumor immune responses following adenovirus-directed enzyme prodrug therapy for the treatment of prostate cancer Hum. Gene Ther. 20 2009 1249 1258
-
(2009)
Hum. Gene Ther.
, vol.20
, pp. 1249-1258
-
-
Onion, D.1
Patel, P.2
Pineda, R.G.3
James, N.4
Mautner, V.5
-
8
-
-
0022978891
-
CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells
-
J.J. Roberts, F. Friedlos, and R.J. Knox CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells Biochem. Biophys. Res. Commun. 140 1986 1073 1078
-
(1986)
Biochem. Biophys. Res. Commun.
, vol.140
, pp. 1073-1078
-
-
Roberts, J.J.1
Friedlos, F.2
Knox, R.J.3
-
9
-
-
0036733759
-
Study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
-
S.O. Freytag, M. Khil, H. Stricker, J. Peabody, M. Menon, M. DePeralta-Venturina, D. Nafziger, J. Pegg, D. Paielli, S. Brown, K. Barton, M. Lu, E. Aguilar-Cordova, J.H. Kim, and I. Phase study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer Cancer Res. 62 2002 4968 4976
-
(2002)
Cancer Res.
, vol.62
, pp. 4968-4976
-
-
Freytag, S.O.1
Khil, M.2
Stricker, H.3
Peabody, J.4
Menon, M.5
DePeralta-Venturina, M.6
Nafziger, D.7
Pegg, J.8
Paielli, D.9
Brown, S.10
Barton, K.11
Lu, M.12
Aguilar-Cordova, E.13
Kim, J.H.14
Phase, I.15
-
10
-
-
67649872626
-
A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]
-
P. Patel, J.G. Young, V. Mautner, D. Ashdown, S. Bonney, R.G. Pineda, S.I. Collins, P.F. Searle, D. Hull, E. Peers, J. Chester, D.M. Wallace, A. Doherty, H. Leung, L.S. Young, and N.D. James A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984] Mol. Ther. 17 2009 1292 1299
-
(2009)
Mol. Ther.
, vol.17
, pp. 1292-1299
-
-
Patel, P.1
Young, J.G.2
Mautner, V.3
Ashdown, D.4
Bonney, S.5
Pineda, R.G.6
Collins, S.I.7
Searle, P.F.8
Hull, D.9
Peers, E.10
Chester, J.11
Wallace, D.M.12
Doherty, A.13
Leung, H.14
Young, L.S.15
James, N.D.16
-
11
-
-
0026745562
-
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) - I. Purification and properties of a nitroreductase enzyme from Escherichia coli - A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
-
G.M. Anlezark, R.G. Melton, R.F. Sherwood, B. Coles, F. Friedlos, and R.J. Knox The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) - I. Purification and properties of a nitroreductase enzyme from Escherichia coli - a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT) Biochem. Pharmacol. 44 1992 2289 2295
-
(1992)
Biochem. Pharmacol.
, vol.44
, pp. 2289-2295
-
-
Anlezark, G.M.1
Melton, R.G.2
Sherwood, R.F.3
Coles, B.4
Friedlos, F.5
Knox, R.J.6
-
12
-
-
68849127873
-
Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954
-
D. Jarrom, M. Jaberipour, C.P. Guise, S. Daff, S.A. White, P.F. Searle, and E.I. Hyde Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954 Biochemistry 48 2009 7665 7672
-
(2009)
Biochemistry
, vol.48
, pp. 7665-7672
-
-
Jarrom, D.1
Jaberipour, M.2
Guise, C.P.3
Daff, S.4
White, S.A.5
Searle, P.F.6
Hyde, E.I.7
-
13
-
-
72149105881
-
Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954
-
G.A. Prosser, J.N. Copp, S.P. Syddall, E.M. Williams, J.B. Smaill, W.R. Wilson, A.V. Patterson, and D.F. Ackerley Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954 Biochem. Pharmacol. 79 2015 678 687
-
(2015)
Biochem. Pharmacol.
, vol.79
, pp. 678-687
-
-
Prosser, G.A.1
Copp, J.N.2
Syddall, S.P.3
Williams, E.M.4
Smaill, J.B.5
Wilson, W.R.6
Patterson, A.V.7
Ackerley, D.F.8
-
14
-
-
0141592778
-
Generation of Esherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954
-
J.I. Grove, A.L. Lovering, C. Guise, P.R. Race, C.J. Wrighton, S.A. White, E.I. Hyde, and P.F. Searle Generation of Esherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954 Cancer Res. 63 2003 5532 5537
-
(2003)
Cancer Res.
, vol.63
, pp. 5532-5537
-
-
Grove, J.I.1
Lovering, A.L.2
Guise, C.3
Race, P.R.4
Wrighton, C.J.5
White, S.A.6
Hyde, E.I.7
Searle, P.F.8
-
15
-
-
34247119256
-
Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle
-
C.P. Guise, J.I. Grove, E.I. Hyde, and P.F. Searle Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle Gene Ther. 14 2007 690 698
-
(2007)
Gene Ther.
, vol.14
, pp. 690-698
-
-
Guise, C.P.1
Grove, J.I.2
Hyde, E.I.3
Searle, P.F.4
-
16
-
-
71749118032
-
Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations
-
M. Jaberipour, S.O. Vass, C.P. Guise, J.I. Grove, R.J. Knox, L. Hu, E.I. Hyde, and P.F. Searle Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations Biochem. Pharmacol. 79 2010 102 111
-
(2010)
Biochem. Pharmacol.
, vol.79
, pp. 102-111
-
-
Jaberipour, M.1
Vass, S.O.2
Guise, C.P.3
Grove, J.I.4
Knox, R.J.5
Hu, L.6
Hyde, E.I.7
Searle, P.F.8
-
17
-
-
34047136503
-
Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954
-
P.R. Race, A.L. Lovering, S.A. White, J.I. Grove, P.F. Searle, C.W. Wrighton, and E.I. Hyde Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954 J. Mol. Biol. 368 2007 481 492
-
(2007)
J. Mol. Biol.
, vol.368
, pp. 481-492
-
-
Race, P.R.1
Lovering, A.L.2
White, S.A.3
Grove, J.I.4
Searle, P.F.5
Wrighton, C.W.6
Hyde, E.I.7
-
18
-
-
84929335232
-
Altering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineering
-
J. Bai, Y. Zhou, Q. Chen, Q. Yang, and J. Yang Altering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineering ChemBioChem 16 2015 1219 1225
-
(2015)
ChemBioChem
, vol.16
, pp. 1219-1225
-
-
Bai, J.1
Zhou, Y.2
Chen, Q.3
Yang, Q.4
Yang, J.5
-
19
-
-
0024520745
-
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
-
S.N. Ho, H.D. Hunt, R.M. Horton, J.K. Pullen, and L.R. Pease Site-directed mutagenesis by overlap extension using the polymerase chain reaction Gene 77 1989 51 59
-
(1989)
Gene
, vol.77
, pp. 51-59
-
-
Ho, S.N.1
Hunt, H.D.2
Horton, R.M.3
Pullen, J.K.4
Pease, L.R.5
-
20
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 276 1997 307 326
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
21
-
-
34447508216
-
Phaser crystallographic software
-
A.J. McCoy, R.W. Grosse-Kunstleve, P.D. Adams, M.D. Winn, L.C. Storoni, and R.J. Read Phaser crystallographic software J. Appl. Crystallogr. 40 2007 658 674
-
(2007)
J. Appl. Crystallogr.
, vol.40
, pp. 658-674
-
-
McCoy, A.J.1
Grosse-Kunstleve, R.W.2
Adams, P.D.3
Winn, M.D.4
Storoni, L.C.5
Read, R.J.6
-
22
-
-
76449098262
-
PHENIX: A comprehensive python-based system for macromolecular structure solution
-
P.D. Adams, P.V. Afonine, G. Bunkoczi, V.B. Chen, I.W. Davis, N. Echols, J.J. Headd, L.W. Hung, G.J. Kapral, R.W. Grosse-Kunstleve, A.J. McCoy, N.W. Moriarty, R. Oeffner, R.J. Read, D.C. Richardson, J.S. Richardson, T.C. Terwilliger, and P.H. Zwart PHENIX: a comprehensive python-based system for macromolecular structure solution Acta Crystallogr. Sect. D: Biol. Crystallogr. 66 2010 213 221
-
(2010)
Acta Crystallogr. Sect. D: Biol. Crystallogr.
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
Afonine, P.V.2
Bunkoczi, G.3
Chen, V.B.4
Davis, I.W.5
Echols, N.6
Headd, J.J.7
Hung, L.W.8
Kapral, G.J.9
Grosse-Kunstleve, R.W.10
McCoy, A.J.11
Moriarty, N.W.12
Oeffner, R.13
Read, R.J.14
Richardson, D.C.15
Richardson, J.S.16
Terwilliger, T.C.17
Zwart, P.H.18
-
24
-
-
84939984900
-
Transformation pathway of 2,4,6-trinitrotoluene by Escherichia coli nitroreductases and improvement of activity using structure-basedmutagenesis
-
J. Bai, J. Yang, P.Y. Liu, and Q. Yang Transformation pathway of 2,4,6-trinitrotoluene by Escherichia coli nitroreductases and improvement of activity using structure-basedmutagenesis Process. Biochem. 50 2015 705 711
-
(2015)
Process. Biochem.
, vol.50
, pp. 705-711
-
-
Bai, J.1
Yang, J.2
Liu, P.Y.3
Yang, Q.4
-
25
-
-
0034609776
-
Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: A prodrug-activating enzyme
-
G.N. Parkinson, J.V. Skelly, and S. Neidle Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme J. Med. Chem. 43 2000 3624 3631
-
(2000)
J. Med. Chem.
, vol.43
, pp. 3624-3631
-
-
Parkinson, G.N.1
Skelly, J.V.2
Neidle, S.3
-
26
-
-
84860116476
-
Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis
-
S.W. LinWu, C.A. Wu, F.C. Peng, and A.H. Wang Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis Biochem. Pharmacol. 83 2012 1690 1699
-
(2012)
Biochem. Pharmacol.
, vol.83
, pp. 1690-1699
-
-
LinWu, S.W.1
Wu, C.A.2
Peng, F.C.3
Wang, A.H.4
-
27
-
-
0035946957
-
The structure of Escherichia coli nitroreductase complexed with nicotinic acid: Three crystal forms at 1.7A, 1.8A and 2.4A resolution
-
A.L. Lovering, E.I. Hyde, P.F. Searle, and S.A. White The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7A, 1.8A and 2.4A resolution J. Mol. Biol. 309 2001 203 213
-
(2001)
J. Mol. Biol.
, vol.309
, pp. 203-213
-
-
Lovering, A.L.1
Hyde, E.I.2
Searle, P.F.3
White, S.A.4
|