Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis

Biochemical Pharmacology

Volumn 83, Issue 12, 2012, Pages 1690-1699

  Linwu, Shiuan Woei ^a   Wu, Che An ^b   Peng, Fu Chuo ^b   Wang, Andrew H J ^a  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Antidote; Escherichia coli type I nitroreductase NfsB; Flunitrazepam; Nitrobenzodiazepine; Rational protein design

Indexed keywords

ANTIDOTE; BACTERIAL ENZYME; FLAVINE MONONUCLEOTIDE; FLUNITRAZEPAM; NICOTINAMIDE; NITROREDUCTASE; TYPE I NITROREDUCTASE NFSB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; HYDROGEN BOND; HYPNOSIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REDUCTION;

ANIMALS; ANTIDOTES; BENZODIAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI PROTEINS; FEMALE; FLUNITRAZEPAM; HYPNOSIS; HYPNOTICS AND SEDATIVES; MICE; MICE, INBRED BALB C; NITROREDUCTASES;

EID: 84860116476     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.003     Document Type: Article

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