Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA a randomized pilot study

Chest

Volumn 148, Issue 5, 2015, Pages 1214-1223

  Dalmases, Mireia ^a,b   Solé Padullés, Cristina ^b   Torres, Marta ^a,b   Embid, Cristina ^a,b   Nuñez, Maria Dolores ^a   Martínez Garcia, Miguel Ángel ^a,c   Farré, Ramon ^b   Bargalló, Nuria ^a,d   Bartrés Faz, David ^b   Montserrat, Josep M ^a,b  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONSERVATIVE TREATMENT; CONTROLLED STUDY; CORTICAL THICKNESS (BRAIN); DEFAULT MODE NETWORK; DISEASE SEVERITY; ELDERLY CARE; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GERIATRIC PATIENT; HUMAN; MALE; MIDDLE FRONTAL GYRUS; NEUROANATOMY; NEUROPSYCHOLOGICAL TEST; OPEN STUDY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PILOT STUDY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SHORT TERM MEMORY; SLEEP DISORDERED BREATHING; THERAPY EFFECT; TREATMENT DURATION; BRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SINGLE BLIND PROCEDURE; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME;

AGED; BRAIN; COGNITION; CONTINUOUS POSITIVE AIRWAY PRESSURE; FEMALE; HUMANS; MALE; PILOT PROJECTS; SINGLE-BLIND METHOD; SLEEP APNEA, OBSTRUCTIVE; TREATMENT OUTCOME;

EID: 84946595109     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.15-0171     Document Type: Article

References (54)

1. Sforza E, Roche F. Sleep apnea syndrome and cognition. Front Neurol. 2012; 3: 87.
2. Morrell MJ, Jackson ML, Twigg GL, et al. Changes in brain morphology in patients with obstructive sleep apnoea. Thorax. 2010; 65 (10): 908-914.
3. Joo EY, Tae WS, Lee MJ, et al. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome. Sleep. 2010; 33 (2): 235-241.
4. Yaouhi K, Bertran F, Clochon P, et al. A combined neuropsychological and brain imaging study of obstructive sleep apnea. J Sleep Res. 2009; 18 (1): 36-48.
5. Prilipko O, Huynh N, Schwartz S, et al. Task positive and default mode networks during a parametric working memory task in obstructive sleep apnea patients and healthy controls. Sleep. 2011; 34 (3): 293-301A.
6. O'Donoghue FJ, Wellard RM, Rochford PD, et al. Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment. Sleep. 2012; 35 (1): 41-48.
7. Canessa N, Castronovo V, Cappa SF, et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med. 2011; 183 (10): 1419-1426.
8. Prilipko O, Huynh N, Schwartz S, et al. The effects of CPAP treatment on task positive and default mode networks in obstructive sleep apnea patients: an fMRI study. PLoS One. 2012; 7 (12): e47433.
9. Castronovo V, Canessa N, Strambi LF, et al. Brain activation changes before and after PAP treatment in obstructive sleep apnea. Sleep. 2009; 32 (9): 1161-1172.
10. Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013; 177 (9): 1006-1014.
11. Dalmases M, Torres M, Márquez-Kisinousky L, et al. Brain tissue hypoxia and oxidative stress induced by obstructive apneas is different in young and aged rats. Sleep. 2014; 37 (7): 1249-1256.
12. Hedden T, Gabrieli JD. Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci. 2004; 5 (2): 87-96.
13. Ayalon L, Ancoli-Israel S, Drummond SP. Obstructive sleep apnea and age: a double insult to brain function? Am J Respir Crit Care Med. 2010; 182 (3): 413-419.
14. Kim H, Dinges DF, Young T. Sleepdisordered breathing and psychomotor vigilance in a community-based sample. Sleep. 2007; 30 (10): 1309-1316.
15. Sforza E, Roche F, Thomas-Anterion C, et al. Cognitive function and sleep related breathing disorders in a healthy elderly population: the SYNAPSE study. Sleep. 2010; 33 (4): 515-521.
16. Aloia MS, Ilniczky N, Di Dio P, Perlis ML, Greenblatt DW, Giles DE. Neuropsychological changes and treatment compliance in older adults with sleep apnea. J Psychosom Res. 2003; 54 (1): 71-76.
17. McMillan A, Bratton DJ, Faria R, et al; PREDICT Investigators. Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial. Lancet Respir Med. 2014; 2 (10): 804-812.
18. Lloberes P, Durán-Cantolla J, Martínez-García MA, et al; Spanish Society of Pulmonology and Thoracic Surgery. Diagnosis and treatment of sleep apnea-hypopnea syndrome. Arch Bronconeumol. 2011; 47 (3): 143-156.
19. Masa JF, Jiménez A, Durán J, et al. Alternative methods of titrating continuous positive airway pressure: a large multicenter study. Am J Respir Crit Care Med. 2004; 170 (11): 1218-1224.
20. Sala-Llonch R, Junqué C, Arenaza-Urquijo EM, et al. Changes in wholebrain functional networks and memory performance in aging. Neurobiol Aging. 2014; 35 (10): 2193-2202.
21. Franco AR, Pritchard A, Calhoun VD, Mayer AR. Interrater and intermethod reliability of default mode network selection. Hum Brain Mapp. 2009; 30 (7): 2293-2303.
22. Ju G, Yoon IY, Lee SD, Kim TH, Choe JY, Kim KW. effects of sleep apnea syndrome on delayed memory and executive function in elderly adults. J Am Geriatr Soc. 2012; 60 (6): 1099-1103.
23. Alchanatis M, Zias N, Deligiorgis N, et al. Comparison of cognitive performance among different age groups in patients with obstructive sleep apnea. Sleep Breath. 2008; 12 (1): 17-24.
24. Park DC, Reuter-Lorenz P. The adaptive brain: aging and neurocognitive scaffolding. Anu Rev Psychol. 2009; 60: 173-196.
25. Onen F, Moreau T, Gooneratne NS, Petit C, Falissard B, Onen SH. Limits of the Epworth Sleepiness Scale in older adults. Sleep Breath. 2013; 17 (1): 343-350.
26. Blackwell T, Yaffe K, Ancoli-Israel S, et al; Osteoporotic Fractures in Men Study Group. Associations between sleep architecture and sleep-disordered breathing and cognition in older communitydwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc. 2011; 59 (12): 2217-2225.
27. Spira AP, Blackwell T, Stone KL, et al. Sleep-disordered breathing and cognition in older women. J Am Geriatr Soc. 2008; 56 (1): 45-50.
28. Yaffe K, Laffan AM, Harrison SL, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 2011; 306 (6): 613-619.
29. Antic NA, Catcheside P, Buchan C, et al. The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA. Sleep. 2011; 34 (1): 111-119.
30. Zimmerman ME, Arnedt JT, Stanchina M, Millman RP, Aloia MS. Normalization of memory performance and positive airway pressure adherence in memory-impaired patients with obstructive sleep apnea. Chest. 2006; 130 (6): 1772-1778.
31. Kilander L, Andrén B, Nyman H, Lind L, Boberg M, Lithell H. Atrial fibrillation is an independent determinant of low cognitive function: a cross-sectional study in elderly men. Stroke. 1998; 29 (9): 1816-1820.
32. Dardiotis E, Giamouzis G, Mastrogiannis D, et al. Cognitive impairment in heart failure. Cardiol Res Pract. 2012;2012: 595821.
33. Zhang Q, Wang D, Qin W, et al. Altered resting-state brain activity in obstructive sleep apnea. Sleep. 2013; 36(5): 651-659B.
34. Ferreira LK, Busatto GF. Resting-state functional connectivity in normal brain aging. Neurosci Biobehav Rev. 2013; 37 (3): 384-400.
35. Andrews-Hanna JR, Snyder AZ, Vincent JL, et al. Disruption of large-scale brain systems in advanced aging. Neuron. 2007; 56 (5): 924-935.
36. Vidal-Piñeiro D, Valls-Pedret C, Fernández-Cabello S, et al. Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes. Front Aging Neurosci. 2014; 6: 256.
37. Solé-Padullés C, Bartrés-Faz D, Lladó A, et al. Donepezil treatment stabilizes functional connectivity during resting state and brain activity during memory encoding in Alzheimer's disease. J Clin Psychopharmacol. 2013; 33 (2): 199-205.
38. Smith SM, Fox PT, Miller KL, et al. Correspondence of the brain's functional architecture during activation and rest. Proc Natl Acad Sci USA. 2009; 106 (31): 13040-13045.
39. Greicius MD, Srivastava G, Reiss AL, Menon V. Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci USA. 2004; 101 (13): 4637-4642.
40. Pacheco J, Goh JO, Kraut MA, Ferrucci L, Resnick SM. Greater cortical thinning in normal older adults predicts later cognitive impairment. Neurobiol Aging. 2015; 36 (2): 903-908.
41. Macey PM, Henderson LA, Macey KE, et al. Brain morphology associated with obstructive sleep apnea. Am J Respir Crit Care Med. 2002; 166 (10): 1382-1387.
42. Joo EY, Jeon S, Kim ST, Lee JM, Hong SB. Localized cortical thinning in patients with obstructive sleep apnea syndrome. Sleep. 2013; 36 (8): 1153-1162.
43. Torelli F, Moscufo N, Garreffa G, et al. Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage. 2011; 54 (2): 787-793.
44. Weng HH, Tsai YH, Chen CF, et al. Mapping gray matter reductions in obstructive sleep apnea: an activation likelihood estimation meta-analysis. Sleep. 2014; 37 (1): 167-175.
45. Hutton C, Draganski B, Ashburner J, Weiskopf N. A comparison between voxel-based cortical thickness and voxelbased morphometry in normal aging. Neuroimage. 2009; 48 (2): 371-380.
46. Colcombe SJ, Kramer AF, McAuley E, Erickson KI, Scalf P. Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci. 2004; 24 (1): 9-14.
47. Colcombe SJ, Erickson KI, Scalf PE, et al. Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci. 2006; 61 (11): 1166-1170.
48. Engvig A, Fjell AM, Westlye LT, et al. effects of memory training on cortical thickness in the elderly. Neuroimage. 2010; 52 (4): 1667-1676.
49. Lacasse Y, Bureau MP, Sériès F. A new standardised and self-administered quality of life questionnaire specific to obstructive sleep apnoea. Thorax. 2004; 59(6): 494-499.
50. McDaid C, Griffin S, Weatherly H, et al. Continuous positive airway pressure devices for the treatment of obstructive sleep apnoea-hypopnoea syndrome: a systematic review and economic analysis. Health Technol Assess. 2009; 13 (4).
51. Andrews-Hanna JR, Reidler JS, Huang C, Buckner RL. Evidence for the default network's role in spontaneous cognition. J Neurophysiol. 2010; 104 (1): 322-335.
52. Fischl B, Dale AM. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA. 2000; 97 (20): 11050-11055.
53. Lerch JP, Evans AC. Cortical thickness analysis examined through power analysis and a population simulation. Neuroimage. 2005; 24 (1): 163-173.
54. Hutton C, De Vita E, Ashburner J, Deichmann R, Turner R. Voxel-based cortical thickness measurements in MRI. Neuroimage. 2008; 40 (4): 1701-1710.