The non-pathogenic Henipavirus Cedar paramyxovirus phosphoprotein has a compromised ability to target STAT1 and STAT2

Antiviral Research

Volumn 124, Issue , 2015, Pages 69-76

  Lieu, Kim G ^a   Marsh, Glenn A ^b   Wang, Lin Fa ^b,c   Netter, Hans J ^a,d  

^a MONASH UNIVERSITY   (Australia)

^b CSIRO   (Australia)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cedar virus; Hendra virus; Henipavirus; Innate immunity; Interferon; Pathogenesis; Signal transducers and activators of transcription

Indexed keywords

ALPHA INTERFERON; MESSENGER RNA; STAT1 PROTEIN; STAT2 PROTEIN; VIRUS PHOSPHOPROTEIN; PHOSPHOPROTEIN; STAT1 PROTEIN, HUMAN; STAT2 PROTEIN, HUMAN; VIRAL PROTEIN;

ARTICLE; CELL NUCLEUS; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HENIPAVIRUS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MESSENGER RNA SYNTHESIS; MXA GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; VIRUS GENE; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HELA CELL LINE; HENIPAVIRUS INFECTION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY;

AMINO ACID SEQUENCE; HEK293 CELLS; HELA CELLS; HENIPAVIRUS; HENIPAVIRUS INFECTIONS; HUMANS; INTERFERON-ALPHA; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; VIRAL PROTEINS;

EID: 84946593734     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.09.017     Document Type: Article

References (31)

1. J. Andrejeva, D.F. Young, S. Goodbourn, and R.E. Randall Degradation of STAT1 and STAT2 by the V proteins of simian virus 5 and human parainfluenza virus type 2, respectively: consequences for virus replication in the presence of alpha/beta and gamma interferons J. Virol. 76 2002 2159 2167
2. J. Ashour, M. Laurent-Rolle, P.-Y. Shi, and A. García-Sastre NS5 of Dengue virus mediates STAT2 binding and degradation J. Virol. 83 2009 5408 5418
3. M.D. Audsley, and G.W. Moseley Paramyxovirus evasion of innate immunity: Diverse strategies for common targets World J. Virol. 2 2013 57 70
4. M.J. Ciancanelli, V.A. Volchkova, M.L. Shaw, V.E. Volchkov, and C.F. Basler Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism J. Virol. 83 2009 7828 7841
5. J.F. Drexler, V.M. Corman, F. Gloza-Rausch, A. Seebens, A. Annan, A. Ipsen, T. Kruppa, M.A. Müller, E.K.V. Kalko, Y. Adu-Sarkodie, S. Oppong, and C. Drosten Henipavirus RNA in African bats PLoS One 4 2009 e6367
6. J.E. Durbin, R. Hackenmiller, M.C. Simon, and D.E. Levy Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease Cell 84 1996 443 450
7. O. Escaffre, V. Borisevich, J.R. Carmical, D. Prusak, J. Prescott, H. Feldmann, and B. Rockx Henipavirus pathogenesis in human respiratory epithelial cells J. Virol. 87 2013 3284 3294
8. K. Hagmaier, N. Stock, S. Goodbourn, L.-F. Wang, and R. Randall A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species J. Gen. Virol. 87 2006 3649 3653
9. K.G. Lieu, A. Brice, L. Wiltzer, B. Hirst, D.A. Jans, D. Blondel, and G.W. Moseley The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling J. Virol. 87 2013 8261 8265
10. M.K. Lo, B.H. Harcourt, B.A. Mungall, A. Tamin, M.E. Peeples, W.J. Bellini, and P.A. Rota Determination of the henipavirus phosphoprotein gene mRNA editing frequencies and detection of the C, V and W proteins of Nipah virus in virus-infected cells J. Gen. Virol. 90 2009 398 404
11. M.K. Lo, M.E. Peeples, W.J. Bellini, S.T. Nichol, P.A. Rota, and C.F. Spiropoulou Distinct and overlapping roles of Nipah virus P gene products in modulating the human endothelial cell antiviral response PLoS One 7 2012 e47790
12. G.A. Marsh, E.R. Virtue, I. Smith, S. Todd, R. Arkinstall, L. Frazer, P. Monaghan, G.A. Smith, C.C. Broder, D. Middleton, and L.-F. Wang Recombinant Hendra viruses expressing a reporter gene retain pathogenicity in ferrets Virol. J. 10 2013 95
13. G.A. Marsh, C. de Jong, J.A. Barr, M. Tachedjian, C. Smith, D. Middleton, M. Yu, S. Todd, A.J. Foord, V. Haring, J. Payne, R. Robinson, I. Broz, G. Crameri, H.E. Field, and L.-F. Wang Cedar virus: a novel henipavirus isolated from Australian bats PLoS Pathog. 8 2012 e1002836
14. C. Mathieu, V. Guillaume, A. Sabine, K.C. Ong, K.T. Wong, C. Legras-Lachuer, and B. Horvat Lethal Nipah virus infection induces rapid overexpression of CXCL10 PLoS One 7 2012 e32157
15. C. Park, S. Li, E. Cha, and C. Schindler Immune response in Stat2 knockout mice Immunity. 13 2000 795 804
16. M.-S. Park, M.L. Shaw, J. Muñoz-Jordan, J.F. Cros, T. Nakaya, N. Bouvier, P. Palese, A. García-Sastre, and C.F. Basler Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins J. Virol. 77 2003 1501 1511
17. O. Pernet, B.S. Schneider, S.M. Beaty, M. LeBreton, T.E. Yun, A. Park, T.T. Zachariah, T.A. Bowden, P. Hitchens, C.M. Ramirez, P. Daszak, J. Mazet, A.N. Freiberg, N.D. Wolfe, and B. Lee Evidence for henipavirus spillover into human populations in Africa Nat. Commun. 5 2014 10.1038/ncomms6342
18. L.C. Platanias Mechanisms of type-I- and type-II-interferon-mediated signalling Nat. Rev. Immunol. 5 2005 375 386
19. A. Ramachandran, J.-P. Parisien, and C.M. Horvath STAT2 is a primary target for Measles virus V protein-mediated alpha/beta interferon signaling inhibition J. Virol. 82 2008 8330 8338
20. R.E. Randall, and S. Goodbourn Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures J. Gen. Virol. 89 2008 1 47
21. J.J. Rodriguez, C.D. Cruz, and C.M. Horvath Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion J. Virol. 78 2004 5358 5367
22. J.J. Rodriguez, J.-P. Parisien, and C.M. Horvath Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation J. Virol. 76 2002 11476 11483
23. J.J. Rodriguez, L.-F. Wang, and C.M. Horvath Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation J. Virol. 77 2003 11842 11845
24. M.L. Shaw, W.B. Cardenas, D. Zamarin, P. Palese, and C.F. Basler Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways J. Virol. 79 2005 6078 6088
25. M.L. Shaw, A. García-Sastre, P. Palese, and C.F. Basler Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively J. Virol. 78 2004 5633 5641
26. C.M. Ulane, J.J. Rodriguez, J.-P. Parisien, and C.M. Horvath STAT3 ubiquitylation and degradation by Mumps virus suppress cytokine and oncogene signaling J. Virol. 77 2003 6385 6393
27. G.A. Versteeg, and A. García-Sastre Viral tricks to grid-lock the type I interferon system Curr. Opin. Microbiol. 13 2010 508 516
28. E.R. Virtue, G.A. Marsh, and L.F. Wang Interferon signaling remains functional during henipavirus infection of human cell lines J. Virol. 85 2011 4031 4034
29. L.F. Wang, J.S. Mackenzie, and C.C. Broder Henipaviruses. Fields Virology vol. 2 2013 Lippincott Williams & Wilkins 286 313 D. M. Knipe and P. M. Howley
30. K.T. Wong Nipah and Hendra viruses: recent advances in pathogenesis Future Virol. 5 2010 129 131
31. F. Yabukarski, P. Lawrence, N. Tarbouriech, J.-M. Bourhis, E. Delaforge, M.R. Jensen, R.W.H. Ruigrok, M. Blackledge, V. Volchkov, and M. Jamin Structure of Nipah virus unassembled nucleoprotein in complex with its viral chaperone Nat. Struct. Mol. Biol. 21 2014 754 759