Genetic risk factors in patients with deep venous thrombosis, a retrospective case control study on Iranian population

Thrombosis Journal

Volumn 13, Issue 1, 2015, Pages

  Hosseini, Soudabeh ^a   Kalantar, Ebrahim ^b   Hosseini, Maryam Sadat ^a   Tabibian, Shadi ^a   Shamsizadeh, Morteza ^c   Dorgalaleh, Akbar ^a  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TARBIAT MODARES UNIVERSITY   (Iran)

^c SHAHROUD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Deep venous thrombosis; FV Leiden; Methylenetetrahydrofolate reductase; Plasminogen activator inhibitor 1; Prothrombin20210

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PROTHROMBIN; PROTHROMBIN 20210; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DNA POLYMORPHISM; FEMALE; GENE; GENE MUTATION; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; IRANIAN PEOPLE; MAJOR CLINICAL STUDY; MALE; MTHFR GENE; PAI 1 GENE; POPULATION BASED CASE CONTROL STUDY; RETROSPECTIVE STUDY; RISK ASSESSMENT;

EID: 84946559396     PISSN: None     EISSN: 14779560     Source Type: Journal    
DOI: 10.1186/s12959-015-0064-y     Document Type: Article

References (27)

1. Esmon CT. Basic mechanisms and pathogenesis of venous thrombosis. Blood Rev. 2009;23(5):225-9.
2. Goldhaber SZ. Venous thromboembolism: epidemiology and magnitude of the problem. Best Pract Res Clin Haematol. 2012;25:235-42.
3. Shaheen K, Alraies MC, Alraiyes AH, Christie R. Factor V Leiden: how great is the risk of venous thromboembolism? Clev Clin J Med. 2012;79(4):265-72.
4. Souto JC, Almasy L, Borrell M, Blanco-Vaca F, Mateo J, Soria JM, et al. Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study. Am J Hum Gen. 2000;67(6):1452-9.
5. Seligsohn U, Lubetsky A. Genetic susceptibility to venous thrombosis. N Engl J Med. 2001;344(16):1222-31.
6. Pop TR, Vesa SC, Trifa AP, CRIşAN S, Buzoianu AD. PAI-1 4G/5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the risk of acute lower extremity deep vein thrombosis. Rom J Morphol Embryol. 2014;55(1):153.
7. Spiroski I, Kedev S, Antov S, Arsov T, Krstevska M, Dzhekova-Stojkova S, et al. Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis. Acta Biochim Pol. 2008;55(3):587-94.
8. JURCUţ R, POP I, Coriu D, Grasu M, ZILIşTEANU D, Giuşcă S, et al. Compound heterozygosity for the C677T and A1298C mutations of the MTHFR gene in a case of hyperhomocysteinemia with recurrent deep thrombosis at young age. Rom J Intern Med. 2008;46(3):255-9.
9. Oztuzcu S, Ergun S, Ulaşli M, Nacarkahya G, Iğci YZ, Iğci M, et al. Evaluation of Factor V G1691A, prothrombin G20210A, Factor XIII V34L, MTHFR A1298C, MTHFR C677T and PAI-1 4G/5G genotype frequencies of patients subjected to cardiovascular disease (CVD) panel in south-east region of Turkey. Mol Biol Rep. 2014;41(6):3671-6.
10. Akhter MS, Biswas A, Ranjan R, Meena A, Yadav BK, Sharma A, et al. Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is seen in higher frequency in the Indian patients with deep vein thrombosis. Clin Appl Thromb Hemost. 2010;16(2):184-8.
11. Alfirevic Z, Simundic AM, Nikolac N, Sobocan N, Alfirevic I, Stefanovic M, et al. Frequency of factor II G20210A, factor V Leiden, MTHFR C677T and PAI-1 5G/4G polymorphism in patients with venous thromboembolism: Croatian case-control study. Biochem Med. 2010;20(2):229-35.
12. Pai N, Ghosh K, Shetty S. Cause of deep venous thrombosis and pulmonary embolism in young patients from India as compared with other ethnic groups. Blood Coagul Fibrinolysis. 2012;23(4):257-61.
13. Bonduel M, Sciuccati G, Hepner M, Pieroni G, Torres AF, Mardaraz C, et al. Factor V Leiden and prothrombin gene G20210A mutation in children with cerebral thromboembolism. Am J Hematol. 2003;73(2):81-6.
14. Kreidy R. Factor V-Leiden mutation: a common risk factor for venous thrombosis among Lebanese patients. Thromb J. 2012; doi: 10.1155/2012/380681.
15. Guzmán N, Lanas F, Salazar LA. Influence of Amerindian mitochondrial DNA haplogroups on thrombosis susceptibility and frequency of four genetic prothrombotic variants in Southern Chilean subjects. Clin Chim Acta. 2010;411(5):444-7.
16. Beauchamp NJ, Daly ME, Hampton KK, Cooper PC, Preston FE, Peake IR. High prevalence of a mutation in the factor V gene within the UK population: relationship to activated protein C resistance and familial thrombosis. Br J Haematol. 1994;88(1):219-22.
17. Naderi M, Alizadeh S, Kazemi A, Tabibian S, Zaker F, Bamedi T, et al. Central nervous system bleeding in pediatric patients with factor XIII deficiency: A study on 23 new cases. Hematology. 2015;20(2):112-8.
18. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88(10):3698-703.
19. Zappacosta B, Romano L, Persichilli S, Cutrone LA, Graziano M, Vitrani A, et al. Genotype prevalence and allele frequencies of 5,10- methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in Italian newborns. Lab Med. 2009;40(12):732-6.
20. Shammaa DM, Sabbagh AS, Taher AT, Zaatari GS, Mahfouz RA. Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G alleles frequency distribution in the Lebanese population. Mol Biol Rep. 2008;35(3):453-7.
21. Janbabai G, Taghipour M, Sharifian R, Sharifpour A, Davoodi M, Farazmandfar T, et al. Survey of thrombophilia risk factors and markers in patients with deep vein thrombosis in Mazandaran Province, Northern Iran. Adv Biol Res. 2013;7(4):139-43.
22. Rahimi Z, Mozafari H, Shahriari-Ahmadi A, Alimogaddam K, Ghavamzadeh A, Aznab M, et al. Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V Leiden. Blood Coagul Fibrinolysis. 2010;21(5):385-8.
23. Hajsadeghi S, Kerman SRJ, Joodat R, Hejratie M, Vaferi H, Farsi N, et al. Deep vein thrombosis, demographic characteristics and risk factors in Iran. Galen Med J. 2013;2(4):135-40.
24. Pourgheysari B, Boroujeni HR, Hasheminia AM, Drees F. PLA2 polymorphism of platelet glycoprotein IIb/IIIa but not Factor V Leiden and prothrombin G20210A polymorphisms is associated with venous thromboembolism and more recurrent events in central Iran. Blood Coagul Fibrinolysis. 2013;24(5):471-6.
25. Simone B, De Stefano V, Leoncini E, Zacho J, Martinelli I, Emmerich J, et al. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls. Eur J Epidemiol. 2013;28(8):621-47.
26. Simsek E, Yesilyurt A, Pinarli F, Eyerci N, Ulus AT. Combined genetic mutations have remarkable effect on deep venous thrombosis and/or pulmonary embolism occurence. Gene. 2014;536(1):171-6.
27. Almawi WY, Tamim H, Kreidy R, Timson G, Rahal E, Nabulsi M, et al. A case control study on the contribution of factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations to the genetic susceptibility of deep venous thrombosis. J Thromb Thrombolysis. 2005;19(3):189-96.