PLA2 polymorphism of platelet glycoprotein IIb/IIIa but not Factor v Leiden and prothrombin G20210A polymorphisms is associated with venous thromboembolism and more recurrent events in central Iran

Blood Coagulation and Fibrinolysis

Volumn 24, Issue 5, 2013, Pages 471-476

  Pourgheysari, Batoul ^a   Boroujeni, Hamid Rouhi ^a   Hasheminia, Ali Mohammad ^a   Drees, Fatima ^a  

^a SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Inherited thrombophilia; PLA2 polymorphism; recurrent episodes; venous thromboembolism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; FIBRINOGEN RECEPTOR; PHOSPHOLIPASE A2; PROTHROMBIN;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DETERMINATION; DNA SEQUENCE; FAMILY HISTORY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HEREDITY; HUMAN; IRAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT DISEASE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VENOUS BLOOD; VENOUS THROMBOEMBOLISM;

DNA; FACTOR V; FEMALE; GENOTYPING TECHNIQUES; HUMANS; IRAN; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTHROMBIN; PULMONARY EMBOLISM; RECURRENCE; THROMBOPHILIA; VENOUS THROMBOEMBOLISM;

EID: 84879925132     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32835e4260     Document Type: Article

References (34)

1. Heit JA. The epidemiology of venous thromboembolism in the community. Arterioscler Thromb Vasc Biol 2008; 28:370-372.
2. Bauer KA, Rosendaal FR, Heit JA. Hypercoagulability: too many tests, too much conflicting data. Hematology Am Soc Hematol Educ Program 2002: 353-368.
3. Dalen JE. Should patients with venous thromboembolism be screened for thrombophilia? Am J Med 2008; 121:458-463.
4. Hooper WC, De Staercke C. The relationship between FV Leiden and pulmonary embolism. Respir Res 2002; 3: 8.
5. Turkstra F, Karemaker R, Kuijer PM, Prins MH, Buller HR. Istheprevalenceof the factor V Leiden mutation in patients with pulmonary embolism and deep vein thrombosis really different? Thromb Haemost 1999; 81:345-348.
6. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation inthe3'-untranslated regionoftheprothrombin gene isassociated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698-3703.
7. Rosendaal FR, Reitsma PH. Genetics of venous thrombosis. J Thromb Haemost 2009; 7:301-304.
8. Gohil R, Peck G, Sharma P. The genetics of venous thromboembolism: a meta-analysis involving similar to 120 000 cases and 180 000 controls. Thromb Haemost 2009; 102:360-370.
9. Ivanov P, Komsa-Penkova R, Kovacheva K, Ivanov Y, Stoyanova A, Ivanov I, et al. Impactofthrombophilic geneticfactorson pulmonary embolism: early onset and recurrent incidences. Lung 2008; 186:27-36.
10. Fermo I, Dangelo SV, Paroni R, Mazzola G, Calori G, Dangelo A. Prevalence of moderatehyperhomocysteinemiain patientswith early-onsetvenousand arterial occlusive disease. Ann Intern Med 1995; 123:747-753.
11. Bezemer ID, Doggen CJM, Vos HL, Rosendaal FR. No association between the common MTHFR 677C->T polymorphism and venous thrombosis: results from the MEGA study. Arch Intern Med 2007; 167:497-501.
12. Rahimi Z, Mozafari H, Shahriari-Ahmadi A, Alimogaddam K, Ghavamzadeh A, Aznab M, et al. Deep venous thrombosis and thrombophilic mutations in western Iran: association with factor V Leiden. Blood Coagul Fibrinolysis 2010; 21:385-388.
13. Said JM, Brennecke SP, Moses EK, Walker SP, Monagle PT, Campbell J, et al. The prevalence of inherited thrombophilic polymorphisms in an asymptomatic Australian antenatal population. Austr N Z J Obstet Gynaecol 2008; 48:536-541.
14. Gibson CS, Mac Lennan AH, Rudzki Z, Hague WM, Haan EA, Sharpe P, et al. The prevalence of inherited thrombophilias in a Caucasian Australian population. Pathology 2005; 37:160-163.
15. Pecheniuk NM, Marsh NA, Walsh TP. Multiple analysis ofthree common genetic alterations associated with thrombophilia. Blood Coagul Fibrinolysis 2000; 11:183-189.
16. Kokturk N, Kanbay A, Aydogdu M, Ozyilmaz E, Bukan N, Ekim N. Hyperhomocysteinemia prevalence among patients with venous thromboembolism. Clin Appl Thromb Hemost 2011; 17:487-493.
17. Isotalo PA, Wells GA, Donnelly JG. Neonatal and fetal methylenetetrahydrofolate reductase genetic polymorphisms: an examination of C677T and A1298C mutations. Am J Hum Genet 2000; 67:986-990.
18. Dolek B, Eraslan S, Eroglu S, Kesim BE, Ulutin T, Yalciner A, et al. Molecular analysis of factor V Leiden, factor V Hong Kong, factor II G20210A, methylenetetrahydrofolate reductase C677T, and A1298C mutations related to Turkish thrombosis patients. Clin Appl Thromb Hemost 2007; 13:435-438.
19. Kamat GV, Metgud SC, Pattanshetti VM, Godhi AS. A cross-sectional study to detect the prevalence of hyperhomocysteinemia in cases of deep vein thrombosis. Indian J Surg 2010; 72:323-326.
20. Hoffman M. Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. Med Hypotheses 2011; 77:1088-1093.
21. Biswas A, Bajaj J, Ranjan R, Meena A, Akhter MS, Yadav BK, et al. Factor V Leiden: is it the chief contributor to activated protein C resistance in Asian-Indian patientswithdeepveinthrombosis? Clin Chim Acta 2008;392:21-24.
22. Coppola A, Tufano A, Cerbone AM, Di Minno G. Inherited thrombophilia: implications for prevention and treatment of venous thromboembolism. Semin Thromb Hemost 2009; 35:683-694.
23. Celik M, Altintas A, Celik Y, Karabulut A, Ayyildiz O.Thrombophilia in young patients with acute myocardial infarction. Saudi Med J 2008; 29:48-54.
24. Kupeli E, Verdi H, Simsek A, Atac FB, Eyuboglu FO. Genetic mutations in Turkish population with pulmonary embolism and deep venous thrombosis. Clin Appl Thromb Hemost 2011; 17:E87-E94.
25. Gialeraki A, Politou M, Rallidis L, Merkouri E, Markatos C, Kremastinos D, et al. Prevalence of prothrombotic polymorphisms in Greece. Genet Test 2008; 12:541-547.
26. Eichinger S, Weltermann A, Minar E, Stain M, Schonauer V, Schneider B, et al. Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism. Arch Intern Med 2004; 164:92-96.
27. Eid SS, Rihani G. Prevalence of factor V Leiden, prothrombin G20210A, and MTHFR C677T mutations in 200 healthy Jordanians. Clin Lab Sci 2004; 17:200-202.
28. Resch B, Gallistl S, Kutschera J, Mannhalter C, Muntean W, Mueller WD. Thrombophilic polymorphisms-factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations-and preterm birth. Wiener Klinische Wochenschrift 2004; 116:622-626.
29. Altinisik J, Ates O, Ulutin T, Cengiz M, Buyru N. Factor V Leiden, prothrombin G20210A and protein C mutation frequency in Turkish venous thrombosis patients. Clin Appl Thromb Hemost 2008; 14:415-420.
30. Feng D, Lindpaintner K, Larson MG, Rao VS, O'Donnell CJ, Lipinska I, et al. Increased platelet aggregability associated with platelet GPIIIa Pl A2 polymorphism: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol 1999; 19:1142-1147.
31. Saidi S, Mahjoub T, Slamia LB, Ammou SB, Al-Subaie AM, Almawi WY. Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke. Cerebrovasc Dis 2008; 25:81-86.
32. Saidi S, Mahjoub T, Slamia LB, Ammou SB, Al-Subaie AM, Almawi WY. Polymorphisms of the human platelet alloantigens HPA-1, HPA-2, HPA-3, and HPA-4 in ischemic stroke. Am J Hematol 2008; 83:570-573.
33. Marchiori A, Mosena L, Prins MH, Prandoni P. The risk of recurrent venous thromboembolism among heterozygous carriers of factor V Leiden or prothrombin G20210A mutation. A systematic review of prospective studies. Haematologica 2007; 92:1107-1114.
34. Couturaud F, Leroyer C, Julian JA, Kahn SR, Ginsberg JS, Wells PS, et al. Factors that predict risk of thrombosis in relatives of patients with unprovokedvenousthromboembolism. Chest 2009; 136:1537-1545. Medical Sciences