Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship

European Journal of Medicinal Chemistry

Volumn 107, Issue , 2016, Pages 1-11

  Manda, Sudhakar ^a   Sharma, Sadhana ^a   Wani, Abubakar ^a   Joshi, Prashant ^a   Kumar, Vikas ^a   Guru, Santosh K ^a   Bharate, Sonali S ^a   Bhushan, Shashi ^a   Vishwakarma, Ram A ^a   Kumar, Ajay ^a   Bharate, Sandip B ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Fascaplysin; P glycoprotein induction; Quaternary analogs; carboline

Indexed keywords

(1H INDOL 3YL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (2 BROMOPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (2 CHLORO 6 FLUOROPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (2 FLUOROPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (2,3,4 TRICHLOROPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (2,4 DICHLORO 5 FLUOROPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (2,4 DICHLOROPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (2,4 DIMETHOXYPHENYL)(9H PYRIDO[3,4 B]INDOL 1YL)METHANONE; (2,5 DICHLOROPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; (4 TRIFLUOROMETHYLPHENYL)(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; 1 (2 BROMO BENZOYL) 2 METHYL BETA CARBOLINIUM IODIDE; 1 (2 CHLORO BENZOYL) 2 METHYL BETA CARBOLINIUM IODIDE; 1 (2 FLUORO BENZOYL) 2 METHYL BETA CARBOLINIUM IODIDE; 1 (3 INDOLOYL) 2 METHYL BETA CARBOLINIUM IODIDE; 1 (4 TRIFLOUROMETHYL BENZOYL) 2 METHYLBETA CARBOLINIUM; 1 BENZOYL 2 METHYL BETA CARBOLINIUM IODIDE; 2 CHLOROPHENYL(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; 3,4 DICHLORO FASCAPLYSIN; 4 CHLORO 5 FLUORO FASCAPLYSIN; 4 CHLORO FASCAPLYSIN; 4,5 DIFLUORO FASCAPLYSIN; 5 CHLORO FASCAPLYSIN; 6 CHLORO FASCAPLYSIN; AMYLOID BETA PROTEIN; ANTINEOPLASTIC AGENT; FASCAPLYSIN; MULTIDRUG RESISTANCE PROTEIN; PHENYL(9H PYRIDO[3,4 B]INDOL 1 YL)METHANONE; RIFAMPICIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; BIOLOGICAL PRODUCT; CHOLINESTERASE INHIBITOR; INDOLE DERIVATIVE;

ALZHEIMER DISEASE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL LOSS; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC50; MEDICINAL CHEMISTRY; NERVE CELL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; CELL LINE; CHEMISTRY; METABOLISM; MOLECULAR DOCKING; PRECLINICAL STUDY; PROCEDURES; SOLUBILITY; SYNTHESIS;

BIOLOGICAL PRODUCTS; CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; CHOLINESTERASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; HUMANS; INDOLES; MOLECULAR DOCKING SIMULATION; P-GLYCOPROTEIN; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84946555317     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.10.049     Document Type: Article

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