Serum ferritin is associated with arterial stiffness in hemodialysis patients: results of a 3-year follow-up study

International Urology and Nephrology

Volumn 47, Issue 11, 2015, Pages 1847-1853

  Lin, Kao Chang ^a,b   Tsai, Meng Yi ^c   Chi, Chun Ling ^c   Yu, Lai King ^c   Huang, Li Hsueh ^c   Chen, Chien An ^c  

^a SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c TAINAN SIN LAU HOSPITAL   (Taiwan)

Author keywords

Arterial stiffness; Brachial ankle pulse wave velocity; Ferritin

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FERRITIN; IRON;

ADULT; AGE; ANKLE BRACHIAL INDEX; ARTERIAL STIFFNESS; ARTICLE; BLOOD PRESSURE REGULATION; BRACHIAL ANKLE PULSE WAVE VELOCITY; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; HEMODIALYSIS PATIENT; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PULSE WAVE; SYSTOLIC BLOOD PRESSURE; AGED; ANEMIA; ARTERY; BLOOD; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; RENAL REPLACEMENT THERAPY;

AGE FACTORS; AGED; ANEMIA; ARTERIES; FEMALE; FERRITINS; FOLLOW-UP STUDIES; HUMANS; IRON; MALE; MIDDLE AGED; PULSE WAVE ANALYSIS; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC; VASCULAR STIFFNESS;

EID: 84946484419     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-015-1090-1     Document Type: Article

References (34)

1. Ramakrishna G, Rooke TW, Cooper LT (2003) Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light. Vasc Med 8:203–210
2. Vinchi F, Muckenthaler MU, Da Silva MC, Balla G, Balla J, Jeney V (2014) Atherogenesis and iron: from epidemiology to cellular level. Front Pharmacol 5:94
3. Drueke T, Witko-Sarsat V, Massy Z et al (2002) Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease. Circulation 106:2212–2217
4. Wolff B, Volzke H, Ludemann J et al (2004) Association between high serum ferritin levels and carotid atherosclerosis in the study of health in pomerania (SHIP). Stroke 35:453–457
5. Sullivan JL (1981) Iron and the sex difference in heart disease risk. Lancet 1981(1):1293–1294
6. Menke A, Fernandez-Real JM, Muntner P, Guallar E (2009) The association of biomarkers of iron status with peripheral arterial disease in us adults. BMC Cardiovasc Disord 9:34
7. Morrison HI, Semenciw RM, Mao Y, Wigle DT (1994) Serum iron and risk of fatal acute myocardial infarction. Epidemiology 5:243–246
8. Ramakrishnan U, Kuklina E, Stein AD (2002) Iron stores and cardiovascular disease risk factors in women of reproductive age in the united states. Am J Clin Nutr 76:1256–1260
9. Baer DM, Tekawa IS, Hurley LB (1994) Iron stores are not associated with acute myocardial infarction. Circulation 89:2915–2918
10. Solymoss BC, Marcil M, Gilfix BM, Gelinas F, Poitras AM, Campeau L (1994) The place of ferritin among risk factors associated with coronary artery disease. Coron Artery Dis 5:231–235
11. Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, London GM (1999) Impact of aortic stiffness on survival in end-stage renal disease. Circulation 99:2434–2439
12. Kimoto E, Shoji T, Shinohara K (2003) Preferential stiffening of central over peripheral arteries in type 2 diabetes. Diabetes 52:448–452
13. O’Rourke M (1995) Mechanical principles in arterial disease. Hypertension 26:2–9
14. Yamashina A, Tomiyama H, Arai T et al (2003) Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk. Hypertens Res 26:615–622
15. Chuang SY, Chen CH, Cheng CM, Chou P (2005) Combined use of brachial-ankle pulse wave velocity and ankle-brachial index for fast assessment of arteriosclerosis and atherosclerosis in a community. Int J Cardiol 98:99–105
16. Kim DH, Kim J, Kim JM, Lee AY (2008) Increased brachial-ankle pulse wave velocity is independently associated with risk of cerebral ischemic small vessel disease in elderly hypertensive patients. Clin Neurol Neurosurg 110:599–604
17. Kitahara T, Ono K, Tsuchida A (2005) Impact of brachial-ankle pulse wave velocity and ankle-brachial blood pressure index on mortality in hemodialysis patients. Am J Kidney Dis 46:688–696
18. Kalantar-Zadeh K, Lee GH (2006) The fascinating but deceptive ferritin: to measure it or not to measure it in chronic kidney disease? Clin J Am Soc Nephrol 1(Suppl 1):S9–18
19. Senol E, Ersoy A, Erdinc S, Sarandol E, Yurtkuran M (2008) Oxidative stress and ferritin levels in haemodialysis patients. Nephrol Dial Transplant 23:665–672
20. KDOQI (2006) clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis 47:S11–145
21. Byon CH, Javed A, Dai Q et al (2008) Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor runx2 by akt signaling. J Biol Chem 283:15319–15327
22. Nakahara T, Sato H, Shimizu T (2010) Fibroblast growth factor-2 induces osteogenic differentiation through a runx2 activation in vascular smooth muscle cells. Biochem Biophys Res Commun 394:243–248
23. Neven E, De Schutter TM, Behets GJ, Gupta A, D’Haese PC (2011) Iron and vascular calcification. Is there a link? Nephrol Dial Transplant 26:1137–1145
24. Rocha LA, Barreto DV, Barreto FC (2009) Serum ferritin level remains a reliable marker of bone marrow iron stores evaluated by histomorphometry in hemodialysis patients. Clin J Am Soc Nephrol 24:105–109
25. Lim PS, Wei YH, Yu YL, Kho B (1999) Enhanced oxidative stress in haemodialysis patients receiving intravenous iron therapy. Nephrol Dial Transplant 14:2680–2687
26. Kuo KL, Hung SC, Wei YH, Tarng DC (2008) Intravenous iron exacerbates oxidative DNA damage in peripheral blood lymphocytes in chronic hemodialysis patients. J Am Soc Nephrol 219:1817–1826
27. Martin-Malo A, Merino A, Carracedo J (2012) Effects of intravenous iron on mononuclear cells during the haemodialysis session. Nephrol Dial Transplant 27:2465–2471
28. de Vecchi AF, Novembrino C, Lonati S, Ippolito S, Bamonti F (2007) Two different modalities of iron gluconate i.v. administration: effects on iron, oxidative and inflammatory status in peritoneal dialysis patients. Nephrol Dial Transplant 22:1709–1713
29. Tomiyama H, Yamashina A, Arai T et al (2003) Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 166:303–309
30. Nomura K, Nakao M, Karita K, Nishikitani M, Yano E (2005) Association between work-related psychological stress and arterial stiffness measured by brachial-ankle pulse-wave velocity in young Japanese males from an information service company. Scand J Work Environ Health 31:352–359
31. Choi KM, Lee KW, Seo JA et al (2004) Relationship between brachial-ankle pulse wave velocity and cardiovascular risk factors of the metabolic syndrome. Diabetes Res Clin Pract 66:57–61
32. Fujiwara Y, Chaves P, Takahashi R et al (2004) Relationships between brachial-ankle pulse wave velocity and conventional atherosclerotic risk factors in community-dwelling people. Prev Med 39:1135–1142
33. Rambod M, Kovesdy CP, Kalantar-Zadeh K (2008) Combined high serum ferritin and low iron saturation in hemodialysis patients: the role of inflammation. Clin J Am Soc Nephrol 3:1691–1701
34. Kalantar-Zadeh K, Rodriguez RA, Humphreys MH (2004) Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant 19:141–149