High reactivity of the cortisol awakening response predicts positive treatment outcome in heterogeneous depressed patients completing an alternate milieu inpatient program

General Hospital Psychiatry

Volumn 37, Issue 6, 2015, Pages 601-605

  Jones, Brett D M ^a,d   Chopra, Kevin K ^a,b   Grummitt, Jessica ^a,d   Ravindran, Arun ^a,b,d   Matthews, Stephen G ^c   Levitan, Robert D ^a,b,c,d  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d Institute of Medical Science   (Canada)

Author keywords

Biomarker; Cortisol awakening response; Depression; Inpatient

Indexed keywords

HYDROCORTISONE; BIOLOGICAL MARKER;

ADULT; ALTERNATE MILIEU INPATIENT PROGRAM; AROUSAL; ARTICLE; CHRONIC DISEASE; CONVALESCENCE; CORTISOL AWAKENING RESPONSE; FEMALE; HORMONE RESPONSE; HOSPITAL PATIENT; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL HEALTH CARE; MILIEU THERAPY; PILOT STUDY; PREDICTION; PSYCHOLOGIC ASSESSMENT; SALIVA LEVEL; SCORING SYSTEM; TREATMENT DURATION; TREATMENT OUTCOME; CHEMISTRY; DEPRESSION; MIDDLE AGED; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; QUESTIONNAIRE; SALIVA; STATISTICAL MODEL; WAKEFULNESS;

ADULT; BIOMARKERS; DEPRESSION; FEMALE; HUMANS; HYDROCORTISONE; LINEAR MODELS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PREDICTIVE VALUE OF TESTS; SALIVA; SURVEYS AND QUESTIONNAIRES; WAKEFULNESS;

EID: 84946484043     PISSN: 01638343     EISSN: 18737714     Source Type: Journal    
DOI: 10.1016/j.genhosppsych.2015.06.006     Document Type: Article

References (19)

1. Adam E.K., Doane L.D., Zinbarg R.E., Mineka S., Craske M.G., Griffith J.W. Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence. Psychoneuroendocrinology 2010, 35(6):921-931.
2. Vreeburg S.A., Hoogendijk W.J.G., van Pelt J., Derijk R.H., Verhagen J.C.M., van Dyck R., et al. Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study. Arch Gen Psychiatry 2009, 66(6):617-626.
3. Vreeburg S.A., Hoogendijk W.J.G., DeRijk R.H., van Dyck R., Smit J.H., Zitman F.G., et al. Salivary cortisol levels and the 2-year course of depressive and anxiety disorders. Psychoneuroendocrinology 2013, 38:1494-1502.
4. Huber T.J., Issa K., Schik G., Wolf O.T. The cortisol awakening response is blunted in psychotherapy inpatients suffering from depression. Psychoneuroendocrinology 2006, 31(7):900-904.
5. Heim C., Ehlert U., Hellhammer D.H. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 2000, 25(1):1-35.
6. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998, 59(Suppl. 2):22-33.
7. Watson S., Gallagher P., Del-Estal D., Hearn A., Ferrier I.N., Young A.H. Hypothalamic-pituitary-adrenal axis function in patients with chronic depression. Psychol Med 2002, 32(6):1021-1028.
8. Chopra K.K., Ravindran A., Kennedy S.H., Mackenzie B., Matthews S., Anisman H., et al. Sex differences in hormonal responses to a social stressor in chronic major depression. Psychoneuroendocrinology 2009, 34(8):1235-1241.
9. Rush A.J., Trivedi M.H., Ibrahim H.M., Carmody T.J., Arnow B., Klein D.N., et al. The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry 2003, 54(5):573-583.
10. Pruessner J.C., Kirschbaum C., Meinlschmid G., Hellhammer D.H. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003, 28(7):916-931.
11. Okun M.L., Krafty R.T., Buysse D.J., Monk T.H., Reynolds C.F., Begley A., et al. What constitutes too long of a delay? Determining the cortisol awakening response (CAR) using self-report and PSG-assessed wake time. Psychoneuroendocrinology 2010, 35(3):460-468.
12. Booij S.H., Bouma E.M.C., de Jonge P., Ormel J., Oldehinkel A.J. Chronicity of depressive problems and the cortisol response to psychosocial stress in adolescents: the TRAILS study. Psychoneuroendocrinology 2013, 38(5):659-666.
13. ten Doesschate M.C., Bockting C.L.H., Koeter M.W.J., Schene A.H. Prediction of recurrence in recurrent depression: a 5.5-year prospective study. J Clin Psychiatry 2010, 71(8):984-991.
14. Fries E., Hesse J., Hellhammer J., Hellhammer D.H. A new view on hypocortisolism. Psychoneuroendocrinology 2005, 30(10):1010-1016.
15. Meinlschmidt G., Heim C. Decreased cortisol awakening response after early loss experience. Psychoneuroendocrinology 2005, 30(6):568-576.
16. O'Connor D.B., Hendrickx H., Dadd T., Elliman T.D., Willis T.A., Talbot D., et al. Cortisol awakening rise in middle-aged women in relation to psychological stress. Psychoneuroendocrinology 2009, 34(10):1486-1494.
17. Clow A., Hucklebridge F., Thorn L. The cortisol awakening response in context. Int Rev Neurobiol 2010, 93:153-175.
18. Gold P.W., Chrousos G.P. The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences. Proc Assoc Am Physicians 1999, 111(1):22-34.
19. Levitan R.D., Vaccarino F.J., Brown G.M., Kennedy S.H. Low-dose dexamethasone challenge in women with atypical major depression: pilot study. J Psychiatry Neurosci 2002, 27(1):47-51.