Human organotypic retinal cultures (HORCs) as a chronic experimental model for investigation of retinal ganglion cell degeneration

Experimental Eye Research

Volumn 143, Issue , 2016, Pages 28-38

  Osborne, Andrew ^a,b   Hopes, Marina ^a,c   Wright, Phillip ^a   Broadway, David C ^a,c   Sanderson, Julie ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Degeneration; Glaucoma; Human; Model; Retina; RGC

Indexed keywords

BETAIII TUBULIN; MESSENGER RNA; NEURON SPECIFIC NUCLEAR PROTEIN; THY 1 ANTIGEN; TUBULIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CELL NUCLEUS ANTIGEN; NERVE PROTEIN; TUBB3 PROTEIN, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; AUTOPSY; CELL CULTURE; CHRONIC DISEASE; DISSECTION; DONOR; EX VIVO STUDY; EXPERIMENTAL MODEL; EXPLANT; GENE EXPRESSION; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MARKER GENE; ORGANOTYPIC RETINAL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA DEGENERATION; RETINA GANGLION CELL; RETINAL GANGLION CELL DEGENERATION; TUNEL ASSAY; CELL DIFFERENTIATION; CELL SURVIVAL; GENETICS; INDIRECT FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; MIDDLE AGED; NERVE DEGENERATION; PATHOLOGY; THEORETICAL MODEL; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NUCLEAR; ANTIGENS, THY-1; APOPTOSIS; BIOMARKERS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IN SITU NICK-END LABELING; MIDDLE AGED; MODELS, THEORETICAL; NERVE DEGENERATION; NERVE TISSUE PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL GANGLION CELLS; RNA, MESSENGER; TISSUE DONORS; TUBULIN;

EID: 84946430825     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2015.09.012     Document Type: Article

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