Hybrid Collagenase Nanocapsules for Enhanced Nanocarrier Penetration in Tumoral Tissues

ACS Applied Materials and Interfaces

Volumn 7, Issue 43, 2015, Pages 24075-24081

  Villegas, María Rocío ^a,b   Baeza, Alejandro ^a,b   Vallet Regí, María ^a,b  

^a Universidad Complutense   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

collagenase nanocapsules; mesoporous silica nanodevices and hybrid nanocarriers; nanomedicine; tumoral tissue penetration

Indexed keywords

ENZYME ACTIVITY; ENZYME INHIBITION; ENZYMES; HISTOLOGY; MEDICAL NANOTECHNOLOGY; NANOCAPSULES; NANOPARTICLES; NANOSTRUCTURED MATERIALS; SILICA;

COLLAGENASE; EXTRACELLULAR MATRICES; HUMAN OSTEOSARCOMA CELLS; MESOPOROUS SILICA NANOPARTICLES; MILD ACIDIC CONDITIONS; NANO-DEVICES; THERAPEUTIC EFFICACY; TUMORAL TISSUE;

TISSUE;

COLLAGEN; COLLAGENASE; CROSS LINKING REAGENT; DRUG CARRIER; ENZYME; LACTATE DEHYDROGENASE; METAL NANOPARTICLE; NANOCAPSULE; NANOPARTICLE; POLYMER; SILICON DIOXIDE;

ANIMAL; BONE TUMOR; CELL SURVIVAL; CHEMISTRY; DRUG DELIVERY SYSTEM; EXTRACELLULAR MATRIX; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; NANOMEDICINE; NEOPLASM; OSTEOSARCOMA; PATHOLOGY; PH; PROCEDURES; RAT; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE;

ANIMALS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; COLLAGEN; COLLAGENASES; CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENZYMES; EXTRACELLULAR MATRIX; HUMANS; HYDROGEN-ION CONCENTRATION; L-LACTATE DEHYDROGENASE; METAL NANOPARTICLES; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; NANOCAPSULES; NANOMEDICINE; NANOPARTICLES; NEOPLASMS; OSTEOSARCOMA; POLYMERS; RATS; SILICON DIOXIDE;

EID: 84946423496     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b07116     Document Type: Article

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