Liver Metastasis from Colorectal Cancer in the Elderly: Is Surgery Justified?

Digestive Diseases and Sciences

Volumn 60, Issue 12, 2015, Pages 3525-3535

  Xie, Minghao ^a   Zhu, Jinling ^a   He, Xiaosheng ^a   Yang, Zihuan ^a   Chen, Xinlin ^b   Lan, Ping ^a   Lian, Lei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Colorectal cancer; Elderly; Liver metastasis; Liver resection

Indexed keywords

ABDOMINAL ABSCESS; BILE DUCT FISTULA; CANCER SURVIVAL; COCHRANE LIBRARY; COLORECTAL LIVER METASTASIS; DISEASE FREE SURVIVAL; EMBASE; HUMAN; LIVER FAILURE; LIVER HEMORRHAGE; LIVER RESECTION; MEDLINE; META ANALYSIS; MORTALITY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PLEURA EFFUSION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; WEB OF SCIENCE; AGE; AGED; COLORECTAL TUMOR; LIVER NEOPLASMS; PATHOLOGY; RISK FACTOR; SECONDARY; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; HUMANS; LIVER NEOPLASMS; RISK FACTORS;

EID: 84946423187     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-015-3789-3     Document Type: Review

References (50)

1. Etzioni DA, Beart RJ, Madoff RD, Ault GT. Impact of the aging population on the demand for colorectal procedures. Dis Colon Rectum. 2009;52:583–591.
2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11–30.
3. Su SY, Huang JY, Jian ZH, Ho CC, Lung CC, Liaw YP. Mortality of colorectal cancer in Taiwan, 1971–2010: temporal changes and age-period-cohort analysis. Int J Colorectal Dis. 2012;27:1665–1672.
4. Sung JJ, Lau JY, Young GP, et al. Asia Pacific consensus recommendations for colorectal cancer screening. Gut. 2008;57:1166–1176.
5. Institute, National Cancer. Surveillance, epidemiology and end results. http://seer.cancer.gov/statfacts/html/colorect.html.
6. Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239:818–827.
7. Weiss MJ, D’Angelica MI. Patient selection for hepatic resection for metastatic colorectal cancer. J Gastrointest Oncol. 2012;3:3–10.
8. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999;230:309–321.
9. Pasetto LM, Stefano T, Rossi E, Paris MK, Monfardini S. Treatment of stage IV colorectal carcinoma in elderly patients. Crit Rev Oncol Hematol. 2005;54:145–155.
10. Hutchins LF, Unger JM, Crowley JJ, Coltman CJ, Albain KS. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341:2061–2067.
11. Simmonds PC. Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis. Colorectal Cancer Collaborative Group. BMJ. 2000;321:531–535.
12. Adam R, Frilling A, Elias D, et al. Liver resection of colorectal metastases in elderly patients. Br J Surg. 2010;97:366–376.
13. Brand MI, Saclarides TJ, Dobson HD, Millikan KW. Liver resection for colorectal cancer: liver metastases in the aged. Am Surg. 2000;66:412–416.
14. Cannon RM, Martin RC, Callender GG, McMasters KM, Scoggins CR. Safety and efficacy of hepatectomy for colorectal metastases in the elderly. J Surg Oncol. 2011;104:804–808.
15. Figueras J, Ramos E, Lopez-Ben S, et al. Surgical treatment of liver metastases from colorectal carcinoma in elderly patients. When is it worthwhile? Clin Transl Oncol. 2007;9:392–400.
16. Kulik U, Framke T, Grosshennig A, et al. Liver resection of colorectal liver metastases in elderly patients. World J Surg. 2011;35:2063–2072.
17. Mann CD, Neal CP, Pattenden CJ, et al. Major resection of hepatic colorectal liver metastases in elderly patients—an aggressive approach is justified. Eur J Surg Oncol. 2008;34:428–432.
18. Mazzoni G, Tocchi A, Miccini M, et al. Surgical treatment of liver metastases from colorectal cancer in elderly patients. Int J Colorectal Dis. 2007;22:77–83.
19. Menon KV, Al-Mukhtar A, Aldouri A, Prasad RK, Lodge PA, Toogood GJ. Outcomes after major hepatectomy in elderly patients. J Am Coll Surg. 2006;203:677–683.
20. Nagano Y, Nojiri K, Matsuo K, et al. The impact of advanced age on hepatic resection of colorectal liver metastases. J Am Coll Surg. 2005;201:511–516.
21. Tamandl D, Gruenberger B, Herberger B, Kaczirek K, Gruenberger T. Surgery after neoadjuvant chemotherapy for colorectal liver metastases is safe and feasible in elderly patients. J Surg Oncol. 2009;100:364–371.
22. Nomi T, Fuks D, Kawaguchi Y, Mal F, Nakajima Y, Gayet B. Laparoscopic major hepatectomy for colorectal liver metastases in elderly patients: a single-center, case-matched study. Surg Endosc. 2014;29:1368–1375.
23. Di Benedetto F, Berretta M, D’Amico G, et al. Liver resection for colorectal metastases in older adults: a paired matched analysis. J Am Geriatr Soc. 2011;59:2282–2290.
24. Fong Y, Blumgart LH, Fortner JG, Brennan MF. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann Surg. 1995;222:426–437.
25. Zieren HU, Muller JM, Zieren J. Resection of colorectal liver metastases in old patients. Hepatogastroenterology. 1994;41:34–37.
26. Golfinopoulos V, Pentheroudakis G, Pavlidis N. Treatment of colorectal cancer in the elderly: a review of the literature. Cancer Treat Rev. 2006;32:1–8.
27. Kurian AA, Wang L, Grunkemeier G, Bhayani NH, Swanstrom LL. Defining “the elderly” undergoing major gastrointestinal resections: receiver operating characteristic analysis of a large ACS-NSQIP cohort. Ann Surg. 2013;258:483–489.
28. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17:2815–2834.
29. Nojiri K, Nagano Y, Tanaka K, et al. Validity of hepatic resection of colorectal liver metastases in the elderly (75 years and older). Anticancer Res. 2009;29:583–588.
30. Cook EJ, Welsh FK, Chandrakumaran K, John TG, Rees M. Resection of colorectal liver metastases in the elderly: does age matter? Colorectal Dis. 2012;14:1210–1216.
31. U.S. Bureau of the Census. Annual estimates of the resident population for selected age groups by sex for the United States. http://www.census.gov/popest/data/national/asrh/2012/index.html; 2012. Accessed October 20, 2013.
32. U.S. Bureau of the Census. Life expectancy—the 2012 statistical abstract. Available at: http://www.census.gov/compendia/statab/cats/births_deaths_marriages_divorces/life_expectancy.html. Accessed October 20, 2013.
33. Colorectal Cancer Collaborative Group. Surgery for colorectal cancer in elderly patients: a systematic review. Lancet. 2000;356:968–974.
34. Wetle T. Age as a risk factor for inadequate treatment. JAMA. 1987;258:516.
35. Manfredi S, Lepage C, Hatem C, Coatmeur O, Faivre J, Bouvier AM. Epidemiology and management of liver metastases from colorectal cancer. Ann Surg. 2006;244:254–259.
36. Cummings LC, Payes JD, Cooper GS. Survival after hepatic resection in metastatic colorectal cancer: a population-based study. Cancer. 2007;109:718–726.
37. Zacharias T, Jaeck D, Oussoultzoglou E, Bachellier P, Weber JC. First and repeat resection of colorectal liver metastases in elderly patients. Ann Surg. 2004;240:858–865.
38. Goldberg RM, Tabah-Fisch I, Bleiberg H, et al. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J Clin Oncol. 2006;24:4085–4091.
39. Folprecht G, Seymour MT, Saltz L, et al. Irinotecan/fluorouracil combination in first-line therapy of older and younger patients with metastatic colorectal cancer: combined analysis of 2,691 patients in randomized controlled trials. J Clin Oncol. 2008;26:1443–1451.
40. Van Cutsem E, Nordlinger B, Cervantes A. Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment. Ann Oncol. 2010;21:v93–v97.
41. Schrag D, Cramer LD, Bach PB, Begg CB. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst. 2001;93:850–857.
42. McNicol L, Story DA, Leslie K, et al. Postoperative complications and mortality in older patients having non-cardiac surgery at three Melbourne teaching hospitals. Med J Aust. 2007;186:447–452.
43. Matsumata T, Taketomi A, Kawahara N, Higashi H, Shirabe K, Takenaka K. Morbidity and mortality after hepatic resection in the modern era. Hepatogastroenterology. 1995;42:456–460.
44. Doci R, Gennari L, Bignami P, et al. Morbidity and mortality after hepatic resection of metastases from colorectal cancer. Br J Surg. 1995;82:377–381.
45. Sulpice L, Rayar M, Campillo B, et al. Advanced age remains an achilles heel for liver resections. World J Surg. 2014;38:918–926.
46. Mamidanna R, Almoudaris AM, Faiz O. Is 30-day mortality an appropriate measure of risk in elderly patients undergoing elective colorectal resection? Colorectal Dis. 2012;14:1175–1182.
47. Visser BC, Keegan H, Martin M, Wren SM. Death after colectomy: it’s later than we think. Arch Surg. 2009;144:1021–1027.
48. Gagner M, Franco D, Vons C, Smadja C, Rossi RL, Braasch JW. Analysis of morbidity and mortality rates in right hepatectomy with the preoperative APACHE II score. Surgery. 1991;110:487–492.
49. Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg. 2000;191:38–46.
50. Makary MA, Segev DL, Pronovost PJ, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010;210:901–908.