Analytical and functional determination of polymyxin b protein binding in serum

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 11, 2015, Pages 7121-7123

  Abodakpi, Henrietta ^a   Gohlke, Jie ^a,b   Chang, Kai Tai ^a   Chow, Diana S L ^a   Tam, Vincent H ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOLEUCINE; POLYMYXIN B; POLYMYXIN; POLYMYXIN B(1); POLYMYXIN B2; PROTEIN BINDING;

ACINETOBACTER BAUMANNII; ARTICLE; BACTERIAL GROWTH; COLONY FORMING UNIT; EQUILIBRIUM DIALYSIS; HUMAN; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION; ANALOGS AND DERIVATIVES; BLOOD; METABOLISM;

HUMANS; POLYMYXIN B; POLYMYXINS; PROTEIN BINDING;

EID: 84946218326     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01815-15     Document Type: Article

References (4)

1. Kwa AL, Lim TP, Low J.G., Hou J., Kurup A, Prince RA, Tam VH 2008. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis 60:163-167. http://dx.doi.org/10.1016/j.diagmicrobio.2007.08.008.
2. Sandri AM, Landersdorfer CB, Jacob J, Boniatti M.M., Dalarosa MG, Falci DR, Behle TF, Bordinhão RC, Wang J., Forrest A, Nation RL, Li J, Zavascki AP 2013. Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens. Clin Infect Dis 57:524-531. http://dx.doi.org/10.1093/cid/cit334.
3. Schmidt S, Gonzalez D, Derendorf H. 2010. Significance of protein binding in pharmacokinetics and pharmacodynamics. J Pharm Sci 99:1107-1122. http://dx.doi.org/10.1002/jps.21916.
4. He J, Gao S, Hu M., Chow DS, Tam VH. 2013. A validated ultraperformance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies. J Antimicrob Chemother 68:1104-1110. http://dx.doi.org/10.1093/jac/dks536.