Conditioned pain modulation

Current Opinion in Supportive and Palliative Care

Volumn 9, Issue 2, 2015, Pages 131-137

  Nir, Rony Reuven ^a   Yarnitsky, David ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

conditioned pain modulation; conditioning stimulus; diffuse noxious inhibitory controls; endogenous analgesia; test stimulus

Indexed keywords

ADVERSE EFFECTS; ANALGESIA; CONDITIONING; HEAT; HUMAN; NEUROPHARMACOLOGY; PAIN THRESHOLD; PERSONALIZED MEDICINE; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY;

ANALGESIA; CONDITIONING (PSYCHOLOGY); HOT TEMPERATURE; HUMANS; NEUROPHARMACOLOGY; PAIN MANAGEMENT; PAIN THRESHOLD; PRECISION MEDICINE;

EID: 84946169209     PISSN: 17514258     EISSN: 17514266     Source Type: Journal    
DOI: 10.1097/SPC.0000000000000126     Document Type: Review

References (48)

1. Yarnitsky D, Arendt-Nielsen L, Bouhassira D, et al. Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain 2010; 14:339.
2. Pud D, Granovsky Y, Yarnitsky D. The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans. Pain 2009; 144:16-19.
3. Le Bars D, Dickenson AH, Besson JM. Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain 1979; 6:283-304.
4. Le Bars D, Dickenson AH, Besson JM. Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on nonconvergent neurones, supraspinal involvement and theoretical implications. Pain 1979; 6:305-327.
5. Le Bars D, Willer J-C. Pain modulation triggered by high-intensity stimulation: implication for acupuncture analgesia? Int Congr Ser 2002; 1238:11-29.
6. Lewis GN, Rice DA, McNair PJ. Conditioned pain modulation in populations with chronic pain: a systematic review and meta-analysis. J Pain 2012; 13:936-944.
7. Ness TJ, Lloyd LK, Fillingim RB. An endogenous pain control system is altered in subjects with interstitial cystitis. J Urol 2014; 191:364-370.
8. Yarnitsky D, Crispel Y, Eisenberg E, et al. Prediction of chronic postoperative pain: preoperative DNIC testing identifies patients at risk. Pain 2008; 138:22-28.
9. Ram KC, Eisenberg E, Haddad M, Pud D. Oral opioid use alters DNIC but not cold pain perception in patients with chronic pain: new perspective of opioid induced hyperalgesia. Pain 2008; 139:431-438.
10. Edwards RR, Ness TJ, Weigent DA, Fillingim RB. Individual differences in diffuse noxious inhibitory controls (DNIC): association with clinical variables. Pain 2003; 106:427-437.
11. Nir RR, Granovsky Y, Yarnitsky D, et al. A psychophysical study of endogenous analgesia: the role of the conditioning pain in the induction and magnitude of conditioned pain modulation. Eur J Pain 2011; 15:491-497.
12. Granot M, Weissman-Fogel I, Crispel Y, et al. Determinants of endogenous analgesia magnitude in a diffuse noxious inhibitory control (DNIC) paradigm: do conditioning-stimulus painfulness, gender and personality variables matter? Pain 2008; 136:142-149.
13. Nir RR, Yarnitsky D, Honigman L, Granot M. Cognitive manipulation targeted at decreasing the conditioning pain perception reduces the efficacy of conditioned pain modulation. Pain 2012; 153:170-176.
14. Jurth C, Rehberg B, von Dincklage F. Reliability of subjective pain ratings and nociceptive flexion reflex responses as measures of conditioned pain modulation. Pain Res Manag 2014; 19:93-96.
15. Biurrun Manresa JA, Fritsche R, Vuilleumier PH, et al. Is the conditioned pain modulation paradigm reliable? A test-retest assessment using the nociceptive withdrawal reflex. PLoS One 2014; 9:e100241.
16. Lewis GN, Heales L, Rice DA, et al. Reliability of the conditioned pain modulation paradigm to assess endogenous inhibitory pain pathways. Pain Res Manag 2012; 17:98-102.
17. Arendt-Nielsen L, Andresen T, Malver LP, et al. A double-blind, placebocontrolled study on the effect of buprenorphine and fentanyl on descending pain modulation: a human experimental study. Clin J Pain 2012; 28:623-627.
18. Klyne DM, Schmid AB, Moseley LG, et al. Effect of types and anatomical arrangement of painful stimuli on conditioned pain modulation. J Pain 2015; 16:176-185.
19. Yarnitsky D, Bouhassira D, Drewes AM, et al. Recommendations on practice of conditioned pain modulation (CPM) testing. Eur J Pain 2014; Epub ahead of print. doi: 10.1002/ejp.605.
20. Haefeli J, Kramer JL, Blum J, Curt A. Heterotopic and homotopic nociceptive conditioning stimulation: distinct effects of pain modulation. Eur J Pain 2014; 18:1112-1119.
21. Oono Y, Wang K, Baad-Hansen L, et al. Conditioned pain modulation in temporomandibular disorders (TMD) pain patients. Exp Brain Res 2014; 232:3111-3119.
22. Chalaye P, Devoize L, Lafrenaye S, et al. Cardiovascular influences on conditioned pain modulation. Pain 2013; 154:1377-1382.
23. Chalaye P, Lafrenaye S, Goffaux P, Marchand S. The role of cardiovascular activity in fibromyalgia and conditioned pain modulation. Pain 2014; 155:1064-1069.
24. Piché M, Arsenault M, Rainville P. Cerebral and cerebrospinal processes underlying counterirritation analgesia. J Neurosci 2009; 29:14236-14246.
25. Sprenger C, Bingel U, Buchel C. Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation. Pain 2011; 152:428-439.
26. Gianaros PJ, Sheu LK. A review of neuroimaging studies of stressor-evoked blood pressure reactivity: emerging evidence for a brain-body pathway to coronary heart disease risk. Neuroimage 2009; 47:922-936.
27. Baba Y, Kohase H, Oono Y, et al. Effects of dexmedetomidine on conditioned pain modulation in humans. Eur J Pain 2012; 16:1137-1147.
28. Lindstedt F, Berrebi J, Greayer E, et al. Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. PLoS ONE 2011; 6:e18252.
29. Treister R, Pud D, Eisenberg E. The dopamine agonist apomorphine enhances conditioned pain modulation in healthy humans. Neurosci Lett 2013; 548:115-119.
30. Cloninger CR. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 1987; 44:573-588.
31. Nahman-Averbuch H, Yarnitsky D, Sprecher E, et al. Relationship between personality traits and endogenous analgesia: the role of harm avoidance. Pain Pract 2014; Epub ahead of print. doi: 10.1111/papr.12256.
32. Ziv M, Tomer R, Defrin R, Hendler T. Individual sensitivity to pain expectancy is related to differential activation of the hippocampus and amygdala. Hum Brain Mapp 2010; 31:326-338.
33. Geva N, Pruessner J, Defrin R. Acute psychosocial stress reduces pain modulation capabilities in healthy men. Pain 2014; 155:2418-2425.
34. Rea K, Olango WM, Okine BN, et al. Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyperresponsivity to noxious stimuli. Pain 2014; 155:69-79.
35. Bernaba M, Johnson KA, Kong JT, Mackey S. Conditioned pain modulation is minimally influenced by cognitive evaluation or imagery of the conditioningstimulus. J Pain Res 2014; 26:689-697.
36. Martini M, Lee MC, Valentini E, Iannetti GD. Intracortical modulation, and not spinal inhibition, mediates placebo analgesia. Eur J Neurosci 2014; Epub ahead of print. doi: 10.1111/ejn.12807.
37. Benarroch EE. Descending monoaminergic pain modulation: bidirectional control and clinical relevance. Neurology 2008; 71:217-221.
38. Lee MA, Walker RW, Hildreth TJ, Prentice WM. A survey of pain in idiopathic Parkinson's disease. J Pain Symptom Manage 2006; 32:462-469.
39. Wood PB1, Schweinhardt P, Jaeger E, et al. Fibromyalgia patients show an abnormal dopamine response to pain. Eur J Neurosci 2007; 25:3576-3582.
40. Piché M, Watanabe N, Sakata M, et al. Basal m-opioid receptor availability in the amygdala predicts the inhibition of pain-related brain activity during heterotopic noxious counter-stimulation. Neurosci Res 2014; 81-82:78-84.
41. Scott DJ, Stohler CS, Egnatuk CM, et al. Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch Gen Psychiatry 2008; 65:220-231.
42. Benedetti F, Amanzio M, Vighetti S, Asteggiano G. The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. J Neurosci 2006; 15:12014-12022.
43. Yarnitsky D, Granot M, Granovsky Y. Pain modulation profile and pain therapy: between pro-and antinociception. Pain 2014; 155:663-665.
44. Wilder-Smith OH, Schreyer T, Scheffer GJ, Arendt-Nielsen L. Patients with chronic pain after abdominal surgery show less preoperative endogenous pain inhibition and more postoperative hyperalgesia: a pilot study. J Pain Palliat Care Pharmacother 2010; 24:119-128.
45. Graven-Nielsen T, Wodehouse T, Langford RM, et al. Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum 2012; 64:2907-2916.
46. Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain 2000; 88:69-78.
47. Yarnitsky D, Granot M, Nahman-Averbuch H, et al. Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy. Pain 2012; 153:1193-1198.
48. Lavand'homme P, Roelants F. Effect of a low dose of ketamine on postoperative pain after elective Cesarean delivery according to the presence of a preoperative temporal summation. SOAP 2009; SOAP Abstract A-258.