The endocrine disruptor cadmium alters human osteoblast-like Saos-2 cells homeostasis in vitro by alteration of Wnt/β-catenin pathway and activation of caspases

Journal of Endocrinological Investigation

Volumn 38, Issue 12, 2015, Pages 1345-1356

  Papa, V ^a,b   Bimonte, V M ^a,b   Wannenes, F ^a,b   D'Abusco, A S ^c   Fittipaldi, S ^a,b   Scandurra, R ^c   Politi, L ^c   Crescioli, C ^a   Lenzi, A ^c   Di Luigi, L ^a   Migliaccio, S ^a  

^a UNIVERSITY OF ROME FORO ITALICO   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Cadmium; Differentiation; Osteoblasts

Indexed keywords

BETA CATENIN; CADMIUM; CASPASE; CASPASE 3; LIM PROTEIN; WNT PROTEIN; ENDOCRINE DISRUPTOR;

ACTIN FILAMENT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DESTRUCTION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; GENE; GENE TARGETING; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOBLAST; OSTEOSARCOMA CELL LINE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SAOS 2 CELL LINE; TUNEL ASSAY; DRUG EFFECTS; TUMOR CELL LINE; WNT SIGNALING PATHWAY;

ACTIN CYTOSKELETON; APOPTOSIS; CADMIUM; CELL DIFFERENTIATION; CELL LINE, TUMOR; ENDOCRINE DISRUPTORS; HOMEOSTASIS; HUMANS; IN VITRO TECHNIQUES; OSTEOBLASTS; WNT SIGNALING PATHWAY;

EID: 84946067923     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-015-0380-x     Document Type: Article

References (50)

1. Adams SV, Quraishi SM, Shafer MM, Passarelli MN, Freney EP, Chlebowski RT, Luo J, Meliker JR, Mu L, Neuhouser ML, Newcomb PA (2014) Dietary cadmium exposure and risk of breast, endometrial, and ovarian cancer in the Women's Health Initiative. Environ Health Perspect 122(6):594-600
2. Ponce E, Aquino NB, Louie MC (2013) Chronic cadmium exposure stimulates SDF-1 expression in an ERα dependent manner. PLoS One. 8(8): e72639. doi: 10.1371/journal.pone.0072639
3. Jiménez-Ortega V, Cano Barquilla P, Fernández-Mateos P, Cardinali DP, Esquifino AI (2012) Cadmium as an endocrine disruptor: correlation with anterior pituitary redox and circadian clock mechanisms and prevention by melatonin. Free Radic Biol Med. 53(12):2287-97. doi: 10.1016/j.freeradbiomed.2012.10.533
4. Ali I, Penttinen-Damdimopoulou PE, Mäkelä SI, Berglund M, Stenius U, Akesson A, Håkansson H, Halldin K (2010) Estrogen-like effects of cadmium in vivo do not appear to be mediated via the classical estrogen receptor transcriptional pathway. Environ Health Perspect.118(10):1389-94. doi: 10.1289/ehp.1001967
5. Järup L, Alfvén T (2004) Low level cadmium exposure, renal and bone effects the OSCAR study. Biometals 17:505-509
6. Kazantzis G (2004) Cadmium, osteoporosis and calcium metabolism. Biometals 17:493-498
7. Ayres RU (1992) Toxic heavy metals: materials cycle optimization. Proc Natl Acad Sci USA 89:815-820
8. Wang B, Du Y (2013) Cadmium and its neurotoxic effects. Oxid Med Cell. Longev 2013(2013):898034. doi: 10.1155/2013/898034
9. Thévenod F, Lee WK (2013) Cadmium and cellular signaling cascades: interactions between cell death and survival pathways. Arch Toxicol 87(10):1743-1786. doi: 10.1007/s00204-013-1110-9
10. Brama M, Gnessi L, Basciani S, Cerulli N, Politi L, Spera G et al (2007) Cadmium induces mitogenic signaling in breast cancer cell by an ERalpha-dependent mechanism. Mol Cell Endocrinol 264:102-108
11. Papa V, Wannenes F, Crescioli C, Caporossi D, Lenzi A, Migliaccio S et al (2014) The environmental pollutant cadmium induces homeostasis alteration in muscle cells in vitro. J Endocrinol Invest 37(11):1073-1080
12. Nordberg M (2004) Environmental exposure and preventive measures in Sweden and EU. Biometals 17:589-592
13. Jancic SA, Stosic BZ (2014) Cadmium effects on the thyroid gland. Vitam Horm 94:391-425
14. Brama M, Politi L, Santini P, Migliaccio S, Scandurra R (2012) Cadmium-induced apoptosis and necrosis in human osteoblasts: role of caspases and mitogen-activated protein kinases pathways. J Endocrinol Invest 35(2):198-208. doi: 10.3275/7801
15. Chen X, Zhu G, Gu S, Jin T, Shao C (2009) Effect of cadmium on osteoblasts and osteoclasts in vitro. Environ Toxicol Pharmacol 28:232-236
16. Kostenuik PJ (2005) Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength. Curr Opin Pharmacol 5:618-625
17. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176
18. Coonse KG, Coonts AJ, Morrison EV, Heggland SJ (2007) Cadmium induces apoptosis in the human osteoblast-like cell line Saos-2. J Toxicol Environ Health A 70:575-581
19. Robertson JD, Orrenius S (2000) Molecular mechanisms of apoptosis induced by cytotoxic chemicals. Crit Rev Toxicol 30:609-627
20. D'Sa-Eipper C, Leonard JR, Putcha G, Zheng TS, Flavell RA, Rakic P, Kuida K, Roth KA (2000) DNA damage-induced neural precursorcell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development 128:137-146
21. Ferri KF, Kroemer G (2001) Mitocondria the suicide organelles. BioEssays 23:111-115
22. Wang Z, Templeton DM (1996) Cellular factors mediate cadmium dependent actin depolymerisation. Toxicol Appl Pharmacol 139:115-121
23. Apostolava MD, Christova T, Templeton MD (2006) Involvement of Gelsolin in cadmium-induced distruption of the mesengial cell cytoskeleton. Toxicol Sci 89:465-474
24. Go YM, Orr M, Jones DP (2013) Actin cytoskeleton redox proteome oxidation by cadmium. Am J Physiol Lung Cell Mol Physiol 305:L831-L843. doi: 10.1152/ajplung.00203.2013
25. Akiyama K, Sutoo D, Reid DG (1990) A 1H-NMR comparison of calmodulin activation by calcium and by cadmium. J Pharmacol 53:393-401
26. Kadrmas JL, Beckerle MC (2004) The LIM domain: from the cytoskeleton to the nucleus. Nat Rev Mol Cell Biol 5:920-931
27. Siewit CL, Gengler B, Vegas E, Puckett R, Louie MC (2010) Cadmium promotes breast cancer cell proliferation by potentiating the interaction between ERα and c-Jun. Mol Endocrinol 24(5):981-992
28. Li J, Sejas DP, Burma S, Chen DJ, Pang Q (2007) Nucleophosmin suppresses oncogene induced apoptosis and and senescence and enhances oncogenic cooperation in cells with genomic instability. Carcinogenesis 28:1163-1170
29. Beyersmann D, Hechtenberg S (1997) Cadmium, gene regulation, and cellular signalling in mammalian cells. Toxicol Appl Pharmacol 144:247-261
30. Hartmann CA (2006) Wnt cannon orchestrating osteoblastogenesis. Trends Cell Biol 16:151-158
31. Li C, Shi X, Zhou G, Liu X, Wu S, Zhao J (2013) The canonical Wnt-β-catenin pathway in development and chemotherapy of osteosarcoma. Front Biosc 18:1384-1391
32. Tanimoto A, Hamada T, Koide O (1993) Cell death and regeneration of renal proximal tubular cells in rats with subchronic cadmium intoxication. Toxicol Pathol. 21:341-352
33. Brzoska MM, Rogalska J (2013) Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats. Toxicol App Pharmacol 272:208-220
34. Long CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781-810
35. Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192:95-117
36. -ΔΔCt method. Methods 25:402-408
37. Cantatore FP, Corrado A, Grano M, Quarta L, Colucci S, Melillo N (2004) Osteocalcin synthesis by human osteoblasts from normal and osteoarthritic bone after vitamin D3 stimulation. Clin Rheumatol 23:490-495
38. Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, Brun AM, Sapino A, Zhang F, Sharma D, Yang XH, Tora AD, Mehta K (2002) Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene 21:8843-8851
39. Templeton DM, Liu Y (2013) Effects of cadmium on the actin cytoskeleton in renal mesangial cells. Can J Physiol Pharmacol 91:1-7
40. Qiu J, Zhu G, Chen X, Shao C, Gu S (2012) Combined effects of γ-irradiation and cadmium exposures on osteoblasts in vitro. Environ Toxicol Pharmacol 33:149-157
41. Levesque M, Martineau C, Jumarie C, Moreau R (2008) Characterization of cadmium uptake and cytotoxicity in human osteoblast-like MG-63 cells. Toxicol Appl Pharmacol 231:308-317
42. Earnshaw WC, Martins LM, Kaufmann SH (1999) Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68:383-424
43. Riedl SJ, Shi Y (2004) Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 5:897-907
44. Liu Y, Templeton DM (2010) Role of the cytoskeleton in Cd2+-induced death of mouse mesangial cells. Can J Physiol Pharmacol 88:341-352
45. Martini FH, Timmons MJ (1997) Human Anatomy, 2nd edn. Prentice Hall, New Jersey, pp 25-48
46. Schneider N, Weber I, Faix J, Prassler J, Müller-Taubenberger A, Köhler J, Burghardt E, Gerisch G, Marriott G (2003) A Lim protein involved in the progression of cytokinesis and regulation of the mitotic spindle. Cell Motil Cytoskeleton 56:130-139
47. Pollard TD, Borisy GG (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112:453-465
48. Schmeichel KL, Beckerle MC (1994) The LIM domain is a modularprotein binding interface. Cell 79:211-219
49. Brun J, Dieudonné FX, Marty C, Müller J, Schüle R, Patiño-García A, Lecanda F, Fromigué O, Marie PJ (2013) FHL2 silencing reduces Wnt signaling and osteosarcoma tumorigenesis in vitro and in vivo. PLoS One. 8:e55034. doi: 10.1371
50. Chen X, Zhu G, Jin T, Zhou Z, Gu S, Qiu J, Xiao H (2012) Cadmium stimulates the osteoclastic differentiation of RAW264.7 cells in presence of osteoblasts. Biol Trace Elem Res 146:349-353