Behavioral and systemic consequences of long-term inflammatory challenge

Journal of Neuroimmunology

Volumn 288, Issue , 2015, Pages 40-46

  Fischer, Christina W ^a   Elfving, Betina ^a   Lund, Sten ^b   Wegener, Gregers ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cytokines; Depression like behavior; Lipopolysaccharide; Sickness behavior

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOKINE; ERYTHROPOIETIN; GAMMA INTERFERON; GLUCOSE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH REGULATED ONCOGENE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CELL ACTIVATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE RESPONSE; DEPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; ILLNESS BEHAVIOR; INSULIN RESISTANCE; MALE; MICROGLIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; ANIMAL; ANIMAL BEHAVIOR; BIOSYNTHESIS; BRAIN; CHRONIC DISEASE; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; METABOLISM; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CHRONIC DISEASE; CYTOKINES; DEPRESSION; DISEASE MODELS, ANIMAL; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84945553970     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2015.08.011     Document Type: Article

References (42)

1. Alexander C., Rietschel E.T. Bacterial lipopolysaccharides and innate immunity. J. Endotoxin Res. 2001, 7(3):167-202.
2. Benjamini Y., Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B Methodol. 1995, 57(1):289-300.
3. Berg B.M., Godbout J.P., Kelley K.W., Johnson R.W. Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice. Brain Behav. Immun. 2004, 18(2):149-157.
4. Biesmans S., Meert T.F., Bouwknecht J.A., Acton P.D., Davoodi N., De Haes P., et al. Systemic immune activation leads to neuroinflammation and sickness behavior in mice. Mediat. Inflamm. 2013, 2013:271359.
5. Bluthe R.M., Dantzer R., Kelley K.W. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res. 1992, 573(2):318-320.
6. Borges B.C., Rorato R., Antunes-Rodrigues J., Elias L.L. Glial cell activity is maintained during prolonged inflammatory challenge in rats. Braz. J. Med. Biol. Res. 2012, 45(8):784-791.
7. Brosnan J.T., Qian D. Endotoxin-induced increase in liver mass and hepatocyte volume. Biochem. Soc. Trans. 1994, 22(2):529-532.
8. Campbell B.M., Charych E., Lee A.W., Moller T. Kynurenines in CNS disease: regulation by inflammatory cytokines. Front. Neurosci. 2014, 8:12.
9. Cani P.D., Amar J., Iglesias M.A., Poggi M., Knauf C., Bastelica D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56(7):1761-1772.
10. Capuron L., Su S., Miller A.H., Bremner J.D., Goldberg J., Vogt G.J., et al. Depressive symptoms and metabolic syndrome: is inflammation the underlying link?. Biol. Psychiatry 2008, 64(10):896-900.
11. Cavaillon J.M., Adib-Conquy M. Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit. Care 2006, 10(5):233.
12. Chen R., Zhou H., Beltran J., Malellari L., Chang S.L. Differential expression of cytokines in the brain and serum during endotoxin tolerance. J. Neuroimmunol. 2005, 163(1-2):53-72.
13. Dantzer R., Bluthe R.M., Gheusi G., Cremona S., Laye S., Parnet P., et al. Molecular basis of sickness behavior. Ann. N. Y. Acad. Sci. 1998, 856:132-138.
14. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9(1):46-56.
15. D'Mello C., Swain M.G. Liver-brain interactions in inflammatory liver diseases: implications for fatigue and mood disorders. Brain Behav. Immun. 2014, 35:9-20.
16. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., et al. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67(5):446-457.
17. Eckel R.H., Grundy S.M., Zimmet P.Z. The metabolic syndrome. Lancet 2005, 365(9468):1415-1428.
18. Elgarf A.S., Aboul-Fotouh S., Abd-Alkhalek H.A., El Tabbal M., Hassan A.N., Kassim S.K., et al. Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. Pharmacol. Biochem. Behav. 2014, 126:152-162.
19. Engeland C.G., Kavaliers M., Ossenkopp K.P. Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats. Pharmacol. Biochem. Behav. 2003, 74(2):433-447.
20. Erickson M.A., Banks W.A. Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav. Immun. 2011, 25(8):1637-1648.
21. Fischer C.W., Madsen A.M., Muller H.K., Lund S., Wegener G. Chronic lipopolysaccharide (LPS) infusion fails to induce depressive-like behaviour in adult male rats. Acta Neuropsychiatr. 2015, 27(3):189-194.
22. Goshen I., Kreisel T., Ben-Menachem-Zidon O., Licht T., Weidenfeld J., Ben-Hur T., et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry 2008, 13(7):717-728.
23. Guillemin G.J., Smythe G., Takikawa O., Brew B.J. Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons. Glia 2005, 49(1):15-23.
24. Hagan P., Poole S., Bristow A.F. Endotoxin-stimulated production of rat hypothalamic interleukin-1 beta in vivo and in vitro, measured by specific immunoradiometric assay. J. Mol. Endocrinol. 1993, 11(1):31-36.
25. Hansen M.K., Nguyen K.T., Goehler L.E., Gaykema R.P., Fleshner M., Maier S.F., et al. Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats. Auton. Neurosci. 2000, 85(1-3):119-126.
26. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 1988, 12(2):123-137.
27. Hotamisligil G.S., Peraldi P., Budavari A., Ellis R., White M.F., Spiegelman B.M. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996, 271(5249):665-668.
28. Kawanokuchi J., Mizuno T., Takeuchi H., Kato H., Wang J., Mitsuma N., et al. Production of interferon-gamma by microglia. Mult. Scler. 2006, 12(5):558-564.
29. Kern P.A., Ranganathan S., Li C., Wood L., Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2001, 280(5):E745-E751.
30. Kubera M., Curzytek K., Duda W., Leskiewicz M., Basta-Kaim A., Budziszewska B., et al. A new animal model of (chronic) depression induced by repeated and intermittent lipopolysaccharide administration for 4months. Brain Behav. Immun. 2013, 31:96-104.
31. Liu Y., Ho R.C., Mak A. Interleukin (IL)-6, tumour necrosis factor alpha (TNF-alpha) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J. Affect. Disord. 2012, 139(3):230-239.
32. McCusker R.H., Kelley K.W. Immune-neural connections: how the immune system's response to infectious agents influences behavior. J. Exp. Biol. 2013, 216(Pt 1):84-98.
33. Meijer M.K., Spruijt B.M., van Zutphen L.F., Baumans V. Effect of restraint and injection methods on heart rate and body temperature in mice. Lab. Anim. 2006, 40(4):382-391.
34. O'Connor J.C., Andre C., Wang Y., Lawson M.A., Szegedi S.S., Lestage J., et al. Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. J. Neurosci. 2009, 29(13):4200-4209.
35. Pan Y., Chen X.Y., Zhang Q.Y., Kong L.D. Microglial NLRP3 inflammasome activation mediates IL-1beta-related inflammation in prefrontal cortex of depressive rats. Brain Behav. Immun. 2014, 41:90-100.
36. Puntener U., Booth S.G., Perry V.H., Teeling J.L. Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia. J. Neuroinflammation 2012, 9:146.
37. Rivest S., Lacroix S., Vallieres L., Nadeau S., Zhang J., Laflamme N. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc. Soc. Exp. Biol. Med. 2000, 223(1):22-38.
38. Smith B.J., Lerner M.R., Bu S.Y., Lucas E.A., Hanas J.S., Lightfoot S.A., et al. Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation. Bone 2006, 38(3):378-386.
39. Straub R.H., Cutolo M., Buttgereit F., Pongratz G. Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J. Intern. Med. 2010, 267(6):543-560.
40. Vitkovic L., Konsman J.P., Bockaert J., Dantzer R., Homburger V., Jacque C. Cytokine signals propagate through the brain. Mol. Psychiatry 2000, 5(6):604-615.
41. Wu K.L., Chan S.H., Chan J.Y. Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation. J. Neuroinflammation 2012, 9(1):212.
42. Yao J., Keri J.E., Taffs R.E., Colton C.A. Characterization of interleukin-1 production by microglia in culture. Brain Res. 1992, 591(1):88-93.