Fractional exhaled nitric oxide monitoring does not improve asthma management in children with concordant and discordant asthma phenotypes

American Journal of Respiratory and Critical Care Medicine

Volumn 192, Issue 8, 2015, Pages 1016-1018

  Voorend Van Bergen, Sandra ^a   Vaessen Verberne, Anja A ^b   Landstra, Anneke M ^c   Brackel, Hein J ^d   Van Den Berg, Norbert J ^e   Merkus, Peter J ^f   De Jongste, Johan C ^a   Pijnenburg, Marielle W ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b AMPHIA HOSPITAL   (Netherlands)

^c RIJNSTATE HOSPITAL   (Netherlands)

^d CATHARINA HOSPITAL   (Netherlands)

^e De Kinderkliniek   (Netherlands)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CORTICOSTEROID; NITRIC OXIDE; ANTIASTHMATIC AGENT;

ALLERGIC ASTHMA; ASTHMA; CHILD; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONCORDANT ASTHMA; DISCORDANT ASTHMA; DISEASE CONTROL; DISEASE COURSE; DISEASE EXACERBATION; DISEASE SEVERITY; EOSINOPHIL COUNT; FOLLOW UP; FRACTIONAL EXHALED NITRIC OXIDE; HEALTH CARE QUALITY; HUMAN; INFLAMMATION; LETTER; LUNG LAVAGE; ONSET AGE; PATIENT MONITORING; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATORY TRACT PARAMETERS; SCORING SYSTEM; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT PLANNING; TREATMENT RESPONSE; ADOLESCENT; BREATH ANALYSIS; CONTROLLED STUDY; DISEASE MANAGEMENT; EOSINOPHILIA; FEMALE; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; MALE; PATIENT CARE PLANNING; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ADOLESCENT; ADRENAL CORTEX HORMONES; ANTI-ASTHMATIC AGENTS; ASTHMA; BIOMARKERS; BREATH TESTS; CHILD; CHILD, PRESCHOOL; DISEASE MANAGEMENT; EOSINOPHILIA; FEMALE; HUMANS; INFLAMMATION; MALE; NITRIC OXIDE; PATIENT CARE PLANNING; PHENOTYPE; TREATMENT OUTCOME;

EID: 84945530074     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201506-1103LE     Document Type: Letter

References (10)

1. Petsky HL, Cates CJ, Lasserson TJ, Li AM, Turner C, Kynaston JA, Chang AB. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax 2012;67:199-208.
2. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008;178:218-224.
3. Voorend-van Bergen S, Vaessen-Verberne AA, Brackel HJ, Landstra AM, van den Berg NJ, Hop WC, de Jongste JC, Merkus PJ, Pijnenburg MW. Monitoring strategies in children with asthma: a randomised controlled trial. Thorax 2015;70:543-550.
4. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 2004; 113:59-65.
5. Voorend-van Bergen S, Vaessen-Verberne AA, Landstra AM, Brackel HJ, van den Berg NJ, Caudri D, de Jongste JC, Merkus PJ, Pijnenburg MW. Monitoring childhood asthma: web-based diaries and the asthma control test. J Allergy Clin Immunol 2014;133: 1599-605.e2.
6. Lex C, Ferreira F, Zacharasiewicz A, Nicholson AG, Haslam PL, Wilson NM, Hansel TT, Payne DN, Bush A. Airway eosinophilia in children with severe asthma: predictive values of noninvasive tests. Am J Respir Crit Care Med 2006;174:1286-1291.
7. Boulay ME, Boulet LP. Discordance between asthma control clinical, physiological and inflammatory parameters in mild asthma. Respir Med 2013;107:511-518.
8. Fleming L, Tsartsali L, Wilson N, Regamey N, Bush A. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax 2012;67:675-681.
9. Tibosch M, de Ridder J, Landstra A, Hugen C, Brouwer M, Gerrits P, van Gent R, Roukema J, Verhaak C, Merkus P. Four of a kind: asthma control, FEV1, FeNO, and psychosocial problems in adolescents. Pediatr Pulmonol 2012;47:933-940.
10. Waibel V, Ulmer H, Horak E. Assessing asthma control: symptom scores, GINA levels of asthma control, lung function, and exhaled nitric oxide. Pediatr Pulmonol 2012;47:113-118.