Platelet and not erythrocyte microparticles are procoagulant in transfused thalassaemia major patients

British Journal of Haematology

Volumn 171, Issue 4, 2015, Pages 615-624

  Agouti, Imane ^a   Cointe, Sylvie ^b,c   Robert, Stéphane ^b   Judicone, Coralie ^d   Loundou, Anderson ^e   Driss, Fathi ^f   Brisson, Alain ^g   Steschenko, Dominique ^h   Rose, Christian ⁱ   Pondarré, Corinne ^j   Bernit, Emmanuelle ^c   Badens, Catherine ^a   Dignat George, Françoise ^b,c   Lacroix, Romaric ^b,c   Thuret, Isabelle ^a  

^a TIMONE HOSPITAL   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c HÔPITAL DE LA CONCEPTION   (France)

^d Biocytex   (France)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE   (France)

^f BICHAT HOSPITAL   (France)

^g UNIVERSITÉ DE BORDEAUX   (France)

^h HÔPITAL D ENFANTS   (France)

ⁱ HÔPITAL SAINT VINCENT DE PAUL   (France)

^j Institut d'Hematologie et d'Oncologie Pediatrique   (France)

more..

Author keywords

Erythrocytes derived microparticles; Platelets derived microparticles; Splenectomy; thalassaemia major

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; LACTATE DEHYDROGENASE; TRANSFERRIN; AUTOANTIBODY; HEMOGLOBIN F; IRON; MEMBRANE LIPID; PHOSPHATIDYLSERINE;

ACUTE CORONARY SYNDROME; ADOLESCENT; AGE; ARTICLE; BLOOD CLOTTING TIME; BLOOD TRANSFUSION; CARDIOVASCULAR RISK; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DYSERYTHROPOIESIS; ERYTHROBLAST; ERYTHROCYTE COUNT; FEMALE; FERRITIN BLOOD LEVEL; HEMOLYSIS; HUMAN; MALE; MEMBRANE MICROPARTICLE; MULTICENTER STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; RETICULOCYTE COUNT; SPLENECTOMY; THALASSEMIA MAJOR; THROMBOCYTE COUNT; THROMBOEMBOLISM; ADULT; ADVERSE EFFECTS; BETA-THALASSEMIA; BLOOD; CLASSIFICATION; COMPLICATION; DIABETES MELLITUS; ERYTHROCYTE MEMBRANE; FLOW CYTOMETRY; HYPOGONADISM; IMMUNOLOGY; IRON OVERLOAD; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PHYSIOLOGY; RISK; THROMBOCYTE; THROMBOPHILIA; ULTRASTRUCTURE; YOUNG ADULT;

ADOLESCENT; ADULT; AUTOANTIBODIES; BETA-THALASSEMIA; BLOOD PLATELETS; BLOOD TRANSFUSION; CELL-DERIVED MICROPARTICLES; COMBINED MODALITY THERAPY; DIABETES MELLITUS; ERYTHROCYTE MEMBRANE; FEMALE; FETAL HEMOGLOBIN; FLOW CYTOMETRY; HUMANS; HYPOGONADISM; IRON; IRON OVERLOAD; MALE; MEMBRANE LIPIDS; MIDDLE AGED; OXIDATIVE STRESS; PHOSPHATIDYLSERINES; RISK; SPLENECTOMY; THROMBOPHILIA; YOUNG ADULT;

EID: 84945490653     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13609     Document Type: Article

References (41)

1. Adly, A.A., El-Sherif, N.H., Ismail, E.A., El-Zaher, Y.A., Farouk, A., El-Refaey, A.M. & Wahba, M.S. (2014) Vascular dysfunction in patients with young ß-Thalassemia: relation to cardiovascular complications and subclinical atherosclerosis. Clinical and Applied Thrombosis/Hemostasis, [Epub ahead of print] pii: 1076029614541515.
2. Atichartakarn, V., Chuncharunee, S., Chandanamattha, P., Likittanasombat, K. & Aryurachai, K. (2004) Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/beta-thalassemia patient. Blood, 103, 2844-2846.
3. Cao, A. & Galanello, R. (2010) Beta-thalassemia. Genetics in Medicine, 12, 61-76.
4. Cappellini, M.D., Robbiolo, L., Bottasso, B.M., Coppola, R., Fiorelli, G. & Mannucci, A.P. (2000) Venous thromboembolism and hypercoagulability in splenectomized patients with thalassaemia intermedia. British Journal of Haematology, 111, 467-473.
5. Cappellini, M.D., Cohen, A., Eleftheriou, A., Piga, A., Porter, J. & Taher, A. (2008) Guidelines for the Clinical Management of Thalassemia, 2nd edn. Thalassemia International Federation, Nicosia, Cyprus.
6. Chaichompoo, P., Kumya, P., Khowawisetsut, L., Chiangjong, W., Chaiyarit, S., Pongsakul, N., Sirithanaratanakul, N., Fucharoen, S., Thongboonkerd, V. & Pattanapanyasat, K. (2012) Characterizations and proteome analysis of platelet-free plasma-derived microparticles in β-thalassemia/hemoglobin E patients. Journal of Proteomics, 5, 239-250.
7. Chueamuangphan, N., Patumanond, J., Wongtheptien, W., Nawarawong, W., Sukonthasarn, A., Chuncharunee, S. & Tawichasri, C. (2014) Benefits of chronic blood transfusion in hemoglobin E/β thalassemia with pulmonary arterial hypertension. International Journal of General Medicine, 7, 411-416.
8. Crary, S. & Buchanan, G. (2009) Vascular complications after splenectomy for hematologic disorders. Blood, 114, 2861-2868.
9. De Franceschi, L., Bertoldi, M., Matte, A., Santos Franco, S., Pantaleo, A., Ferru, E. & Turrini, F. (2013) Oxidative stress and β-thalassemic erythroid cells behind the molecular defect. Oxidative Medicine and Cellular Longevity, 2013, 985210.
10. Duval, A., Helley, D., Capron, L., Youinou, P., Renaudineau, Y., Dubucquoi, S., Fischer, A.M. & Hachulla, E. (2010) Endothelial dysfunction in systemic lupus patients with low disease activity: evaluation by quantification and characterization of circulating endothelial microparticles, role of anti-endothelial cell antibodies. Rheumatology (Oxford), 49, 1049-1055.
11. Eldor, A. & Rachmilewitz, E.A. (2002) The hypercoagulable state in thalassemia. Blood, 99, 36-43.
12. Elsayh, K.I., Zahran, A.M., El-Abaseri, T.B., Mohamed, A.O. & El-Metwally, T.H. (2013) Hypoxia biomarkers, oxidative stress, and circulating microparticles in pediatric patients with thalassemia in upper Egypt. Clinical and Applied Thrombosis/Hemostasis, 20, 536-545.
13. Exner, T., Joseph, J.E., Low, J., Connor, D. & Ma, D.D. (2003) A new activated factor X-based clotting method with improved specificity for procoagulant phospholipid. Blood Coagulation & Fibrinolysis, 14, 773-779.
14. Frey, M.K., Alias, S., Winter, M.P., Redwan, B., Stübiger, G., Panzenboeck, A., Alimohammadi, A., Bonderman, D., Jakowitsch, J., Bergmeister, H., Bochkov, V., Preissner, K.T. & Lang, I.M. (2014) Splenectomy is modifying the vascular remodeling of thrombosis. Journal of the American Heart Association, 3, e000772.
15. Habib, A., Kunzelmann, C., Shamseddeen, W., Zobairi, F., Freyssinet, J.M. & Taher, A. (2008) Elevated levels of circulating procoagulant microparticles in patients with beta-thalassemia intermedia. Haematologica, 93, 941-942.
16. Haute Autorité de santé. (2008) Syndromes thalassémiques majeurs et intermédiaires. Protocole national de diagnostic et de soins pour une maladie rare, HAS. http://www.has-sante.fr/portail/jcms/c_680242/fr/ald-n-10-syndromes-thalassemiques-majeurs-et-intermediaires.
17. Kuypers, F.A. & de Jong, K. (2004) The role of phosphatidylserine in recognition and removal of erythrocytes. Cellular and Molecular Biology, 50, 147-158.
18. Lacroix, R., Robert, S., Poncelet, P. & Dignat-George, F. (2010) Overcoming limitations of microparticle measurement by flow cytometry. Seminars in Thrombosis and Hemostasis, 36, 807-818.
19. Lacroix, R., Judicone, C., Mooberry, M., Boucekine, M., Key, N.S. & Dignat-George, F. & on behalf of the ISTH SSC Workshop. (2013) Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. Journal of Thrombosis and Haemostasis, 11, 1190-1193.
20. Lacroix, R., Robert ., S., Sabatier, F. & Dignat-George, F. (2014) Flow cytometry. In: Extracellular Vesicles in Health and Disease (eds. by P. Harrison, C. Gardiner & I. Sargent ), pp. 201-222. Pan Stanford Publishing, Singapore.
21. Lee, R.D., Barcel, D.A., Williams, J.C., Wang, J.G., Boles, J.C., Manly, D.A., Key, N.S. & Mackman, N. (2012) Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity. Thrombosis Research, 129, 80-85.
22. Mannu, F., Arese, P., Cappellini, M.D., Fiorelli, G., Cappadoro, M., Giribaldi, G. & Turrini, F. (1995) Role of hemichrome binding to erythrocyte membrane in the generation of band-3 alterations in beta-thalassemia intermedia erythrocytes. Blood, 86, 2014-2020.
23. Mannucci, P.M. (2010) Red cells playing as activated platelets in thalassemia intermedia. Journal of Thrombosis and Haemostasis, 8, 2149-2151.
24. Owens, A.P. 3rd & Mackman, N. (2011) Microparticles in hemostasis and thrombosis. Circulation Research, 108, 1284-1297.
25. Pattanapanyasat, K., Noulsri, E., Fucharoen, S., Lerdwana, S., Lamchiagdhase, P., Siritanaratkul, N. & Webster, H.K. (2004) Flow cytometric quantitation of red blood cell vesicles in thalassemia. Cytometry Part B: Clinical Cytometry, 57, 23-31.
26. Pattanapanyasat, K., Gonwong, S., Chaichompoo, P., Noulsri, E., Lerdwana, S., Sukapirom, K., Siritanaratkul, N. & Fucharoen, S. (2007) Activated platelet-derived microparticles in thalassaemia. British Journal of Haematology, 136, 462-471.
27. Piccin, A., Murphy, W.G. & Smith, O.P. (2007) Circulating microparticles: pathophysiology and clinical implications. Blood Reviews, 21, 157-171.
28. Prezelj, M. & Knap, B. (2010) Automated assay for non-transferrin-bound iron in serum samples. Clinical Chemistry and Laboratory Medicine, 48, 1427-1432.
29. Robert, S., Lacroix, R., Poncelet, P., Harhouri, K., Bouriche, T., Judicone, C., Wischhusen, J., Arnaud, L. & Dignat-George, F. (2012) High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles-brief report. Arteriosclerosis, Thrombosis, and Vascular Biology, 32, 1054-1058.
30. Rodeghiero, F. & Ruggeri, M. (2012) Short- and long-term risks of splenectomy for benign haematological disorders: should we revisit the indications? British Journal of Haematology, 158, 16-29.
31. Schrier, S.L. & Mohandas, N. (1992) Globin-chain specificity of oxidation-induced changes in red blood cell membrane properties. Blood, 79, 1586-1592.
32. Sirachainan, N. (2013) Thalassemia and the hypercoagulable state. Thrombosis Research, 132, 637-641.
33. Succar, J., Musallam, K.M. & Taher, A.T. (2011) Thalassemia and venous thromboembolism. Mediterranean Journal of Hematology and Infectious Diseases, 3, e2011025.
34. Taher, A., Isma'eel, H., Mehio, G., Bignamini, D., Kattamis, A., Rachmilewitz, E.A. & Cappellini, M.D. (2006) Prevalence of thromboembolic events among 8, 860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. Thrombosis and Haemostasis, 96, 488-491.
35. Taher, A.T., Musallam, K.M., Karimi, M., El-Beshlawy, A., Belhoul, K., Daar, S., Saned, M., Cesaretti, C. & Cappellini, M.D. (2010a) Splenectomy and thrombosis: the case of thalassemia intermedia. Journal of Thrombosis and Haemostasis, 8, 2152-2158.
36. Taher, A.T., Musallam, K.M., Karimi, M., El-Beshlawy, A., Belhoul, K., Daar, S., Saned, M.S., El-Chafic, A.H., Fasulo, M.R. & Cappellini, M.D. (2010b) Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the Optimal Care study. Blood, 115, 1886-1892.
37. Tantawy, A.A., Adly, A.A., Ismail, E.A. & Habeeb, N.M. (2013) Flow cytometric assessment of circulating platelet and erythrocytes microparticles in young thalassemia major patients: relation to pulmonary hypertension and aortic wall stiffness. European Journal of Haematology, 90, 508-518.
38. Weatherall, D.J. & Clegg, J.B. (2001) The Thalassaemia Syndromes, 4th edn. Blackwell Science, Oxford, UK.
39. Westerman, M., Pizzey, A., Hirschman, J., Cerino, M., Weil-Weiner, Y., Ramotar, P., Eze, A., Lawrie, A., Purdy, G., Mackie, I. & Porter, J. (2008) Microvesicles in haemoglobinopathies offer insights into mechanisms of hypercoagulability, haemolysis and the effects of therapy. British Journal of Haematology, 142, 126-135.
40. Witko-Sarsat, V., Friedlander, M., Capeillère-Blandin, C., Nguyen-Khoa, T., Nguyen, A.T., Zingraff, J., Jungers, P. & Descamps-Latscha, B. (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney International, 49, 1304-1313.
41. Zwaal, R.F. & Schroit, A.J. (1997) Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood, 89, 1121-1132.