Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 19, 2015, Pages 4097-4103

  Chapman, Timothy M ^a   Gillen, Kevin J ^a   Wallace, Claire ^a   Lee, Maximillian T ^a   Bakrania, Preeti ^a   Khurana, Puneet ^a   Coombs, Peter J ^a   Stennett, Laura ^a   Fox, Simon ^a   Bureau, Emilie A ^a   Brownlees, Janet ^a   Melton, David W ^b   Saxty, Barbara ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

3 Hydroxypyridone; Catechol; Cisplatin potentiation; DNA repair; ERCC1 XPF

Indexed keywords

3 HYDROXYPYRIDONE DERIVATIVE; CATECHOL DERIVATIVE; CISPLATIN; DEOXYRIBONUCLEASE I; DNA BINDING PROTEIN; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; HISTONE H2AX; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP F PROTEIN; ENDONUCLEASE; ERCC1 PROTEIN, HUMAN; FEN1 PROTEIN, HUMAN; FLAP ENDONUCLEASE;

ARTICLE; DNA REPAIR; DRUG POTENCY; EXCISION REPAIR; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; MELANOMA; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; TUMOR CELL LINE;

CATECHOLS; CELL LINE, TUMOR; DEOXYRIBONUCLEASE I; DNA REPAIR; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDONUCLEASES; FLAP ENDONUCLEASES; HUMANS; MOLECULAR STRUCTURE; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84945480180     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.08.031     Document Type: Article

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