메뉴 건너뛰기




Volumn 79, Issue 3, 2015, Pages 268-278

Mice overexpressing integrin αv in fibroblasts exhibit dermal thinning of the skin

Author keywords

Integrin v; MMP 1; Transgenic mice

Indexed keywords

BETA3 INTEGRIN; CD51 ANTIGEN; COL1A2 PROTEIN; COL3A1 PROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; FOCAL ADHESION KINASE; INTERSTITIAL COLLAGENASE; UNCLASSIFIED DRUG; ALPHA 2(I) COLLAGEN; ALPHA5 INTEGRIN; COL3A1 PROTEIN, MOUSE; CTGF PROTEIN, MOUSE; FOCAL ADHESION KINASE 1; MESSENGER RNA; PTK2 PROTEIN, MOUSE; SMALL INTERFERING RNA;

EID: 84945478464     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2015.06.008     Document Type: Article
Times cited : (6)

References (24)
  • 1
    • 77957654444 scopus 로고    scopus 로고
    • Integrin αv is necessary for gastrulation movements that regulate vertebrate body asymmetry
    • Ablooglu A.J., Tkachenko E., Kang J., Shattil S.J. Integrin αv is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development 2010, 137:3449-3458.
    • (2010) Development , vol.137 , pp. 3449-3458
    • Ablooglu, A.J.1    Tkachenko, E.2    Kang, J.3    Shattil, S.J.4
  • 2
    • 0024323330 scopus 로고
    • A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor β the answer?
    • LeRoy E.C., Smith E.A., Kahaleh M.B., Trojanowska M., Silver R.M. A strategy for determining the pathogenesis of systemic sclerosis. Is transforming growth factor β the answer?. Arthritis Rheum. 1989, 32:817-825.
    • (1989) Arthritis Rheum. , vol.32 , pp. 817-825
    • LeRoy, E.C.1    Smith, E.A.2    Kahaleh, M.B.3    Trojanowska, M.4    Silver, R.M.5
  • 3
    • 0016302998 scopus 로고
    • Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast
    • LeRoy E.C. Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast. J. Clin. Invest. 1974, 54:880-889.
    • (1974) J. Clin. Invest. , vol.54 , pp. 880-889
    • LeRoy, E.C.1
  • 4
    • 0022493764 scopus 로고
    • Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts
    • Jimenez S.A., Feldman G., Bashey R.I., Bienkowski R., Rosenbloom J. Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts. Biochem. J. 1986, 237:837-843.
    • (1986) Biochem. J. , vol.237 , pp. 837-843
    • Jimenez, S.A.1    Feldman, G.2    Bashey, R.I.3    Bienkowski, R.4    Rosenbloom, J.5
  • 5
    • 0026666859 scopus 로고
    • Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF β1 stimulation
    • Kikuchi K., Hartl C.W., Smith E.A., LeRoy E.C., Trojanowska M. Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: insensitivity to TGF β1 stimulation. Biochem. Biophys. Res. Commun. 1992, 187:45-50.
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 45-50
    • Kikuchi, K.1    Hartl, C.W.2    Smith, E.A.3    LeRoy, E.C.4    Trojanowska, M.5
  • 6
    • 0036448477 scopus 로고    scopus 로고
    • The role of TGF-β signaling in the pathogenesis of fibrosis in scleroderma
    • Ihn H. The role of TGF-β signaling in the pathogenesis of fibrosis in scleroderma. Arch. Immunol. Ther. Exp. 2002, 50:325-331.
    • (2002) Arch. Immunol. Ther. Exp. , vol.50 , pp. 325-331
    • Ihn, H.1
  • 7
    • 33144458448 scopus 로고    scopus 로고
    • Increased expression of integrin αvβ5 induces the myofibroblastic differentiation of dermal fibroblasts
    • Asano Y., Ihn H., Yamane K., Jinnin M., Tamaki K. Increased expression of integrin αvβ5 induces the myofibroblastic differentiation of dermal fibroblasts. Am. J. Pathol. 2006, 168:499-510.
    • (2006) Am. J. Pathol. , vol.168 , pp. 499-510
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Tamaki, K.5
  • 8
    • 0035089825 scopus 로고    scopus 로고
    • Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor β receptors
    • Ihn H., Yamane K., Kubo M., Tamaki K. Blockade of endogenous transforming growth factor β signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor β receptors. Arthritis Rheum. 2001, 44:474-480.
    • (2001) Arthritis Rheum. , vol.44 , pp. 474-480
    • Ihn, H.1    Yamane, K.2    Kubo, M.3    Tamaki, K.4
  • 9
    • 25444501226 scopus 로고    scopus 로고
    • Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor &βetα1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts
    • Asano Y., Ihn H., Yamane K., Jinnin M., Mimura Y., Tamaki K. Involvement of αvβ5 integrin-mediated activation of latent transforming growth factor &βetα1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts. Arthritis Rheum. 2005, 52:2897-2905.
    • (2005) Arthritis Rheum. , vol.52 , pp. 2897-2905
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 10
    • 28244449083 scopus 로고    scopus 로고
    • Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-&βetα signaling in scleroderma fibroblasts
    • Asano Y., Ihn H., Yamane K., Jinnin M., Mimura Y., Tamaki K. Increased expression of integrin αvβ3 contributes to the establishment of autocrine TGF-&βetα signaling in scleroderma fibroblasts. J. Immunol. 2005, 175:7708-7718.
    • (2005) J. Immunol. , vol.175 , pp. 7708-7718
    • Asano, Y.1    Ihn, H.2    Yamane, K.3    Jinnin, M.4    Mimura, Y.5    Tamaki, K.6
  • 11
    • 73449115656 scopus 로고    scopus 로고
    • Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis
    • Maurer B., Busch N., Jüngel A., Pileckyte M., Gay R.E., Michel B.A., et al. Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. Circulation 2009, 120:2367-2376.
    • (2009) Circulation , vol.120 , pp. 2367-2376
    • Maurer, B.1    Busch, N.2    Jüngel, A.3    Pileckyte, M.4    Gay, R.E.5    Michel, B.A.6
  • 12
    • 70349422126 scopus 로고    scopus 로고
    • Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice
    • Higashiyama R., Moro T., Nakao S., Mikami K., Fukumitsu H., Ueda Y., et al. Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology 2009, 137:1459-1466.e1.
    • (2009) Gastroenterology , vol.137 , pp. 1459-1466.e1
    • Higashiyama, R.1    Moro, T.2    Nakao, S.3    Mikami, K.4    Fukumitsu, H.5    Ueda, Y.6
  • 16
    • 78649819162 scopus 로고    scopus 로고
    • αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice
    • Acharya M., Mukhopadhyay S., Païdassi H., Jamil T., Chow C., Kissler S., et al. αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. J. Clin. Invest. 2010, 120:4445-4452.
    • (2010) J. Clin. Invest. , vol.120 , pp. 4445-4452
    • Acharya, M.1    Mukhopadhyay, S.2    Païdassi, H.3    Jamil, T.4    Chow, C.5    Kissler, S.6
  • 17
    • 84889886646 scopus 로고    scopus 로고
    • Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
    • Henderson N.C., Arnold T.D., Katamura Y., Giacomini M.M., Rodriguez J.D., McCarty J.H., et al. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat. Med. 2013, 19:1617-1624.
    • (2013) Nat. Med. , vol.19 , pp. 1617-1624
    • Henderson, N.C.1    Arnold, T.D.2    Katamura, Y.3    Giacomini, M.M.4    Rodriguez, J.D.5    McCarty, J.H.6
  • 18
    • 0037791886 scopus 로고    scopus 로고
    • SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength
    • Bradshaw A.D., Puolakkainen P., Dasgupta J., Davidson J.M., Wight T.N., Helene Sage E. SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J. Invest. Dermatol. 2003, 120:949-955.
    • (2003) J. Invest. Dermatol. , vol.120 , pp. 949-955
    • Bradshaw, A.D.1    Puolakkainen, P.2    Dasgupta, J.3    Davidson, J.M.4    Wight, T.N.5    Helene Sage, E.6
  • 19
    • 33748948208 scopus 로고    scopus 로고
    • δNp63α overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse
    • Sommer M., Poliak N., Upadhyay S., Ratovitski E., Nelkin B.D., Donehower L.A., et al. δNp63α overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle 2006, 5:2005-2011.
    • (2006) Cell Cycle , vol.5 , pp. 2005-2011
    • Sommer, M.1    Poliak, N.2    Upadhyay, S.3    Ratovitski, E.4    Nelkin, B.D.5    Donehower, L.A.6
  • 20
    • 84875210345 scopus 로고    scopus 로고
    • Integrin β1 is required for dermal homeostasis
    • Liu S., Leask A. Integrin β1 is required for dermal homeostasis. J. Invest. Dermatol. 2013, 133:899-906.
    • (2013) J. Invest. Dermatol. , vol.133 , pp. 899-906
    • Liu, S.1    Leask, A.2
  • 21
    • 37349022878 scopus 로고    scopus 로고
    • Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice
    • Clemente C.F., Tornatore T.F., Theizen T.H., Deckmann A.C., Pereira T.C., Lopes-Cendes I., et al. Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice. Circ. Res. 2007, 101:1339-1348.
    • (2007) Circ. Res. , vol.101 , pp. 1339-1348
    • Clemente, C.F.1    Tornatore, T.F.2    Theizen, T.H.3    Deckmann, A.C.4    Pereira, T.C.5    Lopes-Cendes, I.6
  • 22
    • 84869887422 scopus 로고    scopus 로고
    • Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts
    • Yoon J.H., Kim J., Lee H., Kim S.Y., Jang H.H., Ryu S.H., et al. Laminin peptide YIGSR induces collagen synthesis in Hs27 human dermal fibroblasts. Biochem. Biophys. Res. Commun. 2012, 428:416-421.
    • (2012) Biochem. Biophys. Res. Commun. , vol.428 , pp. 416-421
    • Yoon, J.H.1    Kim, J.2    Lee, H.3    Kim, S.Y.4    Jang, H.H.5    Ryu, S.H.6
  • 23
    • 0029816069 scopus 로고    scopus 로고
    • Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
    • Frazier K., Williams S., Kothapalli D., Klapper H., Grotendorst G.R. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J. Invest. Dermatol. 1996, 107:404-411.
    • (1996) J. Invest. Dermatol. , vol.107 , pp. 404-411
    • Frazier, K.1    Williams, S.2    Kothapalli, D.3    Klapper, H.4    Grotendorst, G.R.5
  • 24
    • 3342948366 scopus 로고    scopus 로고
    • αv integrin prolongs collagenase production through Jun activation binding protein 1
    • Levinson H., Sil A.K., Conwell J.E., Hopper J.E., Ehrlich H.P. αv integrin prolongs collagenase production through Jun activation binding protein 1. Ann. Plast. Surg. 2004, 53:155-161.
    • (2004) Ann. Plast. Surg. , vol.53 , pp. 155-161
    • Levinson, H.1    Sil, A.K.2    Conwell, J.E.3    Hopper, J.E.4    Ehrlich, H.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.