Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model

Experimental Neurology

Volumn 272, Issue , 2015, Pages 152-159

  Charles, Mélissa S ^a   Drunalini Perera, Pradilka N ^a   Doycheva, Desislava Met ^a   Tang, Jiping ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenal cortical cells; Cholera toxin; Corticosterone; Granulocyte colony stimulating factor; Hypothalamic pituitary adrenal axis; Hypoxia ischemia; JAK2; PDE; Y1

Indexed keywords

CHOLERA TOXIN; CORTICOSTERONE; CYCLIC AMP; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; JANUS KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHODIESTERASE III; PROTEIN PDE3B; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG; ENZYME INHIBITOR; JAK2 PROTEIN, RAT; PDE3B PROTEIN, RAT;

ADRENAL CORTEX CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HORMONE INHIBITION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IN VITRO STUDY; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; WESTERN BLOTTING; ANIMAL; BODY WEIGHT; BRAIN INFARCTION; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; HYPOXIA-ISCHEMIA, BRAIN; METABOLISM; NERVE DEGENERATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; BRAIN INFARCTION; CELL LINE; CELL SURVIVAL; CHOLERA TOXIN; CORTICOSTERONE; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ENZYME INHIBITORS; GRANULOCYTE COLONY-STIMULATING FACTOR; HYPOXIA-ISCHEMIA, BRAIN; JANUS KINASE 2; NERVE DEGENERATION; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84945472475     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.03.019     Document Type: Article

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