Impact of tamoxifen on adipocyte lineage tracing: Inducer of adipogenesis and prolonged nuclear translocation of Cre recombinase

Molecular Metabolism

Volumn 4, Issue 11, 2015, Pages 771-778

  Ye, Risheng ^a   Wang, Qiong A ^a   Tao, Caroline ^a   Vishvanath, Lavanya ^a   Shao, Mengle ^a   McDonald, Jeffery G ^a   Gupta, Rana K ^a   Scherer, Philipp E ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adipose tissue; Cre recombinase; Lineage tracing; Tamoxifen

Indexed keywords

CRE RECOMBINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TAMOXIFEN;

ADIPOCYTE; ADIPOGENESIS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INFILTRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CONCENTRATION; DRUG EXPOSURE; EPIDIDYMAL WHITE ADIPOSE TISSUE; FAT MASS; GENE INACTIVATION; GENETIC RECOMBINATION; LINEAGE TRACING; LIPOATROPHY; LOSS OF FUNCTION MUTATION; MALE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; PROTEIN LOCALIZATION; SUBCUTANEOUS WHITE ADIPOSE TISSUE; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

EID: 84945456543     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2015.08.004     Document Type: Article

References (27)

1. Kretzschmar K., Watt Fiona M. Lineage tracing. Cell 2012, 148(1-2):33-45.
2. Deroo B.J., Korach K.S. Estrogen receptors and human disease. The Journal of Clinical Investigation 2006, 116(3):561-570.
3. Feil R., Brocard J., Mascrez B., LeMeur M., Metzger D., Chambon P. Ligand-activated site-specific recombination in mice. Proceedings of the National Academy of Sciences 1996, 93(20):10887-10890.
4. Feil S., Valtcheva N., Feil R. Inducible Cre mice. Gene knockout protocols 2009, 343-363. Humana Press. W. Wurst, R. Kühn (Eds.).
5. Reinert R.B., Kantz J., Misfeldt A.A., Poffenberger G., Gannon M., Brissova M., et al. Tamoxifen-induced Cre-loxP recombination is prolonged in pancreatic islets of adult mice. PLoS One 2012, 7(3):e33529.
6. Mauvais-Jarvis F., Clegg D.J., Hevener A.L. The role of estrogens in control of energy balance and glucose homeostasis. Endocrine Reviews 2013, 34(3):309-338.
7. Pallottini V., Bulzomi P., Galluzzo P., Martini C., Marino M. Estrogen regulation of adipose tissue functions: involvement of estrogen receptor isoforms. Infectious Disorders Drug Targets 2008, 8(1):52-60.
8. Heine P.A., Taylor J.A., Iwamoto G.A., Lubahn D.B., Cooke P.S. Increased adipose tissue in male and female estrogen receptor-α knockout mice. Proceedings of the National Academy of Sciences 2000, 97(23):12729-12734.
9. Davis K.E., Neinast D.M., Sun K., Skiles W.M., Bills D.J., Zehr J.A., et al. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Molecular Metabolism 2013, 2(3):227-242.
10. Wang Q.A., Tao C., Gupta R.K., Scherer P.E. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nature Medicine 2013, 19(10):1338-1344.
11. Lee Y.-H., Petkova A.P., Konkar A.A., Granneman J.G. Cellular origins of cold-induced brown adipocytes in adult mice. The FASEB Journal 2015, 29(1):286-299.
12. Perl A.-K.T., Wert S.E., Nagy A., Lobe C.G., Whitsett J.A. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proceedings of the National Academy of Sciences 2002, 99(16):10482-10487.
13. He W., Barak Y., Hevener A., Olson P., Liao D., Le J., et al. Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. PNAS 2003, 100(26):15712-15717.
14. Sassmann A., Offermanns S., Wettschureck N. Tamoxifen-inducible Cre-mediated recombination in adipocytes. Genesis 2010, 48(10):618-625.
15. Muzumdar M.D., Tasic B., Miyamichi K., Li L., Luo L. A global double-fluorescent Cre reporter mouse. Genesis 2007, 45(9):593-605.
16. Sun K., Asterholm I.W., Kusminski C.M., Bueno A.C., Wang Z.V., Pollard J.W., et al. Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proceedings of the National Academy of Sciences 2012, 109(15):5874-5879.
17. Ye R., Holland W.L., Gordillo R., Wang M., Wang Q.A., Shao M., et al. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. eLife 2014, 3:e03851.
18. Wang Q.A., Tao C., Jiang L., Shao M., Ye R., Zhu Y., et al. Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation. Nature Cell Biology 2015, 17(9):1099-1111.
19. Teunissen S.F., Jager N.G.L., Rosing H., Schinkel A.H., Schellens J.H.M., Beijnen J.H. Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography B 2011, 879(19):1677-1685.
20. Wang F., Mullican S.E., DiSpirito J.R., Peed L.C., Lazar M.A. Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ. Proceedings of the National Academy of Sciences 2013, 110(46):18656-18661.
21. Imai T., Takakuwa R., Marchand S., Dentz E., Bornert J.-M., Messaddeq N., et al. Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse. Proceedings of the National Academy of Sciences of the United States of America 2004, 101(13):4543-4547.
22. Moullan N., Mouchiroud L., Wang X., Ryu D., Williams Evan G., Mottis A., et al. Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research. Cell Reports 2015, 10(10):1681-1691.
23. Liu L., Zou P., Zheng L., Linarelli L.E., Amarell S., Passaro A., et al. Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death & Disease 2015, 6:e1586.
24. Ali P.A., Al-Ghorabie F.H., Evans C.J., El-Sharkawi A.M., Hancock D.A. Body composition measurements using DXA and other techniques in Tamoxifen-treated patients. Applied Radiation and Isotopes 1998, 49(5-6):643-645.
25. Nguyen M.C., Stewart R.B., Banerji M.A., Gordon D.H., Kral J.G. Relationships between tamoxifen use, liver fat and body fat distribution in women with breast cancer. International Journal of Obesity and Related Metabolic Disorders 2001, 25(2):296-298.
26. Marttunen M.B., Andersson S., Hietanen P., Karonen S.-L., Koistinen H.A., Koivisto V.A., et al. Antiestrogenic tamoxifen and toremifene increase serum leptin levels in postmenopausal breast cancer patients. Maturitas 2000, 35(2):175-179.
27. Ozet A., Arpaci F., Yilmaz M.I., Ayta H., Ozturk B., Komurcu S., et al. Effects of tamoxifen on the serum leptin level in patients with breast cancer. Japanese Journal of Clinical Oncology 2001, 31(9):424-427.