Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 19, 2011, Pages 1677-1685

  Teunissen, S F ^a   Jager, N G L ^a   Rosing, H ^a   Schinkel, A H ^a   Schellens, J H M ^a,b   Beijnen, J H ^a,b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Endoxifen; Liquid chromatography; Mass spectrometry; Metabolites; Tamoxifen

Indexed keywords

BIOANALYTICAL ASSAYS; CLINICAL STUDY; DOSE OPTIMIZATION; ENDOXIFEN; FOUR-PHASE; HUMAN SERUM; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ASSAYS; LOWER LIMIT OF QUANTIFICATIONS; MULTIPLE REACTION MONITORING; PHASE I; POSITIVE ION MODE; PROTEIN PRECIPITATION; QUANTITATIVE ASSAY; QUANTITATIVE DETERMINATIONS; REVERSED PHASE LIQUID-CHROMATOGRAPHY; SAMPLE PRETREATMENT; SERUM CONCENTRATION; TAMOXIFEN; TANDEM MASS SPECTROMETRY; TWO PHASE; VALIDATION RESULTS;

ACETONITRILE; ASSAYS; BODY FLUIDS; CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PRECIPITATION (CHEMICAL);

BIOMOLECULES;

ACETONITRILE; AFIMOXIFENE; DRUG METABOLITE; N DESMETHYL 4 HYDROXYTAMOXIFEN; N DESMETHYL 4' HYDROXYTAMOXIFEN; NORTAMOXIFEN; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG SENSITIVITY; HUMAN; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE ASSAY; SERUM; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, REVERSE-PHASE; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TAMOXIFEN; TANDEM MASS SPECTROMETRY;

EID: 79955879330     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.04.011     Document Type: Article

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