Association of baseline Vitamin D levels with clinical parameters and treatment outcomes in chronic hepatitis B

Journal of Hepatology

Volumn 63, Issue 5, 2015, Pages 1086-1092

  Chan, Henry Lik Yuen ^a   Elkhashab, Magdy ^b   Trinh, Huy ^c   Tak, Won Young ^d   Ma, Xiaoli ^e   Chuang, Wan Long ^f   Kim, Yoon Jun ^g   Martins, Eduardo B ^h   Lin, Lanjia ^h   Dinh, Phillip ^h   Charuworn, Prista ^h   Foster, Graham R ⁱ   Marcellin, Patrick ^j  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Toronto Liver Centre   (Canada)

^c San Jose Gastroenterology   (United States)

^d Kyungpook National University Hospital   (South Korea)

^e DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^f KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g Seoul National University Hospital   (South Korea)

^h GILEAD SCIENCES   (United States)

ⁱ QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^j UNIVERSITÉ PARIS DESCARTES   (France)

more..

Author keywords

Hepatitis B; Seasonal variation; Tenofovir disoproxil fumarate; Vitamin D deficiency

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; CALCIFEDIOL; CALCIUM; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; MULTIVITAMIN; PEGINTERFERON; PEGINTERFERON ALPHA2A; TENOFOVIR DISOPROXIL; URIC ACID; VIRUS DNA; VITAMIN D; ALPHA INTERFERON; ANTIVIRUS AGENT; BIOLOGICAL MARKER; DRUG CARRIER; MACROGOL DERIVATIVE; RECOMBINANT PROTEIN; TENOFOVIR; VITAMIN;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANTIVIRAL THERAPY; ARTICLE; AUTUMN; CALCIUM BLOOD LEVEL; CHRONIC HEPATITIS B; CONTROLLED STUDY; FEMALE; HEPATITIS B VIRUS GENOTYPE D; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SPRING; SUMMER; TREATMENT OUTCOME; URIC ACID BLOOD LEVEL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WINTER; ADOLESCENT; AGED; BLOOD; COMBINATION DRUG THERAPY; COMPLICATION; FOLLOW UP; GENETICS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; TIME FACTOR; VIROLOGY; VITAMIN B DEFICIENCY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; BIOMARKERS; DNA, VIRAL; DRUG CARRIERS; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; TENOFOVIR; TIME FACTORS; TREATMENT OUTCOME; VITAMIN B DEFICIENCY; VITAMIN D; VITAMINS; YOUNG ADULT;

EID: 84945447968     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.06.025     Document Type: Article

References (24)

1. World Health Organization. Hepatitis B. Fact Sheet No. 204, < http://www.who.int/mediacentre/factsheets/fs204/en/ >; 2013 [accessed 8.8.13].
2. M. Chung, E.M. Balk, M. Brendel, S. Ip, J. Lau, J. Lee, and et al. Vitamin D and calcium: a systematic review of health outcomes Evid Rep Technol Assess (Full Rep) 2009 1 420
3. J.R. Mora, M. Iwata, and U.H. von Andrian Vitamin effects on the immune system: vitamins A and D take centre stage Nat Rev Immunol 8 2008 685 698 10.1038/nri2378
4. H.F. DeLuca Overview of general physiologic features and functions of vitamin D Am J Clin Nutr 80 2004 1689S 1696S
5. N. Salahuddin, F. Ali, Z. Hasan, N. Rao, M. Aqeel, and F. Mahmood Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis' BMC Infect Dis 13 2013 22 10.1186/1471-2334-13-22
6. S. Abu-Mouch, Z. Fireman, J. Jarchovsky, A.-R. Zeina, and N. Assy Vitamin D supplementation improves sustained virologic response in chronic hepatitis C (genotype 1)-naïve patients World J Gastroenterol 17 2011 5184 5190 10.3748/wjg.v17.i47.5184
7. D. Bitetto, C. Fabris, E. Fornasiere, C. Pipan, E. Fumolo, A. Cussigh, and et al. Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C Transpl Int 24 2011 43 50 10.1111/j.1432-2277.2010.01141.x
8. A. Nimer, and A. Mouch Vitamin D improves viral response in hepatitis C genotype 2-3 naïve patients World J Gastroenterol 18 2012 800 805 10.3748/wjg.v18.i8.800
9. C.M. Lange, J. Gouttenoire, F.H.T. Duong, K. Morikawa, M.H. Heim, and D. Moradpour Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-α J Immunol 192 2014 6037 6044 10.4049/jimmunol.1302296
10. H. Farnik, J. Bojunga, A. Berger, R. Allwinn, O. Waidmann, B. Kronenberger, and et al. Low vitamin D serum concentration is associated with high levels of hepatitis B virus replication in chronically infected patients Hepatology 58 2013 1270 1276 10.1002/hep.26488
11. J.A. Beard, A. Bearden, and R. Striker Vitamin D and the anti-viral state J Clin Virol 50 2011 194 200 10.1016/j.jcv.2010.12.006
12. P.T. Liu, S. Stenger, D.H. Tang, and R.L. Modlin Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin J Immunol 179 2007 2060 2063
13. E. Falleti, D. Bitetto, C. Fabris, G. Fattovich, A. Cussigh, S. Cmet, and et al. Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C Hepatology 56 2012 1641 1650 10.1002/hep.25848
14. E. Zitt, H. Sprenger-Mähr, F. Knoll, U. Neyer, and K. Lhotta Vitamin D deficiency is associated with poor response to active hepatitis B immunisation in patients with chronic kidney disease Vaccine 30 2012 931 935 10.1016/j.vaccine.2011.11.086
15. K. Small, M.-A. Protano, D.T. Dieterich, and M.-L.C. Vachon Increased vitamin D levels are associated with undetectable viral loads in patients with chronic hepatitis B Gastroenterology 140 2011 S932
16. J. Shan, L. Wang, Z. Li, Y. Liu, J. Gao, Y. Pang, and et al. Relationship between polymorphisms of vitamin D receptor gene and familial aggregation of HBsAg carriers Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28 2006 148 153
17. L. Boglione, J. Cusato, A. De Nicolò, G. Cariti, G. Di Perri, and A. D'Avolio Role of CYP27B1+2838 promoter polymorphism in the treatment of chronic hepatitis B HBeAg negative with PEG-interferon J Viral Hepat 2014 10.1111/jvh.12288
18. E.A. Yetley Assessing the vitamin D status of the US population Am J Clin Nutr 88 2008 558S 564S
19. H. Peng, H. Li, C. Li, X. Chao, Q. Zhang, and Y. Zhang Association between Vitamin D insufficiency and elevated serum uric acid among middle-aged and elderly Chinese han women PLoS One 8 2013 e61159 10.1371/journal.pone.0061159
20. European Association for the Study of the Liver EASL clinical practice guidelines: management of chronic hepatitis B virus infection J Hepatol 57 2012 167 185 10.1016/j.jhep.2012.02.010
21. P. Marcellin, S.H. Ahn, X. Ma, F.A. Caruntu, W.Y. Tak, M. Elkashab, and et al. HBsAg loss with tenofovir disoproxil fumarate (TDF) plus peginterferon alfa-2a (PEG) in chronic hepatitis B (CHB): results of a global randomized controlled trial Hepatology 60 2014 294A
22. A. Miroliaee, M. Nasiri-Toosi, O. Khalilzadeh, A. Esteghamati, A. Abdollahi, and M. Mazloumi Disturbances of parathyroid hormone-vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study Hepatol Int 4 2010 634 640 10.1007/s12072-010-9194-2
23. L. Fisher, and A. Fisher Vitamin D and parathyroid hormone in outpatients with noncholestatic chronic liver disease Clin Gastroenterol Hepatol 5 2007 513 520 10.1016/j.cgh.2006.10.015
24. J. Arteh, S. Narra, and S. Nair Prevalence of vitamin D deficiency in chronic liver disease Dig Dis Sci 55 2010 2624 2628 10.1007/s10620-009-1069-9