Prenatally buprenorphine-exposed children: health to 3 years of age

European Journal of Pediatrics

Volumn 174, Issue 11, 2015, Pages 1525-1533

  Kivistö, Kaisa ^a,b   Tupola, Sarimari ^a,b   Kivitie Kallio, Satu ^a,b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Birth defects; Buprenorphine; Child maltreatment; Health; Prenatal opioid exposure; Preschool child

Indexed keywords

BUPRENORPHINE; NARCOTIC ANALGESIC AGENT;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BEHAVIOR DISORDER; CAUCASIAN; CAUSE OF DEATH; CHILD; CHILD DEATH; CHILD NEGLECT; CHILD WELFARE; CHILDHOOD MORTALITY; CONGENITAL HEART DISEASE; CONGENITAL MALFORMATION; CRYPTORCHISM; EYE DISEASE; FALLOT TETRALOGY; FEMALE; FOLLOW UP; GESTATIONAL AGE; HEART VENTRICLE SEPTUM DEFECT; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOSPADIAS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; NYSTAGMUS; OPTIC NERVE ATROPHY; OPTICUS ATROPHY; PATENT DUCTUS ARTERIOSUS; PERCEPTION DEAFNESS; PHYSICAL ABUSE; PIERRE ROBIN SYNDROME; PREMATURITY; PRENATAL EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PYLORUS STENOSIS; RADIUS FRACTURE; SKULL FRACTURE; SPEECH DELAY; SPEECH DISORDER; STRABISMUS; SUDDEN INFANT DEATH SYNDROME; URINALYSIS; VIRUS TRANSMISSION; CHEMICALLY INDUCED; CHILD ABUSE; DIAGNOSIS; EPIDEMIOLOGY; FINLAND; HEALTH STATUS; INFANT; NEWBORN; PREGNANCY;

ANALGESICS, OPIOID; BUPRENORPHINE; CHILD; CHILD ABUSE; CHILD, PRESCHOOL; FEMALE; FINLAND; HEALTH STATUS; HUMANS; INFANT; INFANT, NEWBORN; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES;

EID: 84945446013     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-015-2562-0     Document Type: Article

References (70)

1. Broussard CS, Rasmussen SA, Reefhuis J, Friedman JM, Jann MW, Riehle-Colarusso T, Honein MA (2011) Maternal treatment with opioid analgesics and risk for birth defects. Am J Obstet Gynecol 204:314.e311–311. doi:10.1016/j.ajog.2010.12.039
2. Bufferd SJ, Dougherty LR, Carlson GA, Klein DN (2011) Parent-reported mental health in preschoolers: findings using a diagnostic interview. Compr Psychiatry 52:359–369. doi:10.1016/j.comppsych.2010.08.006
3. Bunikowski R, Grimmer I, Heiser A, Metze B, Schafer A, Obladen M (1998) Neurodevelopmental outcome after prenatal exposure to opiates. Eur J Pediatr 157:724–730
4. Centers for Disease Control and Prevention (CDC). Update on overall prevalence of major birth defects—Atlanta, Georgia, 1978–2005 (2008) MMWR Morb Mortal Wkly Rep 57:1–5
5. Chaffin M, Kelleher K, Hollenberg J (1996) Onset of physical abuse and neglect: psychiatric, substance abuse, and social risk factors from prospective community data. Child Abuse Negl 20:191–203
6. Chasnoff IJ, Burns KA, Burns WJ, Schnoll SH (1986) Prenatal drug exposure: effects on neonatal and infant growth and development. Neurobehav Toxicol Teratol 8:357–362
7. Chavez C, Ostrea AM, Stryker JC et al (1979) Ocular abnormalities in infants as sequelae of prenatal drug addiction. Pediatr Res 63:135–141
8. Chew E, Remaley NA, Tamboli A, Zhao J, Podgor MJ, Klebanoff M (1994) Risk factors for esotropia and exotropia. Arch Ophthalmol 112:1349–1355
9. de Koning HJ, de Ridder-Sluiter JG, van Agt HM, Reep-van den Bergh CM, van der Stege HA, Korfage IJ, Polder JJ, van der Maas PJ (2004) A cluster-randomised trial of screening for language disorders in toddlers. J Med Screen 11:109–116. doi:10.1258/0969141041732229
10. de Laffolie J, Turial S, Heckmann M, Zimmer KP, Schier F (2012) Decline in infantile hypertrophic pyloric stenosis in Germany in 2000–2008. Pediatrics 129:e901–e906. doi:10.1542/peds.2011-2845
11. Finlex (2013) Child Welfare Act No. 417/2007; amendments up to 976/2013 included
12. Finnegan LP, Connaughton JF Jr, Kron RE, Emich JP (1975) Neonatal abstinence syndrome: assessment and management. Addict Dis 2:141–158
13. Flaherty EG, Stirling J Jr, American Academy of Pediatrics, Committee on Child Abuse and Neglect (2010) Clinical report-the pediatrician’s role in child maltreatment prevention. Pediatrics 126:833–884
14. Gilbert R, Kemp A, Thoburn J, Sidebotham P, Radford L, Glaser D, Macmillan HL (2009) Recognising and responding to child maltreatment. Lancet 373:167–180
15. Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S (2009) Burden and consequences of child maltreatment in high-income countries. Lancet 373:68–81
16. Gill AC, Oei J, Lewis NL, Younan N, Kennedy I, Lui K (2003) Strabismus in infants of opiate-dependent mothers. Acta Paediatr 92:379–385
17. Graham PA (1974) Epidemiology of strabismus. Br J Ophthalmol 58:224–231
18. Hackshaw A, Rodeck C, Boniface S (2011) Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls. Hum Reprod Update 17:589–604
19. Hamilton R, McGlone L, MacKinnon JR, Russell HC, Bradnam MS, Mactier H (2010) Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. Br J Ophthalmol 94:696–700. doi:10.1136/bjo.2009.169284
20. Hannus S, Kauppila T, Launonen K (2009) Increasing prevalence of specific language impairment (SLI) in primary healthcare of a Finnish town, 1989–99. Int J Lang Commun Disord 44:79–97. doi:10.1080/13682820801903310
21. Hibbard RA, Desch LW, American Academy of Pediatrics Committee on Child Abuse and Neglect, American Academy of Pediatrics Council on Children With Disabilities (2007) Maltreatment of children with disabilities. Pediatrics 119:1018–1025. doi:10.1542/peds.2007-0565
22. Horwitz SM, Irwin JR, Briggs-Gowan MJ, Bosson Heenan JM, Mendoza J, Carter AS (2003) Language delay in a community cohort of young children. J Am Acad Child Adolesc Psychiatry 42:932–940. doi:10.1097/01.CHI.0000046889.27264.5ES0890-8567(09)61099-6
23. Hunt RW, Tzioumi D, Collins E, Jeffery HE (2008) Adverse neurodevelopmental outcome of infants exposed to opiate in-utero. Early Hum Dev 84:29–35. doi:10.1016/j.earlhumdev.2007.01.013
24. Hytinantti T, Kahila H, Renlund M, Jarvenpaa AL, Halmesmaki E, Kivitie-Kallio S (2008) Neonatal outcome of 58 infants exposed to maternal buprenorphine in utero. Acta Paediatr 97:1040–1044. doi:10.1111/j.1651-2227.2008.00838.x
25. Jaudes PK, Ekwo E, Van Voorhis J (1995) Association of drug abuse and child abuse. Child Abuse Negl 19:1065–1075
26. Jelleyman T, Spencer N (2008) Residential mobility in childhood and health outcomes: a systematic review. J Epidemiol Community Health 62:584–592. doi:10.1136/jech.2007.060103
27. Jenkinson RA, Clark NC, Fry CL, Dobbin M (2005) Buprenorphine diversion and injection in Melbourne, Australia: an emerging issue? Addiction 100:197–205. doi:10.1111/j.1360-0443.2004.00958.x
28. Jenny C (2007) Recognizing and responding to medical neglect. Pediatrics 120(6):1385–1389
29. Johnson RE, Jones HE, Fischer G (2003) Use of buprenorphine in pregnancy: patient management and effects on the neonate. Drug Alcohol Depend 70:S87–S101
30. Kahila H, Saisto T, Kivitie-Kallio S, Haukkamaa M, Halmesmäki E (2007) A prospective study on buprenorphine use during pregnancy: effects on maternal and neonatal outcome. Acta Obstet Gynecol Scand 86:185–190. doi:10.1080/00016340601110770
31. Kahlert C, Rudin C, Kind C (2007) Sudden infant death syndrome in infants born to HIV-infected and opiate-using mothers. Arch Dis Child 92:1005–1008. doi:10.1136/adc.2007.117192
32. Kelleher K, Chaffin M, Hollenberg J, Fischer E (1994) Alcohol and drug disorders among physically abusive and neglectful parents in a community-based sample. Am J Public Health 84:1586–1590
33. Kivistö K, Alapulli H, Tupola S, Alaluusua S, Kivitie-Kallio S (2014) Dental health of young children prenatally exposed to buprenorphine. A concern of child neglect? Eur Arch Paediatr Dent 15:197–202. doi:10.1007/s40368-013-0095-7
34. Klein AM, Otto Y, Fuchs S, Reibiger I, von Klitzing K (2014) A prospective study of behavioral and emotional symptoms in preschoolers. Eur Child Adolesc Psychiatry. doi:10.1007/s00787-014-0575-2
35. Krogh C, Gortz S, Wohlfahrt J, Biggar RJ, Melbye M, Fischer TK (2012) Pre- and perinatal risk factors for pyloric stenosis and their influence on the male predominance. Am J Epidemiol 176:24–31. doi:10.1093/aje/kwr493
36. Lejeune C, Simmat-Durand L, Gourarier L, Aubisson S (2006) Prospective multicenter observational study of 260 infants born to 259 opiate-dependent mothers on methadone or high-dose buprenophine substitution. Drug Alcohol Depend 82:250–257. doi:10.1016/j.drugalcdep.2005.10.001
37. Leventhal JM, Forsyth BW, Qi K, Johnson L, Schroeder D, Votto N (1997) Maltreatment of children born to women who used cocaine during pregnancy: a population-based study. Pediatrics 100:e7
38. Macmillan C, Magder LS, Brouwers P, Chase C, Hittelman J, Lasky T, Malee K, Mellins CA, Velez-Borras J (2001) Head growth and neurodevelopment of infants born to HIV-1-infected drug-using women. Neurology 57:1402–1411
39. Mattick RP, Breen C, Kimber J, Davoli M (2014) Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev 2:CD002207. doi:10.1002/14651858.CD002207.pub4
40. Mitchell EA, Tuohy PG, Brunt JM, Thompson JM, Clements MS, Stewart AW, Ford RP, Taylor BJ (1997) Risk factors for sudden infant death syndrome following the prevention campaign in New Zealand: a prospective study. Pediatrics 100:835–840
41. Mulvihill AO, Cackett PD, George ND, Fleck BW (2007) Nystagmus secondary to drug exposure in utero. Br J Ophthalmol 91:613–615. doi:10.1136/bjo.2006.105569
42. National Institute for Health and Welfare Official statistics of Finland, 2014: congenital anomalies 1993–2011
43. Nelson LB, Ehrlich S, Calhoun JH, Matteucci T, Finnegan LP (1987) Occurrence of strabismus in infants born to drug-dependent women. Am J Dis Child 141:175–178
44. Obadia Y, Perrin V, Feroni I, Vlahov D, Moatti JP (2001) Injecting misuse of buprenorphine among French drug users. Addiction 96:267–272. doi:10.1080/09652140020021008
45. Office for National Statistics (2013) Unexplained deaths in infancy: England and Wales, 2011
46. Official Statistics of Finland (OSF). Deaths [e-publication]. ISSN = 1798-2545. Helsinki: Statistics Finland
47. Official Statistics of Finland (OSF): causes of death [e-publication]. ISSN = 1799-5078. 2013, 7. Number of children dying under the age of one record low. Helsinki: Statistics Finland
48. Ornoy A, Segal J, Bar-Hamburger R, Greenbaum C (2001) Developmental outcome of school-age children born to mothers with heroin dependency: importance of environmental factors. Dev Med Child Neurol 43:668–675
49. Ostrea EM Jr, Ostrea AR, Simpson PM (1997) Mortality within the first 2 years in infants exposed to cocaine, opiate, or cannabinoid during gestation. Pediatrics 100:79–83
50. Pihlakoski L, Aromaa M, Sourander A, Rautava P, Helenius H, Sillanp AM (2004) Use of and need for professional help for emotional and behavioral problems among preadolescents: a prospective cohort study of 3- to 12-year-old children. J Am Acad Child Adolesc Psychiatry 43:974–983. doi:10.1097/01.chi.0000127574.41662.fa
51. Rosen TS, Johnson HL (1982) Children of methadone-maintained mothers: follow-up to 18 months of age. J Pediatr 101:192–196
52. Salo S, Kivistö K, Korja R, Biringen Z, Tupola S, Kahila H, Kivitie-Kallio S (2009) Emotional availability, parental self-efficacy beliefs, and child development in caregiver-child relationships with buprenorphine-exposed 3-year-olds. Parent Sci Pract 9:244–259
53. Sarkola T, Kahila H, Gissler M, Halmesmäki E (2007) Risk factors for out-of-home custody child care among families with alcohol and substance abuse problems. Acta Paediatr 96:1571–1576. doi:10.1111/j.1651-2227.2007.00474.x
54. Saxen I (1975) Associations between oral clefts and drugs taken during pregnancy. Int J Epidemiol 4:37–44
55. Sidebotham P, Golding J (2001) Child maltreatment in the “children of the nineties” a longitudinal study of parental risk factors. Child Abuse Negl 25:1177–1200
56. Silva PA, McGee R, Williams SM (1983) Developmental language delay from three to seven years and its significance for low intelligence and reading difficulties at age seven. Dev Med Child Neurol 25:783–793
57. Sørensen HT, Nørgard B, Pedersen L, Larsen H, Johnsen SP (2002) Maternal smoking and risk of hypertrophic infantile pyloric stenosis: 10 year population based cohort study. BMJ 325:1011–1012
58. Strömland K (2004) Visual impairment and ocular abnormalities in children with fetal alcohol syndrome. Addict Biol 9:153–157. doi:10.1080/13556210410001717024NH8XQBFXM3YX0PWF, discussion 159–160
59. Sundelin Wahlsten V, Sarman I (2013) Neurobehavioural development of preschool-age children born to addicted mothers given opiate maintenance treatment with buprenorphine during pregnancy. Acta Paediatr 102:544–549
60. Tomblin JB, Records NL, Buckwalter P, Zhang X, Smith E, O’Brien M (1997) Prevalence of specific language impairment in kindergarten children. J Speech Lang Hear Res 40:1245–1260
61. Torp-Pedersen T, Boyd HA, Poulsen G, Haargaard B, Wohlfahrt J, Holmes JM, Melbye M (2010) In-utero exposure to smoking, alcohol, coffee, and tea and risk of strabismus. Am J Epidemiol 171:868–875. doi:10.1093/aje/kwq010
62. Trocmé N, Fallon B, MacLaurin B, Daciuk J, Felstiner C, Black T, Tonmyr L, Blackstock C, Barter K, Turcotte D, Cloutier R (2005) Canadian incidence study of reported child abuse and neglect—2003: major findings. Minister of Public Works and Government Services Canada
63. UNODC World Drug Report 2010. United Nations Publication, Sales No E10XI13
64. U.S. Department of Health and Human Services AfCaF, Administration on Children, Youth and Families, Children’s Bureau, (2012) Child Maltreatment 2011. http://www.acf.hhs.gov/programs/cb/research-data-technology/statistics-research/child-maltreatment
65. Uosukainen H, Kauhanen J, Voutilainen S, Fohr J, Paasolainen M, Tiihonen J, Laitinen K, Onyeka IN, Bell JS (2013) Twelve-year trend in treatment seeking for buprenorphine abuse in Finland. Drug Alcohol Depend 127:207–214. doi:10.1016/j.drugalcdep.2012.07.002
66. Vucinovic M, Roje D, Vucinovic Z, Capkun V, Bucat M, Banovic I (2008) Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience. Yonsei Med J 49:705–713. doi:10.3349/ymj.2008.49.5.705
67. Wichstrøm L, Berg-Nielsen TS, Angold A, Egger HL, Solheim E, Sveen TH (2012) Prevalence of psychiatric disorders in preschoolers. J Child Psychol Psychiatry 53:695–705. doi:10.1111/j.1469-7610.2011.02514.x
68. Williams C, Northstone K, Howard M, Harvey I, Harrad RA, Sparrow JM (2008) Prevalence and risk factors for common vision problems in children: data from the ALSPAC study. Br J Ophthalmol 92:959–964. doi:10.1136/bjo.2007.134700
69. Wilson GS, McCreary R, Kean J, Baxter JC (1979) The development of preschool children of heroin-addicted mothers: a controlled study. Pediatrics 63:135–141
70. Wish ED, Artigiani E, Billing A, Hauser W, Hemberg J, Shiplet M, DuPont RL (2012) The emerging buprenorphine epidemic in the United States. J Addict Dis 31:3–7. doi:10.1080/10550887.2011.642757