Comparison of HFNC, bubble CPAP and SiPAP on aerosol delivery in neonates: An in-vitro study

Pediatric Pulmonology

Volumn 50, Issue 11, 2015, Pages 1099-1106

  Sunbul, Fatemah S ^a   Fink, James B ^a   Harwood, Robert ^a   Sheard, Meryl M ^a   Zimmerman, Ralph D ^a   Ari, Arzu ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Aerosols; bubble CPAP; continuous positive airway pressure; high flow nasal cannula; nebulizer; neonate; SiPAP

Indexed keywords

SALBUTAMOL SULFATE; AEROSOL; SALBUTAMOL;

AEROSOL; ARTICLE; BREATHING PATTERN; BUBBLE CPAP DEVICE; BUBBLE POSITIVE END EXPIRATORY PRESSURE; COMPARATIVE STUDY; CPAP DEVICE; DRUG DELIVERY SYSTEM; HIGH FLOW NASAL CANNULA; IN VITRO STUDY; MANOMETER; NASAL CANNULA; NEBULIZER; POSITIVE END EXPIRATORY PRESSURE; PREMATURITY; PRIORITY JOURNAL; QUANTITATIVE STUDY; RESPIRATORY FLOWMETER; SIPAP DEVICE; SYNCHRONIZED INSPIRATORY POSITIVE AIRWAY PRESSURE; ADMINISTRATION AND DOSAGE; ANATOMIC MODEL; BREATHING; CATHETER; DEVICES; DRUG EFFECTS; HUMAN; INFANT; NEWBORN;

AEROSOLS; ALBUTEROL; CATHETERS; CONTINUOUS POSITIVE AIRWAY PRESSURE; HUMANS; INFANT; INFANT, NEWBORN; INFANT, PREMATURE; MODELS, ANATOMIC; NEBULIZERS AND VAPORIZERS; RESPIRATION;

EID: 84945442401     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.23123     Document Type: Article

References (18)

1. Ari A, Fink JB,. Guidelines for aerosol devices in infants, children and adults: which to choose, why and how to achieve effective aerosol therapy. Expert Rev Respir Med 2011; 5: 561-572.
2. Ari A, Hess D, Myers T, Rau JL,. A guide to aerosol delivery devices for respiratory therapists. 2nd ed. Dallas (TX). American Association for Respiratory Care; 2009. p 58.
3. Ari A, Restrepo RD,. Aerosol delivery device selection for spontaneously breathing patients. Respir Care 2012; 57: 613-626.
4. Fok TF, Monkman S, Dolovich M, Gray S, Coates G, Paes B, Rashid F, Newhouse M, Kirpalani H,. Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1996; 21: 301-309.
5. Dhand R,. Inhalation therapy in invasive and noninvasive mechanical ventilation. Curr Opin Crit Care 2007; 13: 27-38.
6. Kahn D, Habib R, Courtney S,. Effects of flow amplitudes on intraprong pressures during bubble versus ventilator-generated nasal continuous positive airway pressure in premature infants. Pediatrics 2008; 122: 1009-1013.
7. Smedsaas-Löfvenberg A, Nilsson K, Moa G, Axelsson I,. Nebulization of drugs in a nasal CPAP system. Acta Paediatr 1999; 88: 89-92.
8. Ari A, Atalay OT, Harwood R, Sheard MM, Aljamhan EA, Fink JB,. Influence of nebulizer type, position, and bias flow on aerosol drug delivery in simulated pediatric and adult lung models during mechanical ventilation. Respir Care 2010; 55: 845-851.
9. Berlinski A, Willis JR,. Albuterol delivery by 4 different nebulizers placed in 4 different positions in a pediatric ventilator in vitro model. Respir Care 2013; 58: 1124 -1133.
10. Youngquist TM, Richardson CP, DiBlasi RM,. Effects of condensate in the exhalation limb of neonatal circuits on airway pressure during bubble CPAP. Respir Care 2013; 58: 1840 -1846.
11. Wilkinson D, Andersen C, O'Donnell C, De Paoli A,. High flow nasal cannula for respiratory support in preterm infants. Cochrane Database Syst Rev; 2011. p 33.
12. Nikischin W, Petridis M, Noeske J, Spengler D, von Bismarck P,. Effect on work of breathing of different continuous positive airway pressure devices evaluated in a premature neonatal lung model. Pediatr Crit Care Med 2011; 12: 376-382.
13. DiBlasi RM,. Nasal continuous positive airway pressure (CPAP) for the respiratory care of the newborn infant. Respir Care 2009; 54: 1209-1235.
14. Ari A, Harwood R, Sheard MM, Dailey P, Fink JB,. In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula. Pediatr Pulmonol 2011; 46: 795 -801.
15. Bhashyam AR, Wolf MT, Marcinkowski AL, Saville A, Thomas K, Carcillo JA, Corcoran TE,. Aerosol delivery through nasal cannulas: an in vitro study. J Aerosol Med Pulm Drug Deliv 2008; 21: 181 -188.
16. Zweifel NS,. In vitro aerosol delivery from nebulizers through two set ups of continuous positive airway pressure (CPAP) ventilation using an infant model [dissertation]. Zurich: University of Zurich; 2010.
17. Farney KD, Kuehne BT, Gibson LA, Nelin LD, Shepherd EG,. In vitro evaluation of radiolabeled aerosol delivery via a variable flow infant CPAP system. Respir Care 2014; 59: 340-344.
18. Kahn DJ, Courtney SE, Steele AM, Habib RH,. Unpredictability of delivered bubble nasal continuous positive airway pressure: role of bias flow magnitude and nares-prong air leaks. Pediatr Res 2007; 62: 343-347.