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Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials
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Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
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Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
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EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries
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Regional and practice variation in adherence to guideline recommendations for secondary and primary prevention among outpatients with atherothrombosis or risk factors in the United States: a report from the REACH registry
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Kumar A, Fonarow GC, Eagle KA, et al. Regional and practice variation in adherence to guideline recommendations for secondary and primary prevention among outpatients with atherothrombosis or risk factors in the United States: a report from the REACH registry. Crit Pathways Cardiol. 2009;8:104–11.
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Gaps in cardiovascular disease risk management in Australian general practice
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WHO study on prevention of recurrences of myocardial infarction and stroke (WHO-PREMISE)
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Low use of statins and other coronary secondary prevention therapies in primary and secondary care in India
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Sharma KK, Gupta R, Agrawal A, et al. Low use of statins and other coronary secondary prevention therapies in primary and secondary care in India. Vasc Health Risk Manage. 2009;5:1007–14.
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Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE study): a prospective epidemiological survey
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Yusuf S, Islam S, Chow CK, et al. Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE study): a prospective epidemiological survey. Lancet. 2011;378:1231–43.
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A strategy to reduce cardiovascular disease by more than 80 %
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Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80 %. Br Med J. 2003;326:1419.
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A pilot double-blind randomised placebo-controlled trial of the effects of fixed-dose combination therapy (‘polypill’) on cardiovascular risk factors
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Malekzadeh F, Marshall T, Pourshams A, et al. A pilot double-blind randomised placebo-controlled trial of the effects of fixed-dose combination therapy (‘polypill’) on cardiovascular risk factors. Int J Clin Pract. 2010;64:1220–7.
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An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk
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Pill Collaborative Group, Rodgers A, Patel A, et al. An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk. PLoS One. 2011;6:e19857.
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Randomized polypill crossover trial in people aged 50 and over
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COI: 1:CAS:528:DC%2BC38XhtV2msLvO, PID: 22815989, Results from a 12 week cross over RCT of polypill vs placebo in primary prevention
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Wald DS, Morris JK, Wald NJ. Randomized polypill crossover trial in people aged 50 and over. PLoS One. 2012;7:e41297. Results from a 12 week cross over RCT of polypill vs placebo in primary prevention.
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Wald, D.S.1
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Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (Polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators. Circulation
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Showed incremental improvement in risk factor reduction when full-dose polypill was used in patients at high CVD risk compared to low-dose polypill
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Yusuf S, Pais P, Sigamani A, et al. Comparison of risk factor reduction and tolerability of a full-dose polypill (with potassium) versus low-dose polypill (Polycap) in individuals at high risk of cardiovascular diseases: the Second Indian Polycap Study (TIPS-2) investigators. Circulation. Cardiovasc Qual Outcome. 2012;5:463–71. Showed incremental improvement in risk factor reduction when full-dose polypill was used in patients at high CVD risk compared to low-dose polypill.
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Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial.[see comment]
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Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial
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COI: 1:CAS:528:DC%2BC3sXhsFCjsb7K, First large scale RCT of polypill vs usual care in secondary prevention of 2004 patients from Western Europe and India. Showed improvement in adherence, systolic blood pressure and LDL-cholesterol
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Acceptance of a polypill approach to prevent cardiovascular disease among a sample of U.S. physicians
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