-
1
-
-
19044380618
-
Targeting ligand-activated ErbB 2 signaling inhibits breast and prostate tumor growth
-
Agus D. Akita R. Fox W. Lewis G. Higgins B. Pisacane P. et al. (2002) Targeting ligand-activated ErbB 2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2: 127–137.
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.1
Akita, R.2
Fox, W.3
Lewis, G.4
Higgins, B.5
Pisacane, P.6
-
2
-
-
84941994745
-
Interim safety and efficacy of pertuzumab, trastuzumab and vinorelbine for first-line (1l) treatment of patients (pts) with HER2-positive locally advanced or metastatic breast cancer (MBC)
-
Andersson M. Lopez-Vega J. Petit T. Zamagni C. Freudensprung U. Robb S. et al. (2014) Interim safety and efficacy of pertuzumab, trastuzumab and vinorelbine for first-line (1l) treatment of patients (pts) with HER2-positive locally advanced or metastatic breast cancer (MBC). Ann Oncol 25: iv116–iv136.
-
(2014)
Ann Oncol
, vol.25
, pp. iv116-iv136
-
-
Andersson, M.1
Lopez-Vega, J.2
Petit, T.3
Zamagni, C.4
Freudensprung, U.5
Robb, S.6
-
3
-
-
84899992665
-
Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial
-
André F. O'Regan R. Ozguroglu M. Toi M. Xu B. Jerusalem G. et al. (2014) Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol 15: 580–591.
-
(2014)
Lancet Oncol
, vol.15
, pp. 580-591
-
-
André, F.1
O'Regan, R.2
Ozguroglu, M.3
Toi, M.4
Xu, B.5
Jerusalem, G.6
-
4
-
-
84871722407
-
Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study
-
Bachelot T. Romieu G. Campone M. Dieras V. Cropet C. Dalenc F. et al. (2013) Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study. Lancet Oncol 14: 64–71.
-
(2013)
Lancet Oncol
, vol.14
, pp. 64-71
-
-
Bachelot, T.1
Romieu, G.2
Campone, M.3
Dieras, V.4
Cropet, C.5
Dalenc, F.6
-
5
-
-
84891754753
-
Breast cancer brain metastases responding to primary systemic therapy with T-DM1
-
Bartsch R. Berghoff A. Preusser M. (2014) Breast cancer brain metastases responding to primary systemic therapy with T-DM1. J Neurooncol 116: 205–206.
-
(2014)
J Neurooncol
, vol.116
, pp. 205-206
-
-
Bartsch, R.1
Berghoff, A.2
Preusser, M.3
-
7
-
-
84911926434
-
Biomarker analyses in cleopatra: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer
-
Baselga J. Cortés J. Im S. Clark E. Ross G. Kiermaier A. et al. (2014) Biomarker analyses in cleopatra: a phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer. J Clin Oncol 32: 3753–3761.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3753-3761
-
-
Baselga, J.1
Cortés, J.2
Im, S.3
Clark, E.4
Ross, G.5
Kiermaier, A.6
-
8
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J. Cortés J. Kim S. Im S. Hegg R. Im Y. et al. (2012) Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 366: 109–119.
-
(2012)
N Engl J Med
, vol.366
, pp. 109-119
-
-
Baselga, J.1
Cortés, J.2
Kim, S.3
Im, S.4
Hegg, R.5
Im, Y.6
-
9
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
Baselga J. Gelmon K. Verma S. Wardley A. Conte P. Miles D. et al. (2010) Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 28: 1138–1144.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.2
Verma, S.3
Wardley, A.4
Conte, P.5
Miles, D.6
-
10
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
Berns K. Horlings H. Hennessy B. Madiredjo M. Hijmans E. Beelen K. et al. (2007) A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 12: 395–402.
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.2
Hennessy, B.3
Madiredjo, M.4
Hijmans, E.5
Beelen, K.6
-
11
-
-
84864066561
-
Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF 104900 study
-
Blackwell K. Burstein H. Storniolo A. Rugo H. Sledge G. Aktan G. et al. (2012) Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF 104900 study. J Clin Oncol 30: 2585–2592.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2585-2592
-
-
Blackwell, K.1
Burstein, H.2
Storniolo, A.3
Rugo, H.4
Sledge, G.5
Aktan, G.6
-
12
-
-
77949884661
-
Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
Blackwell K. Burstein H. Storniolo A. Rugo H. Sledge G. Koehler M. et al. (2010) Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 28: 1124–1130.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1124-1130
-
-
Blackwell, K.1
Burstein, H.2
Storniolo, A.3
Rugo, H.4
Sledge, G.5
Koehler, M.6
-
13
-
-
84945171996
-
A phase 1b study of ONT-380, an oral HER2-specific inhibitor, combined with ado-trastuzumab emtansine (T-DM1), in HER2+ metastatic breast cancer (MBC)
-
abstract TPS662.
-
Borges V. Hamilton E. Yardley D. Chaves J. Aucoin N. Ferrario C. et al. (2015) A phase 1b study of ONT-380, an oral HER2-specific inhibitor, combined with ado-trastuzumab emtansine (T-DM1), in HER2+ metastatic breast cancer (MBC). Cancer Res 32: abstract TPS662.
-
(2015)
Cancer Res
, vol.32
-
-
Borges, V.1
Hamilton, E.2
Yardley, D.3
Chaves, J.4
Aucoin, N.5
Ferrario, C.6
-
15
-
-
84945171997
-
Updated findings of a first-in-human, phase I study of margetuximab (M), an Fc-optimized chimeric monoclonal antibody (MAb), in patients (pts) with HER2-positive advanced solid tumors
-
abstract 523.
-
Burris H. Giaccone G. Im S. Bauer T. Oh D. Jones S. et al. (2015) Updated findings of a first-in-human, phase I study of margetuximab (M), an Fc-optimized chimeric monoclonal antibody (MAb), in patients (pts) with HER2-positive advanced solid tumors. J Clin Oncol 3 (Suppl.): abstract 523.
-
(2015)
J Clin Oncol
, vol.3
-
-
Burris, H.1
Giaccone, G.2
Im, S.3
Bauer, T.4
Oh, D.5
Jones, S.6
-
16
-
-
84941997654
-
Phase I study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody (MAb), in patients (pts) with advanced solid tumors expressing the HER 2 oncoprotein
-
abstract 3004.
-
Burris H. Giaccone G. Im S. Bauer T. Trepel J. Nordstrom J. et al. (2013) Phase I study of margetuximab (MGAH22), an Fc-modified chimeric monoclonal antibody (MAb), in patients (pts) with advanced solid tumors expressing the HER 2 oncoprotein. J Clin Oncol 31(Suppl. 15): abstract 3004.
-
(2013)
J Clin Oncol
, vol.31
-
-
Burris, H.1
Giaccone, G.2
Im, S.3
Bauer, T.4
Trepel, J.5
Nordstrom, J.6
-
17
-
-
77950497981
-
Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer
-
Burstein H. Sun Y. Dirix L. Jiang Z. Paridaens R. Tan A. et al. (2010) Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 28: 1301–1307.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1301-1307
-
-
Burstein, H.1
Sun, Y.2
Dirix, L.3
Jiang, Z.4
Paridaens, R.5
Tan, A.6
-
18
-
-
77957771125
-
Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trial
-
Cameron D. Casey M. Oliva C. Newstat B. Imwalle B. Geyer C. (2010) Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trial. Oncologist 15: 924–934.
-
(2010)
Oncologist
, vol.15
, pp. 924-934
-
-
Cameron, D.1
Casey, M.2
Oliva, C.3
Newstat, B.4
Imwalle, B.5
Geyer, C.6
-
20
-
-
84884644183
-
Health-related quality-of-life assessment in cleopatra, a phase III study combining pertuzumab with trastuzumab and docetaxel in metastatic breast cancer
-
Cortés J. Baselga J. Im Y. Im S. Pivot X. Ross G. et al. (2013) Health-related quality-of-life assessment in cleopatra, a phase III study combining pertuzumab with trastuzumab and docetaxel in metastatic breast cancer. Ann Oncol 24: 2630–2635.
-
(2013)
Ann Oncol
, vol.24
, pp. 2630-2635
-
-
Cortés, J.1
Baselga, J.2
Im, Y.3
Im, S.4
Pivot, X.5
Ross, G.6
-
21
-
-
84945171998
-
Randomized phase II trial of afatinib alone or with vinorelbine versus investigator's choice of treatment in patients with HER2-positive breast cancer with progressive brain metastases after trastuzumab and / or lapatinib-based therapy: Lux-Breast 3
-
P5–19–07.
-
Cortés J. Dieras V. Ro J. Barriere J. Bachelot T. Hurvitz S. et al. (2014) Randomized phase II trial of afatinib alone or with vinorelbine versus investigator's choice of treatment in patients with HER2-positive breast cancer with progressive brain metastases after trastuzumab and / or lapatinib-based therapy: Lux-Breast 3. Cancer Res 75: P5–19–07.
-
(2014)
Cancer Res
, vol.75
-
-
Cortés, J.1
Dieras, V.2
Ro, J.3
Barriere, J.4
Bachelot, T.5
Hurvitz, S.6
-
22
-
-
84922384344
-
Phase II study of paclitaxel given once per week along with trastuzumab and pertuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Dang C. Iyengar N. Datko F. D'andrea G. Theodoulou M. Dickler M. et al. (2015) Phase II study of paclitaxel given once per week along with trastuzumab and pertuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 33: 442–447.
-
(2015)
J Clin Oncol
, vol.33
, pp. 442-447
-
-
Dang, C.1
Iyengar, N.2
Datko, F.3
D'andrea, G.4
Theodoulou, M.5
Dickler, M.6
-
23
-
-
84906819100
-
Trastuzumab emtansine in human epidermal growth factor receptor 2-positive metastatic breast cancer: an integrated safety analysis
-
Dieras V. Harbeck N. Budd G. Greenson J. Guardino A. Samant M. et al. (2014) Trastuzumab emtansine in human epidermal growth factor receptor 2-positive metastatic breast cancer: an integrated safety analysis. J Clin Oncol 32: 2750–2757.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2750-2757
-
-
Dieras, V.1
Harbeck, N.2
Budd, G.3
Greenson, J.4
Guardino, A.5
Samant, M.6
-
24
-
-
84937530294
-
Phase III, randomized study of trastuzumab emtansine (T-DM1) ± pertuzumab (P) Vs trastuzumab + taxane (Ht) for first-line treatment of HER2-positive MBC: primary results from the marianne study
-
abstract 507.
-
Ellis P. Barrios C. Eiermann W. Toi M. Im Y. Conte P. et al. (2015) Phase III, randomized study of trastuzumab emtansine (T-DM1) ± pertuzumab (P) Vs trastuzumab + taxane (Ht) for first-line treatment of HER2-positive MBC: primary results from the marianne study. J Clin Oncol 33(Suppl): abstract 507.
-
(2015)
J Clin Oncol
, vol.33
, Issue.Suppl
-
-
Ellis, P.1
Barrios, C.2
Eiermann, W.3
Toi, M.4
Im, Y.5
Conte, P.6
-
25
-
-
84867842898
-
Marianne: a phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC)
-
abstract TPS102.
-
Ellis P. Barrios C. Im Y. Patre M. Branle F. Perez E. (2011) Marianne: a phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatment of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC). J Clin Oncol 29(Suppl): abstract TPS102.
-
(2011)
J Clin Oncol
, vol.29
, Issue.Suppl
-
-
Ellis, P.1
Barrios, C.2
Im, Y.3
Patre, M.4
Branle, F.5
Perez, E.6
-
26
-
-
84945171999
-
Ont-380 in the treatment of HER2+ breast cancer central nervous system (CNS) metastases (Mets)
-
abstract 612.
-
Ferrario C. Welch S. Chaves J. Walker L. Krop I. Hamilton E. et al. (2015) Ont-380 in the treatment of HER2+ breast cancer central nervous system (CNS) metastases (Mets). J Clin Oncol 33(Suppl.): abstract 612.
-
(2015)
J Clin Oncol
, vol.33
-
-
Ferrario, C.1
Welch, S.2
Chaves, J.3
Walker, L.4
Krop, I.5
Hamilton, E.6
-
28
-
-
84933564599
-
Lapatinib or trastuzumab plus taxane therapy for human epidermal growth factor receptor 2-positive advanced breast cancer: final results of NCIC CTG MA.31
-
Gelmon K. Boyle F. Kaufman B. Huntsman D. Manikhas A. Di Leo A. et al. (2015) Lapatinib or trastuzumab plus taxane therapy for human epidermal growth factor receptor 2-positive advanced breast cancer: final results of NCIC CTG MA.31. J Clin Oncol 33: 1574–1583.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1574-1583
-
-
Gelmon, K.1
Boyle, F.2
Kaufman, B.3
Huntsman, D.4
Manikhas, A.5
Di Leo, A.6
-
29
-
-
3042676349
-
Use of trastuzumab beyond disease progression: observations from a retrospective review of case histories
-
discussion 59–62.
-
Gelmon K. Mackey J. Verma S. Gertler S. Bangemann N. Klimo P. et al. (2004) Use of trastuzumab beyond disease progression: observations from a retrospective review of case histories. Clin Breast Cancer 5: 52–58; discussion 59–62.
-
(2004)
Clin Breast Cancer
, vol.5
, pp. 52-58
-
-
Gelmon, K.1
Mackey, J.2
Verma, S.3
Gertler, S.4
Bangemann, N.5
Klimo, P.6
-
31
-
-
84899954624
-
Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort
-
Gianni L. Eiermann W. Semiglazov V. Lluch A. Tjulandin S. Zambetti M. et al. (2014) Neoadjuvant and adjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer (NOAH): follow-up of a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet Oncol 15: 640–647.
-
(2014)
Lancet Oncol
, vol.15
, pp. 640-647
-
-
Gianni, L.1
Eiermann, W.2
Semiglazov, V.3
Lluch, A.4
Tjulandin, S.5
Zambetti, M.6
-
32
-
-
84879477431
-
Averel: a randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent / metastatic breast cancer
-
Gianni L. Romieu G. Lichinitser M. Serrano S. Mansutti M. Pivot X. et al. (2013) Averel: a randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent / metastatic breast cancer. J Clin Oncol 31: 1719–1725.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1719-1725
-
-
Gianni, L.1
Romieu, G.2
Lichinitser, M.3
Serrano, S.4
Mansutti, M.5
Pivot, X.6
-
33
-
-
84905842097
-
Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American society of clinical oncology clinical practice guideline
-
Giordano S. Temin S. Kirshner J. Chandarlapaty S. Crews J. Davidson N. et al. (2014) Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American society of clinical oncology clinical practice guideline. J Clin Oncol 32: 2078–2099.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2078-2099
-
-
Giordano, S.1
Temin, S.2
Kirshner, J.3
Chandarlapaty, S.4
Crews, J.5
Davidson, N.6
-
34
-
-
84884418164
-
2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial
-
Goldhirsch A. Gelber R. Piccart-Gebhart M. de Azambuja E. Procter M. Suter T. et al. (2013) 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet 382: 1021–1028.
-
(2013)
Lancet
, vol.382
, pp. 1021-1028
-
-
Goldhirsch, A.1
Gelber, R.2
Piccart-Gebhart, M.3
de Azambuja, E.4
Procter, M.5
Suter, T.6
-
35
-
-
84945172000
-
A phase 1b study of ONT-380, an oral HER2-specific inhibitor, combined with capecitabine and / or trastuzumab, in HER2+ metastatic breast cancer (MBC)
-
P4–15–19.
-
Hamilton E. Yardley D. Hortobagyi G. Walker L. Borges V. Moulder S. (2015 a) A phase 1b study of ONT-380, an oral HER2-specific inhibitor, combined with capecitabine and / or trastuzumab, in HER2+ metastatic breast cancer (MBC). Cancer Res 75: P4–15–19.
-
(2015)
Cancer Res
, vol.75
-
-
Hamilton, E.1
Yardley, D.2
Hortobagyi, G.3
Walker, L.4
Borges, V.5
Moulder, S.6
-
36
-
-
84945115067
-
Phase 1b study of ONT-380, an oral HER2-specific inhibitor, in combination with capecitabine (C) and trastuzumab (T) in third line + treatment of HER2+ metastatic breast cancer (MBC)
-
abstract 602.
-
Hamilton E. Yardley D. Hortobagyi G. Walker L. Borges V. Moulder S. (2015 b) Phase 1b study of ONT-380, an oral HER2-specific inhibitor, in combination with capecitabine (C) and trastuzumab (T) in third line + treatment of HER2+ metastatic breast cancer (MBC). J Clin Oncol 33(Suppl.): abstract 602.
-
(2015)
J Clin Oncol
, vol.33
-
-
Hamilton, E.1
Yardley, D.2
Hortobagyi, G.3
Walker, L.4
Borges, V.5
Moulder, S.6
-
37
-
-
84959194134
-
Randomized phase III trial of afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one prior trastuzumab treatment: LUX-breast 1
-
P5–19–1.
-
Harbeck N. Huang C. Hurvitz S. Yeh D. Shao Z. Im S. et al. (2014) Randomized phase III trial of afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one prior trastuzumab treatment: LUX-breast 1. Cancer Res 75: P5–19–1.
-
(2014)
Cancer Res
, vol.75
-
-
Harbeck, N.1
Huang, C.2
Hurvitz, S.3
Yeh, D.4
Shao, Z.5
Im, S.6
-
38
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin D. Ellis L. (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 1011–1027.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.1
Ellis, L.2
-
39
-
-
84993725240
-
Phase 3, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and paclitaxel as first-line therapy in women with HER2+ advanced breast cancer: BOLERO-1
-
Poster presentation, S6–01, San Antonio Breast Cancer Symposium
-
Hurvitz S. Andre F. Jiang Z. Shao Z. Neciosup S. Mano M. et al. (2014) Phase 3, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and paclitaxel as first-line therapy in women with HER2+ advanced breast cancer: BOLERO-1. Poster presentation, S6–01, San Antonio Breast Cancer Symposium, December 2014.
-
(2014)
-
-
Hurvitz, S.1
Andre, F.2
Jiang, Z.3
Shao, Z.4
Neciosup, S.5
Mano, M.6
-
40
-
-
84876011018
-
Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Hurvitz S. Dirix L. Kocsis J. Bianchi G. Lu J. Vinholes J. et al. (2013) Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 31: 1157–1163.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1157-1163
-
-
Hurvitz, S.1
Dirix, L.2
Kocsis, J.3
Bianchi, G.4
Lu, J.5
Vinholes, J.6
-
41
-
-
84890405678
-
Safety and efficacy of neratinib in combination with weekly paclitaxel and trastuzumab in women with metastatic HER2-positive breast cancer: an NSABP foundation research program phase I study
-
Jankowitz R. Abraham J. Tan A. Limentani S. Tierno M. Adamson L. et al. (2013) Safety and efficacy of neratinib in combination with weekly paclitaxel and trastuzumab in women with metastatic HER2-positive breast cancer: an NSABP foundation research program phase I study. Cancer Chemother Pharmacol 72: 1205–1212.
-
(2013)
Cancer Chemother Pharmacol
, vol.72
, pp. 1205-1212
-
-
Jankowitz, R.1
Abraham, J.2
Tan, A.3
Limentani, S.4
Tierno, M.5
Adamson, L.6
-
42
-
-
73349115249
-
Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FINHER trial
-
Joensuu H. Bono P. Kataja V. Alanko T. Kokko R. Asola R. et al. (2009) Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FINHER trial. J Clin Oncol 27: 5685–5692.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5685-5692
-
-
Joensuu, H.1
Bono, P.2
Kataja, V.3
Alanko, T.4
Kokko, R.5
Asola, R.6
-
43
-
-
12144291334
-
Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients
-
Konecny G. Meng Y. Untch M. Wang H. Bauerfeind I. Epstein M. et al. (2004) Association between HER-2/neu and vascular endothelial growth factor expression predicts clinical outcome in primary breast cancer patients. Clin Cancer Res 10: 1706–1716.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1706-1716
-
-
Konecny, G.1
Meng, Y.2
Untch, M.3
Wang, H.4
Bauerfeind, I.5
Epstein, M.6
-
44
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
Konecny G. Pegram M. Venkatesan N. Finn R. Yang G. Rahmeh M. et al. (2006) Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res 66: 1630–1639.
-
(2006)
Cancer Res
, vol.66
, pp. 1630-1639
-
-
Konecny, G.1
Pegram, M.2
Venkatesan, N.3
Finn, R.4
Yang, G.5
Rahmeh, M.6
-
45
-
-
84901639476
-
Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial
-
Krop I. Kim S. González-Martín A. Lorusso P. Ferrero J. Smitt M. et al. (2014) Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial. Lancet Oncol 15: 689–699.
-
(2014)
Lancet Oncol
, vol.15
, pp. 689-699
-
-
Krop, I.1
Kim, S.2
González-Martín, A.3
Lorusso, P.4
Ferrero, J.5
Smitt, M.6
-
46
-
-
84922507404
-
Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA
-
Krop I. Lin N. Blackwell K. Guardino E. Huober J. Lu M. et al. (2015) Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA. Ann Oncol 26: 113–119.
-
(2015)
Ann Oncol
, vol.26
, pp. 113-119
-
-
Krop, I.1
Lin, N.2
Blackwell, K.3
Guardino, E.4
Huober, J.5
Lu, M.6
-
47
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung D. Cachianes G. Kuang W. Goeddel D. Ferrara N. (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306–1309.
-
(1989)
Science
, vol.246
, pp. 1306-1309
-
-
Leung, D.1
Cachianes, G.2
Kuang, W.3
Goeddel, D.4
Ferrara, N.5
-
48
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips G. Li G. Dugger D. Crocker L. Parsons K. Mai E. et al. (2008) Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 68: 9280–9290.
-
(2008)
Cancer Res
, vol.68
, pp. 9280-9290
-
-
Lewis Phillips, G.1
Li, G.2
Dugger, D.3
Crocker, L.4
Parsons, K.5
Mai, E.6
-
49
-
-
63149110733
-
Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer
-
Lin N. Dieras V. Paul D. Lossignol D. Christodoulou C. Stemmler H. et al. (2009) Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res 15: 1452–1459.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1452-1459
-
-
Lin, N.1
Dieras, V.2
Paul, D.3
Lossignol, D.4
Christodoulou, C.5
Stemmler, H.6
-
50
-
-
84878757223
-
A phase II study of bevacizumab in combination with vinorelbine and trastuzumab in HER2-positive metastatic breast cancer
-
Lin N. Seah D. Gelman R. Desantis S. Mayer E. Isakoff S. et al. (2013) A phase II study of bevacizumab in combination with vinorelbine and trastuzumab in HER2-positive metastatic breast cancer. Breast Cancer Res Treat 139: 403–410.
-
(2013)
Breast Cancer Res Treat
, vol.139
, pp. 403-410
-
-
Lin, N.1
Seah, D.2
Gelman, R.3
Desantis, S.4
Mayer, E.5
Isakoff, S.6
-
51
-
-
84863715765
-
A phase II study of afatinib (BIBW 2992), an irreversible Erbb family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab
-
Lin N. Winer E. Wheatley D. Carey L. Houston S. Mendelson D. et al. (2012) A phase II study of afatinib (BIBW 2992), an irreversible Erbb family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab. Breast Cancer Res Treat 133: 1057–1065.
-
(2012)
Breast Cancer Res Treat
, vol.133
, pp. 1057-1065
-
-
Lin, N.1
Winer, E.2
Wheatley, D.3
Carey, L.4
Houston, S.5
Mendelson, D.6
-
52
-
-
35348917266
-
Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency
-
Lu C. Wyszomierski S. Tseng L. Sun M. Lan K. Neal C. et al. (2007) Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. Clin Cancer Res 13: 5883–5888.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5883-5888
-
-
Lu, C.1
Wyszomierski, S.2
Tseng, L.3
Sun, M.4
Lan, K.5
Neal, C.6
-
53
-
-
0035915421
-
Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
-
Lu Y. Zi X. Zhao Y. Mascarenhas D. Pollak M. (2001) Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 93: 1852–1857.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1852-1857
-
-
Lu, Y.1
Zi, X.2
Zhao, Y.3
Mascarenhas, D.4
Pollak, M.5
-
54
-
-
84888004978
-
A phase two randomised trial of neratinib monotherapy versus lapatinib plus capecitabine combination therapy in patients with HER2+ advanced breast cancer
-
Martin M. Bonneterre J. Geyer C. Jr. Ito Y. Ro J. Lang I. et al. (2013) A phase two randomised trial of neratinib monotherapy versus lapatinib plus capecitabine combination therapy in patients with HER2+ advanced breast cancer. Eur J Cancer 49: 3763–3772.
-
(2013)
Eur J Cancer
, vol.49
, pp. 3763-3772
-
-
Martin, M.1
Bonneterre, J.2
Geyer, C.3
Ito, Y.4
Ro, J.5
Lang, I.6
-
55
-
-
84860148054
-
Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer
-
Martin M. Makhson A. Gligorov J. Lichinitser M. Lluch A. Semiglazov V. et al. (2012) Phase II study of bevacizumab in combination with trastuzumab and capecitabine as first-line treatment for HER-2-positive locally recurrent or metastatic breast cancer. Oncologist 17: 469–475.
-
(2012)
Oncologist
, vol.17
, pp. 469-475
-
-
Martin, M.1
Makhson, A.2
Gligorov, J.3
Lichinitser, M.4
Lluch, A.5
Semiglazov, V.6
-
56
-
-
22344446208
-
Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M 77001 study group
-
Marty M. Cognetti F. Maraninchi D. Snyder R. Mauriac L. Tubiana-Hulin M. et al. (2005) Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M 77001 study group. J Clin Oncol 23: 4265–4274.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4265-4274
-
-
Marty, M.1
Cognetti, F.2
Maraninchi, D.3
Snyder, R.4
Mauriac, L.5
Tubiana-Hulin, M.6
-
57
-
-
79952017724
-
Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine
-
Metro G. Foglietta J. Russillo M. Stocchi L. Vidiri A. Giannarelli D. et al. (2011) Clinical outcome of patients with brain metastases from HER2-positive breast cancer treated with lapatinib and capecitabine. Ann Oncol 22: 625–630.
-
(2011)
Ann Oncol
, vol.22
, pp. 625-630
-
-
Metro, G.1
Foglietta, J.2
Russillo, M.3
Stocchi, L.4
Vidiri, A.5
Giannarelli, D.6
-
58
-
-
84993786879
-
Assessment of safety and activity in an expanded phase 1 study of MM-302, a HER2-targeted liposomal doxorubicin, in patients with advanced HER2-positive (HER2+) breast cancer
-
Poster presentation, P4–12–29, San Antonio Breast Cancer Symposium
-
Munster P. Krop I. Miller K. Dhindsa N. Niyijiza C. Nielsen U. et al. (2013) Assessment of safety and activity in an expanded phase 1 study of MM-302, a HER2-targeted liposomal doxorubicin, in patients with advanced HER2-positive (HER2+) breast cancer. Poster presentation, P4–12–29, San Antonio Breast Cancer Symposium, December 2013.
-
(2013)
-
-
Munster, P.1
Krop, I.2
Miller, K.3
Dhindsa, N.4
Niyijiza, C.5
Nielsen, U.6
-
59
-
-
28244432561
-
Insulin-like growth factor-I receptor / human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
Nahta R. Yuan L. Zhang B. Kobayashi R. Esteva F. (2005) Insulin-like growth factor-I receptor / human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 65: 11118–11128.
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.2
Zhang, B.3
Kobayashi, R.4
Esteva, F.5
-
60
-
-
84871713793
-
Efficacy of HER2-targeted therapy in metastatic breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors
-
Nielsen D. Kumler I. Palshof J. Andersson M. (2013) Efficacy of HER2-targeted therapy in metastatic breast cancer. Monoclonal antibodies and tyrosine kinase inhibitors. Breast 22: 1–12.
-
(2013)
Breast
, vol.22
, pp. 1-12
-
-
Nielsen, D.1
Kumler, I.2
Palshof, J.3
Andersson, M.4
-
61
-
-
82255167636
-
Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties
-
Nordstrom J. Gorlatov S. Zhang W. Yang Y. Huang L. Burke S. et al. (2011) Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties. Breast Cancer Res 13: R123.
-
(2011)
Breast Cancer Res
, vol.13
, pp. R123
-
-
Nordstrom, J.1
Gorlatov, S.2
Zhang, W.3
Yang, Y.4
Huang, L.5
Burke, S.6
-
62
-
-
84945115103
-
A single-arm, open-label, phase 2 study of MGAH 22 (Margetuximab) [fc-optimized chimeric anti-HER2 monoclonal antibody (mAb)] in patients with relapsed or refractory advanced breast cancer whose tumors express HER 2 at the 2+ level by immunohistochemistry and lack evidence of HER 2 gene amplification by FISH
-
abstract TPS671.
-
Pegram M. Tan-Chiu E. Miller K. Rugo H. Yardley D. Liv S. et al. (2014) A single-arm, open-label, phase 2 study of MGAH 22 (Margetuximab) [fc-optimized chimeric anti-HER2 monoclonal antibody (mAb)] in patients with relapsed or refractory advanced breast cancer whose tumors express HER 2 at the 2+ level by immunohistochemistry and lack evidence of HER 2 gene amplification by FISH. J Clin Oncol 32(Suppl. 15): abstract TPS671.
-
(2014)
J Clin Oncol
, vol.32
-
-
Pegram, M.1
Tan-Chiu, E.2
Miller, K.3
Rugo, H.4
Yardley, D.5
Liv, S.6
-
63
-
-
84911908120
-
Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831
-
Perez E. Romond E. Suman V. Jeong J. Sledge G. Geyer C. Jr. et al. (2014) Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831. J Clin Oncol 32: 3744–3752.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3744-3752
-
-
Perez, E.1
Romond, E.2
Suman, V.3
Jeong, J.4
Sledge, G.5
Geyer, C.6
-
64
-
-
84892724922
-
Dual targeting of HER2-positive cancer with trastuzumab emtansine and pertuzumab: critical role for neuregulin blockade in antitumor response to combination therapy
-
Phillips G. Fields C. Li G. Dowbenko D. Schaefer G. Miller K. et al. (2014) Dual targeting of HER2-positive cancer with trastuzumab emtansine and pertuzumab: critical role for neuregulin blockade in antitumor response to combination therapy. Clin Cancer Res 20: 456–468.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 456-468
-
-
Phillips, G.1
Fields, C.2
Li, G.3
Dowbenko, D.4
Schaefer, G.5
Miller, K.6
-
65
-
-
84933556321
-
Cerebel (EGF111438): a phase III, randomized, open-label study of lapatinib plus capecitabine versus trastuzumab plus capecitabine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Pivot X. Manikhas A. Zurawski B. Chmielowska E. Karaszewska B. Allerton R. et al. (2015) Cerebel (EGF111438): a phase III, randomized, open-label study of lapatinib plus capecitabine versus trastuzumab plus capecitabine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 33: 1564–1573.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1564-1573
-
-
Pivot, X.1
Manikhas, A.2
Zurawski, B.3
Chmielowska, E.4
Karaszewska, B.5
Allerton, R.6
-
66
-
-
2542582261
-
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
-
Rabindran S. Discafani C. Rosfjord E. Baxter M. Floyd M. Golas J. et al. (2004) Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 64: 3958–3965.
-
(2004)
Cancer Res
, vol.64
, pp. 3958-3965
-
-
Rabindran, S.1
Discafani, C.2
Rosfjord, E.3
Baxter, M.4
Floyd, M.5
Golas, J.6
-
67
-
-
33745530224
-
Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer
-
Robert N. Leyland-Jones B. Asmar L. Belt R. Ilegbodu D. Loesch D. et al. (2006) Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 24: 2786–2792.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2786-2792
-
-
Robert, N.1
Leyland-Jones, B.2
Asmar, L.3
Belt, R.4
Ilegbodu, D.5
Loesch, D.6
-
68
-
-
2942621888
-
Bevacizumab in the treatment of breast cancer: rationale and current data
-
Rugo H. (2004) Bevacizumab in the treatment of breast cancer: rationale and current data. Oncologist 9(Suppl. 1): 43–49.
-
(2004)
Oncologist
, vol.9
, pp. 43-49
-
-
Rugo, H.1
-
69
-
-
84911943039
-
Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer
-
Saura C. Garcia-Saenz J. Xu B. Harb W. Moroose R. Pluard T. et al. (2014) Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 32: 3626–3633.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3626-3633
-
-
Saura, C.1
Garcia-Saenz, J.2
Xu, B.3
Harb, W.4
Moroose, R.5
Pluard, T.6
-
70
-
-
73649149433
-
Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models
-
Scheuer W. Friess T. Burtscher H. Bossenmaier B. Endl J. Hasmann M. (2009) Strongly enhanced antitumor activity of trastuzumab and pertuzumab combination treatment on HER2-positive human xenograft tumor models. Cancer Res 69: 9330–9336.
-
(2009)
Cancer Res
, vol.69
, pp. 9330-9336
-
-
Scheuer, W.1
Friess, T.2
Burtscher, H.3
Bossenmaier, B.4
Endl, J.5
Hasmann, M.6
-
71
-
-
43249115659
-
Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of cancer and leukemia group B protocol 9840
-
Seidman A. Berry D. Cirrincione C. Harris L. Muss H. Marcom P. et al. (2008) Randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors: final results of cancer and leukemia group B protocol 9840. J Clin Oncol 26: 1642–1649.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1642-1649
-
-
Seidman, A.1
Berry, D.2
Cirrincione, C.3
Harris, L.4
Muss, H.5
Marcom, P.6
-
73
-
-
37049183697
-
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon D. Clark G. Wong S. Levin W. Ullrich A. Mcguire W. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177–182.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.1
Clark, G.2
Wong, S.3
Levin, W.4
Ullrich, A.5
Mcguire, W.6
-
75
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon D. Godolphin W. Jones L. Holt J. Wong S. Keith D. et al. (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244: 707–712.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.1
Godolphin, W.2
Jones, L.3
Holt, J.4
Wong, S.5
Keith, D.6
-
76
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER 2 for metastatic breast cancer that overexpresses HER2
-
Slamon D. Leyland-Jones B. Shak S. Fuchs H. Paton V. Bajamonde A. et al. (2001) Use of chemotherapy plus a monoclonal antibody against HER 2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344: 783–792.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
-
77
-
-
84899906863
-
Primary results from beth, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab ± bevacizumab in patients with HER2-positive, node-positive, or high-risk node-negative breast cancer
-
Post Presentation: S1–03, San Antonio Breast Cancer Symposium
-
Slamon D. Swain S. Buyse M. Martin M. Geyer C. Im Y. et al. (2013) Primary results from beth, a phase 3 controlled study of adjuvant chemotherapy and trastuzumab ± bevacizumab in patients with HER2-positive, node-positive, or high-risk node-negative breast cancer. Post Presentation: S1–03, San Antonio Breast Cancer Symposium, December 2013.
-
(2013)
-
-
Slamon, D.1
Swain, S.2
Buyse, M.3
Martin, M.4
Geyer, C.5
Im, Y.6
-
78
-
-
77949542447
-
Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases – the UK experience
-
Sutherland S. Ashley S. Miles D. Chan S. Wardley A. Davidson N. et al. (2010) Treatment of HER2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases – the UK experience. Br J Cancer 102: 995–1002.
-
(2010)
Br J Cancer
, vol.102
, pp. 995-1002
-
-
Sutherland, S.1
Ashley, S.2
Miles, D.3
Chan, S.4
Wardley, A.5
Davidson, N.6
-
79
-
-
84923052492
-
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
-
Swain S. Baselga J. Kim S. Ro J. Semiglazov V. Campone M. et al. (2015) Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med 372: 724–734.
-
(2015)
N Engl J Med
, vol.372
, pp. 724-734
-
-
Swain, S.1
Baselga, J.2
Kim, S.3
Ro, J.4
Semiglazov, V.5
Campone, M.6
-
80
-
-
84903885321
-
Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: results from the randomized phase III study cleopatra
-
Swain S. Baselga J. Miles D. Im Y. Quah C. Lee L. et al. (2014) Incidence of central nervous system metastases in patients with HER2-positive metastatic breast cancer treated with pertuzumab, trastuzumab, and docetaxel: results from the randomized phase III study cleopatra. Ann Oncol 25: 1116–1121.
-
(2014)
Ann Oncol
, vol.25
, pp. 1116-1121
-
-
Swain, S.1
Baselga, J.2
Miles, D.3
Im, Y.4
Quah, C.5
Lee, L.6
-
81
-
-
84876970810
-
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (Cleopatra Study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
-
Swain S. Kim S. Cortés J. Ro J. Semiglazov V. Campone M. et al. (2013) Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (Cleopatra Study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol 14: 461–471.
-
(2013)
Lancet Oncol
, vol.14
, pp. 461-471
-
-
Swain, S.1
Kim, S.2
Cortés, J.3
Ro, J.4
Semiglazov, V.5
Campone, M.6
-
82
-
-
84925503345
-
Phase I / II study of pilaralisib (SAR245408) in combination with trastuzumab or trastuzumab plus paclitaxel in trastuzumab-refractory HER2-positive metastatic breast cancer
-
Tolaney S. Burris H. Gartner E. Mayer I. Saura C. Maurer M. et al. (2015) Phase I / II study of pilaralisib (SAR245408) in combination with trastuzumab or trastuzumab plus paclitaxel in trastuzumab-refractory HER2-positive metastatic breast cancer. Breast Cancer Res Treat 149: 151–161.
-
(2015)
Breast Cancer Res Treat
, vol.149
, pp. 151-161
-
-
Tolaney, S.1
Burris, H.2
Gartner, E.3
Mayer, I.4
Saura, C.5
Maurer, M.6
-
83
-
-
84924271853
-
Global cancer statistics, 2012
-
Torre L. Bray F. Siegel R. Ferlay J. Lortet-Tieulent J. Jemal A. (2015) Global cancer statistics, 2012. CA Cancer J Clin 65: 87–108.
-
(2015)
CA Cancer J Clin
, vol.65
, pp. 87-108
-
-
Torre, L.1
Bray, F.2
Siegel, R.3
Ferlay, J.4
Lortet-Tieulent, J.5
Jemal, A.6
-
84
-
-
1842614245
-
Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
-
Tripathy D. Slamon D. Cobleigh M. Arnold A. Saleh M. Mortimer J. et al. (2004) Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol 22: 1063–1070.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1063-1070
-
-
Tripathy, D.1
Slamon, D.2
Cobleigh, M.3
Arnold, A.4
Saleh, M.5
Mortimer, J.6
-
86
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel C. Cobleigh M. Tripathy D. Gutheil J. Harris L. Fehrenbacher L. et al. (2002) Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20: 719–726.
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.1
Cobleigh, M.2
Tripathy, D.3
Gutheil, J.4
Harris, L.5
Fehrenbacher, L.6
-
87
-
-
65349110371
-
Trastuzumab Beyond Progression in Human Epidermal Growth Factor Receptor 2-Positive Advanced Breast Cancer: A German Breast Group 26/Breast International Group 03-05 Study
-
von Minckwitz G. Du Bois A. Schmidt M. Maass N. Cufer T. de Jongh F.E. et al. (2009) Trastuzumab Beyond Progression in Human Epidermal Growth Factor Receptor 2-Positive Advanced Breast Cancer: A German Breast Group 26/Breast International Group 03-05 Study. J Clin Oncol 27: 1999–2006.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1999-2006
-
-
von Minckwitz, G.1
Du Bois, A.2
Schmidt, M.3
Maass, N.4
Cufer, T.5
de Jongh, F.E.6
-
88
-
-
80053362290
-
Trastuzumab beyond progression: overall survival analysis of the GBG 26/BIG 3–05 phase III study in HER2-positive breast cancer
-
von Minckwitz G. Schwedler K. Schmidt M. Barinoff J. Mundhenke C. Cufer T. et al. (2011) Trastuzumab beyond progression: overall survival analysis of the GBG 26/BIG 3–05 phase III study in HER2-positive breast cancer. Eur J Cancer 47: 2273–2281.
-
(2011)
Eur J Cancer
, vol.47
, pp. 2273-2281
-
-
von Minckwitz, G.1
Schwedler, K.2
Schmidt, M.3
Barinoff, J.4
Mundhenke, C.5
Cufer, T.6
-
89
-
-
0034691674
-
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
-
Yen L. You X. Al Moustafa A. Batist G. Hynes N. Mader S. et al. (2000) Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene 19: 3460–3469.
-
(2000)
Oncogene
, vol.19
, pp. 3460-3469
-
-
Yen, L.1
You, X.2
Al Moustafa, A.3
Batist, G.4
Hynes, N.5
Mader, S.6
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