A 9-Year Prospective Population-Based Study on the Association between the APOE∗E4 Allele and Late-Life Depression in Sweden

Biological Psychiatry

Volumn 78, Issue 10, 2015, Pages 730-736

  Skoog, Ingmar ^a   Waern, Margda ^a   Duberstein, Paul ^c   Blennow, Kaj ^b   Zetterberg, Henrik ^b,d   Börjesson Hanson, Anne ^a   Östling, Svante ^a   Guo, Xinxin ^a   Kern, Jürgen ^a   Gustafson, Deborah ^a   Gudmundsson, Pia ^a   Marlow, Thomas ^a   Kern, Silke ^a,b  

^a Neuropsychiatric Epidemiology Unit   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apolipoprotein E 4 (APOE; Dementia; Depression; E4) allele; Older adults; Population based study; Prospective

Indexed keywords

APOLIPOPROTEIN E4;

AGED; ALLELE; ARTICLE; DEMENTIA; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HIGH RISK POPULATION; HUMAN; LATE LIFE DEPRESSION; MAJOR CLINICAL STUDY; MALE; MENTAL DETERIORATION; MINI INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; SWEDEN; DEPRESSIVE DISORDER; DEPRESSIVE DISORDER, MAJOR; GENETICS; LATE ONSET DISORDER; VERY ELDERLY;

AGED; AGED, 80 AND OVER; APOLIPOPROTEIN E4; DEPRESSIVE DISORDER; DEPRESSIVE DISORDER, MAJOR; FEMALE; FOLLOW-UP STUDIES; HUMANS; LATE ONSET DISORDERS; MALE; PROSPECTIVE STUDIES; SWEDEN;

EID: 84945128004     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.01.006     Document Type: Article

References (85)

1. J. Kim, J.M. Basak, and D.M. Holtzman The role of apolipoprotein E in Alzheimers disease Neuron 63 2009 287 303
2. P.B. Verghese, J.M. Castellano, and D.M. Holtzman Apolipoprotein E in Alzheimers disease and other neurological disorders Lancet Neurol 10 2011 241 252
3. B.V. Zlokovic Cerebrovascular effects of apolipoprotein E: Implications for Alzheimer disease JAMA Neurol 70 2013 440 444
4. M.F. Weiner, G. Vega, R.C. Risser, L.S. Honig, C.M. Cullum, D. Crumpacker, and et al. Apolipoprotein E epsilon 4, other risk factors, and course of Alzheimers disease Biol Psychiatry 45 1999 633 638
5. A.M. Saunders, W.J. Strittmatter, D. Schmechel, P.H. George-Hyslop, M.A. Pericak-Vance, S.H. Joo, and et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimers disease Neurology 43 1993 1467 1472
6. Y.Q. Song, M.J. Stampfer, and S.M. Liu Meta-analysis: Apolipoprotein E genotypes and risk for coronary heart disease Ann Intern Med 141 2004 137 147
7. A.M. Saunders, O. Hulette, K.A. Welsh-Bohmer, D.E. Schmechel, B. Crain, J.R. Burke, and et al. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimers disease Lancet 348 1996 90 93
8. S. Lehtinen, T. Lehtimaki, T. Sisto, J.P. Salenius, M. Nikkila, H. Jokela, and et al. Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women Atherosclerosis 114 1995 83 91
9. M.O. McCarron, D. Delong, and M.J. Alberts APOE genotype as a risk factor for ischemic cerebrovascular disease: A meta-analysis Neurology 53 1999 1308 1311
10. K.R. Krishnan, L.A. Tupler, J.C. Ritchie Jr, W.M. McDonald, D.L. Knight, C.B. Nemeroff, and et al. Apolipoprotein E-epsilon 4 frequency in geriatric depression Biol Psychiatry 40 1996 69 71
11. G. Ramachandran, K. Marder, M. Tang, P.W. Schofield, M.R. Chun, D.P. Devanand, and et al. A preliminary study of apolipoprotein E genotype and psychiatric manifestations of Alzheimers disease Neurology 47 1996 256 259
12. A.S. Rigaud, L. Traykov, L. Caputo, J. Coste, F. Latour, R. Couderc, and et al. Association of the apolipoprotein E epsilon4 allele with late-onset depression Neuroepidemiology 20 2001 268 272
13. M.A. Butters, R.A. Sweet, B.H. Mulsant, M. Ilyas Kamboh, B.G. Pollock, A.E. Begley, and et al. APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression Int J Geriatr Psychiatry 18 2003 1075 1081
14. J.P. Hwang, C.H. Yang, C.J. Hong, J.F. Lirng, Y.M. Yang, and S.J. Tsai Association of APOE genetic polymorphism with cognitive function and suicide history in geriatric depression Dement Geriatr Cogn Disord 22 2006 334 338
15. K. Ohara, M. Nagai, Y. Suzuki, K. Yoshida, and T. Tsukamoto Apolipoprotein E epsilon 4 allele and Japanese late-onset depressive disorders Biol Psychiatry 45 1999 308 312
16. M.A. Slifer, E.R. Martin, J.R. Gilbert, J.L. Haines, and M.A. Pericak-Vance Resolving the relationship between apolipoproteinE and depression Neurosci Lett 455 2009 116 119
17. D.G. Blazer, B.B. Burchett, and G.G. Fillenbaum APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample Am J Geriatr Psychiatry 10 2002 515 520
18. D.C. Steffens, E. Otey, G.S. Alexopoulos, M.A. Butters, B. Cuthbert, M. Ganguli, and et al. Perspectives on depression, mild cognitive impairment, and cognitive decline Arch Gen Psychiatry 63 2006 130 138
19. M. Nose, C. Kodama, C. Ikejima, K. Mizukami, A. Matsuzaki, S. Tanaka, and et al. ApoE4 is not associated with depression when mild cognitive impairment is considered Int J Geriatr Psychiatry 28 2013 155 163
20. H.R. Bogner, M.B. Richie, H.F. de Vries, and K.H. Morales Depression, cognition, apolipoprotein E genotype: Latent class approach to identifying subtype Am J Geriatr Psychiatry 1 2009 344 352
21. D.G. Harwood, W.W. Barker, R.L. Ownby, M. Mullan, and R. Duara Factors associated with depressive symptoms in non-demented community-dwelling elderly Int J Geriatr Psychiatry 14 1999 331 337
22. R. Stewart, C. Russ, M. Richards, C. Brayne, S. Lovestone, and A. Mann Depression, APOE genotype and subjective memory impairment: A cross-sectional study in an African-Caribbean population Psychol Med 31 2001 431 440
23. Y.C. Yen, G.W. Rebok, J.J. Gallo, M.J. Yang, F.W. Lung, and C.H. Shih ApoE4 allele is associated with late-life depression: A population-based study Am J Geriatr Psychiatry 15 2007 858 868
24. R. Sureshkumar, S. Bharath, S. Jain, O. Prakash, M. Purushottam, K. Thennarasu, and et al. ApoE4 and late onset depression in Indian population J Affect Disord 136 2012 244 248
25. D.C. Steffens, M.C. Norton, A.D. Hart, I. Skoog, C. Corcoran, and J.C. Breitner Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study Psychol Med 33 2003 541 547
26. M. Mauricio, R. O'Hara, J.A. Yesavage, L. Friedman, H.C. Kraemer, M. Van De Water, and et al. A longitudinal study of apolipoprotein-E genotype and depressive symptoms in community-dwelling older adults Am J Geriatr Psychiatry 8 2000 196 200
27. H. Lavretsky, L. Ercoli, P. Siddarth, S. Bookheimer, K. Miller, and G. Small Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia Am J Geriatr Psychiatry 11 2003 667 673
28. P.G. Surtees, N.W. Wainwright, R. Bowman, R.N. Luben, N.J. Wareham, K.T. Khaw, and et al. No association between APOE and major depressive disorder in a community sample of 17,507 adults J Psychiatr Res 43 2009 843 847
29. M. Niti, K.B. Yap, E.H. Kua, and T.P. Ng APOE-epsilon4, depressive symptoms, and cognitive decline in Chinese older adults: Singapore Longitudinal Aging Studies J Gerontol A Biol Sci Med Sci 64 2009 306 311
30. D.E. Locke, A.C. Dueck, C.M. Stonnington, D.S. Knopman, Y.E. Geda, and R.J. Caselli Depressive symptoms in healthy apolipoprotein E epsilon4 carriers and noncarriers: A longitudinal study J Clin Psychiatry 74 2013 1256 1261
31. J.A. Brommelhoff, M. Gatz, B. Johansson, J.J. McArdle, L. Fratiglioni, and N.L. Pedersen Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins Psychol Aging 24 2009 373 384
32. B. Steen, and H. Djurfeldt The gerontological and geriatric population studies in Gothenburg, Sweden Z Gerontol 26 1993 163 169
33. C. Bengtsson, M. Ahlqwist, K. Andersson, C. Bjorkelund, L. Lissner, and M. Soderstrom The Prospective Population Study of Women in Gothenburg, Sweden, 1968-69 to 1992-93. A 24-year follow-up study with special reference to participation, representativeness, and mortality Scand J Prim Health Care 15 1997 214 219
34. I. Skoog Psychiatric epidemiology of old age: The H70 study - the NAPE lecture 2003 Acta Psychiatr Scand 109 2004 4 18
35. B. Karlsson, I.F. Klenfeldt, R. Sigstrom, M. Waern, S. Ostling, D. Gustafson, and et al. Prevalence of social phobia in non-demented elderly from a Swedish population study Am J Geriatr Psychiatry 17 2009 127 135
36. M. Asberg, S.A. Montgomery, C. Perris, D. Schalling, and G. Sedvall A comprehensive psychopathological rating scale Acta Psychiatr Scand Suppl 271 1978 5 27
37. N.C. van der Laan, A. Schimmel, and T.J. Heeren The applicability and the inter-rater reliability of the Comprehensive Psychopathological Rating Scale in an elderly clinical population Int J Geriatr Psychiatry 20 2005 35 40
38. D.V. Sheehan, Y. Lecrubier, K.H. Sheehan, P. Amorim, J. Janavs, E. Weiller, and et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 J Clin Psychiatry 59 suppl 20 1998 22 33 quiz 4-57
39. I. Skoog, L. Nilsson, B. Palmertz, L.A. Andreasson, and A. Svanborg A population-based study of dementia in 85-year-olds N Engl J Med 328 1993 153 158
40. X. Guo, M. Waern, K. Sjogren, L. Lissner, C. Bengtsson, C. Bjorkelund, and et al. Midlife respiratory function and incidence of Alzheimers disease: A 29-year longitudinal study in women Neurobiol Aging 28 2007 343 350
41. M.F. Folstein, S.E. Folstein, and P.R. McHugh "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
42. J. Wancata, A. Borjesson-Hanson, S. Ostling, K. Sjogren, and I. Skoog Diagnostic criteria influence dementia prevalence Am J Geriatr Psychiatry 15 2007 1034 1045
43. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4th ed. 1994 American Psychiatric Press Washington, DC
44. I. Skoog, L. Nilsson, S. Landahl, and B. Steen Mental disorders and the use of psychotropic drugs in an 85-year-old urban population Int Psychogeriatr 5 1993 33 48
45. M. Maj Bereavement-related depression in the DSM-5 and ICD-11 World Psychiatry 11 2012 1 2
46. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 3rd ed, rev 1987 American Psychiatric Association Washington, DC
47. K. Blennow, A. Ricksten, J.A. Prince, A.J. Brookes, T. Emahazion, C. Wasslavik, and et al. No association between the alpha2-macroglobulin (A2M) deletion and Alzheimers disease, and no change in A2M mRNA, protein, or protein expression J Neural Transm 107 2000 1065 1079
48. H.C. Hendrie, K.S. Hall, S. Hui, F.W. Unverzagt, C.E. Yu, D.K. Lahiri, and et al. Apolipoprotein E genotypes and Alzheimers disease in a community study of elderly African Americans Ann Neurol 37 1995 118 120
49. A. Sahota, M. Yang, S. Gao, S.L. Hui, O. Baiyewu, O. Gureje, and et al. Apolipoprotein E-associated risk for Alzheimers disease in the African-American population is genotype dependent Ann Neurol 42 1997 659 661
50. O. Gureje, A. Ogunniyi, O. Baiyewu, B. Price, F.W. Unverzagt, R.M. Evans, and et al. APOE epsilon4 is not associated with Alzheimers disease in elderly Nigerians Ann Neurol 59 2006 182 185
51. D.A. Evans, D.A. Bennett, R.S. Wilson, J.L. Bienias, M.C. Morris, P.A. Scherr, and et al. Incidence of Alzheimer disease in a biracial urban community: Relation to apolipoprotein E allele status Arch Neurol 60 2003 185 189
52. D.V. Jeste, C.A. Depp, and I.V. Vahia Successful cognitive and emotional aging World Psychiatry 9 2010 78 84
53. R.M. Corbo, and R. Scacchi Apolipoprotein E (APOE) allele distribution in the world. Is APOE∗4 a "thrifty" allele? Ann Hum Genet 63 pt 4 1999 301 310
54. L.U. Gerdes The common polymorphism of apolipoprotein E: Geographical aspects and new pathophysiological relations Clin Chem Lab Med 41 2003 628 631
55. S. Drefahl, A. Ahlbom, and K. Modig Losing ground - Swedish life expectancy in a comparative perspective PloS One 9 2014 e88357
56. D.M. Girling, C. Barkley, E.S. Paykel, E. Gehlhaar, C. Brayne, C. Gill, and et al. The prevalence of depression in a cohort of the very elderly J Affect Disord 34 1995 319 329
57. G. Sozeri-Varma Depression in the elderly: Clinical features and risk factors Aging Dis 3 2012 465 471
58. M. Polyakova, N. Sonnabend, C. Sander, R. Mergl, M.L. Schroeter, J. Schroeder, and et al. Prevalence of minor depression in elderly persons with and without mild cognitive impairment: A systematic review J Affect Disord 152-154 2014 28 38
59. A. Paivarinta, A. Verkkoniemi, L. Niinisto, S.L. Kivela, and R. Sulkava The prevalence and associates of depressive disorders in the oldest-old Finns Soc Psychiatry Psychiatr Epidemiol 34 1999 352 359
60. K. Jongenelis, A.M. Pot, A.M. Eisses, A.T. Beekman, H. Kluiter, and M.W. Ribbe Prevalence and risk indicators of depression in elderly nursing home patients: The AGED study J Affect Disord 83 2004 135 142
61. P.J. Olesen, D.R. Gustafson, M. Simoni, L. Pantoni, S. Ostling, X. Guo, and et al. Temporal lobe atrophy and white matter lesions are related to major depression over 5 years in the elderly Neuropsychopharmacology 35 2010 2638 2645
62. S.D. Moffat, C.A. Szekely, A.B. Zonderman, N.J. Kabani, and S.M. Resnick Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype Neurology 55 2000 134 136
63. K. Chen, E.M. Reiman, G.E. Alexander, R.J. Caselli, R. Gerkin, D. Bandy, and et al. Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates Am J Psychiatry 164 2007 916 921
64. P. Videbech, and B. Ravnkilde Hippocampal volume and depression: A meta-analysis of MRI studies Am J Psychiatry 161 2004 1957 1966
65. S. Campbell, M. Marriott, C. Nahmias, and G.M. MacQueen Lower hippocampal volume in patients suffering from depression: A meta-analysis Am J Psychiatry 161 2004 598 607
66. N. Sachs-Ericsson, K. Sawyer, E. Corsentino, N. Collins, and D.C. Steffens The moderating effect of the APOE [small element of] 4 allele on the relationship between hippocampal volume and cognitive decline in older depressed patients Am J Geriatr Psychiatry 19 2011 23 32
67. A. Qiu, W.D. Taylor, Z. Zhao, J.R. MacFall, M.I. Miller, C.R. Key, and et al. APOE related hippocampal shape alteration in geriatric depression Neuroimage 44 2009 620 626
68. Y. Yuan, Z. Zhang, F. Bai, J. You, H. Yu, Y. Shi, and et al. Genetic variation in apolipoprotein E alters regional gray matter volumes in remitted late-onset depression J Affect Disord 121 2010 273 277
69. J.A. Schneider, J.L. Bienias, R.S. Wilson, E. Berry-Kravis, D.A. Evans, and D.A. Bennett The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons Stroke 36 2005 954 959
70. D. Woo, R. Kaushal, R. Chakraborty, J. Woo, M. Haverbusch, P. Sekar, and et al. Association of apolipoprotein E4 and haplotypes of the apolipoprotein E gene with lobar intracerebral hemorrhage Stroke 36 2005 1874 1879
71. A. Biffi, A. Sonni, C.D. Anderson, B. Kissela, J.M. Jagiella, H. Schmidt, and et al. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage Ann Neurol 68 2010 934 943
72. T. Linden, C. Blomstrand, and I. Skoog Depressive disorders after 20 months in elderly stroke patients: A case-control study Stroke 38 2007 1860 1863
73. M.L. Hackett, C. Yapa, V. Parag, and C.S. Anderson Frequency of depression after stroke: A systematic review of observational studies Stroke 36 2005 1330 1340
74. L. Traykov, A.C. Bayle, F. Latour, H. Lenoir, M.L. Seux, O. Hanon, and et al. Apolipoprotein E epsilon4 allele frequency in elderly depressed patients with and without cerebrovascular disease J Neurol Sci 257 2007 280 283
75. D.M. Norden, and J.P. Godbout Microglia of the aged brain: Primed to be activated and resistant to regulation Neuropathol Appl Neurobiol 39 2013 19 34
76. B.S. Diniz, M.A. Butters, S.M. Albert, M.A. Dew, and C.F. Reynolds 3rd Late-life depression and risk of vascular dementia and Alzheimers disease: Systematic review and meta-analysis of community-based cohort studies Br J Psychiatry 202 2013 329 335
77. A. Verdelho, S. Madureira, C. Moleiro, J.M. Ferro, J.T. O'Brien, A. Poggesi, and et al. Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: The LADIS study J Neurol Neurosurg Psychiatry 84 2013 1250 1254
78. F. Irie, K.H. Masaki, H. Petrovitch, R.D. Abbott, G.W. Ross, D.R. Taaffe, and et al. Apolipoprotein E epsilon4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: The Honolulu-Asia Aging Study Arch Gen Psychiatry 65 2008 906 912
79. P.A. Boyle, A.S. Buchman, R.S. Wilson, J.F. Kelly, and D.A. Bennett The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons Neuroepidemiology 34 2010 43 49
80. Y.E. Geda, D.S. Knopman, D.A. Mrazek, G.A. Jicha, G.E. Smith, S. Negash, and et al. Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: A prospective cohort study Arch Neurol 63 2006 435 440
81. J.M. Kim, S.Y. Kim, K.Y. Bae, S.W. Kim, I.S. Shin, S.J. Yang, and et al. Apolipoprotein e4 genotype and depressive symptoms as risk factors for dementia in an older Korean population Psychiatry Investig 7 2010 135 140
82. R.L. Ownby, E. Crocco, A. Acevedo, V. John, and D. Loewenstein Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis Arch Gen Psychiatry 63 2006 530 538
83. F. Fritze, U. Ehrt, H. Sonnesyn, M. Kurz, T. Hortobagyi, S.P. Nore, and et al. Depression in mild dementia: Associations with diagnosis, APOE genotype and clinical features Int J Geriatr Psychiatry 26 2011 1054 1061
84. J.M. Kim, R. Stewart, S.Y. Kim, S.W. Kim, K.Y. Bae, S.J. Yang, and et al. Synergistic associations of depression and apolipoprotein E genotype with incidence of dementia Int J Geriatr Psychiatry 26 2011 893 898
85. F. Smit, A. Ederveen, P. Cuijpers, D. Deeg, and A. Beekman Opportunities for cost-effective prevention of late-life depression: An epidemiological approach Arch General Psychiatry 63 2006 290 296