SMAD4 Defect Causes Auditory Neuropathy Via Specialized Disruption of Cochlear Ribbon Synapses in Mice

Molecular Neurobiology

Volumn 53, Issue 8, 2016, Pages 5679-5691

  Liu, Ke ^a   Ji, Fei ^a   Yang, Guan ^b   Hou, Zhaohui ^a   Sun, Jianhe ^a   Wang, Xiaoyu ^a   Guo, Weiwei ^a   Sun, Wei ^c   Yang, Weiyan ^a   Yang, Xiao ^b   Yang, Shiming ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Auditory neuropathy; Cochlea; Deafness; Retina; Ribbon synapse; SMAD4

Indexed keywords

SMAD4 PROTEIN; SMAD4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASILAR MEMBRANE; COCHLEA; COCHLEA POTENTIAL; COCHLEAR NERVE; COCHLEAR RIBBON SYNAPSE; CONTROLLED STUDY; DISTORTION PRODUCT OTOACOUSTIC EMISSION; ELECTROSTIMULATION; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING IMPAIRMENT; IN VITRO STUDY; INNER HAIR CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OUTER HAIR CELL; RETINA; RETINAL RIBBON SYNAPSE; SMAD4 GENE; SPIRAL GANGLION; SYNAPSE; SYNAPTOGENESIS; VESTIBULOCOCHLEAR NERVE DISEASE; ANIMAL; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PATHOLOGY; ULTRASTRUCTURE; VISION;

ANIMALS; BASILAR MEMBRANE; COCHLEA; COCHLEAR NERVE; ELECTRIC STIMULATION; HAIR CELLS, AUDITORY, INNER; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS; HEARING LOSS, CENTRAL; MICE, KNOCKOUT; SMAD4 PROTEIN; SYNAPSES; TRANSCRIPTION, GENETIC; VISION, OCULAR;

EID: 84944937444     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9454-1     Document Type: Article

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