Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice

Developmental Dynamics

Volumn 238, Issue 8, 2008, Pages 1897-1908

  Yang, Shi Ming ^a   Hou, Zhao Hui ^a   Yang, Guan ^b   Zhang, Ji Shuai ^b   Hu, Yin Yan ^a   Sun, Jian He ^a   Guo, Wei Wei ^a   He, David Z Z ^c   Han, Dong Yi ^a   Young, Wie Yen ^a   Yang, Xiao ^b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BMPs signal; Conditional knockout; Hearing loss; Inner ear development; Inner ear malformation; Smad4 gene

Indexed keywords

SMAD4 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASILAR MEMBRANE; BONE MALFORMATION; CARTILAGE CELL; COCHLEA; CONTROLLED STUDY; GENE EXPRESSION; HAIR CELL; HEARING LOSS; INNER EAR; INNER EAR MALFORMATION; INNERVATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PERCEPTION DEAFNESS; PRIORITY JOURNAL; PROTEIN FUNCTION; SPIRAL LAMINA; STEREOCILIUM;

ANIMALS; BASE SEQUENCE; CHONDROCYTES; COCHLEA; DNA PRIMERS; EAR, INNER; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; HAIR CELLS, AUDITORY; HEARING LOSS, SENSORINEURAL; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN SPECIFICITY; PHENOTYPE; SMAD4 PROTEIN; SYNAPSES;

MAMMALIA; MUS;

EID: 67650831266     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22014     Document Type: Article

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