Formaldehyde exposure and its effects during pregnancy: Recommendations for laboratory attendance based on available data

Clinical Anatomy

Volumn 28, Issue 8, 2015, Pages 972-979

  Haffner, Matthew J ^a   Oakes, Peter ^b   Demerdash, Amin ^b   Yammine, Kaissar Cesar ^c   Watanabe, Koichi ^b   Loukas, Marios ^a   Tubbs, R Shane ^d  

^a ST GEORGE S UNIVERSITY   (Grenada)

^b Children's of Alabama   (United States)

^c Emirates Hospital   (United Arab Emirates)

^d SEATTLE SCIENCE FOUNDATION   (United States)

Author keywords

anatomy; cadavers; dissection; embalming; formaldehyde; formalin; laboratory; medical students; pregnancy; pregnant; women

Indexed keywords

FORMALDEHYDE; IMMUNOGLOBULIN E;

ADVERSE OUTCOME; ARTICLE; CONCENTRATION (PARAMETERS); CONGENITAL MALFORMATION; ENVIRONMENTAL EXPOSURE; FETUS MALFORMATION; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LABORATORY; LOW BIRTH WEIGHT; MEDICAL STUDENT; POPULATION RISK; PREGNANCY; PREGNANCY OUTCOME; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURITY; PRIORITY JOURNAL; SPONTANEOUS ABORTION; ADVERSE EFFECTS; ANATOMY; CHEMICALLY INDUCED; EDUCATION; EXPOSURE; FEMALE; INDOOR AIR POLLUTION; MEDICAL SCHOOL; OCCUPATIONAL EXPOSURE; PREGNANCY COMPLICATIONS; PREVENTION AND CONTROL;

AIR POLLUTION, INDOOR; ANATOMY; FACULTY, MEDICAL; FEMALE; FORMALDEHYDE; HUMANS; INHALATION EXPOSURE; LABORATORIES; OCCUPATIONAL EXPOSURE; PREGNANCY; PREGNANCY COMPLICATIONS; SCHOOLS, MEDICAL; STUDENTS, MEDICAL;

EID: 84944748606     PISSN: 08973806     EISSN: 10982353     Source Type: Journal    
DOI: 10.1002/ca.22623     Document Type: Article

References (33)

1. Akbar-Khanzadeh F, Park CK., 1997. Field precision of formaldehyde sampling and analysis using NIOSH method 3500. Am Ind Hyg Assoc J 58: 657-660.
2. Bendino JH., 2002. Pregnancy and embalming: Formaldehyde and other dangers for female embalmers. Champion: Expanding Encyclopedia of Mortuary Practices 647: 2603-2606.
3. Casanova M, Heck HA., 1987. Further studies of the metabolic incorporation and covalent binding of inhaled [3H]- and [14C]formaldehyde in Fischer-344 rats: Effects of glutathionine depletion. Toxicol Appl Pharmacol 89: 105-121.
4. Casanova M, Morgan KT, Steinhagen WH, Everitt JI, Popp JA, Heck HD., 1991. Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: Pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. Fund Appl Toxicol 17: 409-428.
5. Casanova M, Morgan KT, Gross EA, Moss OR, Heck HA., 1994. DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde. Fund Appl Toxicol 23: 525-536.
6. Coskey A, Gest TR., 2015. Effectiveness of various methods of formaldehyde neutralization using monoethanolamine. Clin Anat 28: 449-454.
7. Duong A, Steinmaus C, McHale CM, Vaughn CP, Zhang L., 2011. Reproductive and developmental toxicity of formaldehyde: A systematic review. Mutat Res 728: 118-138.
8. Goyer N., 2007. Prevention Fact Sheet: Exposure to Formaldehyde in the Workplace: Pathology Lab. Tech Data Sheet RG3-473. p 1-4. Available at: http://biology.mcgill.ca/safety/Formaldehyde-guide.pdf.
9. Goyer N, Begin D, Beaudry C, Bouchard M, Carrier G, Lavoue J, Noisel N, Gerin M., 2006. IRST studies and research project: Prevention guide-formaldehyde in the workplace. Guide RG-473, p 1-51.
10. Heck HA, Chin TY, Schmitz MC., 1983. Distribution of [C-14] Formaldehyde in rats after inhalation exposure. In:, Gibson JE, editor. Formaldehyde Toxicity. New York. p 26-37.
11. Heck HD, Casanova-Schmitz M, Dodd PB, Schachter EN, Wiltek TJ, Tosun T., 1985. Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions. Am Ind Hyg Assoc J 46: 1-3.
12. Hemminki K, Mutanen P, Saloniemi I, Niemi ML, Vainio H., 1982. Spontaneous abortions in hospital staff engaged in sterilising instruments with chemical agents. Br Med J (Clin Res Ed) 285: 1461-1463.
13. Hemminki K, Kyyrönen P, Lindbohm ML., 1985. Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome. J Epidemiol Commun Health 39: 141-147.
14. Hisamitsu M, Okamoto Y, Chazono H, Yonekura S, Sakurai D, Horiguchi S, Hanazawa T, Terada N, Konno A, Matsuno Y, Tokada E, Mori C., 2011. The influence of environmental exposure to formaldehyde in nasal mucosa of medical students during cadaver dissection. Allergol Int 60: 373-379.
15. Keil CB, Akbar-Khanzadeh F, Konecny KA., 2001. Characterizing formaldehyde emission rates in a gross anatomy laboratory. Appl Occup Environ Hyg 16: 962-972.
16. Klein RC, King C, Castagna P., 2013. Controlling formaldehyde exposures in an academic gross anatomy lab. J Occup Environ Hygiene 11: 127-132.
17. Kligerman AD, Phelps MC, Erexson GL., 1984. Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation. Toxicol Lett 21: 241-246.
18. Kulle TJ, Sauder LR, Hebel JR, Green DJ, Chatham MD., 1987. Formaldehyde dose-response in healthy nonsmokers. Japca 37: 919-924.
19. Lam CW, Casanova M, Heck HD., 1985. Depletion of nasal mucosal glutathione by acrolein and enhancement of formaldehyde-induced DNA-protein cross-linking by simultaneous exposure to acrolein. Arch Toxicol 58: 67-71.
20. Liteplo RG, Meek ME., 2003. Inhaled formaldehyde: Exposure estimation, hazard characterization, and exposure-response analysis. J Toxicol Environ Health B Crit Rev 6: 85-114.
21. Maroziene L, Grazuleviciene R., 2002. Maternal exposure to low-level air pollution and pregnancy outcomes: a population-based study. Environ Health 1: 6.
22. McMartin KI, Chu M, Kopecky E, Einarson TR, Korn G., 1998. Pregnancy outcome following maternal organic solvent exposure: A meta-analysis of epidemiologic studies. Am J Ind Med 34: 288-292.
23. Morgan KT, Patterson DL, Gross EA., 1986. Responses of the nasal mucociliary apparatus of F-344 rats to formaldehyde gas. Toxicol Appl Pharmacol 82: 1-13.
24. Rahimifard H, Heidari H, Abbasinia M, Noruzi M, Mahdinia M, Arast Y., 2013. Respiratory effects induced by occupational exposure to formaldehyde among health care staff. Int J Occup Hygiene 5: 26-30.
25. Ryan TJ, Burroughs GE, Taylor K, Kovein RJ., 2003. Video exposure assessments demonstrate excessive laboratory formaldehyde exposures. Appl Occup Environ Hyg 18: 450-457.
26. Sauder LR, Chatham MD, Green DJ, Kulle TJ., 1986. Acute pulmonary response to formaldehyde exposure in healthy nonsmokers. J Occup Med 28: 420-424.
27. Sauder LR, Green DJ, Chatham MD, Kulle TJ., 1987. Acute pulmonary response of asthmatics to 3.0 ppm formaldehyde. Toxicol Ind Health 3: 569-578.
28. Saurel-Cubizolles MJ, Hays M, Estryn-Behar M., 1994. Work in operating rooms and pregnancy outcome among nurses. Int Arch Occup Environ Health 66: 235-241.
29. Swenberg JA, Gross EA, Martin J, Popp JA., 1983. Mechanisms of formaldehyde toxicity. In:, Gibson JE, editor. Washington, DC: Hemisphere Publishing. p 132-142.
30. Thrasher JD, Kilburn KH., 2001. Embryo toxicity and teratogenicity of formaldehyde. Arch Environ Health 56: 300-311.
31. UNEP Chemicals 2002. Formaldehyde CAS N: 50-00-0. SIDS Initial Assessment Report for SIAM 14: 1-43.
32. US Center for Disease Control and Prevention. What you should know about formaldehyde. Available at: http://www.cdc.gov/nceh/drywall/docs/whatyoushouldknowaboutformaldehyde.pdf.
33. Zhu JL, Knudsen LE, Andersen AM, Hjollund NH, Olsen J., 2006. Laboratory work and pregnancy outcomes: A study within the National Birth Cohort in Denmark. Occup Environ Med 63: 53-58.