The adenosine A2A receptor antagonist, istradefylline enhances anti-parkinsonian activity induced by combined treatment with low doses of L-DOPA and dopamine agonists in MPTP-treated common marmosets

European Journal of Pharmacology

Volumn 766, Issue , 2015, Pages 25-30

  Uchida, Shin Ichi ^a   Soshiroda, Kazuhiro ^a   Okita, Eri ^a   Kawai Uchida, Mika ^a   Mori, Akihisa ^a   Jenner, Peter ^b   Kanda, Tomoyuki ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Adenosine A2A receptor antagonist; Anti parkinsonian; Dopamine agonist; L DOPA; MPTP

Indexed keywords

ISTRADEFYLLINE; LEVODOPA; PERGOLIDE; ROPINIROLE; ADENOSINE A2 RECEPTOR ANTAGONIST; ANTIPARKINSON AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; INDOLE DERIVATIVE; PURINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPARKINSONIAN ACTIVITY; ARTICLE; CALLITRICHINAE; CONTROLLED STUDY; DISEASE CONTROL; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; DYSKINESIA; FEMALE; LOCOMOTION; LOW DRUG DOSE; MALE; MONOTHERAPY; MOTOR CONTROL; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANIMAL BEHAVIOR; CALLITHRIX; CHEMICALLY INDUCED; COMBINATION DRUG THERAPY; DRUG EFFECTS; MOTOR ACTIVITY; MPTP POISONING;

ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; ANTIPARKINSON AGENTS; BEHAVIOR, ANIMAL; CALLITHRIX; DOPAMINE AGONISTS; DRUG THERAPY, COMBINATION; FEMALE; INDOLES; LEVODOPA; MALE; MOTOR ACTIVITY; MPTP POISONING; PERGOLIDE; PURINES;

EID: 84944724421     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.09.028     Document Type: Article

References (27)

1. J.E. Ahlskog, and M.D. Muenter Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature Mov. Disord. 16 2001 448 458
2. S. Aoyama, H. Kase, and E. Borrelli Rescue of locomotor impairment in dopamine D2 receptor deficient mice by an adenosine A2A receptor antagonist J. Neurosci. 20 2000 5848 5852
3. F. Blandini, and M.T. Armentero Dopamine receptor agonists for Parkinson's disease Expert Opin. Investig. Drugs 23 2014 387 410
4. 2 receptor heterotetramer Proc. Natl. Acad. Sci. USA 112 2015 E3609 E3618
5. U. Bonuccelli, P. Del Dotto, and O. Rascol Role of dopamine receptor agonists in the treatment of early Parkinson's disease Parkinsonism Relat. Disord. Suppl 4 2009 S44 S53
6. 2 receptor knockout mice Proc. Natl. Acad. Sci. USA 98 2001 1970 1975
7. V. Fernández-Dueñas, J.J. Taura, M. Cottet, M. Gómez-Soler, M. López-Cano, C. Ledent, M. Watanabe, E. Trinquet, J.-P. Pin, R. Luján, T. Durroux, and F. Ciruela Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats Dis. Model. Mech. 8 2015 57 63
8. 2 receptor heterotetramer Neuropharmacology. 2015 http://dx.doi.org/10.1016/j.neuropharm.2015.05.028
9. K. Fuxe, I. Strömberg, P. Popoli, R. Rimondini-Giorgini, M. Torvinen, S.O. Ogren, R. Franco, L.F. Agnati, and S. Ferré Adenosine receptors and Parkinson's disease. Relevance of antagonistic adenosine and dopamine receptor interactions in the striatum Adv. Neurol. 86 2001 345 353
10. R.A. Hauser, L.M. Shulman, J.M. Trugman, J.W. Roberts, A. Mori, R. Ballerini, and N.M. Sussman Study of istradefylline in patients with Parkinson's disease on levodopa with motor fluctuations Mov. Disord. 23 2008 2177 2185
11. 2 receptor internalization and ERK phosphorylation Acta Pharmacol. Sin. 34 2013 1292 1300
12. 2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys Ann. Neurol. 43 1998 507 513
13. 2A receptor antagonists KF17837 and KW-6002 potentiate rotation induced by dopaminergic drugs in hemi-parkinsonian rats Eur. J. Pharmacol. 408 2000 249 255
14. 2A receptor antagonist istradefylline (KW-6002) reduces "off" time in Parkinson's disease: a double-blind, randomized, multicenter clinical trial (6002-US-005) Ann. Neurol. 63 2008 295 302
15. S.Z. Marsala, M. Gioulis, R. Ceravolo, and M. Tinazzi A systematic review of catechol-o-methyltransferase inhibitors: efficacy and safety in clinical practice Clin. Neuropharmacol. 35 2012 185 190
16. 2A receptor antagonist istradefylline reduces daily off time in Parkinson's disease Mov. Disord. 28 2013 1138 1141
17. J.G. Nutt Motor fluctuations and dyskinesia in Parkinson's disease Parkinsonism Relat. Disord. 8 2001 101 108
18. S. Perez-Lloret, and O. Rascol Dopamine receptor agonists for the treatment of early or advanced Parkinson's disease CNS Drugs 24 2010 941 968
19. M. Raja, and A.R. Bentivoglio Impulsive and compulsive behaviors during dopamine replacement treatment in Parkinson's Disease and other disorders Curr. Drug Saf. 7 2012 63 75
20. A.H. Schapira Monoamine oxidase B inhibitors for the treatment of Parkinson's disease: a review of symptomatic and potential disease-modifying effects CNS Drugs 25 2011 1061 1071
21. 2A receptors in Parkinson's disease Trends Neurosci. 29 2006 647 654
22. L.A. Smith, A. Gordin, P. Jenner, and C.D. Marsden Entacapone enhances levodopa-induced reversal of motor disability in MPTP-treated common marmosets Mov. Disord. 12 1997 935 945
23. K.A. Tayarani-Binazir, M.J. Jackson, S. Rose, C.W. Olanow, and P. Jenner Pramipexole combined with levodopa improves motor function but reduces dyskinesia in MPTP-treated common marmosets Mov. Disord. 25 2010 377 384
24. 2A receptor antagonist, istradefylline enhances the anti-parkinsonian activity of low doses of dopamine agonists in MPTP-treated common marmosets Eur. J. Pharmacol. 747 2015 160 165
25. 2A receptor antagonist, istradefylline enhances the motor response of l-DOPA without worsening dyskinesia in MPTP-treated common marmosets J. Pharmacol. Sci. 124 2014 480 485
26. C. Warren Olanow, K. Kieburtz, O. Rascol, W. Poewe, A.H. Schapira, M. Emre, H. Nissinen, M. Leinonen, and F. Stocchi Factors predictive of the development of Levodopa-induced dyskinesia and wearing-off in Parkinson's disease Mov. Disord. 28 2013 1064 1071
27. D. Weintraub, and M.J. Nirenberg Impulse control and related disorders in Parkinson's disease Neurodegener. Dis. 11 2013 63 71