COMT gene locus: New functional variants

Pain

Volumn 156, Issue 10, 2015, Pages 2072-2083

  Meloto, Carolina B ^a   Segall, Samantha K ^b   Smith, Shad ^c   Parisien, Marc ^d   Shabalina, Svetlana A ^a   Rizzatti Barbosa, Celia M ^e   Gauthier, Josee ^f   Tsao, Douglas ^b   Convertino, Marino ^c   Piltonen, Marjo H ^e   Slade, Gary Dmitri ^g   Fillingim, Roger B ^h   Greenspan, Joel D ⁱ   Ohrbach, Richard ^j   Knott, Charles ^k   Maixner, William ^a   Zaykin, Dmitri ^b   Dokholyan, Nikolay V ^e   Reenila, Ilkka ^d   Mannisto, Pekka T ^e   Diatchenko, Luda ^a   more..

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF CAMPINAS   (Brazil)

^e UNIVERSITY OF FLORIDA   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

^h UNIVERSITY AT BUFFALO   (United States)

ⁱ BATTELLE MEMORIAL INSTITUTE   (United States)

^j NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^k UNIVERSITY OF HELSINKI   (Finland)

more..

Author keywords

Association study; Chronic pain; COMT; Functional polymorphism; Genetics

Indexed keywords

CATECHOL METHYLTRANSFERASE; MESSENGER RNA;

ADRENERGIC ACTIVITY; ADULT; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; NOCICEPTION; NONHUMAN; PAIN; PHENOTYPE; PRIMATE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SUBSTRATE CONCENTRATION; TEMPOROMANDIBULAR JOINT DISORDER; BRAIN; CASE CONTROL STUDY; COHORT ANALYSIS; COMPLICATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETIC VARIATION; GENETICS; METABOLISM; NEUROBLASTOMA; PAIN THRESHOLD; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

BRAIN; CASE-CONTROL STUDIES; CATECHOL O-METHYLTRANSFERASE; CELL LINE, TUMOR; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC VARIATION; HUMANS; MALE; NEUROBLASTOMA; PAIN; PAIN THRESHOLD; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; TEMPOROMANDIBULAR JOINT DISORDERS; TRANSFECTION;

EID: 84944712945     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000273     Document Type: Article

References (58)

1. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, MillerW, Lipman DJ. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997;25:3389-402
2. Andersen HC. Molecular dynamics simulations at constant pressure and/or temperature. J Chem Phys 1980;72:2384-94
3. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5
4. Belfer I, Segall SK, Lariviere WR, Smith SB, Dai F, Slade GD, Rashid NU, Mogil JS, Campbell CM, Edwards RR, Liu Q, Bair E, Maixner W, Diatchenko L. Pain modality-And sex-specific effects of COMT genetic functional variants. PAIN 2013;154:1368-76
5. Bhalang K, Sigurdsson A, Slade GD, Maixner W. Associations among four modalities of experimental pain in women. J Pain 2005;6:604-11
6. Brawand D, Soumillon M, Necsulea A, Julien P, Csardi G, Harrigan P, Weier M, Liechti A, Aximu-Petri A, Kircher M, Albert FW, Zeller U, Khaitovich P, Grutzner F, Bergmann S, Nielsen R, Paabo S, Kaessmann H. The evolution of gene expression levels in mammalian organs. Nature 2011;478:343-8
7. Diatchenko L, Fillingim RB, Smith SB, Maixner W. The phenotypic and genetic signatures of common musculoskeletal pain conditions. Nat Rev Rheumatol 2013;9:340-50
8. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005;14: 135-43
9. Ding F, Yin S, Dokholyan NV. Rapid flexible docking using a stochastic rotamer library of ligands. J Chem Inf Model 2010;50:1623-32
10. Dokholyan NV, Buldyrev SV, Stanley HE, Shakhnovich EI. Discrete molecular dynamics studies of the folding of a protein-like model. Fold Des 1998;3:577-87
11. Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord 1992;6:301-55
12. Edgar RC. MUSCLE: a multiple sequence alignment method with reduced time and space complexity. BMC Bioinformatics 2004;5:113
13. Friesner RA, Banks JL, Murphy RB, Halgren TA, Klicic JJ, Mainz DT, Repasky MP, Knoll EH, Shelley M, Perry JK, Shaw DE, Francis P, Shenkin PS. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem 2004;47: 1739-49
14. Greenspan JD, Slade GD, Bair E, Dubner R, Fillingim RB, Ohrbach R, Knott C, Mulkey F, Rothwell R, Maixner W. Pain sensitivity risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case control study. J Pain 2011;12(11 suppl):T61-74
15. Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010;466: 835-40
16. Hagelberg N, Jaaskelainen SK, Martikainen IK, Mansikka H, Forssell H, Scheinin H, Hietala J, Pertovaara A. Striatal dopamine D2 receptors in modulation of pain in humans: a review. Eur J Pharmacol 2004;500: 187-92
17. Jacobsen LM, Eriksen GS, Pedersen LM, Gjerstad J. Catechol-Omethyltransferase (COMT) inhibition reduces spinal nociceptive activity. Neurosci Lett 2010;473:212-15
18. Ka enma ki M, Tammima ki A, Garcia-Horsman JA, Myo ha nen T, Schendzielorz N, Karayiorgou M, Gogos JA, Ma nnisto PT. Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice. Br J Pharmacol 2009;158:1884-94
19. Kambur O, Kaunisto MA, Tikkanen E, Leal SM, Ripatti S, Kalso EA. Effect of catechol-o-methyltransferase-gene (COMT) variants on experimental and acute postoperative pain in 1, 000 women undergoing surgery for breast cancer. Anesthesiology 2013;119:1422-33
20. Karolchik D, Barber GP, Casper J, Clawson H, Cline MS, Diekhans M, Dreszer TR, Fujita PA, Guruvadoo L, Haeussler M, Harte RA, Heitner S, Hinrichs AS, Learned K, Lee BT, Li CH, Raney BJ, Rhead B, Rosenbloom KR, Sloan CA, Speir ML, Zweig AS, Haussler D, Kuhn RM, Kent WJ. The UCSC Genome Browser database: 2014 update. Nucleic Acids Res 2014;42:D764-770
21. Kern AD, Kondrashov FA. Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs. Nat Genet 2004;36:1207-12
22. Khasar SG, McCarter G, Levine JD. Epinephrine produces a betaadrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 1999;81:1104-12
23. Kirby DA, Muse SV, Stephan W. Maintenance of pre-mRNA secondary structure by epistatic selection. Proc Natl Acad Sci U S A 1995;92:9047-51
24. Kondrashov AS, Sunyaev S, Kondrashov FA. Dobzhansky-Muller incompatibilities in protein evolution. Proc Natl Acad Sci U S A 2002; 99:14878-83
25. Langmead B, Trapnell C, Pop M, Salzberg SL. Ultrafast and memoryefficient alignment of short DNA sequences to the human genome. Genome Biol 2009;10:R25
26. Lazaridis T, Karplus M. Effective energy function for proteins in solution. Proteins 1999;35:133-52
27. Li J, Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 2005;95:221-7
28. Lotta T, Vidgren J, Tilgmann C, Ulmanen I, Melen K, Julkunen I, Taskinen J. Kinetics of human soluble and membrane-bound catechol Omethyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995;34:4202-10
29. Maixner W, Diatchenko L, Dubner R, Fillingim RB, Greenspan JD, Knott C, Ohrbach R, Weir B, Slade GD. Orofacial pain prospective evaluation and risk assessment study-The OPPERA study. J Pain 2011;12(11 suppl): T4-11 e11-12
30. Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR. Catechol-O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience 2003;16:127-37
31. Matveeva O, Nechipurenko Y, Rossi L, Moore B, Saetrom P, Ogurtsov AY, Atkins JF, Shabalina SA. Comparison of approaches for rational siRNA design leading to a new efficient and transparent method. Nucleic Acids Res 2007;35:e63
32. Merkin J, Russell C, Chen P, Burge CB. Evolutionary dynamics of gene and isoform regulation in Mammalian tissues. Science 2012;338:1593-9
33. Nackley AG, Shabalina SA, Tchivileva IE, Satterfield K, Korchynskyi O, Makarov SS, Maixner W, Diatchenko L. Human catechol-Omethyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. Science 2006;314:1930-3
34. Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2-And beta3-Adrenergic receptors. PAIN 2007;128:199-208
35. Ogurtsov AY, Shabalina SA, Kondrashov AS, Roytberg MA. Analysis of internal loops within the RNA secondary structure in almost quadratic time. Bioinformatics 2006;22:1317-24
36. Okamoto Y. Generalized-ensemble algorithms: enhanced sampling techniques for Monte Carlo and molecular dynamics simulations. J Mol Graph Model 2004;22:425-39
37. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC. PLINK: a tool set for whole-genome association and population-based linkage analyses. AmJ Hum Genet 2007;81:559-75
38. Rutherford K, Le Trong I, Stenkamp RE, Parson WW. Crystal structures of human 108V and 108M catechol O-methyltransferase. J Mol Biol 2008; 380:120-30
39. Schmahl C, Ludascher P, Greffrath W, Kraus A, Valerius G, Schulze TG, Treutlein J, Rietschel M, Smolka MN, Bohus M. COMT val158met polymorphism and neural pain processing. PLoS One 2012;7: e23658
40. Segall SK, Maixner W, Belfer I, Wiltshire T, Seltzer Z, Diatchenko L. Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities. CNS Neurol Disord Drug Targets 2012;11: 222-35
41. Shabalina SA, Ogurtsov AY, Spiridonov NA, Koonin EV. Evolution at protein ends: major contribution of alternative transcription initiation and termination to the transcriptome and proteome diversity in mammals. Nucleic Acids Res 2014;42:7132-44
42. Shabalina SA, Spiridonov AN, Ogurtsov AY. Computational models with thermodynamic and composition features improve siRNA design. BMC Bioinformatics 2006;7:65
43. Shabalina SA, Spiridonov AN, Spiridonov NA, Koonin EV. Connections between alternative transcription and alternative splicing in mammals. Genome Biol Evol 2010;2:791-9
44. Shibata K, Diatchenko L, Zaykin DV. Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. Genet Epidemiol 2009;33:63-78
45. Shirvanyants D, Ding F, Tsao D, Ramachandran S, Dokholyan NV. Discrete molecular dynamics: an efficient and versatile simulation method for fine protein characterization. J Phys Chem B 2012;116:8375-82
46. Smith SB, Maixner DW, Greenspan JD, Dubner R, Fillingim RB, Ohrbach R, Knott C, Slade GD, Bair E, Gibson DG, Zaykin DV, Weir BS, Maixner W, Diatchenko L. Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study. J Pain 2011;12(11 suppl):T92-101
47. Stamatakis A, Aberer AJ, Goll C, Smith SA, Berger SA, Izquierdo-Carrasco F. RAxML-Light: a tool for computing terabyte phylogenies. Bioinformatics 2012;28:2064-6
48. Tammima ki A, Ma nnisto PT. Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and metaanalysis. Pharmacogenet Genomics 2012;22:673-91
49. Tamura K, Peterson D, Peterson N, Stecher G, NeiM, Kumar S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 2011;28:2731-9
50. Tchivileva IE, Lim PF, Smith SB, Slade GD, Diatchenko L, McLean SA, Maixner W. Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet Genomics 2010;20:239-48
51. Team RC. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing, 2013
52. Tsao D, Diatchenko L, Dokholyan NV. Structural mechanism of Sadenosyl methionine binding to catechol O-methyltransferase. PloS One 2011;6:e24287
53. Tsao D, Shabalina SA, Gauthier J, Dokholyan NV, Diatchenko L. Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant. Nucleic Acids Res 2011;39:6201-12
54. Tunbridge EM, Lane TA, Harrison PJ. Expression of multiple catechol-omethyltransferase (COMT) mRNA variants in human brain. Am J Med Genet B Neuropsychiatr Genet 2007;144B:834-9
55. Viechtbauer W. Conducting meta-Analyses in R with the metafor package. J Stat Softw 2010;36:48
56. Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, Mayr C, Kingsmore SF, Schroth GP, Burge CB. Alternative isoform regulation in human tissue transcriptomes. Nature 2008;456:470-6
57. Yin S, Biedermannova L, Vondrasek J, Dokholyan NV. MedusaScore: an accurate force field-based scoring function for virtual drug screening. J Chem Inf Model 2008;48:1656-62
58. Zhou R, Berne BJ, Germain R. The free energy landscape for beta hairpin folding in explicit water. Proc Natl Acad Sci U S A 2001;98: 14931-6