Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 70, Issue 10, 2014, Pages 1289-1295

  Vasunilashorn, Sarinnapha M ^a,b,c   Ngo, Long ^a,c   Inouye, Sharon K ^a,b,c   Libermann, Towia A ^a,c   Jones, Richard N ^b,d   Alsop, David C ^b,c   Guess, Jamey ^c   Jastrzebski, Sandra ^e   McElhaney, Janet E ^f   Kuchel, George A ^e   Marcantonio, Edward R ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Hebrew Senior Life   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BROWN UNIVERSITY   (United States)

^e UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^f Advanced Medical Research Institute of Canada   (Canada)

Author keywords

Delirium; Inflammation; Postoperative

Indexed keywords

CYTOKINE;

AGED; BLOOD; CASE CONTROL STUDY; DELIRIUM; ELECTIVE SURGERY; FEMALE; HUMAN; MALE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDY; RISK;

AGED; CASE-CONTROL STUDIES; CYTOKINES; DELIRIUM; ELECTIVE SURGICAL PROCEDURES; FEMALE; HUMANS; MALE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RISK;

EID: 84944678854     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glv083     Document Type: Article

References (28)

1. Walston J, McBurnie MA, Newman A, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities. Arch Intern Med. 2002;162:2333-2341. doi:10.1001/archinte.162.20.2333
2. Schmidt R, Schmidt H, Curb JD, et al. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol. 2002;52:168-174. doi:10.1002/ana.10265
3. Palta P, Xue QL, Deal JA, Fried LP, Walston JD, Carlson MC. Interleukin-6 and C-reactive protein levels and 9-year cognitive decline in communitydwelling older women: The Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2014 [Epub ahead of print]. doi:10.1093/gerona/glu132
4. de Rooij SE, van Munster BC, Korevaar JC, Levi M. Cytokines and acute phase response in delirium. J Psychosom Res. 2007;62:521-525. doi:http://dx.doi.org/10.1016/j.jpsychores.2006.11.013
5. Girard TD, Ware LB, Bernard GR, et al. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med. 2012;38:1965-1973. doi:10.1007/s00134-012-2678-x
6. Rudolph JL, Ramlawi B, Kuchel GA, et al. Chemokines are associated with delirium after cardiac surgery. J Gerontol A Biol Sci Med Sci. 2008;63:184-189.
7. van Munster BC, Korevaar JC, Zwinderman AH, Levi M, Wiersinga WJ, De Rooij SE. Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc. 2008;56:1704-1709. doi:10.1111/ j.1532-5415.2008.01851.x
8. Marcantonio ER. Postoperative delirium: a 76-year-old woman with delirium following surgery. JAMA. 2012;308:73-81. doi:10.1001/jama.2012.6857
9. Cunningham C, Maclullich AM. At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. Brain Behav Immun. 2013;28:1-13. doi:10.1016/j.bbi.2012.07.012
10. Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet. 2014;383:911-922. doi:10.1016/S0140-6736(13)60688-1
11. Hshieh TT, Fong TG, Marcantonio ER, Inouye SK. Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence. J Gerontol A Biol Sci Med Sci. 2008;63:764-772.
12. Cerejeira J, Nogueira V, Luis P, Vaz-Serra A, Mukaetova-Ladinska EB. The cholinergic system and inflammation: common pathways in delirium pathophysiology. J Am Geriatr Soc. 2012;60:669-675. doi:10.1111/ j.1532-5415.2011.03883.x
13. Pol RA, van Leeuwen BL, Izaks GJ, et al. C-reactive protein predicts postoperative delirium following vascular surgery. Ann Vasc Surg. 2014;28:1923-1930. doi:10.1016/j.avsg.2014.07.004
14. Schmitt EM, Marcantonio ER, Alsop DC, et al. Novel risk markers and long-term outcomes of delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods. JAMDA. 2012;13:1-10. doi:10.1016/j.jamda.2012.08.004
15. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987;48:314-318.
16. Jones RN, Rudolph JL, Inouye SK, et al. Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision. J Clin Exp Neuropsychol. 2010;32:1041-1049. doi:10.1080/13803391003662728
17. Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: The confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990;113:941-948. doi:10.7326/0003-4819-113-12-941
18. Saczynski JS, Kosar CM, Xu G, et al. A tale of two methods: chart and interview methods for identifying delirium. J Am Geriatr Soc. 2014;62:518-524. doi:10.1111/jgs.12684
19. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:1977-1981.
20. Rosenbaum PR. Optimal matching for observational studies. J Am Stat Assoc. 1989;84:1024-1032. doi:http://www.jstor.org/stable/2290079
21. Plaschke K, Fichtenkamm P, Schramm C, et al. Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6. Intensive Care Med. 2010;36:2081-2089. doi:10.1007/s00134-010-2004-4
22. Ferrucci L, Corsi A, Lauretani F, et al. The origins of age-related proinflammatory state. Blood. 2005;105:2294-2299. doi:http://dx.doi.org/10.1182/ blood-2004-07-2599
23. Ellison MD, Povlishock JT, Merchant RE. Blood-brain barrier dysfunction in cats following recombinant interleukin-2 infusion. Cancer Res. 1987;47:5765-5770.
24. Ng T, Cheung YT, Ng QS, Ho HK, Chan A. Vascular endothelial growth factor inhibitors and cognitive impairment: evidence and controversies. Expert Opin Drug Saf. 2014;13:83-92. doi:10.1517/14740338.2013.82 8034
25. Trollor JN, Smith E, Agars E, et al. The association between systemic inflammation and cognitive performance in the elderly: The Sydney Memory and Ageing Study. Age (Dordr). 2012;34:1295-1308. doi:10.1007/ s11357-011-9301-x
26. Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK. Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci. 2006;61:1281-1286.
27. Vasunilashorn S, Ferrucci L, Crimmins EM, Bandinelli S, Guralnik JM, Patel KV. Association of inflammation with loss of ability to walk 400 meters: longitudinal findings from the Invecchiare in Chianti Study. J Am Geriatr Soc. 2013;61:1743-1749. doi:10.1111/ jgs.12446
28. Kiely DK, Jones RN, Bergmann MA, Murphy KM, Orav EJ, Marcantonio ER. Association between delirium resolution and functional recovery among newly admitted postacute facility patients. J Gerontol A Biol Sci Med Sci. 2006;61:204-208.