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Volumn 9, Issue 4, 2015, Pages 586-593

Deregulation of microRNA expression in peripheral blood mononuclear cells from patients with HCV-related malignancies

Author keywords

Biomarker; Hepatitis C virus; Hepatocellular carcinoma; microRNA; Non Hodgkin s lymphoma

Indexed keywords

MICRORNA; MICRORNA 155; MICRORNA 16; MICRORNA 26B; TUMOR MARKER; UNCLASSIFIED DRUG; HEPATITIS B ANTIBODY; RNA; VIRUS DNA;

EID: 84944513479     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-015-9658-5     Document Type: Article
Times cited : (9)

References (43)
  • 2
    • 8244245756 scopus 로고    scopus 로고
    • Hepatitis C virus infection in mixed cryoglobulinemia and B-cell non-Hodgkin’s lymphoma: evidence for a pathogenetic role
    • COI: 1:CAS:528:DyaK2sXivFGrur4%3D, PID: 9349300
    • Zignego AL, Ferri C, Giannini C, La Civita L, Careccia G, Longombardo G, et al. Hepatitis C virus infection in mixed cryoglobulinemia and B-cell non-Hodgkin’s lymphoma: evidence for a pathogenetic role. Arch Virol 1997;142:545–555
    • (1997) Arch Virol , vol.142 , pp. 545-555
    • Zignego, A.L.1    Ferri, C.2    Giannini, C.3    La Civita, L.4    Careccia, G.5    Longombardo, G.6
  • 3
    • 66149135640 scopus 로고    scopus 로고
    • Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer
    • COI: 1:CAS:528:DC%2BD1MXis1ahsr8%3D, PID: 18928409
    • McGivern DR, Lemon SM. Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancer. Annu Rev Pathol 2009;4:399–415
    • (2009) Annu Rev Pathol , vol.4 , pp. 399-415
    • McGivern, D.R.1    Lemon, S.M.2
  • 4
    • 84879190562 scopus 로고    scopus 로고
    • Hepatitis C-associated B-cell non-Hodgkin lymphomas. Epidemiology, molecular signature and clinical management
    • COI: 1:CAS:528:DC%2BC3sXmsFaitbg%3D, PID: 23542089
    • Peveling-Oberhag J, Arcaini L, Hansmann ML, Zeuzem S. Hepatitis C-associated B-cell non-Hodgkin lymphomas. Epidemiology, molecular signature and clinical management. J Hepatol 2013;59:169–177
    • (2013) J Hepatol , vol.59 , pp. 169-177
    • Peveling-Oberhag, J.1    Arcaini, L.2    Hansmann, M.L.3    Zeuzem, S.4
  • 6
    • 84864957845 scopus 로고    scopus 로고
    • Zignego AL, Giannini C, Gragnani L. HCV and lymphoproliferation. Clin Dev Immunol 2012:980942
    • Zignego AL, Giannini C, Gragnani L. HCV and lymphoproliferation. Clin Dev Immunol 2012:980942
  • 7
    • 84867737234 scopus 로고    scopus 로고
    • The hepatitis C virus infection as a systemic disease
    • PID: 23073858
    • Zignego AL, Gragnani L, Giannini C, Laffi G. The hepatitis C virus infection as a systemic disease. Intern Emerg Med 2012;7(Suppl 3):S201–S208
    • (2012) Intern Emerg Med , vol.7 , pp. S201-S208
    • Zignego, A.L.1    Gragnani, L.2    Giannini, C.3    Laffi, G.4
  • 8
    • 84890921892 scopus 로고    scopus 로고
    • Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame?
    • COI: 1:CAS:528:DC%2BC2cXntVWgs7Y%3D, PID: 24379615
    • Gragnani L, Fognani E, Piluso A, Zignego AL. Hepatitis C virus-related mixed cryoglobulinemia: Is genetics to blame? World J Gastroenterol 2013;19:8910–8915
    • (2013) World J Gastroenterol , vol.19 , pp. 8910-8915
    • Gragnani, L.1    Fognani, E.2    Piluso, A.3    Zignego, A.L.4
  • 10
    • 79751484450 scopus 로고    scopus 로고
    • Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhvFeksbk%3D, PID: 21316602
    • Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, et al. Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 2011;19:232–243
    • (2011) Cancer Cell , vol.19 , pp. 232-243
    • Hou, J.1    Lin, L.2    Zhou, W.3    Wang, Z.4    Ding, G.5    Dong, Q.6
  • 11
    • 84873296666 scopus 로고    scopus 로고
    • MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?
    • COI: 1:CAS:528:DC%2BC3sXit1Wgsr4%3D, PID: 23081718
    • Giordano S, Columbano A. MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? Hepatology 2013;57:840–847
    • (2013) Hepatology , vol.57 , pp. 840-847
    • Giordano, S.1    Columbano, A.2
  • 12
    • 34447117003 scopus 로고    scopus 로고
    • Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BD2sXnsVyqsbo%3D, PID: 17616664
    • Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res 2007;67:6092–6099
    • (2007) Cancer Res , vol.67 , pp. 6092-6099
    • Gramantieri, L.1    Ferracin, M.2    Fornari, F.3    Veronese, A.4    Sabbioni, S.5    Liu, C.G.6
  • 13
    • 84861619812 scopus 로고    scopus 로고
    • MicroRNAs in liver disease
    • COI: 1:CAS:528:DC%2BC38XnslSnsrc%3D, PID: 22504185
    • Wang XW, Heegaard NH, Orum H. MicroRNAs in liver disease. Gastroenterology 2012;142:1431–1443
    • (2012) Gastroenterology , vol.142 , pp. 1431-1443
    • Wang, X.W.1    Heegaard, N.H.2    Orum, H.3
  • 14
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • COI: 1:CAS:528:DC%2BD2sXhtVWqsr3L, PID: 17681183
    • Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007;133:647–658
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3    Ghoshal, K.4    Jacob, S.T.5    Patel, T.6
  • 15
    • 84885175599 scopus 로고    scopus 로고
    • Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma
    • PID: 23810247
    • Koberle V, Kronenberger B, Pleli T, Trojan J, Imelmann E, Peveling-Oberhag J, et al. Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma. Eur J Cancer 2013;49:3442–3449
    • (2013) Eur J Cancer , vol.49 , pp. 3442-3449
    • Koberle, V.1    Kronenberger, B.2    Pleli, T.3    Trojan, J.4    Imelmann, E.5    Peveling-Oberhag, J.6
  • 16
    • 84863778143 scopus 로고    scopus 로고
    • Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection
    • COI: 1:CAS:528:DC%2BC38XhtVelsr%2FF, PID: 22307176
    • Peveling-Oberhag J, Crisman G, Schmidt A, Doring C, Lucioni M, Arcaini L, et al. Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection. Leukemia 2012;26:1654–1662
    • (2012) Leukemia , vol.26 , pp. 1654-1662
    • Peveling-Oberhag, J.1    Crisman, G.2    Schmidt, A.3    Doring, C.4    Lucioni, M.5    Arcaini, L.6
  • 19
    • 84887993987 scopus 로고    scopus 로고
    • Hepatitis C-associated B-cell non-Hodgkin lymphomas: the emerging role of miRNA-26b
    • COI: 1:CAS:528:DC%2BC3sXhsVylurzI, PID: 23978716
    • Gragnani L, Fognani E, Piluso A, Zignego AL. Hepatitis C-associated B-cell non-Hodgkin lymphomas: the emerging role of miRNA-26b. J Hepatol 2013;59:1362–1363
    • (2013) J Hepatol , vol.59 , pp. 1362-1363
    • Gragnani, L.1    Fognani, E.2    Piluso, A.3    Zignego, A.L.4
  • 21
    • 70349871321 scopus 로고    scopus 로고
    • MicroRNA expression, survival, and response to interferon in liver cancer
    • COI: 1:CAS:528:DC%2BD1MXht1GiurnE, PID: 19812400
    • Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, et al. MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med 2009;361:1437–1447
    • (2009) N Engl J Med , vol.361 , pp. 1437-1447
    • Ji, J.1    Shi, J.2    Budhu, A.3    Yu, Z.4    Forgues, M.5    Roessler, S.6
  • 22
    • 84877017662 scopus 로고    scopus 로고
    • Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia
    • COI: 1:CAS:528:DC%2BC3sXnsFWqsr0%3D, PID: 23650540
    • Fognani E, Giannini C, Piluso A, Gragnani L, Monti M, Caini P, et al. Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia. PLoS ONE 2013;8:e62965
    • (2013) PLoS ONE , vol.8 , pp. e62965
    • Fognani, E.1    Giannini, C.2    Piluso, A.3    Gragnani, L.4    Monti, M.5    Caini, P.6
  • 23
    • 0029778988 scopus 로고    scopus 로고
    • An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group
    • COI: 1:STN:280:DyaK28zhvFClug%3D%3D, PID: 8690394
    • Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996;24:289–293
    • (1996) Hepatology , vol.24 , pp. 289-293
    • Bedossa, P.1    Poynard, T.2
  • 24
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: an update
    • PID: 21374666
    • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology 2011;53:1020–1022
    • (2011) Hepatology , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 25
    • 0028064764 scopus 로고
    • A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]
    • COI: 1:STN:280:DyaK2czkvVSmtQ%3D%3D, PID: 8068936
    • Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments]. Blood 1994;84:1361–1392
    • (1994) Blood , vol.84 , pp. 1361-1392
    • Harris, N.L.1    Jaffe, E.S.2    Stein, H.3    Banks, P.M.4    Chan, J.K.5    Cleary, M.L.6
  • 26
    • 84859931528 scopus 로고    scopus 로고
    • Qi R, Weiland M, Gao XH, Zhou L, Mi QS. Identification of endogenous normalizers for serum microRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer. Hepatology 2012;55:1640–1642; author reply 1642–1643
    • Qi R, Weiland M, Gao XH, Zhou L, Mi QS. Identification of endogenous normalizers for serum microRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer. Hepatology 2012;55:1640–1642; author reply 1642–1643
  • 27
    • 79952813995 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers for hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXivFWhtL4%3D, PID: 21278583
    • Qu KZ, Zhang K, Li H, Afdhal NH, Albitar M. Circulating microRNAs as biomarkers for hepatocellular carcinoma. J Clin Gastroenterol 2011;45:355–360
    • (2011) J Clin Gastroenterol , vol.45 , pp. 355-360
    • Qu, K.Z.1    Zhang, K.2    Li, H.3    Afdhal, N.H.4    Albitar, M.5
  • 28
    • 84878787217 scopus 로고    scopus 로고
    • Differential combinatorial regulatory network analysis related to venous metastasis of hepatocellular carcinoma
    • Zeng L, Yu J, Huang T, Jia H, Dong Q, He F, et al. Differential combinatorial regulatory network analysis related to venous metastasis of hepatocellular carcinoma. BMC Genom 2012;13(Suppl. 8):S14
    • (2012) BMC Genom , vol.13 , pp. S14
    • Zeng, L.1    Yu, J.2    Huang, T.3    Jia, H.4    Dong, Q.5    He, F.6
  • 29
    • 80053096230 scopus 로고    scopus 로고
    • Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells
    • COI: 1:CAS:528:DC%2BC3MXhtleku7bI, PID: 21750860
    • Grek M, Piekarska A, Bartkowiak J, Fendler W, Kuydowicz J, Wroblewski P, et al. Coordinated increase of miRNA-155 and miRNA-196b expression correlates with the detection of the antigenomic strand of hepatitis C virus in peripheral blood mononuclear cells. Int J Mol Med 2011;28:875–880
    • (2011) Int J Mol Med , vol.28 , pp. 875-880
    • Grek, M.1    Piekarska, A.2    Bartkowiak, J.3    Fendler, W.4    Kuydowicz, J.5    Wroblewski, P.6
  • 30
    • 84905510366 scopus 로고    scopus 로고
    • MicroRNA-21 identified as predictor of cancer outcome: a meta-analysis
    • PID: 25098165
    • Zhu W, Xu B. MicroRNA-21 identified as predictor of cancer outcome: a meta-analysis. PLoS ONE 2014;9:e103373
    • (2014) PLoS ONE , vol.9 , pp. e103373
    • Zhu, W.1    Xu, B.2
  • 31
    • 84887219361 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of circulating miR-21 for cancer: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXhs1ert73J, PID: 24076132
    • Wang Y, Gao X, Wei F, Zhang X, Yu J, et al. Diagnostic and prognostic value of circulating miR-21 for cancer: a systematic review and meta-analysis. Gene 2014;533:389–397
    • (2014) Gene , vol.533 , pp. 389-397
    • Wang, Y.1    Gao, X.2    Wei, F.3    Zhang, X.4    Yu, J.5
  • 32
    • 84940043946 scopus 로고    scopus 로고
    • Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression
    • PID: 25979949
    • Junker F, Chabloz A, Koch U, Radtke F. Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression. Blood 2015. doi:10.1182/blood-2014-12-61882
    • (2015) Blood
    • Junker, F.1    Chabloz, A.2    Koch, U.3    Radtke, F.4
  • 33
    • 84877263372 scopus 로고    scopus 로고
    • Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
    • COI: 1:CAS:528:DC%2BC3MXhs1OiurbJ, PID: 22213236
    • Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G, Voros D. Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog 2013;52:297–303
    • (2013) Mol Carcinog , vol.52 , pp. 297-303
    • Karakatsanis, A.1    Papaconstantinou, I.2    Gazouli, M.3    Lyberopoulou, A.4    Polymeneas, G.5    Voros, D.6
  • 34
    • 80055103381 scopus 로고    scopus 로고
    • Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhsV2ltbbF, PID: 22066022
    • Bihrer V, Waidmann O, Friedrich-Rust M, Forestier N, Susser S, Haupenthal J, et al. Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. PLoS ONE 2011;6:e26971
    • (2011) PLoS ONE , vol.6 , pp. e26971
    • Bihrer, V.1    Waidmann, O.2    Friedrich-Rust, M.3    Forestier, N.4    Susser, S.5    Haupenthal, J.6
  • 35
    • 78651417662 scopus 로고    scopus 로고
    • Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis
    • COI: 1:CAS:528:DC%2BC3MXksFKqtA%3D%3D, PID: 21229610
    • Xu J, Wu C, Che X, Wang L, Yu D, Zhang T, et al. Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Mol Carcinog 2011;50:136–142
    • (2011) Mol Carcinog , vol.50 , pp. 136-142
    • Xu, J.1    Wu, C.2    Che, X.3    Wang, L.4    Yu, D.5    Zhang, T.6
  • 36
    • 84555202717 scopus 로고    scopus 로고
    • Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC38Xhslygsrk%3D, PID: 22105822
    • Zhou J, Yu L, Gao X, Hu J, Wang J, Dai Z, et al. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. J Clin Oncol 2011;29:4781–4788
    • (2011) J Clin Oncol , vol.29 , pp. 4781-4788
    • Zhou, J.1    Yu, L.2    Gao, X.3    Hu, J.4    Wang, J.5    Dai, Z.6
  • 37
    • 80055117557 scopus 로고    scopus 로고
    • Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXhs1GhsbjN, PID: 21749846
    • Tomimaru Y, Eguchi H, Nagano H, Wada H, Kobayashi S, Marubashi S, et al. Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol 2012;56:167–175
    • (2012) J Hepatol , vol.56 , pp. 167-175
    • Tomimaru, Y.1    Eguchi, H.2    Nagano, H.3    Wada, H.4    Kobayashi, S.5    Marubashi, S.6
  • 38
    • 43449102192 scopus 로고    scopus 로고
    • Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
    • PID: 18318758
    • Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 2008;141:672–675
    • (2008) Br J Haematol , vol.141 , pp. 672-675
    • Lawrie, C.H.1    Gal, S.2    Dunlop, H.M.3    Pushkaran, B.4    Liggins, A.P.5    Pulford, K.6
  • 39
    • 84893857210 scopus 로고    scopus 로고
    • Serum miR-21 is a diagnostic and prognostic marker of primary central nervous system lymphoma
    • PID: 23832112
    • Mao X, Sun Y, Tang J. Serum miR-21 is a diagnostic and prognostic marker of primary central nervous system lymphoma. Neurol Sci 2014;35:233–238
    • (2014) Neurol Sci , vol.35 , pp. 233-238
    • Mao, X.1    Sun, Y.2    Tang, J.3
  • 40
    • 84899101403 scopus 로고    scopus 로고
    • Lymphocytes as liver damage mirror of HCV related adipogenesis deregulation
    • PID: 24658135
    • Minutolo A, Conti B, Grelli S, Viscomi C, Labbadia G, Balsano C. Lymphocytes as liver damage mirror of HCV related adipogenesis deregulation. PLoS ONE 2014;9:e92343
    • (2014) PLoS ONE , vol.9 , pp. e92343
    • Minutolo, A.1    Conti, B.2    Grelli, S.3    Viscomi, C.4    Labbadia, G.5    Balsano, C.6
  • 41
    • 84885584261 scopus 로고    scopus 로고
    • Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis
    • PID: 24151514
    • Long L, Yu P, Liu Y, Wang S, Li R, Shi J, et al. Upregulated microRNA-155 expression in peripheral blood mononuclear cells and fibroblast-like synoviocytes in rheumatoid arthritis. Clin Dev Immunol 2013;2013:296139
    • (2013) Clin Dev Immunol , vol.2013 , pp. 296139
    • Long, L.1    Yu, P.2    Liu, Y.3    Wang, S.4    Li, R.5    Shi, J.6
  • 42
    • 84892470703 scopus 로고    scopus 로고
    • Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection
    • PID: 24503097
    • Gupta P, Liu B, Wu JQ, Soriano V, Vispo E, Carroll AP, et al. Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection. Virology 2014;450–451:336–349
    • (2014) Virology , vol.450-451 , pp. 336-349
    • Gupta, P.1    Liu, B.2    Wu, J.Q.3    Soriano, V.4    Vispo, E.5    Carroll, A.P.6
  • 43
    • 84875300687 scopus 로고    scopus 로고
    • Development of a miR-26 companion diagnostic test for adjuvant interferon-alpha therapy in hepatocellular carcinoma
    • PID: 23569435
    • Ji J, Yu L, Yu Z, Forgues M, Uenishi T, Kubo S, et al. Development of a miR-26 companion diagnostic test for adjuvant interferon-alpha therapy in hepatocellular carcinoma. Int J Biol Sci 2013;9:303–312
    • (2013) Int J Biol Sci , vol.9 , pp. 303-312
    • Ji, J.1    Yu, L.2    Yu, Z.3    Forgues, M.4    Uenishi, T.5    Kubo, S.6


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