Lymphocytes as liver damage mirror of HCV related adipogenesis deregulation

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Minutolo, Antonella ^a   Conti, Beatrice ^a   Grelli, Sandro ^c   Viscomi, Carmela ^a   Labbadia, Giancarlo ^d   Balsano, Clara ^a,b  

^a Laboratory of Molecular Virology and Oncology   (Italy)

^b CNR   (Italy)

^c TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

^d POLICLINICO UMBERTO I   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT FACTOR D; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; VIRUS RNA;

ADIPOGENESIS; ADULT; ARTICLE; CELL TRANSFORMATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEREGULATION; DISEASE COURSE; FATTY LIVER; FEMALE; GENE EXPRESSION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INFLAMMATION; LIFE CYCLE; LIPID METABOLISM; LIVER CELL CARCINOMA; LIVER INJURY; LYMPHOCYTE; MALE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; UPREGULATION; AGED; COMPLICATION; HEPATITIS B; LIPID METABOLISM DISORDERS; LIVER; LIVER DISEASE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; NORMAL HUMAN;

ADIPOGENESIS; ADULT; AGED; FEMALE; HEALTHY VOLUNTEERS; HEPATITIS B, CHRONIC; HEPATITIS C; HEPATITIS C, CHRONIC; HUMANS; LEUKOCYTES, MONONUCLEAR; LIPID METABOLISM DISORDERS; LIVER; LIVER DISEASES; MALE; MIDDLE AGED; UP-REGULATION;

EID: 84899101403     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092343     Document Type: Article

References (43)

1. Kensicki E, Mohney R, Hall WW (2011) Metabolomic Profile of Hepatitis C Virus-Infected Hepatocytes. PLoS One 6(8):e23641.
2. Negro F, Sanyal AJ (2009) Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int 29 Suppl2:26-37.
3. Ploen D, Hafirassou ML, Himmelsbach K, Sauter D, Biniossek ML, et al. (2013) TIP47 plays a crucial role in the life cycle of hepatitis C virus. J Hepatol S0168-8278(13)00066-4.
4. Roque-Cuéllar MC, Sánchez B, García-Lozano JR, Garrido-Serrano A, Sayago M, et al. (2012) Expression of CD81, SR-BI and LDLR in lymphocytes and monocytes from patients with classic and occult hepatitis C virus infection. Journal of Medical Virology 84(11):1727-36.
5. Alisi A, Giannini C, Spaziani A, Anticoli S, Caini P, et al. (2007) Hepatitis C virus core protein enhances B lymphocyte proliferation. Digestive and Liver Disease 39 Suppl 1:S72-5. (Pubitemid 47541926)
6. Alisi A, Giannini C, Spaziani A, Caini P, Zignego AL, et al. (2008) Involvement of PI3K in HCV-related lymphoproliferative disorders. Journal of Cellular Physiology 214(2):396-404. (Pubitemid 350308996)
7. Mancone C, Steindler C, Santangelo L, Simonte G, Vlassi C, et al. (2011) Hepatitis C virus production requires apolipoprotein A-I and affects its association with nascent low-density lipoproteins. Gut 60(3):378-86.
8. Negro F (2010) Abnormalities of lipid metabolism in hepatitis C virus infection. Gut 59(9):1279-1287.
9. Wu C, Gilroy R, Taylor R, Olyaee M, Abdulkarim B, et al. (2011) Alteration of hepatic nuclear receptor-mediated signaling pathways in hepatitis C virus patients with and without a history of alcohol drinking. Hepatology 54(6):1966-74.
10. Negro F (2012) Steatosis and insulin resistance in response to treatment of chronic hepatitis C. Journal of Viral Hepatitis 19 Suppl 1:42-7.
11. Albecka A, Belouzard S, Op de Beeck A, Descamps V, Goueslain L, et al. (2012) Role of low-density lipoprotein receptor in the hepatitis C virus life cycle. Hepatology 55(4):998-1007.
12. Mazumdar B, Banerjee A, Meyer K, Ray R (2011) Hepatitis c virus e1 envelope glycoprotein interacts with apolipoproteins in facilitating entry into hepatocytes. Hepatology 54(4):1149-56.
13. Nielsen SU, Bassendine MF, Burt AD, Martin C, Pumeechockchai W, et al. (2006) Association between hepatitis C virus and very-low-density lipoprotein (VLDL)/LDL analyzed in iodixanol density gradients. Journal of Virology 80(5):2418-28. (Pubitemid 43271547)
14. Scholtes C, Ramière C, Rainteau D, Perrin-Cocon L, Wolf C, et al. (2012) High plasma level of nucleocapsid-free envelope glycoprotein-positive lipoproteins in hepatitis C patients. Hepatology 56(1): 39-48.
15. Nkontchou G, Bastard JP, Ziol M, Aout M, Cosson E, et al. (2010) Insulin resistance, serum leptin, and adiponectin levels and outcomes of viral hepatitis C cirrhosis. Journal of Hepatology 53(5):827-33.
16. Corey KE, Kane E, Munroe C, Barlow LL, Zheng H, et al. (2009) Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up. Hepatology 50:1030-1037.
17. Lambert JE, Bain VG, Ryan EA, Thomson AB, Clandinin MT (2013) Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans. Hepatology 57(5):1697-704.
18. Durazzo M, Belci P, Niro G, Collo A, Grisoglio E, et al. (2013) Variations of serum levels of adiponectin and resistin in chronic viral hepatitis. Journal of Endocrinological Investigation 36(8):600-5.
19. Khattab MA, Eslam M, Shatat M, Abd-Aalhalim H, Mousa YI, et al. (2012) Changes in adipocytokines and insulin sensitivity during and after antiviral therapy for hepatitis C genotype 4. Journal of Gastrointestinal and Liver Diseases 21(1):59-65.
20. Hong YH, Hishikawa D, Miyahara H, Tsuzuki H, Nishimura Y, et al. (2005) Up-regulation of adipogenin, an adipocyte plasma transmembrane protein, during adipogenesis. Molecular and Cellular Biochemistry 276(1-2):133-41. (Pubitemid 41236218)
21. Diamond DL, Syder AJ, Jacobs JM, Sorensen CM, Walters KA, et al. (2010) Temporal proteome and lipidome profiles reveal hepatitis C virus-associated reprogramming of hepatocellular metabolism and bioenergetics. PLoS Pathogen 6(1):e1000719.
22. Zhang M, Zhu W, Li Y (2013) Small Molecule Inhibitors of Human Adipocyte Fatty Acid Binding Protein (FABP4). Medicinal Chemistry Sep 12.
23. Baranova A, Lal P, Birerdinc A, Younossi ZM (2011) Non-invasive markers for hepatic fibrosis. BMC Gastroenterology 11:91.
24. Scheuer PJ (1991) Classification of chronic viral hepatitis: a need for reassessment Journal of Hepatology 13:372-374.
25. Lindenbach BD, Evans MJ, Syder AJ, Wölk B, Tellinghuisen TL, et al. (2005) Complete replication of hepatitis C virus in cell culture. Science 309(5734):623.
26. Mankouri J,Tedbury PR, Gretton S, Hughes ME, Griffin SD, et al. (2010) Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. Proc Natl Acad Sci U S A. 107(25): 11549-11554.
27. Hartling HJ, Gaardbo JC, Ronit A, Salem M, Laye M, et al. (2013) Impaired thymic output in patients with chronic hepatitis C virus infection. Scand J Immunol. 378-86.
28. Sarhan MA, Chen AY, Russell RS, Michalak TI (2012) Patient-derived hepatitis C virus and JFH-1 clones differ in their ability to infect human hepatoma cells and lymphocytes. The Journal of General Virology 93(Pt 11):2399-407.
29. Sarhan MA, Chen AY, Michalak TI (2013) Differential expression of candidate virus receptors in human T lymphocytes prone or resistant to infection with patient-derived hepatitis C virus. PLoS One 8(4):e62159.
30. Pham TN, Lin DM, Mulrooney-Cousins PM, Churchill ND, Kowala-Piaskowska A, et al. (2013) Hepatitis C virus load and expression of a unique subset of cellular genes in circulating lymphoid cells differentiate non-responders from responders to pegylated interferon alpha-ribavirin treatment. Journal of Medical Virology. 85(3):441-8.
31. Wu Z, Wang S (2013) Role of kruppel-like transcription factors in adipogenesis. Developmental Biological 373(2):235-43.
32. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, et al. (2007) Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metababolism 5(4):305-12.
33. McConnell BB, Yang VW (2010) Mammalian Krüppel-like factors in health and diseases. Physiological Review 90(4):1337-81.
34. Zhou J, Tan T, Tian Y, Zheng B, Ou JH, et al. (2011) Krüppel-like factor 15 activates hepatitis B virus gene expression and replication. Hepatology 54(1):109-21.
35. Cao Z, Sun X, Icli B, Wara AK, Feinberg MW (2010) Role of Kruppel-like factors in leukocyte development, function, and disease. Blood 116(22):4404-14.
36. Katschke KJ Jr, Wu P, Ganesan R, Kelley RF, Mathieu MA, et al. (2012) Inhibiting alternative pathway complement activation by targeting the factor D exosite. Journal of Biological Chemistry 287(16):12886-92.
37. Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, et al. (2003) Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. Journal of Biological Chemistry 278(1):498-505. (Pubitemid 36043602)
38. Tsedensodnom O, Koga H, Rosenberg SA, Nambotin SB, Carroll JJ, et al. (2011) Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells. Experimental Cell Research 317(7):920-31.
39. Koga H, Tsedensodnom O, Tomimaru Y, Walker EJ, Lee HC, et al. (2012) Loss of the SxxSS motif in a human T-cell factor-4 isoform confers hypoxia resistance to liver cancer: an oncogenic switch in Wnt signaling. PLoS One 7(6):e39981.
40. Yang J, Mani S-A, Donaher J-L, Ramaswamy S, Itzykson R-A, et al. (2004). Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117:927-939 (Pubitemid 38798858)
41. Kwok W-K, Ling MT, Lee TW, Lau TC, Zhou C, et al. (2005) Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Research 65(12):5153-5162. (Pubitemid 40827324)
42. Yang M-H, Chen CL, Chau GY, Chiou SH, Su CW, et al. (2009) Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 50(5):1464-74.
43. Conti B, Minutolo A, Arciello M, Balsano C (2013) Are Hedgehog and Wnt/β-catenin pathways involved in hepatitis C virus-mediated EMT? Journal of Hepatology 58(3):636-7.