Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature

Oncotarget

Volumn 6, Issue 28, 2015, Pages 25429-25440

  Rybinski, Katherine ^a   Imtiyaz, Hongxia Z ^a   Mittica, Barrie ^a   Drozdowski, Brian ^a   Fulmer, James ^a   Furuuchi, Keiji ^a   Fernando, Shawn ^a   Henry, Marianne ^a   Chao, Qimin ^a   Kline, Brad ^a   Albone, Earl ^a   Wustner, Jason ^a   Lin, JianMin ^a   Nicolaides, Nicholas C ^a   Grasso, Luigi ^a   Zhou, Yuhong ^a  

^a Morphotek Inc   (United States)

Author keywords

a SMA; CD248; endosialin; MORAb 004; Tumor microvasculature

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ENDOSIALIN; MONOCLONAL ANTIBODY; MORAB 004 MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; ACTA2 PROTEIN, MOUSE; ACTIN; ANGIOGENESIS INHIBITOR; CD248 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MORAB-004; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL MATURATION; CELL MEMBRANE DEPOLARIZATION; CELL SURFACE; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INTERNALIZATION; METASTASIS INHIBITION; MICROVASCULATURE; MOUSE; NONHUMAN; PERICYTE; PROTEIN EXPRESSION; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM; ANIMAL; C57BL MOUSE; CARCINOMA, LEWIS LUNG; CELL CULTURE; CELL MOTION; DOSE RESPONSE; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; MALE; MELANOMA, EXPERIMENTAL; METABOLISM; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; RNA INTERFERENCE; TIME FACTOR; TRANSGENIC MOUSE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR VOLUME; VASCULARIZATION;

ACTINS; ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS, CD; ANTIGENS, NEOPLASM; BIOLOGICAL TRANSPORT; CARCINOMA, LEWIS LUNG; CELL MOVEMENT; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FEMALE; HUMANS; MALE; MELANOMA, EXPERIMENTAL; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROVESSELS; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PERICYTES; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; TUMOR BURDEN;

EID: 84944474761     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4559     Document Type: Article

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