메뉴 건너뛰기




Volumn 6, Issue 29, 2015, Pages 27083-27096

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

Author keywords

Epithelial to mesenchymal transition (EMT); Invadopodia; MiR 200; MYLK (MLCK); ZEB1

Indexed keywords

ACTIN; CELL PROTEIN; MICRORNA 200C; MYOSIN LIGHT CHAIN KINASE; TKS5 PROTEIN; TRANSCRIPTION FACTOR ZEB1; UNCLASSIFIED DRUG; CADHERIN; CALCIUM BINDING PROTEIN; CDH1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; MICRORNA; MIRN200 MICRORNA, HUMAN; MYLK PROTEIN, HUMAN; SH3PXD2A PROTEIN, HUMAN; TRANSCRIPTION FACTOR; VESICULAR TRANSPORT ADAPTOR PROTEIN; ZEB1 PROTEIN, HUMAN;

EID: 84944474572     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4807     Document Type: Article
Times cited : (55)

References (69)
  • 1
    • 70450198396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelialmesenchymal transitions in development and disease. Cell. 2009; 139:871-890.
    • (2009) Cell. , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 2
    • 34548565806 scopus 로고    scopus 로고
    • Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin
    • Hurteau GJ, Carlson JA, Spivack SD, Brock GJ. Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. Cancer research. 2007; 67:7972-7976.
    • (2007) Cancer research. , vol.67 , pp. 7972-7976
    • Hurteau, G.J.1    Carlson, J.A.2    Spivack, S.D.3    Brock, G.J.4
  • 3
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, Brabletz T. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO reports. 2008; 9:582-589.
    • (2008) EMBO reports. , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 5
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. The Journal of biological chemistry. 2008; 283:14910-14914.
    • (2008) The Journal of biological chemistry. , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 6
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes & development. 2008; 22:894-907.
    • (2008) Genes & development. , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 7
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, Goodall GJ. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer research. 2008; 68:7846-7854.
    • (2008) Cancer research. , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 8
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop- a motor of cellular plasticity in development and cancer?
    • Brabletz S, Brabletz T. The ZEB/miR-200 feedback loop- a motor of cellular plasticity in development and cancer? EMBO reports. 2010; 11:670-677.
    • (2010) EMBO reports. , vol.11 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 11
    • 33847343034 scopus 로고    scopus 로고
    • The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
    • Linder S. The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends in cell biology. 2007; 17:107-117.
    • (2007) Trends in cell biology. , vol.17 , pp. 107-117
    • Linder, S.1
  • 12
  • 16
    • 84862629472 scopus 로고    scopus 로고
    • Hic-5 promotes invadopodia formation and invasion during TGF-beta-induced epithelial-mesenchymal transition
    • Pignatelli J, Tumbarello DA, Schmidt RP, Turner CE. Hic-5 promotes invadopodia formation and invasion during TGF-beta-induced epithelial-mesenchymal transition. The Journal of cell biology. 2012; 197:421-437.
    • (2012) The Journal of cell biology. , vol.197 , pp. 421-437
    • Pignatelli, J.1    Tumbarello, D.A.2    Schmidt, R.P.3    Turner, C.E.4
  • 19
    • 79955102595 scopus 로고    scopus 로고
    • Targets of miR-200c mediate suppression of cell motility and anoikis resistance
    • Howe E, Cochrane D, Richer J. Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Research. 2011; 13:R45.
    • (2011) Breast Cancer Research. , vol.13 , pp. R45
    • Howe, E.1    Cochrane, D.2    Richer, J.3
  • 20
    • 78049283348 scopus 로고    scopus 로고
    • MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion
    • Elson-Schwab I, Lorentzen A, Marshall CJ. MicroRNA-200 family members differentially regulate morphological plasticity and mode of melanoma cell invasion. PLoS One. 2010; 5.
    • (2010) PLoS One. , vol.5
    • Elson-Schwab, I.1    Lorentzen, A.2    Marshall, C.J.3
  • 21
    • 66849140943 scopus 로고    scopus 로고
    • MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents
    • Cochrane DR, Spoelstra NS, Howe EN, Nordeen SK, Richer JK. MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents. Mol Cancer Ther. 2009; 8:1055-1066.
    • (2009) Mol Cancer Ther. , vol.8 , pp. 1055-1066
    • Cochrane, D.R.1    Spoelstra, N.S.2    Howe, E.N.3    Nordeen, S.K.4    Richer, J.K.5
  • 24
    • 79960583982 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor signaling by miR-200b
    • Choi YC, Yoon S, Jeong Y, Yoon J, Baek K. Regulation of vascular endothelial growth factor signaling by miR-200b. Mol Cells. 2011; 32:77-82.
    • (2011) Mol Cells. , vol.32 , pp. 77-82
    • Choi, Y.C.1    Yoon, S.2    Jeong, Y.3    Yoon, J.4    Baek, K.5
  • 25
    • 84874456193 scopus 로고    scopus 로고
    • A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells
    • Luo D, Wilson JM, Harvel N, Liu J, Pei L, Huang S, Hawthorn L, Shi H. A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cells. J Transl Med. 2013; 11:57.
    • (2013) J Transl Med. , vol.11 , pp. 57
    • Luo, D.1    Wilson, J.M.2    Harvel, N.3    Liu, J.4    Pei, L.5    Huang, S.6    Hawthorn, L.7    Shi, H.8
  • 29
    • 67651161854 scopus 로고    scopus 로고
    • Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation
    • Crimaldi L, Courtneidge SA, Gimona M. Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation. Experimental cell research. 2009; 315:2581-2592.
    • (2009) Experimental cell research. , vol.315 , pp. 2581-2592
    • Crimaldi, L.1    Courtneidge, S.A.2    Gimona, M.3
  • 30
    • 0035895901 scopus 로고    scopus 로고
    • Dedicated myosin light chain kinases with diverse cellular functions
    • Kamm KE, Stull JT. Dedicated myosin light chain kinases with diverse cellular functions. The Journal of biological chemistry. 2001; 276:4527-4530.
    • (2001) The Journal of biological chemistry. , vol.276 , pp. 4527-4530
    • Kamm, K.E.1    Stull, J.T.2
  • 33
    • 79955497173 scopus 로고    scopus 로고
    • Phosphoglucose Isomerase/ Autocrine Motility Factor Mediates Epithelial-Mesenchymal Transition Regulated by miR-200 in Breast Cancer Cells
    • Ahmad A, Aboukameel A, Kong D, Wang Z, Sethi S, Chen W, Sarkar FH, Raz A. Phosphoglucose Isomerase/ Autocrine Motility Factor Mediates Epithelial-Mesenchymal Transition Regulated by miR-200 in Breast Cancer Cells. Cancer research. 2011; 71:3400-3409.
    • (2011) Cancer research. , vol.71 , pp. 3400-3409
    • Ahmad, A.1    Aboukameel, A.2    Kong, D.3    Wang, Z.4    Sethi, S.5    Chen, W.6    Sarkar, F.H.7    Raz, A.8
  • 36
    • 69249156944 scopus 로고    scopus 로고
    • miR-200 Regulates PDGF-D-Mediated Epithelial-Mesenchymal Transition, Adhesion, and Invasion of Prostate Cancer Cells
    • Kong D, Li Y, Wang Z, Banerjee S, Ahmad A, Kim HRC, Sarkar FH. miR-200 Regulates PDGF-D-Mediated Epithelial-Mesenchymal Transition, Adhesion, and Invasion of Prostate Cancer Cells. STEM CELLS. 2009; 27:1712-1721.
    • (2009) STEM CELLS. , vol.27 , pp. 1712-1721
    • Kong, D.1    Li, Y.2    Wang, Z.3    Banerjee, S.4    Ahmad, A.5    Kim, H.R.C.6    Sarkar, F.H.7
  • 37
    • 13844264301 scopus 로고    scopus 로고
    • The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells
    • Seals DF, Azucena EF Jr, Pass I, Tesfay L, Gordon R, Woodrow M, Resau JH, Courtneidge SA. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer cell. 2005; 7:155-165.
    • (2005) Cancer cell. , vol.7 , pp. 155-165
    • Seals, D.F.1    Azucena, E.F.2    Pass, I.3    Tesfay, L.4    Gordon, R.5    Woodrow, M.6    Resau, J.H.7    Courtneidge, S.A.8
  • 39
    • 79959541003 scopus 로고    scopus 로고
    • The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function
    • Murphy DA, Courtneidge SA. The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nature reviews Molecular cell biology. 2011; 12:413-426.
    • (2011) Nature reviews Molecular cell biology. , vol.12 , pp. 413-426
    • Murphy, D.A.1    Courtneidge, S.A.2
  • 42
    • 47849092068 scopus 로고    scopus 로고
    • Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins
    • Xu J, Gao XP, Ramchandran R, Zhao YY, Vogel SM, Malik AB. Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins. Nature immunology. 2008; 9:880-886.
    • (2008) Nature immunology. , vol.9 , pp. 880-886
    • Xu, J.1    Gao, X.P.2    Ramchandran, R.3    Zhao, Y.Y.4    Vogel, S.M.5    Malik, A.B.6
  • 45
    • 59149101254 scopus 로고    scopus 로고
    • Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is upregulated in prostate and breast cancer
    • Ayala I, Giacchetti G, Caldieri G, Attanasio F, Mariggio S, Tete S, Polishchuk R, Castronovo V, Buccione R. Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is upregulated in prostate and breast cancer. Cancer research. 2009; 69:747-752.
    • (2009) Cancer research. , vol.69 , pp. 747-752
    • Ayala, I.1    Giacchetti, G.2    Caldieri, G.3    Attanasio, F.4    Mariggio, S.5    Tete, S.6    Polishchuk, R.7    Castronovo, V.8    Buccione, R.9
  • 47
    • 84911966142 scopus 로고    scopus 로고
    • miR-206 inhibits cell migration through direct targeting of the actin-binding protein Coronin 1C in triple-negative breast cancer
    • Wang J, Tsouko E, Jonsson P, Bergh J, Hartman J, Aydogdu E, Williams C. miR-206 inhibits cell migration through direct targeting of the actin-binding protein Coronin 1C in triple-negative breast cancer. Mol Oncol. 2014.
    • (2014) Mol Oncol.
    • Wang, J.1    Tsouko, E.2    Jonsson, P.3    Bergh, J.4    Hartman, J.5    Aydogdu, E.6    Williams, C.7
  • 50
    • 0141613922 scopus 로고    scopus 로고
    • Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain
    • Tohtong R, Phattarasakul K, Jiraviriyakul A, Sutthiphongchai T. Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain. Prostate Cancer Prostatic Dis. 2003; 6:212-216.
    • (2003) Prostate Cancer Prostatic Dis. , vol.6 , pp. 212-216
    • Tohtong, R.1    Phattarasakul, K.2    Jiraviriyakul, A.3    Sutthiphongchai, T.4
  • 53
    • 0032883786 scopus 로고    scopus 로고
    • Identification of a novel actin binding motif in smooth muscle myosin light chain kinase
    • Smith L, Su X, Lin P, Zhi G, Stull JT. Identification of a novel actin binding motif in smooth muscle myosin light chain kinase. The Journal of biological chemistry. 1999; 274:29433-29438.
    • (1999) The Journal of biological chemistry. , vol.274 , pp. 29433-29438
    • Smith, L.1    Su, X.2    Lin, P.3    Zhi, G.4    Stull, J.T.5
  • 58
    • 34250170819 scopus 로고    scopus 로고
    • Roles of cortactin in tumor pathogenesis
    • Buday L, Downward J. Roles of cortactin in tumor pathogenesis. Biochim Biophys Acta. 2007; 1775:263-273.
    • (2007) Biochim Biophys Acta. , vol.1775 , pp. 263-273
    • Buday, L.1    Downward, J.2
  • 61
    • 0036136080 scopus 로고    scopus 로고
    • Myosin Light Chain Kinase Inhibitors Can Block Invasion and Adhesion of Human Pancreatic Cancer Cell Lines
    • Kaneko K, Satoh K, Masamune A, Satoh A, Shimosegawa T. Myosin Light Chain Kinase Inhibitors Can Block Invasion and Adhesion of Human Pancreatic Cancer Cell Lines. Pancreas. 2002; 24:34-41.
    • (2002) Pancreas. , vol.24 , pp. 34-41
    • Kaneko, K.1    Satoh, K.2    Masamune, A.3    Satoh, A.4    Shimosegawa, T.5
  • 62
    • 84856287423 scopus 로고    scopus 로고
    • Cell migration and invasion in human disease: the Tks adaptor proteins
    • Courtneidge SA. Cell migration and invasion in human disease: the Tks adaptor proteins. Biochemical Society transactions. 2012; 40:129-132.
    • (2012) Biochemical Society transactions. , vol.40 , pp. 129-132
    • Courtneidge, S.A.1
  • 63
    • 84886164927 scopus 로고    scopus 로고
    • LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells
    • Harrison S, Knifley T, Chen M, O'Connor K. LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells. BMC Cancer. 2013; 13:501.
    • (2013) BMC Cancer. , vol.13 , pp. 501
    • Harrison, S.1    Knifley, T.2    Chen, M.3    O'Connor, K.4
  • 64
    • 33846815057 scopus 로고    scopus 로고
    • Regulation of Myosin II Dynamics by Phosphorylation and Dephosphorylation of Its Light Chain in Epithelial Cells
    • Watanabe T, Hosoya H, Yonemura S. Regulation of Myosin II Dynamics by Phosphorylation and Dephosphorylation of Its Light Chain in Epithelial Cells. Molecular Biology of the Cell. 2007; 18:605-616.
    • (2007) Molecular Biology of the Cell. , vol.18 , pp. 605-616
    • Watanabe, T.1    Hosoya, H.2    Yonemura, S.3
  • 65
    • 33645119345 scopus 로고    scopus 로고
    • Differential roles of Rho-kinase and myosin light chain kinase in regulating shape, adhesion, and migration of HT1080 fibrosarcoma cells
    • Niggli V, Schmid M, Nievergelt A. Differential roles of Rho-kinase and myosin light chain kinase in regulating shape, adhesion, and migration of HT1080 fibrosarcoma cells. Biochemical and biophysical research communications. 2006; 343:602-608.
    • (2006) Biochemical and biophysical research communications. , vol.343 , pp. 602-608
    • Niggli, V.1    Schmid, M.2    Nievergelt, A.3
  • 69
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic acids research. 2001; 29:e45.
    • (2001) Nucleic acids research. , vol.29
    • Pfaffl, M.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.