Epidemiology of NAFLD and Type 2 Diabetes: Health Disparities Among Persons of Hispanic Origin

Current Diabetes Reports

Volumn 15, Issue 12, 2015, Pages

  Lazo, Mariana ^a,b,c   Bilal, Usama ^b,c   Perez Escamilla, Rafael ^d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

Epidemiology; Health disparities; Hispanics; Non alcoholic fatty liver disease; PNPLA3; Type 2 diabetes

Indexed keywords

BLACK PERSON; CONCEPTUAL FRAMEWORK; DISEASE CONTROL; DNA POLYMORPHISM; ETHNICITY; GENOTYPE ENVIRONMENT INTERACTION; HEALTH AUXILIARY; HEALTH CARE DISPARITY; HEALTH CARE SYSTEM; HISPANIC; HUMAN; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PATHOGENESIS; PNPLA3 GENE; POPULATION RESEARCH; PREVALENCE; REVIEW; RISK ASSESSMENT; RISK FACTOR; ANIMAL; DIABETES MELLITUS, TYPE 2; ETHNOLOGY;

ANIMALS; DIABETES MELLITUS, TYPE 2; HISPANIC AMERICANS; HUMANS; INSULIN RESISTANCE; NON-ALCOHOLIC FATTY LIVER DISEASE; OBESITY; PREVALENCE; RISK FACTORS;

EID: 84944447059     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-015-0674-6     Document Type: Review

References (49)

1. Argo CK, Caldwell SH. Epidemiology and natural history of non-alcoholic steatohepatitis. Clin Liver Dis. 2009;13:511–31.
2. Lazo M, Clark JM. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis. 2008;28:339–50.
3. Brunt EM. Pathology of fatty liver disease. Mod Pathol. 2007;20 Suppl 1:S40–8.
4. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40:1387–95.
5. Tota-Maharaj R, Blaha MJ, Zeb I, Katz R, Blankstein R, Blumenthal RS, et al. Ethnic and sex differences in fatty liver on cardiac computed tomography: the multi-ethnic study of atherosclerosis. Mayo Clin Proc. 2014;89:493–503.
6. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844–50.
7. Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology. 2011;140:124–31.
8. Lazo M, Hernaez R, Eberhardt MS, Bonekamp S, Kamel I, Guallar E, et al. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988–1994. Am J Epidemiol. 2013;178:38–45. Only U.S. representative study of the prevalence of NAFLD.
9. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 2012;142:1592–609. Current clinical guideline for NAFLD.
10. Browning JD, Kumar KS, Saboorian MH, Thiele DL. Ethnic differences in the prevalence of cryptogenic cirrhosis. Am J Gastroenterol. 2004;99:292–8.
11. CDC Vital signs—Hispanic health. Vital signs. http://www.cdc.gov/vitalsigns/pdf/2015-05-vitalsigns.pdf.
12. Carrion AF, Ghanta R, Carrasquillo O, Martin P. Chronic liver disease in the Hispanic population of the United States. Clin Gastroenterol Hepatol. 2011;9:834–41. quiz e109-10.
13. Vega WA, Rodriguez MA, Gruskin E. Health disparities in the Latino population. Epidemiol Rev. 2009;31:99–112.
14. Schneider AL, Lazo M, Selvin E, Clark JM. Racial differences in nonalcoholic fatty liver disease in the U.S. population. Obesity (Silver Spring). 2013.
15. Hernaez R. Genetic factors associated with the presence and progression of nonalcoholic fatty liver disease: a narrative review. Gastroenterol Hepatol. 2012;35:32–41.
16. Al Rifai M, Silverman MG, Nasir K, Budoff MJ, Blankstein R, Szklo M, et al. The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2015;239:629–33.
17. Fleischman MW, Budoff M, Zeb I, Li D, Foster T. NAFLD prevalence differs among Hispanic subgroups: the Multi-Ethnic Study of Atherosclerosis. World J Gastroenterol. 2014;20:4987–93. One of the first population based studies that highlighted the heterogeneity in the presence of liver fat among Hispanics subgroups.
18. Kallwitz ER, Daviglus ML, Allison MA, Emory KT, Zhao L, Kuniholm MH, et al. Prevalence of suspected nonalcoholic fatty liver disease in Hispanic/Latino individuals differs by heritage. Clin Gastroenterol Hepatol. 2015;13:569–76. One of the first population based studies that highlighted the heterogeneity in the presence of liver fat among Hispanics subgroups.
19. Schneiderman N, Llabre M, Cowie CC, Barnhart J, Carnethon M, Gallo LC, et al. Prevalence of diabetes among Hispanics/Latinos from diverse backgrounds: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Diabetes Care. 2014;37:2233–9.
20. Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008;40:1461–5.
21. Santoro N, Feldstein AE, Enoksson E, Pierpont B, Kursawe R, Kim G, et al. The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants. Diabetes Care. 2013;36:1353–60.
22. Santoro N, Savoye M, Kim G, Marotto K, Shaw MM, Pierpont B, et al. Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake. PLoS One. 2012;7, e37827.
23. Browning JD, Cohen JC, Hobbs HH. Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease. Hepatology. 2010;52:1189–92.
24. Hernaez R, McLean J, Lazo M, Brancati FL, Hirschhorn JN, Borecki IB, et al. Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the Third National Health and Nutrition Examination Survey. Clin Gastroenterol Hepatol. 2013;11:1183–1190 e2.
25. Santoro N, Kursawe R, D’Adamo E, Dykas DJ, Zhang CK, Bale AE, et al. A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. Hepatology. 2010;52:1281–90.
26. Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011;7, e1001324.
27. Wagenknecht LE, Palmer ND, Bowden DW, Rotter JI, Norris JM, Ziegler J, et al. Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study. Liver Int. 2011;31:412–6.
28. Speliotes EK, Butler JL, Palmer CD, Voight BF, Hirschhorn JN. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. Hepatology. 2010;52:904–12.
29. Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science. 2011;332:1519–23.
30. Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, et al. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J Clin Invest. 2012;122:4130–44.
31. Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet. 2008;83:520–8.
32. Stickel F, Buch S, Lau K, Meyer zu SH, Berg T, Ridinger M, et al. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in Caucasians. Hepatology. 2011;53:86–95.
33. Tian C, Stokowski RP, Kershenobich D, Ballinger DG, Hinds DA. Variant in PNPLA3 is associated with alcoholic liver disease. Nat Genet. 2010;42:21–3.
34. 1000 Genomes Project. http://browser.1000genomes.org/Homo_sapiens/Variation/Population?db=core;r=22:44324227-44325227;v=rs738409;vdb=variation;vf=580774.
35. Rose G. Sick individuals and sick populations. Int J Epidemiol. 2001;30:427–32. Discussion 433-4.
36. Krieger N. A glossary for social epidemiology. J Epidemiol Community Health. 2001;55:693–700.
37. Glass TA, McAtee MJ. Behavioral science at the crossroads in public health: extending horizons, envisioning the future. Soc Sci Med. 2006;62:1650–71.
38. Krieger N. Proximal, distal, and the politics of causation: what’s level got to do with it? Am J Public Health. 2008;98:221–30.
39. Ortega AN, Rodriguez HP, Vargas Bustamante A. Policy dilemmas in Latino health care and implementation of the Affordable Care Act. Annu Rev Public Health. 2015;36:525–44. Comprehensive review of the implications of the ACA for Latino health.
40. Pérez-Escamilla R. Health care access among Latinos: implications for social and health care reforms. J Hisp High Educ. 2010;9:43–60.
41. Perez-Escamilla R, Garcia J, Song D. Health care access among Hispanic immigrants: alguien esta escuchando? Is anybody listening? NAPA Bull. 2010;34:47–67.
42. Bermudez-Millan A, Damio G, Cruz J, D’Angelo K, Segura-Perez S, Hromi-Fiedler A, et al. Stress and the social determinants of maternal health among Puerto Rican women: a CBPR approach. J Health Care Poor Underserved. 2011;22:1315–30.
43. Kollannoor-Samuel G, Vega-Lopez S, Chhabra J, Segura-Perez S, Damio G, Perez-Escamilla R. Food insecurity and low self-efficacy are associated with health care access barriers among Puerto-Ricans with type 2 diabetes. J Immigr Minor Health. 2012;14:552–62.
44. Kollannoor-Samuel G, Wagner J, Damio G, Segura-Perez S, Chhabra J, Vega-Lopez S, et al. Social support modifies the association between household food insecurity and depression among Latinos with uncontrolled type 2 diabetes. J Immigr Minor Health. 2011;13:982–9.
45. Palmas W, March D, Darakjy S, Findley SE, Teresi J, Carrasquillo O, et al. Community health worker interventions to improve glycemic control in people with diabetes: a systematic review and meta-analysis. J Gen Intern Med. 2015;30:1004–12. Systematic review of the efficacy of community health workers based interventions to improve diabetes.
46. Perez-Escamilla R, Damio G, Chhabra J, Fernandez ML, Segura-Perez S, Vega-Lopez S, et al. Impact of a community health workers-led structured program on blood glucose control among Latinos with type 2 diabetes: the DIALBEST trial. Diabetes Care. 2015;38:197–205. One of the first RCT demonstrating the efficacy of community health workers to improve diabetes among Latinos.
47. Ford CL, Harawa NT. A new conceptualization of ethnicity for social epidemiologic and health equity research. Soc Sci Med. 2010;71:251–8.
48. Hayes-Bautista DE, Chapa J. Latino terminology: conceptual bases for standardized terminology. Am J Public Health. 1987;77:61–8.
49. Telles E. Project of ethnicity and race in Latin America. Pigmentocracies: ethnicity, race, and color in Latin America. University of North Carolina Press; 2014.