Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for Three-Dimensional Organotypic Cultures

Nano Letters

Volumn 15, Issue 10, 2015, Pages 6919-6925

  Loo, Yihua ^a   Lakshmanan, Anupama ^a,c   Ni, Ming ^a   Toh, Lai Ling ^a   Wang, Shi ^b   Hauser, Charlotte A E ^a  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^c California Institute of Technology   (United States)

Author keywords

bioprinting; nanofibrous scaffold; Peptide bioink; smart biomaterials; stimuli responsive self assembly; ultrashort peptides

Indexed keywords

AMINO ACIDS; BIOCOMPATIBILITY; CELL ENGINEERING; HYDROGELS; NANOFIBERS; PEPTIDES; SELF ASSEMBLY; STEM CELLS; STIFFNESS; TISSUE; TISSUE ENGINEERING;

BIOCOMPATIBLE SCAFFOLDS; BIOPRINTING; HIGH THROUGHPUT SCREENING; NANOFIBROUS SCAFFOLDS; SMART BIOMATERIALS; STIMULI-RESPONSIVE; STRENGTH AND STIFFNESS; THREE-DIMENSIONAL CULTURE;

SCAFFOLDS (BIOLOGY);

HYDROGEL; NANOFIBER; PEPTIDE;

CACO 2 CELL LINE; CHEMISTRY; HUMAN; HYDROGEL; SCANNING ELECTRON MICROSCOPY; TISSUE SCAFFOLD;

CACO-2 CELLS; HUMANS; HYDROGELS; MICROSCOPY, ELECTRON, SCANNING; NANOFIBERS; PEPTIDES; TISSUE SCAFFOLDS;

EID: 84944406931     PISSN: 15306984     EISSN: 15306992     Source Type: Journal    
DOI: 10.1021/acs.nanolett.5b02859     Document Type: Article

References (28)

1. Derby, B. Printing and prototyping of tissues and scaffolds Science (Washington, DC, U. S.) 2012, 338 (6109) 921-6 10.1126/science.1226340
2. Murphy, S. V.; Atala, A. 3D bioprinting of tissues and organs Nat. Biotechnol. 2014, 32 (8) 773-785 10.1038/nbt.2958
3. Elliott, N. T.; Yuan, F. A review of three-dimensional in vitro tissue models for drug discovery and transport studies J. Pharm. Sci. 2011, 100 (1) 59-74 10.1002/jps.22257
4. Vaidya, M. Startups tout commercially 3D-printed tissue for drug screening Nat. Med. 2015, 21 (1) 2-2 10.1038/nm0115-2
5. Loo, Y.; Zhang, S.; Hauser, C. A. E. From short peptides to nanofibers to macromolecular assemblies in biomedicine Biotechnol. Adv. 2012, 30 (3) 593-603 10.1016/j.biotechadv.2011.10.004
6. Wu, E. C.; Zhang, S.; Hauser, C. A. E. Self-Assembling Peptides as Cell-Interactive Scaffolds Adv. Funct. Mater. 2012, 22 (3) 456-468 10.1002/adfm.201101905
7. Hauser, C. A. E.; Deng, R.; Mishra, A.; Loo, Y.; Khoe, U.; Zhuang, F.; Cheong, D. W.; Accardo, A.; Sullivan, M. B.; Riekel, C.; Ying, J. Y.; Hauser, U. A. Natural tri- to hexapeptides self-assemble in water to amyloid beta-type fiber aggregates by unexpected alpha-helical intermediate structures Proc. Natl. Acad. Sci. U. S. A. 2011, 108 (4) 1361-6 10.1073/pnas.1014796108
8. Mishra, A.; Loo, Y. H.; Deng, R. H.; Chuah, Y. J.; Hee, H. T.; Ying, J. Y.; Hauser, C. A. E. Ultrasmall natural peptides self-assemble to strong temperature-resistant helical fibers in scaffolds suitable for tissue engineering Nano Today 2011, 6 (3) 232-239 10.1016/j.nantod.2011.05.001
9. Guilak, F.; Cohen, D. M.; Estes, B. T.; Gimble, J. M.; Liedtke, W.; Chen, C. S. Control of stem cell fate by physical interactions with the extracellular matrix Cell Stem Cell 2009, 5 (1) 17-26 10.1016/j.stem.2009.06.016
10. Gazit, E. Self-assembled peptide nanostructures: the design of molecular building blocks and their technological utilization Chem. Soc. Rev. 2007, 36 (8) 1263-9 10.1039/b605536m
11. Yan, C.; Pochan, D. J. Rheological properties of peptide-based hydrogels for biomedical and other applications Chem. Soc. Rev. 2010, 39 (9) 3528-40 10.1039/b919449p
12. Discher, D. E.; Janmey, P.; Wang, Y. L. Tissue cells feel and respond to the stiffness of their substrate Science (Washington, DC, U. S.) 2005, 310 (5751) 1139-1143 10.1126/science.1116995
13. Discher, D. E.; Mooney, D. J.; Zandstra, P. W. Growth factors, matrices, and forces combine and control stem cells Science (Washington, DC, U. S.) 2009, 324 (5935) 1673-7 10.1126/science.1171643
14. Engler, A. J.; Sen, S.; Sweeney, H. L.; Discher, D. E. Matrix elasticity directs stem cell lineage specification Cell 2006, 126 (4) 677-89 10.1016/j.cell.2006.06.044
15. Leight, J. L.; Wozniak, M. A.; Chen, S.; Lynch, M. L.; Chen, C. S. Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition Mol. Biol. Cell 2012, 23 (5) 781-91 10.1091/mbc.E11-06-0537
16. Wei, S. C.; Fattet, L.; Tsai, J. H.; Guo, Y.; Pai, V. H.; Majeski, H. E.; Chen, A. C.; Sah, R. L.; Taylor, S. S.; Engler, A. J.; Yang, J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway Nat. Cell Biol. 2015, 17 (5) 678-88 10.1038/ncb3157
17. Gidrol, X.; Fouque, B.; Ghenim, L.; Haguet, V.; Picollet-D'hahan, N.; Schaack, B. 2D and 3D cell microarrays in pharmacology Curr. Opin. Pharmacol. 2009, 9 (5) 664-8 10.1016/j.coph.2009.05.002
18. Brafman, D. A.; Chang, C. W.; Fernandez, A.; Willert, K.; Varghese, S.; Chien, S. Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces Biomaterials 2010, 31 (34) 9135-44 10.1016/j.biomaterials.2010.08.007
19. Villa-Diaz, L. G.; Kim, J. K.; Lahann, J.; Krebsbach, P. H. Derivation and long-term culture of transgene-free human induced pluripotent stem cells on synthetic substrates Stem Cells Transl. Med. 2014, 3 (12) 1410-7 10.5966/sctm.2014-0087
20. Kandasamy, K.; Narayanan, K.; Ni, M.; Du, C.; Wan, A. C.; Zink, D. Polysulfone membranes coated with polymerized 3,4-dihydroxy-l-phenylalanine are a versatile and cost-effective synthetic substrate for defined long-term cultures of human pluripotent stem cells Biomacromolecules 2014, 15 (6) 2067-78 10.1021/bm5001907
21. Rodin, S.; Domogatskaya, A.; Strom, S.; Hansson, E. M.; Chien, K. R.; Inzunza, J.; Hovatta, O.; Tryggvason, K. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511 Nat. Biotechnol. 2010, 28 (6) 611-5 10.1038/nbt.1620
22. Gerecht, S.; Burdick, J. A.; Ferreira, L. S.; Townsend, S. A.; Langer, R.; Vunjak-Novakovic, G. Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells Proc. Natl. Acad. Sci. U. S. A. 2007, 104 (27) 11298-303 10.1073/pnas.0703723104
23. Yim, E. K.; Darling, E. M.; Kulangara, K.; Guilak, F.; Leong, K. W. Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells Biomaterials 2010, 31 (6) 1299-306 10.1016/j.biomaterials.2009.10.037
24. Masoumi, N.; Annabi, N.; Assmann, A.; Larson, B. L.; Hjortnaes, J.; Alemdar, N.; Kharaziha, M.; Manning, K. B.; Mayer, J. E., Jr.; Khademhosseini, A. Tri-layered elastomeric scaffolds for engineering heart valve leaflets Biomaterials 2014, 35 (27) 7774-85 10.1016/j.biomaterials.2014.04.039
25. Loo, Y.; Wong, Y. C.; Cai, E. Z.; Ang, C. H.; Raju, A.; Lakshmanan, A.; Koh, A. G.; Zhou, H. J.; Lim, T. C.; Moochhala, S. M.; Hauser, C. A. E. Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds Biomaterials 2014, 35 (17) 4805-14 10.1016/j.biomaterials.2014.02.047
26. Reithofer, M. R.; Lakshmanan, A.; Ping, A. T.; Chin, J. M.; Hauser, C. A. E. In situ synthesis of size-controlled, stable silver nanoparticles within ultrashort peptide hydrogels and their anti-bacterial properties Biomaterials 2014, 35 (26) 7535-42 10.1016/j.biomaterials.2014.04.102
27. Reithofer, M. R.; Chan, K.-H.; Lakshmanan, A.; Lam, D. H.; Mishra, A.; Gopalan, B.; Joshi, M.; Wang, S.; Hauser, C. A. E. Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy Chem. Sci. 2014, 5 (2) 625-630 10.1039/C3SC51930A
28. Seow, W. Y.; Hauser, C. A. E. Tunable mechanical properties of ultrasmall peptide hydrogels by crosslinking and functionalization to achieve the 3D distribution of cells Adv. Healthcare Mater. 2013, 2 (9) 1219-23 10.1002/adhm.201200463