Fast intracellular dissolution and persistent cellular uptake of silver nanoparticles in CHO-K1 cells: Implication for cytotoxicity

Nanotoxicology

Volumn 9, Issue 2, 2015, Pages 181-189

  Jiang, Xiumei ^a,b   Micləuş, Teodora ^b   Wang, Liming ^c   Foldbjerg, Rasmus ^b   Sutherland, Duncan S ^b   Autrup, Herman ^b   Chen, Chunying ^a   Beer, Christiane ^b  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b AARHUS UNIVERSITY   (Denmark)

^c INSTITUTE OF HIGH ENERGY PHYSICS   (China)

Author keywords

Degradation; N acetyl l cysteine; Reactive oxygen species; Silver nanoparticles; Uptake pathway; XANES

Indexed keywords

ACETYLCYSTEINE; CHEMICAL COMPOUND; OXYGEN; REACTIVE OXYGEN METABOLITE; SILVER; SILVER NANOPARTICLE; SULFUR; METAL NANOPARTICLE;

ANIMAL CELL; ARTICLE; CELL CLONE; CELL LEVEL; CELL VIABILITY; CHEMICAL BOND; CHO CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DEGRADATION; DIFFUSION; DISSOLUTION; DRUG CYTOTOXICITY; ENDOCYTOSIS; FEMALE; INTERNALIZATION; LIPID RAFT; MASS SPECTROMETRY; MOLECULAR STABILITY; NANOTOXICOLOGY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN FUNCTION; STAINING; X RAY ABSORPTION SPECTROSCOPY; ADVERSE EFFECTS; ANIMAL; CELL SURVIVAL; CHEMISTRY; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; HAMSTER; METABOLIC CLEARANCE RATE; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY;

CRICETULUS GRISEUS;

ANIMALS; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; METABOLIC CLEARANCE RATE; METAL NANOPARTICLES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SILVER;

EID: 84944180432     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2014.907457     Document Type: Article

References (34)

1. Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y. 2008. DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol 233: 404-10.
2. AshaRani P, Low Kah Mun G, Hande MP, Valiyaveettil S. 2008. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279-90.
3. Beer C, Foldbjerg R, Hayashi Y, Sutherland DS, Autrup H. 2012. Toxicity of silver nanoparticles-nanoparticle or silver ion?. Toxicol Lett 208: 286-92.
4. Chairuangkitti P, Lawanprasert S, Roytrakul S, Aueviriyavit S, Phummiratch D, Kulthong K, et al. 2012. Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways. Toxicol in Vitro 27:330-8.
5. Cheng X, Zhang W, Ji Y, Meng J, Guo H, Liu J, et al. 2013. Revealing silver cytotoxicity using Au nanorods/Ag shell nanostructures: disrupting cell membrane and causing apoptosis through oxidative damage. RSC Advances 3:2296-305.
6. Chopra I. 2007. The increasing use of silver-based products as antimicrobial agents: a useful development or a cause for concern?. J Antimicrob Chemother 59:587-90.
7. Cohen MS, Stern JM, Vanni AJ, Kelley RS, Baumgart E, Field D, et al. 2007. In vitro analysis of a nanocrystalline silver-coated surgical mesh. Surg Infect 8:397-404.
8. Flower N, Brabu B, Revathy M, Gopalakrishnan C, Raja S, Murugan S, Kumaravel T. 2012. Characterization of synthesized silver nanoparticles and assessment of its genotoxicity potentials using the alkaline comet assay. Mutat Res-Gen Tox En 742:61-5.
9. Foldbjerg R, Dang DA, Autrup H. 2011. Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch Toxicol 85:743-50.
10. Foldbjerg R, Irving ES, Hayashi Y, Sutherland DS, Thorsen K, Autrup H, Beer C. 2012. Global gene expression profiling of human lung epithelial cells after exposure to nanosilver. Toxicol Sci 130:145-57.
11. Foldbjerg R, Olesen P, Hougaard M, Dang DA, Hoffmann HJ, Autrup H. 2009. PVP-coated silver nanoparticles and silver ions induce reactive oxygen species, apoptosis and necrosis in THP-1 monocytes. Toxicol Lett 190:156-62.
12. Fu J, Ji J, Fan D, Shen J. 2006. Construction of antibacterial multilayer films containing nanosilver via layer-by-layer assembly of heparin and chitosan-silver ions complex. J Biomed Mater Res A 79:665-74.
13. Guo D, Zhu L, Huang Z, Zhou H, Ge Y, Ma W, et al. 2013. Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 34: 7884-94.
14. Hayashi Y, Engelmann P, Foldbjerg R, Szabo M, Somogyi I, Pollak E, et al. 2012. Earthworms and humans in vitro: characterizing evolutionarily conserved stress and immune responses to silver nanoparticles. Environ Sci Technol 46:4166-73.
15. Jiang X, Foldbjerg R, Miclaus T, Wang L, Singh R, Hayashi Y, et al. 2013. Multi-platform genotoxicity analysis of silver nanoparticles in the model cell line CHO-K1. Toxicol Lett 22:55-63.
16. Kim HR, Kim MJ, Lee SY, Oh SM, Chung KH. 2011. Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells. Mutat Res-Gen Tox En 726: 129-35.
17. Kim TH, Kim M, Park HS, Shin US, Gong MS, Kim HW. 2012. Size-dependent cellular toxicity of silver nanoparticles. J Biomed Mater Res A 100:1033-43.
18. Kim YJ, Yang SI, Ryu JC. 2010. Cytotoxicity and genotoxicity of nano-silver in mammalian cell lines. Mol Cell Toxicol 6:119-25.
19. Kittler S, Greulich C, Diendorf J, Koller M, Epple M. 2010. Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions. J Mater Chem 22:4548-54.
20. Levard C, Hotze EM, Colman BP, Dale AL, Truong L, Yang X, et al. 2013. Sulfidation of silver nanoparticles: natural antidote to their toxicity. Environ Sci Technol 47:13440-8.
21. Lima R, Seabra AB, Duran N. 2012. Silver nanoparticles: a brief review of cytotoxicity and genotoxicity of chemically and biogenically synthesized nanoparticles. J Appl Toxicol 32:867-79.
22. Liu J, Hurt RH. 2010. Ion release kinetics and particle persistence in aqueous nano-silver colloids. Environ Sci Technol 44:2169-75.
23. Lok C-N, Ho C-M, Chen R, He Q-Y, Yu W-Y, Sun H, et al. 2007. Silver nanoparticles: partial oxidation and antibacterial activities. J Biol Inorg Chem 12:527-34.
24. Lubick N. 2008. Nanosilver toxicity: ions, nanoparticles or both?. Environ Sci Technol 42:8617.
25. Navarro E, Piccapietra F, Wagner B, Marconi F, Kaegi R, Odzak N, et al. 2008. Toxicity of silver nanoparticles to Chlamydomonas reinhardtii. Environ Sci Technol 42:8959-64.
26. Nel AE, Madler L, Velegol D, Xia T, Hoek EM, Somasundaran P, et al. 2009. Understanding biophysicochemical interactions at the nano-bio interface. Nat Mater 8:543-57.
27. Qu Y, Li W, Zhou Y, Liu X, Zhang L, Wang L, et al. 2011. Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism. Nano Lett 11:3174-83.
28. Verma A, Stellacci F. 2010. Effect of surface properties on nanoparticle-cell interactions. Small 6:12-21.
29. Wang L, Li J, Pan J, Jiang X, Ji Y, Li Y, et al. 2013. Revealing the binding structure of the protein corona on gold nanorods using synchrotron radiation-based techniques: understanding the reduced damage in cell membranes. J Am Chem Soc 135:17359-68.
30. Wang LM, Liu Y, Li W, Jiang XM, Ji YL, Wu XC, et al. 2011. Selective targeting of gold nanorods at the mitochondria of cancer cells: implications for cancer therapy. Nano Lett 11:772-80.
31. Wang X, Ji Z, Chang CH, Zhang H, Wang M, Liao YP, et al. 2014. Use of coated silver nanoparticles to understand the relationship of particle dissolution and bioavailability to cell and lung toxicological potential. Small 10:385-98.
32. Yang X, Gondikas AP, Marinakos SM, Auffan M, Liu J, Hsu-Kim H, Meyer JN. 2011. Mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans. Environ Sci Technol 46:1119-27.
33. Yu S, Chao J-b, Sun J, Yin Y, Liu J, Jiang G-B. 2013. Quantification of the uptake of silver nanoparticles and ions to HepG2 cells. Environ Sci Technol 47:3268-74.
34. Zhao F, Zhao Y, Liu Y, Chang X, Chen C. 2011. Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small 7: 1322-37.