Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 21, 2015, Pages 4878-4880

  Cominetti, Marco M D ^a   Goffin, Sarah A ^a   Raffel, Ewan ^a   Turner, Kerrie D ^a   Ramoutar, Jordann C ^a   O'Connell, Maria A ^a   Howell, Lesley A ^a   Searcey, Mark ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Chlorofusin; Click chemistry; MDM2; p53; Proteinprotein interactions

Indexed keywords

4 METHYLPHENYL; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG; CHLOROFUSIN; CYCLOPEPTIDE; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CLICK CHEMISTRY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC50; MASS SPECTROMETRY; PROTEIN PROTEIN INTERACTION; SOLID PHASE SYNTHESIS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMINO ACID MOTIFS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR CONFORMATION; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84944148784     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.06.014     Document Type: Article

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