Nanomemulsion of megestrol acetate for improved oral bioavailability and reduced food effect

Archives of Pharmacal Research

Volumn 38, Issue 10, 2015, Pages 1850-1856

  Li, Yixian ^a   Song, Chung Kil ^a   Kim, Min Kyoung ^a   Lim, Hyosang ^a   Shen, Qingbo ^a   Lee, Don Haeng ^b   Yang, Su Geun ^a  

^a Inha University School of Medicine   (South Korea)

^b Inha University Hospital   (South Korea)

Author keywords

BCS class II drugs; Food effect; Megestrol acetate; Nanoemulsion; Oral bioavailability

Indexed keywords

MEGESTROL ACETATE; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; EMULSION; NANOPARTICLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BEAGLE; CONTROLLED STUDY; CRYSTAL; DIET RESTRICTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; FOOD INTAKE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; CROSSOVER PROCEDURE; DOG; EMULSION; FOOD DRUG INTERACTION; ORAL DRUG ADMINISTRATION; RANDOMIZATION; SOLUBILITY; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; CROSS-OVER STUDIES; DOGS; EMULSIONS; FOOD-DRUG INTERACTIONS; MALE; MEGESTROL ACETATE; NANOPARTICLES; RANDOM ALLOCATION; SOLUBILITY; TANDEM MASS SPECTROMETRY;

EID: 84944145818     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-015-0604-9     Document Type: Article

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