Interaction kinetics of serum proteins with liposomes and their effect on phospholipase-induced liposomal drug release

International Journal of Pharmaceutics

Volumn 495, Issue 2, 2015, Pages 827-839

  Shibata, Hiroko ^a   Yoshida, Hiroyuki ^a   Izutsu, Ken Ichi ^a   Haishima, Yuji ^a   Kawanishi, Toru ^a   Okuda, Haruhiro ^a   Goda, Yukihiro ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Drug release; Liposomes; Phospholipase A2; Serum protein; Surface plasmon resonance

Indexed keywords

1,2 DISTEAROYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; ALPHA 2 MACROGLOBULIN; APOLIPOPROTEIN A; APOLIPOPROTEIN E; CD5L; CHOLESTEROL; CLUSTERIN; COMPLEMENT COMPONENT C3; DOXORUBICIN; FIBRONECTIN; FICOLIN 3; GLYCEROPHOSPHOETHANOLAMINE; HAPTOGLOBIN; HUMAN ALBUMIN; LIPOSOME; MACROGOL; MACROGOL 2000; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PLASMA PROTEIN; SECRETORY PHOSPHOLIPASE A2; UNCLASSIFIED DRUG; VITRONECTIN; VON WILLEBRAND FACTOR; MACROGOL DERIVATIVE; PHOSPHOLIPASE A2; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION RATE CONSTANT; DRUG FORMULATION; DRUG RELEASE; HUMAN; KINETICS; LIPID HYDROLYSIS; LIPOSOMAL DELIVERY; LIPOSOME MEMBRANE; MOLECULAR INTERACTION; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; CHEMISTRY; METABOLISM; SECRETION (PROCESS);

BLOOD PROTEINS; DRUG LIBERATION; KINETICS; LIPOSOMES; PHOSPHOLIPASES A2; POLYETHYLENE GLYCOLS; PROTEIN BINDING; SURFACE PLASMON RESONANCE;

EID: 84944096644     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.09.053     Document Type: Article

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