메뉴 건너뛰기




Volumn 56, Issue 11, 2015, Pages 6501-6505

Ranibizumab and aflibercept: Intraocular pharmacokinetics and their effects on aqueous VEGF level in vitrectomized and nonvitrectomized macaque eyes

Author keywords

Aflibercept; Ranibizumab; VEGF

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; RANIBIZUMAB; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; HYBRID PROTEIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

EID: 84944089141     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-17279     Document Type: Article
Times cited : (128)

References (25)
  • 1
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419–1431.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 2
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A. 2002;99:11393–11398.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 3
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419–1431.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 4
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432–1444.
    • (2006) N Engl J Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 5
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • Brown DM, Michels M, Kaiser PK, Heier JS, Sy JP, Ianchulev T. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology. 2009;116:57–65.
    • (2009) Ophthalmology , vol.116 , pp. 57-65
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3    Heier, J.S.4    Sy, J.P.5    Ianchulev, T.6
  • 6
    • 84870723704 scopus 로고    scopus 로고
    • Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
    • Heier JS, Brown DM, Chong V, et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 2012;119:2537–2548.
    • (2012) Ophthalmology , vol.119 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 7
    • 45249101565 scopus 로고    scopus 로고
    • Therapeutic anti-VEGF in age-related macular degeneration: Ranibizumab and bevacizumab controversy
    • Moreno SF, Paloma JB. Therapeutic anti-VEGF in age-related macular degeneration: ranibizumab and bevacizumab controversy. Br J Ophthalmol. 2008;92:866–867.
    • (2008) Br J Ophthalmol , vol.92 , pp. 866-867
    • Moreno, S.F.1    Paloma, J.B.2
  • 8
    • 67650424032 scopus 로고    scopus 로고
    • Safety of repeat intravitreal injections of bevacizumab versus ranibizumab: Our experience after 2,000 injections
    • Ladas ID, Karagiannis DA, Rouvas AA, Kotsolis AI, Liotsou A, Vergados I. Safety of repeat intravitreal injections of bevacizumab versus ranibizumab: our experience after 2,000 injections. Retina. 2009;29:313–318.
    • (2009) Retina , vol.29 , pp. 313-318
    • Ladas, I.D.1    Karagiannis, D.A.2    Rouvas, A.A.3    Kotsolis, A.I.4    Liotsou, A.5    Vergados, I.6
  • 9
    • 33747874091 scopus 로고    scopus 로고
    • A phase I trial of an IVadministered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration
    • Nguyen QD, Shah SM, Hafiz G, et al. A phase I trial of an IVadministered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology. 2006;113: 1522.e1-e4.
    • (2006) Ophthalmology. , vol.113 , Issue.113 , pp. e1-e4
    • Nguyen, Q.D.1    Shah, S.M.2    Hafiz, G.3
  • 10
    • 70350757650 scopus 로고    scopus 로고
    • A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration
    • Nguyen QD, Shah SM, Browning DJ, et al. A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology. 2009;116:2141–2148.e1.
    • (2009) Ophthalmology. , vol.116 , pp. 2141-2148
    • Nguyen, Q.D.1    Shah, S.M.2    Browning, D.J.3
  • 11
    • 79957986348 scopus 로고    scopus 로고
    • Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration
    • Brown DM, Heier JS, Ciulla T, et al. Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration. Ophthalmology. 2011;118:1089–1097.
    • (2011) Ophthalmology , vol.118 , pp. 1089-1097
    • Brown, D.M.1    Heier, J.S.2    Ciulla, T.3
  • 12
    • 77949887728 scopus 로고    scopus 로고
    • Pharmacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes
    • Miyake T, Sawada O, Kakinoki M, et al. Pharmacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes. Invest Ophthalmol Vis Sci. 2010;51:1606–1608.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 1606-1608
    • Miyake, T.1    Sawada, O.2    Kakinoki, M.3
  • 13
    • 84871683928 scopus 로고    scopus 로고
    • Effect of vitrectomy on aqueous VEGF concentration and pharmacokinetics of bevacizumab in macaque monkeys
    • Kakinoki M, Sawada O, Sawada T, Saishin Y, Kawamura H, Ohji M. Effect of vitrectomy on aqueous VEGF concentration and pharmacokinetics of bevacizumab in macaque monkeys. Invest Ophthalmol Vis Sci. 2012;53:5877–5880.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 5877-5880
    • Kakinoki, M.1    Sawada, O.2    Sawada, T.3    Saishin, Y.4    Kawamura, H.5    Ohji, M.6
  • 14
    • 84877005677 scopus 로고    scopus 로고
    • Anatomic and pharmacokinetic properties of intravitreal bevacizumab and ranibizumab after vitrectomy and lensectomy
    • Christoforidis JB, Williams MM, Wang J, et al. Anatomic and pharmacokinetic properties of intravitreal bevacizumab and ranibizumab after vitrectomy and lensectomy. Retina. 2013; 33:946.
    • (2013) Retina , vol.33 , pp. 946
    • Christoforidis, J.B.1    Williams, M.M.2    Wang, J.3
  • 15
    • 84893174095 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics of ranibizumab in vitrectomized versus nonvitrectomized eyes
    • Ahn SJ, Ahn J, Park S, et al. Intraocular pharmacokinetics of ranibizumab in vitrectomized versus nonvitrectomized eyes. Invest Ophthalmol Vis Sci. 2014;55:567–573.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 567-573
    • Ahn, S.J.1    Ahn, J.2    Park, S.3
  • 16
    • 13944266313 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of ranibizumab (RhuFabV2) after a single intravitreal administration
    • Gaudreault J, Fei D, Rusit J, Suboc P, Shiu V. Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci. 2005; 46:726–733.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 726-733
    • Gaudreault, J.1    Fei, D.2    Rusit, J.3    Suboc, P.4    Shiu, V.5
  • 17
    • 84866398752 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans
    • Krohne TU, Liu Z, Holz FG, Meyer CH. Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans. Am J Ophthalmol. 2012;154:682–686. e682.
    • (2012) Am J Ophthalmol. , vol.154 , pp. 682-686
    • Krohne, T.U.1    Liu, Z.2    Holz, F.G.3    Meyer, C.H.4
  • 18
    • 84861722422 scopus 로고    scopus 로고
    • What are the half-lives of ranibizumab and aflibercept (Trap-eyeVEGF) in human eyes? Calculations with a mathematical model
    • Stewart MW. What are the half-lives of ranibizumab and aflibercept (Trap-eyeVEGF) in human eyes? Calculations with a mathematical model. Eye Reports. 2011;1:5.
    • (2011) Eye Reports , vol.1 , pp. 5
    • Stewart, M.W.1
  • 19
    • 0022370634 scopus 로고
    • Amphotericin clearance in vitrectomized versus nonvitrectomized eyes
    • Doft BH, Weiskopf J, Nilsson-Ehle I, Wingard LB. Amphotericin clearance in vitrectomized versus nonvitrectomized eyes. Ophthalmology. 1985;92:1601–1605.
    • (1985) Ophthalmology , vol.92 , pp. 1601-1605
    • Doft, B.H.1    Weiskopf, J.2    Nilsson-Ehle, I.3    Wingard, L.B.4
  • 20
    • 0022006067 scopus 로고
    • Clearance of intravitreal fluorouracil: Normal and aphakic vitrectomized eyes
    • Jarus G, Blumenkranz M, Hernandez E, Sossi N. Clearance of intravitreal fluorouracil: normal and aphakic vitrectomized eyes. Ophthalmology. 1985;92:91–96.
    • (1985) Ophthalmology , vol.92 , pp. 91-96
    • Jarus, G.1    Blumenkranz, M.2    Hernandez, E.3    Sossi, N.4
  • 21
    • 84883261965 scopus 로고    scopus 로고
    • Pharmacokinetics of intravitreally injected bevacizumab in vitrectomized eyes
    • Ahn J, Kim H, Woo SJ, et al. Pharmacokinetics of intravitreally injected bevacizumab in vitrectomized eyes. J Ocul Pharmacol Ther. 2013;29:612–618.
    • (2013) J Ocul Pharmacol Ther , vol.29 , pp. 612-618
    • Ahn, J.1    Kim, H.2    Woo, S.J.3
  • 22
    • 79956218863 scopus 로고    scopus 로고
    • Ranibizumab and bevacizumab for neovascular agerelated macular degeneration
    • Group CR. Ranibizumab and bevacizumab for neovascular agerelated macular degeneration. N Engl J Med. 2011;364:1897.
    • (2011) N Engl J Med , vol.364 , pp. 1897
  • 23
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • Papadopoulos N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15:171–185.
    • (2012) Angiogenesis , vol.15 , pp. 171-185
    • Papadopoulos, N.1    Martin, J.2    Ruan, Q.3
  • 24
    • 43649083100 scopus 로고    scopus 로고
    • Predicted biological activity of intravitreal VEGF Trap
    • Stewart MW, Rosenfeld PJ. Predicted biological activity of intravitreal VEGF Trap. Br J Ophthalmol. 2008;92:667–668.
    • (2008) Br J Ophthalmol , vol.92 , pp. 667-668
    • Stewart, M.W.1    Rosenfeld, P.J.2
  • 25
    • 84908553704 scopus 로고    scopus 로고
    • Serum and plasma vascular endothelial growth factor concentrations before and after intravitreal injection of aflibercept or ranibizumab for age-related macular degeneration
    • Wang X, Sawada T, Sawada O, Saishin Y, Liu P, Ohji M. Serum and plasma vascular endothelial growth factor concentrations before and after intravitreal injection of aflibercept or ranibizumab for age-related macular degeneration. Am J Ophthalmol. 2014;158:738–744. e731.
    • (2014) Am J Ophthalmol , vol.158 , pp. 738-744
    • Wang, X.1    Sawada, T.2    Sawada, O.3    Saishin, Y.4    Liu, P.5    Ohji, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.