PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Grellety, Thomas ^a,b   Laroche Clary, Audrey ^a,b   Chaire, Vanessa ^a   Lagarde, Pauline ^a,b   Chibon, Frédéric ^a   Neuville, Agnes ^a,b   Italiano, Antoine ^a  

^a INSTITUT BERGONIÉ   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Apoptosis; Oxidative stress; P53; PRIMA 1MET; Soft tissue sarcoma

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; PRIMA 1 MET; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 2-HYDROXYMETHYL-2-METHOXYMETHYLAZABICYCLO(2.2.2)OCTAN-3-ONE; QUINUCLIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CELL CYCLE; CELL DEATH; CELL VIABILITY; DRUG EFFICACY; ENZYME ACTIVATION; FIBROSARCOMA CELL LINE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IB117 CELL LINE; IB130 CELL LINE; IB134 CELL LINE; IB136 CELL LINE; IB138 CELL LINE; IB139 CELL LINE; IMMUNOBLOTTING; LEIOMYOSARCOMA; LIPOSARCOMA; MOLECULARLY TARGETED THERAPY; OXIDATIVE STRESS; SARCOMA CELL LINE; SOFT TISSUE SARCOMA; UTERUS SARCOMA; APOPTOSIS; CELL CYCLE CHECKPOINT; CELL SURVIVAL; DRUG EFFECTS; GENETICS; IC50; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; SARCOMA; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; INHIBITORY CONCENTRATION 50; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; QUINUCLIDINES; REACTIVE OXYGEN SPECIES; SARCOMA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84944076638     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1667-1     Document Type: Article

References (31)

1. Gatta G, van der Zwan JM, Casali PG, Siesling S, Dei Tos AP, Kunkler I, et al. Rare cancers are not so rare: the rare cancer burden in Europe. Eur J Cancer. 2011;47:2493-511.
2. Clark MA, Fisher C, Judson I, Thomas JM. Soft-tissue sarcomas in adults. N Engl J Med. 2005;353:701-11.
3. Linch M, Miah AB, Thway K, Judson IR, Benson C. Systemic treatment of soft-tissue sarcoma-gold standard and novel therapies. Nat Rev Clin Oncol. 2014;11:187-202.
4. Italiano A, Mathoulin-Pelissier S, Cesne AL, Terrier P, Bonvalot S, Collin F, et al. Trends in survival for patients with metastatic soft-tissue sarcoma. Cancer. 2011;117:1049-54.
5. Bieging KT, Mello SS, Attardi LD. Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer. 2014;14:359-70.
6. Pérot G, Chibon F, Montero A, Lagarde P, de Thé H, Terrier P, et al. Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics. Am J Pathol. 2010;177:2080-90.
7. Olivier M, Hollstein M, Hainaut P. TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb Perspect Biol. 2010;2:a001008.
8. Lehmann BD, Pietenpol JA. Targeting mutant p53 in human tumors. J Clin Oncol. 2012;30:3648-50.
9. Bykov VJ, Issaeva N, Shilov A, Hultcrantz M, Pugacheva E, Chumakov P, et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med. 2002;8:282-8.
10. Lambert JM, Gorzov P, Veprintsev DB, Söderqvist M, Segerbäck D, Bergman J, et al. PRIMA-1 reactivates mutant p53 by covalent binding to the core domain. Cancer Cell. 2009;15:376-88.
11. Aryee DN, Niedan S, Ban J, Schwentner R, Muehlbacher K, Kauer M, et al. Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma. Br J Cancer. 2013;109:2696-704.
12. Lambert JM, Moshfegh A, Hainaut P, Wiman KG, Bykov VJ. Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010;29:1329-38.
13. Zandi R, Selivanova G, Christensen CL, Gerds TA, Willumsen BM, Poulsen HS. PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53. Clin Cancer Res. 2011;17:2830-41.
14. Tansey WP. Freeze-thaw lysis for extraction of proteins from Mammalian cells. CSH Protoc. 2006;2006(7).
15. Harlow E, Lane D. Lysing tissue-culture cells for immunoprecipitation. CSH Protoc. 2006;2006(4).
16. Peng X, Zhang MQ, Conserva F, Hosny G, Selivanova G, Bykov VJ, et al. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 2013;4, e881.
17. Tessoulin B, Descamps G, Moreau P, Maïga S, Lodé L, Godon C, et al. PRIMA-1Met induces myeloma cell death independently of p53 by impairing the GSH/ROS balance. Blood. 2014;124:1626-36.
18. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med. 2010;48:749-62.
19. Bao W, Chen M, Zhao X, Kumar R, Spinnler C, Thullberg M, et al. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell Cycle. 2011;10:301-7.
20. Supiot S, Zhao H, Wiman K, Hill RP, Bristow RG. PRIMA-1(met) radiosensitizes prostate cancer cells independent of their MTp53-status. Radiother Oncol. 2008;86:407-11.
21. Sobhani M, Abdib J, Chenc C, Changa H. PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53. Cancer Biol Ther. 2015;16:799-806.
22. Chipuk JE, Maurer U, Green DR, Schuler M. Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell. 2003;4:371-81.
23. MET induces mitochondrial apoptosis through activation of caspase-2. Oncogene. 2008;27:6571-80.
24. Miwa S, Muller FL, Beckman KB. The Basics of Oxidative Biochemistry. In Oxidative Stress in Aging; 2008. p. 11-35.
25. Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev. 2010;90:1383-435.
26. Russo D, Ottaggio L, Foggetti G, Masini M, Masiello P, Fronza G, et al. PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53. Biochim Biophys Acta. 1833;2013:1904-13.
27. Loos B, Engelbrecht AM, Lockshin RA, Klionsky DJ, Zakeri Z. The variability of autophagy and cell death susceptibility: unanswered questions. Autophagy. 2013;9:1270-85.
28. Cano E, Hazzalin CA, Mahadevan LC. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol Cell Biol. 1994;14:7352-62.23.
29. Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X, et al. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal. 2007;9:49-89.
30. Li Y, Mao Y, Brandt-Rauf PW, Williams AC, Fine RL. Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway. Mol Cancer Ther. 2005;4:901-9.
31. Tsang WP, Chau SP, Kong SK, Fung KP, Kwok TT. Reactive oxygen species mediate doxorubicin induced p53-independent apoptosis. Life Sci. 2003;73:2047-58.