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Volumn 34, Issue 5, 2015, Pages 250-257

Clinical Neuropathology practice guide 5-2015: MGMT methylation pyrosequencing in glioblastoma: Unresolved issues and open questions

Author keywords

Glioblastoma; Management; MGMT promoter methylation; Prognosis; Pyrosequencing

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; DNA LIGASE; DNA METHYLTRANSFERASE; MGMT PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

EID: 84944059659     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: 10.5414/NP300904     Document Type: Article
Times cited : (40)

References (49)
  • 1
    • 34347269034 scopus 로고    scopus 로고
    • World Health Organization classification of tumours of the central nervous system
    • IARC, Lyon
    • Louis D, Ohgaki H, Wiestler O, Cavenee W. World Health Organization classification of tumours of the central nervous system. IARC, Lyon. 2007.
    • (2007)
    • Louis, D.1    Ohgaki, H.2    Wiestler, O.3    Cavenee, W.4
  • 4
    • 84865558322 scopus 로고    scopus 로고
    • Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial
    • PubMed
    • Malmström A, Grønberg BH, Marosi C, Stupp R, Frappaz D, Schultz H, Abacioglu U, Tavelin B, Lhermitte B, Hegi ME, Rosell J, Henriksson R; Nordic Clinical Brain Tumour Study Group (NCBTSG). Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol. 2012, 13: 916-926. PubMed
    • (2012) Lancet Oncol , vol.13 , pp. 916-926
    • Malmström, A.1    Grønberg, B.H.2    Marosi, C.3    Stupp, R.4    Frappaz, D.5    Schultz, H.6    Abacioglu, U.7    Tavelin, B.8    Lhermitte, B.9    Hegi, M.E.10    Rosell, J.11    Henriksson, R.12
  • 5
    • 84876353208 scopus 로고    scopus 로고
    • Clinical neuropathology practice guide 06-2012: MGMT testing in elderly glioblastoma patients - yes, but how?
    • CrossRef PubMed
    • BerghoffAS, Preusser M. Clinical neuropathology practice guide 06-2012: MGMT testing in elderly glioblastoma patients - yes, but how? Clin Neuropathol. 2012; 31: 405-408. CrossRef PubMed
    • (2012) Clin Neuropathol. , vol.31 , pp. 405-408
    • Berghoff, A.S.1    Preusser, M.2
  • 17
    • 84856098344 scopus 로고    scopus 로고
    • Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China
    • CrossRef PubMed
    • Yan W, Zhang W, You G, Bao Z, Wang Y, Liu Y, Kang C, You Y, Wang L, Jiang T. Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China. PLoS ONE. 2012; 7: e30339. CrossRef PubMed
    • (2012) PLoS ONE. , vol.7
    • Yan, W.1    Zhang, W.2    You, G.3    Bao, Z.4    Wang, Y.5    Liu, Y.6    Kang, C.7    You, Y.8    Wang, L.9    Jiang, T.10
  • 18
    • 84863413030 scopus 로고    scopus 로고
    • Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma
    • CrossRef PubMed
    • Christians A, Hartmann C, Benner A, Meyer J, von Deimling A, Weller M, Wick W, Weiler M. Prognostic value of three different methods of MGMT promoter methylation analysis in a prospective trial on newly diagnosed glioblastoma. PLoS ONE. 2012; 7: e33449. CrossRef PubMed
    • (2012) PLoS ONE. , vol.7
    • Christians, A.1    Hartmann, C.2    Benner, A.3    Meyer, J.4    von Deimling, A.5    Weller, M.6    Wick, W.7    Weiler, M.8
  • 20
    • 84864134056 scopus 로고    scopus 로고
    • Comparative assessment of 5 methods (methylation-specific polymerase chain reaction, MethyLight, pyrosequencing, methylation-sensitive high-resolution melting, and immunohistochemistry) to analyze O6-methylguanine-DNA-methyltranferase in a series of 100 glioblastoma patients
    • CrossRef PubMed
    • Quillien V, Lavenu A, Karayan-Tapon L, Carpentier C, Labussière M, Lesimple T, Chinot O, Wager M, Honnorat J, Saikali S, Fina F, Sanson M, Figarella-Branger D. Comparative assessment of 5 methods (methylation-specific polymerase chain reaction, MethyLight, pyrosequencing, methylation-sensitive high-resolution melting, and immunohistochemistry) to analyze O6-methylguanine-DNA-methyltranferase in a series of 100 glioblastoma patients. Cancer. 2012; 118: 4201-4211. CrossRef PubMed
    • (2012) Cancer. , vol.118 , pp. 4201-4211
    • Quillien, V.1    Lavenu, A.2    Karayan-Tapon, L.3    Carpentier, C.4    Labussière, M.5    Lesimple, T.6    Chinot, O.7    Wager, M.8    Honnorat, J.9    Saikali, S.10    Fina, F.11    Sanson, M.12    Figarella-Branger, D.13
  • 23
    • 84872099058 scopus 로고    scopus 로고
    • The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients
    • CrossRef PubMed
    • McDonald KL, Rapkins RW, Olivier J, Zhao L, Nozue K, Lu D, Tiwari S, Kuroiwa-Trzmielina J, Brewer J, Wheeler HR, Hitchins MP. The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients. Eur J Cancer. 2013; 49: 360-368. CrossRef PubMed
    • (2013) Eur J Cancer. , vol.49 , pp. 360-368
    • McDonald, K.L.1    Rapkins, R.W.2    Olivier, J.3    Zhao, L.4    Nozue, K.5    Lu, D.6    Tiwari, S.7    Kuroiwa-Trzmielina, J.8    Brewer, J.9    Wheeler, H.R.10    Hitchins, M.P.11
  • 28
    • 84944063563 scopus 로고    scopus 로고
    • MGMT promoter methylation correlates with an overall survival benefit in Chinese high-grade glioblastoma patients treated with radiotherapy and alkylating agent-based chemotherapy: a single-institution study
    • CrossRef PubMed
    • Shen D, Liu T, Lin Q, Lu X, Wang Q, Lin F, Mao W. MGMT promoter methylation correlates with an overall survival benefit in Chinese high-grade glioblastoma patients treated with radiotherapy and alkylating agent-based chemotherapy: a single-institution study. PLoS ONE. 2014; 9: e107558. CrossRef PubMed
    • (2014) PLoS ONE. , vol.9
    • Shen, D.1    Liu, T.2    Lin, Q.3    Lu, X.4    Wang, Q.5    Lin, F.6    Mao, W.7
  • 30
    • 84928170538 scopus 로고    scopus 로고
    • Detection of MGMT promoter methylation in glioblastoma using pyrosequencing
    • PubMed
    • Xie H, Tubbs R, Yang B. Detection of MGMT promoter methylation in glioblastoma using pyrosequencing. Int J Clin Exp Pathol. 2015; 8: 636-642. PubMed
    • (2015) Int J Clin Exp Pathol. , vol.8 , pp. 636-642
    • Xie, H.1    Tubbs, R.2    Yang, B.3
  • 32
    • 84942375312 scopus 로고    scopus 로고
    • The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide
    • epub ahead of print. CrossRef PubMed
    • Rapkins RW, Wang F, Nguyen HN, Cloughesy TF, Lai A, Ha W, Nowak AK, Hitchins MP, McDonald KL. The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide. Neuro-oncol. 2015; epub ahead of print. CrossRef PubMed
    • (2015) Neuro-oncol
    • Rapkins, R.W.1    Wang, F.2    Nguyen, H.N.3    Cloughesy, T.F.4    Lai, A.5    Ha, W.6    Nowak, A.K.7    Hitchins, M.P.8    McDonald, K.L.9
  • 33
    • 84929346753 scopus 로고    scopus 로고
    • Identification of a 6-cytokine prognostic signature in patients with primary glioblastoma harboring M2 microglia/macrophage phenotype relevance
    • PubMed
    • Cai J, Zhang W, Yang P, Wang Y, Li M, Zhang C, Wang Z, Hu H, Liu Y, Li Q, Wen J, Sun B, Wang X, Jiang T, Jiang C. Identification of a 6-cytokine prognostic signature in patients with primary glioblastoma harboring M2 microglia/macrophage phenotype relevance. 2015, 10: e0126022. PubMed
    • (2015) , vol.10
    • Cai, J.1    Zhang, W.2    Yang, P.3    Wang, Y.4    Li, M.5    Zhang, C.6    Wang, Z.7    Hu, H.8    Liu, Y.9    Li, Q.10    Wen, J.11    Sun, B.12    Wang, X.13    Jiang, T.14    Jiang, C.15
  • 34
    • 79958165458 scopus 로고    scopus 로고
    • A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts
    • CrossRef PubMed
    • Malley DS, Hamoudi RA, Kocialkowski S, Pearson DM, Collins VP, Ichimura K. A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts. Acta Neuropathol. 2011; 121: 651-661. CrossRef PubMed
    • (2011) Acta Neuropathol. , vol.121 , pp. 651-661
    • Malley, D.S.1    Hamoudi, R.A.2    Kocialkowski, S.3    Pearson, D.M.4    Collins, V.P.5    Ichimura, K.6
  • 35
    • 0028138905 scopus 로고
    • Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene
    • CrossRef PubMed
    • Harris LC, Remack JS, Brent TP. Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene. Nucleic Acids Res. 1994; 22: 4614-4619. CrossRef PubMed
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4614-4619
    • Harris, L.C.1    Remack, J.S.2    Brent, T.P.3
  • 36
    • 84866542816 scopus 로고    scopus 로고
    • MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMPstatus
    • CrossRef PubMed
    • Bady P, Sciuscio D, Diserens A-C, Bloch J, van den Bent MJ, Marosi C, Dietrich P-Y, Weller M, Mariani L, Heppner FL, Mcdonald DR, Lacombe D, Stupp R, Delorenzi M, Hegi ME. MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMPstatus. Acta Neuropathol. 2012; 124: 547-560. CrossRef PubMed
    • (2012) Acta Neuropathol. , vol.124 , pp. 547-560
    • Bady, P.1    Sciuscio, D.2    Diserens, A.-C.3    Bloch, J.4    van den Bent, M.J.5    Marosi, C.6    Dietrich, P.-Y.7    Weller, M.8    Mariani, L.9    Heppner, F.L.10    Mcdonald, D.R.11    Lacombe, D.12    Stupp, R.13    Delorenzi, M.14    Hegi, M.E.15
  • 37
    • 78649923786 scopus 로고    scopus 로고
    • Predictive biomarker validation in practice: lessons from real trials
    • CrossRef PubMed
    • Mandrekar SJ, Sargent DJ. Predictive biomarker validation in practice: lessons from real trials. Clin Trials. 2010; 7: 567-573. CrossRef PubMed
    • (2010) Clin Trials. , vol.7 , pp. 567-573
    • Mandrekar, S.J.1    Sargent, D.J.2
  • 38
    • 69849108427 scopus 로고    scopus 로고
    • Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges
    • CrossRef PubMed
    • Mandrekar SJ, Sargent DJ. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J Clin Oncol. 2009; 27: 4027-4034. CrossRef PubMed
    • (2009) J Clin Oncol. , vol.27 , pp. 4027-4034
    • Mandrekar, S.J.1    Sargent, D.J.2
  • 39
    • 67651030311 scopus 로고    scopus 로고
    • Clinical trial designs for predictive biomarker validation: one size does not fit all
    • CrossRef PubMed
    • Mandrekar SJ, Sargent DJ. Clinical trial designs for predictive biomarker validation: one size does not fit all. J Biopharm Stat. 2009; 19: 530-542. CrossRef PubMed
    • (2009) J Biopharm Stat. , vol.19 , pp. 530-542
    • Mandrekar, S.J.1    Sargent, D.J.2
  • 40
    • 15744374441 scopus 로고    scopus 로고
    • Clinical trial designs for predictive marker validation in cancer treatment trials
    • CrossRef PubMed
    • Sargent DJ, Conley BA, Allegra C, Collette L. Clinical trial designs for predictive marker validation in cancer treatment trials. J Clin Oncol. 2005; 23: 2020-2027. CrossRef PubMed
    • (2005) J Clin Oncol. , vol.23 , pp. 2020-2027
    • Sargent, D.J.1    Conley, B.A.2    Allegra, C.3    Collette, L.4
  • 41
    • 79551557586 scopus 로고    scopus 로고
    • Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments
    • CrossRef PubMed
    • Galanis E, Wu W, Sarkaria J, Chang SM, Colman H, Sargent D, Reardon DA. Incorporation of biomarker assessment in novel clinical trial designs: personalizing brain tumor treatments. Curr Oncol Rep. 2011; 13: 42-49. CrossRef PubMed
    • (2011) Curr Oncol Rep. , vol.13 , pp. 42-49
    • Galanis, E.1    Wu, W.2    Sarkaria, J.3    Chang, S.M.4    Colman, H.5    Sargent, D.6    Reardon, D.A.7
  • 42
    • 84895905845 scopus 로고    scopus 로고
    • Biomarker enrichment strategies: matching trial design to biomarker credentials
    • Cross-Ref PubMed
    • Freidlin B, Korn EL. Biomarker enrichment strategies: matching trial design to biomarker credentials. Nat Rev Clin Oncol. 2014; 11: 81-90. Cross-Ref PubMed
    • (2014) Nat Rev Clin Oncol. , vol.11 , pp. 81-90
    • Freidlin, B.1    Korn, E.L.2
  • 43
    • 84864330096 scopus 로고    scopus 로고
    • Study designs and statistical analyses for biomarker research
    • CrossRef PubMed
    • Gosho M, Nagashima K, Sato Y. Study designs and statistical analyses for biomarker research. Sensors (Basel). 2012; 12: 8966-8986. CrossRef PubMed
    • (2012) Sensors (Basel). , vol.12 , pp. 8966-8986
    • Gosho, M.1    Nagashima, K.2    Sato, Y.3
  • 44
    • 34447264769 scopus 로고    scopus 로고
    • Biomarker-adaptive threshold design: a procedure for evaluating treatment with possible biomarker-defined subset effect
    • CrossRef PubMed
    • Jiang W, Freidlin B, Simon R. Biomarker-adaptive threshold design: a procedure for evaluating treatment with possible biomarker-defined subset effect. J Natl Cancer Inst. 2007; 99: 1036-1043. CrossRef PubMed
    • (2007) J Natl Cancer Inst. , vol.99 , pp. 1036-1043
    • Jiang, W.1    Freidlin, B.2    Simon, R.3
  • 45
    • 84866791471 scopus 로고    scopus 로고
    • Biomarkers, subgroup evaluation, and clinical trial design
    • PubMed
    • Baker SG, Kramer BS, Sargent DJ, Bonetti M. Biomarkers, subgroup evaluation, and clinical trial design. Discov Med. 2012; 13: 187-192. PubMed
    • (2012) Discov Med. , vol.13 , pp. 187-192
    • Baker, S.G.1    Kramer, B.S.2    Sargent, D.J.3    Bonetti, M.4
  • 46
    • 84903445433 scopus 로고    scopus 로고
    • Identifying cut points for biomarker defined subset effects in clinical trials with survival endpoints
    • CrossRef PubMed
    • He P. Identifying cut points for biomarker defined subset effects in clinical trials with survival endpoints. Contemp Clin Trials. 2014; 38: 333-337. CrossRef PubMed
    • (2014) Contemp Clin Trials. , vol.38 , pp. 333-337
    • He, P.1
  • 47
    • 77954634393 scopus 로고    scopus 로고
    • What constitutes reasonable evidence of efficacy and effectiveness to guide oncology treatment decisions?
    • CrossRef PubMed
    • Sargent D. What constitutes reasonable evidence of efficacy and effectiveness to guide oncology treatment decisions? Oncologist. 2010; 15 (Suppl 1): 19-23. CrossRef PubMed
    • (2010) Oncologist. , vol.15 , pp. 19-23
    • Sargent, D.1
  • 48
    • 0025940865 scopus 로고
    • Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene
    • CrossRef PubMed
    • Harris LC, Potter PM, Tano K, Shiota S, Mitra S, Brent TP. Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene. Nucleic Acids Res. 1991; 19: 6163-6167. CrossRef PubMed
    • (1991) Nucleic Acids Res. , vol.19 , pp. 6163-6167
    • Harris, L.C.1    Potter, P.M.2    Tano, K.3    Shiota, S.4    Mitra, S.5    Brent, T.P.6
  • 49
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • PubMed
    • Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 1999; 59: 793-797. PubMed
    • (1999) Cancer Res. , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.