메뉴 건너뛰기




Volumn 16, Issue 11, 2015, Pages

An Update on the Role of Immunotherapy and Vaccine Strategies for Primary Brain Tumors

Author keywords

Autologous T cells; CAR T cells; Checkpoint blockade; EGFRvIII; GBM; Immunotherapy; Rindopepimut; Vaccines

Indexed keywords

BEVACIZUMAB; BMS 936559; CANCER VACCINE; CYCLOPHOSPHAMIDE; DACLIZUMAB; DENDRITIC CELL VACCINE; DURVALUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; GLIOVAC; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PEPTIDE COMPLEX VACCINE; INTERLEUKIN 12; IPILIMUMAB; MPDL 3280A; NIVOLUMAB; PEMBROLIZUMAB; PEPTIDE VACCINE; PIDILIZUMAB; PLACEBO; PROGRAMMED DEATH 1 LIGAND 1; RINDOPEPIMUT; SIPULEUCEL T; TEMOZOLOMIDE; TICILIMUMAB; TRASTUZUMAB; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DACARBAZINE; TISSUE EXTRACT;

EID: 84944058669     PISSN: 15272729     EISSN: 15346277     Source Type: Journal    
DOI: 10.1007/s11864-015-0371-3     Document Type: Review
Times cited : (41)

References (104)
  • 1
    • 84929620816 scopus 로고    scopus 로고
    • CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011
    • PID: 25304271
    • Ostrom QT, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro-Oncology. 2014;16 Suppl 4:iv1–63. doi:10.1093/neuonc/nou223.
    • (2014) Neuro-Oncology , vol.16 , pp. iv1-iv63
    • Ostrom, Q.T.1    Gittleman, H.2    Liao, P.3    Rouse, C.4    Chen, Y.5    Dowling, J.6
  • 3
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • COI: 1:CAS:528:DC%2BD1cXpt1Sgsrw%3D, PID: 18669428
    • Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med. 2008;359(5):492–507. doi:10.1056/NEJMra0708126.
    • (2008) N Engl J Med , vol.359 , Issue.5 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 5
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • COI: 1:CAS:528:DC%2BD2MXit1Wksbk%3D, PID: 15758009
    • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–96. doi:10.1056/NEJMoa043330.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3    Weller, M.4    Fisher, B.5    Taphoorn, M.J.6
  • 6
    • 78650271417 scopus 로고    scopus 로고
    • Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004
    • PID: 20364023
    • Bauchet L, Mathieu-Daude H, Fabbro-Peray P, Rigau V, Fabbro M, Chinot O, et al. Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004. Neuro-Oncology. 2010;12(7):725–35. doi:10.1093/neuonc/noq030.
    • (2010) Neuro-Oncology , vol.12 , Issue.7 , pp. 725-735
    • Bauchet, L.1    Mathieu-Daude, H.2    Fabbro-Peray, P.3    Rigau, V.4    Fabbro, M.5    Chinot, O.6
  • 7
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • COI: 1:CAS:528:DC%2BD1MXlsVKhs74%3D, PID: 19269895
    • Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10(5):459–66. doi:10.1016/S1470-2045(09)70025-7.
    • (2009) Lancet Oncol , vol.10 , Issue.5 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    van den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6
  • 8
    • 84900989849 scopus 로고    scopus 로고
    • Bevacizumab for newly diagnosed glioblastoma
    • PID: 24860870
    • Chinot OL, Wick W, Cloughesy T. Bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370(21):2049.
    • (2014) N Engl J Med , vol.370 , Issue.21 , pp. 2049
    • Chinot, O.L.1    Wick, W.2    Cloughesy, T.3
  • 10
    • 84894114159 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab for newly diagnosed glioblastoma
    • COI: 1:CAS:528:DC%2BC2cXjt1alu7o%3D, PID: 24552317
    • Gilbert MR, Dignam JJ, Armstrong TS, Wefel JS, Blumenthal DT, Vogelbaum MA, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):699–708. doi:10.1056/NEJMoa1308573.
    • (2014) N Engl J Med , vol.370 , Issue.8 , pp. 699-708
    • Gilbert, M.R.1    Dignam, J.J.2    Armstrong, T.S.3    Wefel, J.S.4    Blumenthal, D.T.5    Vogelbaum, M.A.6
  • 11
    • 84904913239 scopus 로고    scopus 로고
    • Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial
    • COI: 1:CAS:528:DC%2BC2cXhtFGltr%2FL, PID: 25035291
    • Taal W, Oosterkamp HM, Walenkamp AM, Dubbink HJ, Beerepoot LV, Hanse MC, et al. Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial. Lancet Oncol. 2014;15(9):943–53. doi:10.1016/S1470-2045(14)70314-6.
    • (2014) Lancet Oncol , vol.15 , Issue.9 , pp. 943-953
    • Taal, W.1    Oosterkamp, H.M.2    Walenkamp, A.M.3    Dubbink, H.J.4    Beerepoot, L.V.5    Hanse, M.C.6
  • 12
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • COI: 1:CAS:528:DC%2BC3sXmsFKgtLo%3D, PID: 23527958, This study shows the first clinical efficacy of adoptive CAR T cell transfer
    • Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368(16):1509–18. doi:10.1056/NEJMoa1215134. This study shows the first clinical efficacy of adoptive CAR T cell transfer.
    • (2013) N Engl J Med , vol.368 , Issue.16 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3    Aplenc, R.4    Porter, D.L.5    Rheingold, S.R.6
  • 13
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 20525992
    • Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711–23. doi:10.1056/NEJMoa1003466.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O’Day, S.J.2    McDermott, D.F.3    Weber, R.W.4    Sosman, J.A.5    Haanen, J.B.6
  • 14
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3cXhtVGlurrN, PID: 20818862
    • Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363(5):411–22. doi:10.1056/NEJMoa1001294.
    • (2010) N Engl J Med , vol.363 , Issue.5 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3    Berger, E.R.4    Small, E.J.5    Penson, D.F.6
  • 15
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • COI: 1:CAS:528:DC%2BC2MXisFGqsLg%3D, PID: 25399552, This study shows durable and robust anti-tumor effects of PD-1 blockade in melanoma
    • Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320–30. doi:10.1056/NEJMoa1412082. This study shows durable and robust anti-tumor effects of PD-1 blockade in melanoma.
    • (2015) N Engl J Med , vol.372 , Issue.4 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3    Dutriaux, C.4    Maio, M.5    Mortier, L.6
  • 16
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
    • COI: 1:CAS:528:DC%2BC2cXhtFGlsb%2FN, PID: 25034862
    • Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet. 2014;384(9948):1109–17. doi:10.1016/S0140-6736(14)60958-2.
    • (2014) Lancet , vol.384 , Issue.9948 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6
  • 17
    • 84916936048 scopus 로고    scopus 로고
    • Immunotherapy for primary brain tumors: no longer a matter of privilege
    • COI: 1:CAS:528:DC%2BC2cXhvFGgs7nF
    • Fecci PE, Heimberger AB, Sampson JH. Immunotherapy for primary brain tumors: no longer a matter of privilege. Clin Cancer Res: Off J Am Assoc Cancer Res. 2014;20(22):5620–9. doi:10.1158/1078-0432.CCR-14-0832.
    • (2014) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.20 , Issue.22 , pp. 5620-5629
    • Fecci, P.E.1    Heimberger, A.B.2    Sampson, J.H.3
  • 19
    • 0026541255 scopus 로고
    • Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia
    • COI: 1:CAS:528:DyaK38Xhslajsbo%3D, PID: 1538124
    • Constam DB, Philipp J, Malipiero UV, ten Dijke P, Schachner M, Fontana A. Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia. J Immunol. 1992;148(5):1404–10.
    • (1992) J Immunol , vol.148 , Issue.5 , pp. 1404-1410
    • Constam, D.B.1    Philipp, J.2    Malipiero, U.V.3    ten Dijke, P.4    Schachner, M.5    Fontana, A.6
  • 20
    • 84860358785 scopus 로고    scopus 로고
    • Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy
    • COI: 1:CAS:528:DC%2BC38Xhtl2hsLfP, PID: 22406925
    • Crane CA, Ahn BJ, Han SJ, Parsa AT. Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy. Neuro-Oncology. 2012;14(5):584–95. doi:10.1093/neuonc/nos014.
    • (2012) Neuro-Oncology , vol.14 , Issue.5 , pp. 584-595
    • Crane, C.A.1    Ahn, B.J.2    Han, S.J.3    Parsa, A.T.4
  • 21
    • 28544444135 scopus 로고    scopus 로고
    • Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors
    • COI: 1:CAS:528:DC%2BD2MXht1KjsrjL
    • Facoetti A, Nano R, Zelini P, Morbini P, Benericetti E, Ceroni M, et al. Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors. Clin Cancer Res: Off J Am Assoc Cancer Res. 2005;11(23):8304–11. doi:10.1158/1078-0432.CCR-04-2588.
    • (2005) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.11 , Issue.23 , pp. 8304-8311
    • Facoetti, A.1    Nano, R.2    Zelini, P.3    Morbini, P.4    Benericetti, E.5    Ceroni, M.6
  • 22
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • COI: 1:CAS:528:DyaK1MXntlGlu7w%3D
    • Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res: Off J Am Assoc Cancer Res. 1999;5(10):2963–70.
    • (1999) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.5 , Issue.10 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 24
    • 0028888764 scopus 로고
    • Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas
    • COI: 1:CAS:528:DyaK2MXkslahsbc%3D, PID: 7856743
    • Huettner C, Paulus W, Roggendorf W. Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas. Am J Pathol. 1995;146(2):317–22.
    • (1995) Am J Pathol , vol.146 , Issue.2 , pp. 317-322
    • Huettner, C.1    Paulus, W.2    Roggendorf, W.3
  • 25
    • 33748532939 scopus 로고    scopus 로고
    • The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
    • COI: 1:CAS:528:DC%2BD28Xot1agtLs%3D, PID: 16775224
    • Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro-Oncology. 2006;8(3):261–79. doi:10.1215/15228517-2006-008.
    • (2006) Neuro-Oncology , vol.8 , Issue.3 , pp. 261-279
    • Hussain, S.F.1    Yang, D.2    Suki, D.3    Aldape, K.4    Grimm, E.5    Heimberger, A.B.6
  • 26
    • 77955658133 scopus 로고    scopus 로고
    • Prognostic significance and mechanism of Treg infiltration in human brain tumors
    • COI: 1:CAS:528:DC%2BC3cXhtVKhu7zN, PID: 20537408
    • Jacobs JF, Idema AJ, Bol KF, Grotenhuis JA, de Vries IJ, Wesseling P, et al. Prognostic significance and mechanism of Treg infiltration in human brain tumors. J Neuroimmunol. 2010;225(1-2):195–9. doi:10.1016/j.jneuroim.2010.05.020.
    • (2010) J Neuroimmunol , vol.225 , Issue.1-2 , pp. 195-199
    • Jacobs, J.F.1    Idema, A.J.2    Bol, K.F.3    Grotenhuis, J.A.4    de Vries, I.J.5    Wesseling, P.6
  • 27
    • 77954741566 scopus 로고    scopus 로고
    • FasL gene knock-down therapy enhances the antiglioma immune response
    • COI: 1:CAS:528:DC%2BC3cXotVWmtr8%3D, PID: 20406899
    • Jansen T, Tyler B, Mankowski JL, Recinos VR, Pradilla G, Legnani F, et al. FasL gene knock-down therapy enhances the antiglioma immune response. Neuro-Oncology. 2010;12(5):482–9. doi:10.1093/neuonc/nop052.
    • (2010) Neuro-Oncology , vol.12 , Issue.5 , pp. 482-489
    • Jansen, T.1    Tyler, B.2    Mankowski, J.L.3    Recinos, V.R.4    Pradilla, G.5    Legnani, F.6
  • 28
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • COI: 1:CAS:528:DC%2BD1cXltlWktrY%3D, PID: 18173375
    • Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 2008;26:677–704. doi:10.1146/annurev.immunol.26.021607.090331.
    • (2008) Annu Rev Immunol , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3    Sharpe, A.H.4
  • 29
    • 25444471021 scopus 로고    scopus 로고
    • Impaired capacity for upregulation of MHC class II in tumor-associated microglia
    • PID: 15818597
    • Schartner JM, Hagar AR, Van Handel M, Zhang L, Nadkarni N, Badie B. Impaired capacity for upregulation of MHC class II in tumor-associated microglia. Glia. 2005;51(4):279–85. doi:10.1002/glia.20201.
    • (2005) Glia , vol.51 , Issue.4 , pp. 279-285
    • Schartner, J.M.1    Hagar, A.R.2    Van Handel, M.3    Zhang, L.4    Nadkarni, N.5    Badie, B.6
  • 30
    • 33646879823 scopus 로고    scopus 로고
    • T-cell apoptosis in human glioblastoma multiforme: implications for immunotherapy
    • COI: 1:CAS:528:DC%2BD28XkvVOmu7Y%3D, PID: 16631933
    • Walker DG, Chuah T, Rist MJ, Pender MP. T-cell apoptosis in human glioblastoma multiforme: implications for immunotherapy. J Neuroimmunol. 2006;175(1–2):59–68. doi:10.1016/j.jneuroim.2006.03.006.
    • (2006) J Neuroimmunol , vol.175 , Issue.1-2 , pp. 59-68
    • Walker, D.G.1    Chuah, T.2    Rist, M.J.3    Pender, M.P.4
  • 31
    • 84929044807 scopus 로고    scopus 로고
    • First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity
    • COI: 1:CAS:528:DC%2BC2MXmsFSjtbY%3D, PID: 25865468
    • Schijns VE, Pretto C, Devillers L, Pierre D, Hofman FM, Chen TC, et al. First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity. Vaccine. 2015;33(23):2690–6. doi:10.1016/j.vaccine.2015.03.095.
    • (2015) Vaccine , vol.33 , Issue.23 , pp. 2690-2696
    • Schijns, V.E.1    Pretto, C.2    Devillers, L.3    Pierre, D.4    Hofman, F.M.5    Chen, T.C.6
  • 32
    • 84879066269 scopus 로고    scopus 로고
    • An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma
    • COI: 1:CAS:528:DC%2BC3sXptFCgt7c%3D, PID: 23750791
    • Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, et al. An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013;12(6):597–615. doi:10.1586/erv.13.41.
    • (2013) Expert Rev Vaccines , vol.12 , Issue.6 , pp. 597-615
    • Reardon, D.A.1    Wucherpfennig, K.W.2    Freeman, G.3    Wu, C.J.4    Chiocca, E.A.5    Wen, P.Y.6
  • 33
    • 84919400100 scopus 로고    scopus 로고
    • Vaccine therapies for patients with glioblastoma
    • COI: 1:CAS:528:DC%2BC2cXhsVGjs7fM
    • Sayegh ET, Oh T, Fakurnejad S, Bloch O, Parsa AT. Vaccine therapies for patients with glioblastoma. J Neuro-Oncol. 2014;119(3):531–46. doi:10.1007/s11060-014-1502-6.
    • (2014) J Neuro-Oncol , vol.119 , Issue.3 , pp. 531-546
    • Sayegh, E.T.1    Oh, T.2    Fakurnejad, S.3    Bloch, O.4    Parsa, A.T.5
  • 34
    • 84925045090 scopus 로고    scopus 로고
    • Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients
    • COI: 1:CAS:528:DC%2BC2MXks1yqsLc%3D, PID: 25762141, This is elegant study demonstrates that tetanus toxoid can significantly augment anti-glioma immune responses from vaccination
    • Mitchell DA, Batich KA, Gunn MD, Huang MN, Sanchez-Perez L, Nair SK, et al. Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients. Nature. 2015;519(7543):366–9. doi:10.1038/nature14320. This is elegant study demonstrates that tetanus toxoid can significantly augment anti-glioma immune responses from vaccination.
    • (2015) Nature , vol.519 , Issue.7543 , pp. 366-369
    • Mitchell, D.A.1    Batich, K.A.2    Gunn, M.D.3    Huang, M.N.4    Sanchez-Perez, L.5    Nair, S.K.6
  • 35
    • 84927565296 scopus 로고    scopus 로고
    • Immunotherapy for secondary glioblastoma multiforme: toward an isocitrate dehydrogenase vaccine
    • PID: 25311977
    • Abecassis IJ, Morton RP, Nerva JD, Kim LJ. Immunotherapy for secondary glioblastoma multiforme: toward an isocitrate dehydrogenase vaccine. World Neurosurg. 2014;82(6):933–5. doi:10.1016/j.wneu.2014.10.006.
    • (2014) World Neurosurg , vol.82 , Issue.6 , pp. 933-935
    • Abecassis, I.J.1    Morton, R.P.2    Nerva, J.D.3    Kim, L.J.4
  • 36
    • 84906557615 scopus 로고    scopus 로고
    • A vaccine targeting mutant IDH1 induces antitumour immunity
    • COI: 1:CAS:528:DC%2BC2cXhsVSitrjM, PID: 25043048, A systematic approach to creating an anti-IDH-1 R132H petide vaccine, which may in time allow for targeting lower grade gliomas. This paper also shows that IDH-1R132H may be an inherently immunogenic target in patients
    • Schumacher T, Bunse L, Pusch S, Sahm F, Wiestler B, Quandt J, et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature. 2014;512(7514):324–7. doi:10.1038/nature13387. A systematic approach to creating an anti-IDH-1 R132H petide vaccine, which may in time allow for targeting lower grade gliomas. This paper also shows that IDH-1R132H may be an inherently immunogenic target in patients.
    • (2014) Nature , vol.512 , Issue.7514 , pp. 324-327
    • Schumacher, T.1    Bunse, L.2    Pusch, S.3    Sahm, F.4    Wiestler, B.5    Quandt, J.6
  • 37
    • 84871546020 scopus 로고    scopus 로고
    • alpha-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial
    • COI: 1:CAS:528:DC%2BC3sXjtVKitLg%3D, PID: 23270484
    • Akiyama Y, Oshita C, Kume A, Iizuka A, Miyata H, Komiyama M, et al. alpha-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial. BMC Cancer. 2012;12:623. doi:10.1186/1471-2407-12-623.
    • (2012) BMC Cancer , vol.12 , pp. 623
    • Akiyama, Y.1    Oshita, C.2    Kume, A.3    Iizuka, A.4    Miyata, H.5    Komiyama, M.6
  • 38
    • 84873989551 scopus 로고    scopus 로고
    • Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients
    • COI: 1:CAS:528:DC%2BC3sXitlCis7c%3D, PID: 23377664
    • Prins RM, Wang X, Soto H, Young E, Lisiero DN, Fong B, et al. Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients. J Immunother. 2013;36(2):152–7. doi:10.1097/CJI.0b013e3182811ae4.
    • (2013) J Immunother , vol.36 , Issue.2 , pp. 152-157
    • Prins, R.M.1    Wang, X.2    Soto, H.3    Young, E.4    Lisiero, D.N.5    Fong, B.6
  • 39
    • 70350236627 scopus 로고    scopus 로고
    • An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme
    • COI: 1:CAS:528:DC%2BD1MXht1CqtbfK, PID: 19825799
    • Sampson JH, Archer GE, Mitchell DA, Heimberger AB, Herndon 2nd JE, Lally-Goss D, et al. An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Mol Cancer Ther. 2009;8(10):2773–9. doi:10.1158/1535-7163.MCT-09-0124.
    • (2009) Mol Cancer Ther , vol.8 , Issue.10 , pp. 2773-2779
    • Sampson, J.H.1    Archer, G.E.2    Mitchell, D.A.3    Heimberger, A.B.4    Herndon, J.E.5    Lally-Goss, D.6
  • 40
    • 84872498982 scopus 로고    scopus 로고
    • Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
    • COI: 1:CAS:528:DC%2BC3sXosl2ksw%3D%3D, PID: 22847020, This multi-epitope vaccine has now shown promising results in Phase 2 trials
    • Phuphanich S, Wheeler CJ, Rudnick JD, Mazer M, Wang H, Nuno MA, et al. Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma. Cancer Immunol, Immunother: CII. 2013;62(1):125–35. doi:10.1007/s00262-012-1319-0. This multi-epitope vaccine has now shown promising results in Phase 2 trials.
    • (2013) Cancer Immunol, Immunother : CII , vol.62 , Issue.1 , pp. 125-135
    • Phuphanich, S.1    Wheeler, C.J.2    Rudnick, J.D.3    Mazer, M.4    Wang, H.5    Nuno, M.A.6
  • 41
    • 84863154888 scopus 로고    scopus 로고
    • Targeting EGF receptor variant III: tumor-specific peptide vaccination for malignant gliomas
    • PID: 22309662
    • Del Vecchio CA, Li G, Wong AJ. Targeting EGF receptor variant III: tumor-specific peptide vaccination for malignant gliomas. Expert Rev Vaccines. 2012;11(2):133–44. doi:10.1586/erv.11.177.
    • (2012) Expert Rev Vaccines , vol.11 , Issue.2 , pp. 133-144
    • Del Vecchio, C.A.1    Li, G.2    Wong, A.J.3
  • 42
    • 84937687818 scopus 로고    scopus 로고
    • Rindopepimut vaccine and bevacizumab combination therapy: improving survival rates in relapsed glioblastoma patients?
    • PID: 26100271
    • Neagu MR, Reardon DA. Rindopepimut vaccine and bevacizumab combination therapy: improving survival rates in relapsed glioblastoma patients? Immunotherapy. 2015. doi:10.2217/imt.15.39.
    • (2015) Immunotherapy
    • Neagu, M.R.1    Reardon, D.A.2
  • 43
    • 84907664033 scopus 로고    scopus 로고
    • The future of glioblastoma therapy: synergism of standard of care and immunotherapy
    • COI: 1:CAS:528:DC%2BC2MXisV2qurg%3D, PID: 25268164
    • Patel MA, Kim JE, Ruzevick J, Li G, Lim M. The future of glioblastoma therapy: synergism of standard of care and immunotherapy. Cancers. 2014;6(4):1953–85. doi:10.3390/cancers6041953.
    • (2014) Cancers , vol.6 , Issue.4 , pp. 1953-1985
    • Patel, M.A.1    Kim, J.E.2    Ruzevick, J.3    Li, G.4    Lim, M.5
  • 46
    • 78149254368 scopus 로고    scopus 로고
    • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    • Sampson JH, Heimberger AB, Archer GE, Aldape KD, Friedman AH, Friedman HS, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol: Off J Am Soc Clin Oncol. 2010;28(31):4722–9. doi:10.1200/JCO.2010.28.6963.
    • (2010) J Clin Oncol : Off J Am Soc Clin Oncol , vol.28 , Issue.31 , pp. 4722-4729
    • Sampson, J.H.1    Heimberger, A.B.2    Archer, G.E.3    Aldape, K.D.4    Friedman, A.H.5    Friedman, H.S.6
  • 48
    • 79955784386 scopus 로고    scopus 로고
    • Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma
    • COI: 1:CAS:528:DC%2BC3MXktl2ls7c%3D, PID: 21149254
    • Sampson JH, Aldape KD, Archer GE, Coan A, Desjardins A, Friedman AH, et al. Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma. Neuro-Oncology. 2011;13(3):324–33. doi:10.1093/neuonc/noq157.
    • (2011) Neuro-Oncology , vol.13 , Issue.3 , pp. 324-333
    • Sampson, J.H.1    Aldape, K.D.2    Archer, G.E.3    Coan, A.4    Desjardins, A.5    Friedman, A.H.6
  • 49
    • 84873204700 scopus 로고    scopus 로고
    • Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma
    • COI: 1:CAS:528:DC%2BC38XhsFKjtLbN, PID: 23055947
    • Babu R, Adamson DC. Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma. Core Evid. 2012;7:93–103. doi:10.2147/CE.S29001.
    • (2012) Core Evid , vol.7 , pp. 93-103
    • Babu, R.1    Adamson, D.C.2
  • 50
    • 84937515633 scopus 로고    scopus 로고
    • Heat shock protein vaccines against glioblastoma: from bench to bedside
    • COI: 1:CAS:528:DC%2BC2MXhtVKhs7zF
    • Ampie L, Choy W, Lamano JB, Fakurnejad S, Bloch O, Parsa AT. Heat shock protein vaccines against glioblastoma: from bench to bedside. J Neuro-Oncol. 2015;123(3):441–8. doi:10.1007/s11060-015-1837-7.
    • (2015) J Neuro-Oncol , vol.123 , Issue.3 , pp. 441-448
    • Ampie, L.1    Choy, W.2    Lamano, J.B.3    Fakurnejad, S.4    Bloch, O.5    Parsa, A.T.6
  • 51
    • 84871951211 scopus 로고    scopus 로고
    • Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein
    • COI: 1:CAS:528:DC%2BC3sXktFGgtw%3D%3D
    • Crane CA, Han SJ, Ahn B, Oehlke J, Kivett V, Fedoroff A, et al. Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein. Clin Cancer Res: Off J Am Assoc Cancer Res. 2013;19(1):205–14. doi:10.1158/1078-0432.CCR-11-3358.
    • (2013) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.19 , Issue.1 , pp. 205-214
    • Crane, C.A.1    Han, S.J.2    Ahn, B.3    Oehlke, J.4    Kivett, V.5    Fedoroff, A.6
  • 52
    • 84893073441 scopus 로고    scopus 로고
    • Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial
    • COI: 1:CAS:528:DC%2BC2cXpslOisw%3D%3D, PID: 24335700, This autologous heat-shock protein vaccine shows intriguing results
    • Bloch O, Crane CA, Fuks Y, Kaur R, Aghi MK, Berger MS, et al. Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial. Neuro-Oncology. 2014;16(2):274–9. doi:10.1093/neuonc/not203. This autologous heat-shock protein vaccine shows intriguing results.
    • (2014) Neuro-Oncology , vol.16 , Issue.2 , pp. 274-279
    • Bloch, O.1    Crane, C.A.2    Fuks, Y.3    Kaur, R.4    Aghi, M.K.5    Berger, M.S.6
  • 53
    • 84944127820 scopus 로고    scopus 로고
    • Newly diagnosed glioblastoma patients treated with an autologous heat shock protein peptide vaccine: PD-L1 expression and response to therapy. Journal of clinical oncology: official journal of the American Society of Clinical Oncology
    • Bloch O, Raizer JJ, Lim M, Sughrue M, Komotar R, Abrahams J, O’Rourke D, D’Ambrosio A, Bruce JN, Parsa A. Newly diagnosed glioblastoma patients treated with an autologous heat shock protein peptide vaccine: PD-L1 expression and response to therapy. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2015;33(suppl; abstr 2011).
    • (2011) 2015;33(suppl; abstr
    • Bloch, O.1    Raizer, J.J.2    Lim, M.3    Sughrue, M.4    Komotar, R.5    Abrahams, J.6    O’Rourke, D.7    D’Ambrosio, A.8    Bruce, J.N.9    Parsa, A.10
  • 54
    • 84937518799 scopus 로고    scopus 로고
    • Cytomegalovirus and glioblastoma: controversies and opportunities
    • COI: 1:CAS:528:DC%2BC2MXivVSnsbY%3D
    • Lawler SE. Cytomegalovirus and glioblastoma: controversies and opportunities. J Neuro-Oncol. 2015;123(3):465–71. doi:10.1007/s11060-015-1734-0.
    • (2015) J Neuro-Oncol , vol.123 , Issue.3 , pp. 465-471
    • Lawler, S.E.1
  • 55
    • 39149136486 scopus 로고    scopus 로고
    • Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma
    • PID: 17951512
    • Mitchell DA, Xie W, Schmittling R, Learn C, Friedman A, McLendon RE, et al. Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. Neuro-Oncology. 2008;10(1):10–8. doi:10.1215/15228517-2007-035.
    • (2008) Neuro-Oncology , vol.10 , Issue.1 , pp. 10-18
    • Mitchell, D.A.1    Xie, W.2    Schmittling, R.3    Learn, C.4    Friedman, A.5    McLendon, R.E.6
  • 56
    • 84920696061 scopus 로고    scopus 로고
    • Human cytomegalovirus viral load in tumor and peripheral blood samples of patients with malignant gliomas
    • Priel E, Wohl A, Teperberg M, Nass D, Cohen ZR. Human cytomegalovirus viral load in tumor and peripheral blood samples of patients with malignant gliomas. J Clin Neurosci: Off J Neurosurg Soc Australasia. 2015;22(2):326–30. doi:10.1016/j.jocn.2014.06.099.
    • (2015) J Clin Neurosci : Off J Neurosurg Soc Australasia , vol.22 , Issue.2 , pp. 326-330
    • Priel, E.1    Wohl, A.2    Teperberg, M.3    Nass, D.4    Cohen, Z.R.5
  • 57
    • 43249090418 scopus 로고    scopus 로고
    • Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme
    • COI: 1:CAS:528:DC%2BD1cXmtFSrsrw%3D, PID: 18447714
    • Izumoto S, Tsuboi A, Oka Y, Suzuki T, Hashiba T, Kagawa N, et al. Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme. J Neurosurg. 2008;108(5):963–71. doi:10.3171/JNS/2008/108/5/0963.
    • (2008) J Neurosurg , vol.108 , Issue.5 , pp. 963-971
    • Izumoto, S.1    Tsuboi, A.2    Oka, Y.3    Suzuki, T.4    Hashiba, T.5    Kagawa, N.6
  • 58
    • 23844524128 scopus 로고    scopus 로고
    • Immunologic evaluation of personalized peptide vaccination for patients with advanced malignant glioma
    • COI: 1:CAS:528:DC%2BD2MXos1Cju78%3D
    • Yajima N, Yamanaka R, Mine T, Tsuchiya N, Homma J, Sano M, et al. Immunologic evaluation of personalized peptide vaccination for patients with advanced malignant glioma. Clin Cancer Res: Off J Am Assoc Cancer Res. 2005;11(16):5900–11. doi:10.1158/1078-0432.CCR-05-0559.
    • (2005) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.11 , Issue.16 , pp. 5900-5911
    • Yajima, N.1    Yamanaka, R.2    Mine, T.3    Tsuchiya, N.4    Homma, J.5    Sano, M.6
  • 59
    • 27644534576 scopus 로고    scopus 로고
    • The response of autologous T cells to a human melanoma is dominated by mutated neoantigens
    • COI: 1:CAS:528:DC%2BD2MXht1Wqsr7F, PID: 16247014
    • Lennerz V, Fatho M, Gentilini C, Frye RA, Lifke A, Ferel D, et al. The response of autologous T cells to a human melanoma is dominated by mutated neoantigens. Proc Natl Acad Sci U S A. 2005;102(44):16013–8. doi:10.1073/pnas.0500090102.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.44 , pp. 16013-16018
    • Lennerz, V.1    Fatho, M.2    Gentilini, C.3    Frye, R.A.4    Lifke, A.5    Ferel, D.6
  • 60
    • 84904472602 scopus 로고    scopus 로고
    • Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia
    • COI: 1:CAS:528:DC%2BC2cXht1Cqu7zJ, PID: 24891321
    • Rajasagi M, Shukla SA, Fritsch EF, Keskin DB, DeLuca D, Carmona E, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 2014;124(3):453–62. doi:10.1182/blood-2014-04-567933.
    • (2014) Blood , vol.124 , Issue.3 , pp. 453-462
    • Rajasagi, M.1    Shukla, S.A.2    Fritsch, E.F.3    Keskin, D.B.4    DeLuca, D.5    Carmona, E.6
  • 61
    • 81255157774 scopus 로고    scopus 로고
    • Machine learning competition in immunology—prediction of HLA class I binding peptides
    • COI: 1:CAS:528:DC%2BC3MXhsV2msLnP, PID: 21986107
    • Zhang GL, Ansari HR, Bradley P, Cawley GC, Hertz T, Hu X, et al. Machine learning competition in immunology—prediction of HLA class I binding peptides. J Immunol Methods. 2011;374(1–2):1–4. doi:10.1016/j.jim.2011.09.010.
    • (2011) J Immunol Methods , vol.374 , Issue.1-2 , pp. 1-4
    • Zhang, G.L.1    Ansari, H.R.2    Bradley, P.3    Cawley, G.C.4    Hertz, T.5    Hu, X.6
  • 62
    • 84857725402 scopus 로고    scopus 로고
    • Exploiting the mutanome for tumor vaccination
    • COI: 1:CAS:528:DC%2BC38Xjt1Wju7c%3D, PID: 22237626
    • Castle JC, Kreiter S, Diekmann J, Lower M, van de Roemer N, de Graaf J, et al. Exploiting the mutanome for tumor vaccination. Cancer Res. 2012;72(5):1081–91. doi:10.1158/0008-5472.CAN-11-3722.
    • (2012) Cancer Res , vol.72 , Issue.5 , pp. 1081-1091
    • Castle, J.C.1    Kreiter, S.2    Diekmann, J.3    Lower, M.4    van de Roemer, N.5    de Graaf, J.6
  • 63
    • 84859393995 scopus 로고    scopus 로고
    • CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC38XkvFOlsrk%3D
    • Prieto PA, Yang JC, Sherry RM, Hughes MS, Kammula US, White DE, et al. CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res: Off J Am Assoc Cancer Res. 2012;18(7):2039–47. doi:10.1158/1078-0432.CCR-11-1823.
    • (2012) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.18 , Issue.7 , pp. 2039-2047
    • Prieto, P.A.1    Yang, J.C.2    Sherry, R.M.3    Hughes, M.S.4    Kammula, U.S.5    White, D.E.6
  • 64
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rsbnJ, PID: 22658128
    • Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455–65. doi:10.1056/NEJMoa1200694.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 65
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • COI: 1:CAS:528:DC%2BC38XhtV2rs7fN, PID: 22658127
    • Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–54. doi:10.1056/NEJMoa1200690.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3    Gettinger, S.N.4    Smith, D.C.5    McDermott, D.F.6
  • 66
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3MXosVegtro%3D, PID: 21639810
    • Robert C, Thomas L, Bondarenko I, O’Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517–26. doi:10.1056/NEJMoa1104621.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O’Day, S.4    Weber, J.5    Garbe, C.6
  • 67
    • 84864052441 scopus 로고    scopus 로고
    • Management of immune-related adverse events and kinetics of response with ipilimumab
    • COI: 1:CAS:528:DC%2BC38Xht1ygsr%2FK
    • Weber JS, Kahler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol: Off J Am Soc Clin Oncol. 2012;30(21):2691–7. doi:10.1200/JCO.2012.41.6750.
    • (2012) J Clin Oncol : Off J Am Soc Clin Oncol , vol.30 , Issue.21 , pp. 2691-2697
    • Weber, J.S.1    Kahler, K.C.2    Hauschild, A.3
  • 68
    • 84860446616 scopus 로고    scopus 로고
    • Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial
    • COI: 1:CAS:528:DC%2BC38Xmslyhsb4%3D, PID: 22456429
    • Margolin K, Ernstoff MS, Hamid O, Lawrence D, McDermott D, Puzanov I, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 2012;13(5):459–65. doi:10.1016/S1470-2045(12)70090-6.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 459-465
    • Margolin, K.1    Ernstoff, M.S.2    Hamid, O.3    Lawrence, D.4    McDermott, D.5    Puzanov, I.6
  • 69
    • 34247502076 scopus 로고    scopus 로고
    • Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function
    • COI: 1:CAS:528:DC%2BD2sXjs12rtL8%3D
    • Fecci PE, Ochiai H, Mitchell DA, Grossi PM, Sweeney AE, Archer GE, et al. Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function. Clin Cancer Res: Off J Am Assoc Cancer Res. 2007;13(7):2158–67. doi:10.1158/1078-0432.CCR-06-2070.
    • (2007) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.13 , Issue.7 , pp. 2158-2167
    • Fecci, P.E.1    Ochiai, H.2    Mitchell, D.A.3    Grossi, P.M.4    Sweeney, A.E.5    Archer, G.E.6
  • 70
    • 84890846323 scopus 로고    scopus 로고
    • Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection
    • COI: 1:CAS:528:DC%2BC3sXhvFynurzE, PID: 24277150
    • Vom Berg J, Vrohlings M, Haller S, Haimovici A, Kulig P, Sledzinska A, et al. Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection. J Exp Med. 2013;210(13):2803–11. doi:10.1084/jem.20130678.
    • (2013) J Exp Med , vol.210 , Issue.13 , pp. 2803-2811
    • Vom Berg, J.1    Vrohlings, M.2    Haller, S.3    Haimovici, A.4    Kulig, P.5    Sledzinska, A.6
  • 71
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
    • COI: 1:CAS:528:DC%2BC3sXivFyku7k%3D, PID: 23462419
    • Zeng J, See AP, Phallen J, Jackson CM, Belcaid Z, Ruzevick J, et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys. 2013;86(2):343–9. doi:10.1016/j.ijrobp.2012.12.025.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , Issue.2 , pp. 343-349
    • Zeng, J.1    See, A.P.2    Phallen, J.3    Jackson, C.M.4    Belcaid, Z.5    Ruzevick, J.6
  • 72
    • 85028580374 scopus 로고    scopus 로고
    • Immune checkpoint blockade for glioblastoma: preclinical activity of single agent and combinagtorial therapy
    • Reardon D, Gokhale P, Ligon K, Liao X, Rodig S, Zhou J, et al. Immune checkpoint blockade for glioblastoma: preclinical activity of single agent and combinagtorial therapy. Neuro-Oncology. 2014;16:v110–8. doi:10.1093/neuonc/nou258.
    • (2014) Neuro-Oncology , vol.16 , pp. v110-v118
    • Reardon, D.1    Gokhale, P.2    Ligon, K.3    Liao, X.4    Rodig, S.5    Zhou, J.6
  • 74
    • 0023115642 scopus 로고
    • A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone
    • COI: 1:STN:280:DyaL2s7ksVGitA%3D%3D, PID: 3493432
    • Rosenberg SA, Lotze MT, Muul LM, Chang AE, Avis FP, Leitman S, et al. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med. 1987;316(15):889–97. doi:10.1056/NEJM198704093161501.
    • (1987) N Engl J Med , vol.316 , Issue.15 , pp. 889-897
    • Rosenberg, S.A.1    Lotze, M.T.2    Muul, L.M.3    Chang, A.E.4    Avis, F.P.5    Leitman, S.6
  • 75
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • COI: 1:CAS:528:DC%2BC3MXos1Smtbg%3D
    • Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res: Off J Am Assoc Cancer Res. 2011;17(13):4550–7. doi:10.1158/1078-0432.CCR-11-0116.
    • (2011) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.17 , Issue.13 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3    Kammula, U.S.4    Hughes, M.S.5    Phan, G.Q.6
  • 76
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • COI: 1:CAS:528:DC%2BD2MXjsVyhsrs%3D
    • Dudley ME, Wunderlich JR, Yang JC, Sherry RM, Topalian SL, Restifo NP, et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol: Off J Am Soc Clin Oncol. 2005;23(10):2346–57. doi:10.1200/JCO.2005.00.240.
    • (2005) J Clin Oncol : Off J Am Soc Clin Oncol , vol.23 , Issue.10 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3    Sherry, R.M.4    Topalian, S.L.5    Restifo, N.P.6
  • 77
    • 77649221824 scopus 로고    scopus 로고
    • Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
    • COI: 1:CAS:528:DC%2BC3cXhvFOitr0%3D, PID: 19880495
    • Heslop HE, Slobod KS, Pule MA, Hale GA, Rousseau A, Smith CA, et al. Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood. 2010;115(5):925–35. doi:10.1182/blood-2009-08-239186.
    • (2010) Blood , vol.115 , Issue.5 , pp. 925-935
    • Heslop, H.E.1    Slobod, K.S.2    Pule, M.A.3    Hale, G.A.4    Rousseau, A.5    Smith, C.A.6
  • 78
    • 84903621256 scopus 로고    scopus 로고
    • Autologous T-cell therapy for cytomegalovirus as a consolidative treatment for recurrent glioblastoma
    • COI: 1:CAS:528:DC%2BC2cXhtVKlurjE, PID: 24795429, This approach uses autologous T cell transfer to target CMV epitopes expressed by glioma cells
    • Schuessler A, Smith C, Beagley L, Boyle GM, Rehan S, Matthews K, et al. Autologous T-cell therapy for cytomegalovirus as a consolidative treatment for recurrent glioblastoma. Cancer Res. 2014;74(13):3466–76. doi:10.1158/0008-5472.CAN-14-0296. This approach uses autologous T cell transfer to target CMV epitopes expressed by glioma cells.
    • (2014) Cancer Res , vol.74 , Issue.13 , pp. 3466-3476
    • Schuessler, A.1    Smith, C.2    Beagley, L.3    Boyle, G.M.4    Rehan, S.5    Matthews, K.6
  • 79
    • 84875068031 scopus 로고    scopus 로고
    • Myeloablative temozolomide enhances CD8(+) T-cell responses to vaccine and is required for efficacy against brain tumors in mice
    • COI: 1:CAS:528:DC%2BC3sXltVKnsbk%3D, PID: 23527092
    • Sanchez-Perez LA, Choi BD, Archer GE, Cui X, Flores C, Johnson LA, et al. Myeloablative temozolomide enhances CD8(+) T-cell responses to vaccine and is required for efficacy against brain tumors in mice. PLoS One. 2013;8(3), e59082. doi:10.1371/journal.pone.0059082.
    • (2013) PLoS One , vol.8 , Issue.3
    • Sanchez-Perez, L.A.1    Choi, B.D.2    Archer, G.E.3    Cui, X.4    Flores, C.5    Johnson, L.A.6
  • 80
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • COI: 1:CAS:528:DC%2BC38XkvFalt7o%3D, PID: 22160384
    • Kochenderfer JN, Dudley ME, Feldman SA, Wilson WH, Spaner DE, Maric I, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood. 2012;119(12):2709–20. doi:10.1182/blood-2011-10-384388.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3    Wilson, W.H.4    Spaner, D.E.5    Maric, I.6
  • 81
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
    • COI: 1:CAS:528:DC%2BD1cXhtlCjtLrF, PID: 18978797
    • Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008;14(11):1264–70. doi:10.1038/nm.1882.
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1264-1270
    • Pule, M.A.1    Savoldo, B.2    Myers, G.D.3    Rossig, C.4    Russell, H.V.5    Dotti, G.6
  • 82
    • 84875215925 scopus 로고    scopus 로고
    • T cells redirected to EphA2 for the immunotherapy of glioblastoma
    • COI: 1:CAS:528:DC%2BC38XhsFWru7nE
    • Chow KK, Naik S, Kakarla S, Brawley VS, Shaffer DR, Yi Z, et al. T cells redirected to EphA2 for the immunotherapy of glioblastoma. Mol Ther: J Am Soc Gene Ther. 2013;21(3):629–37. doi:10.1038/mt.2012.210.
    • (2013) Mol Ther : J Am Soc Gene Ther , vol.21 , Issue.3 , pp. 629-637
    • Chow, K.K.1    Naik, S.2    Kakarla, S.3    Brawley, V.S.4    Shaffer, D.R.5    Yi, Z.6
  • 83
    • 84887471195 scopus 로고    scopus 로고
    • Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma
    • COI: 1:CAS:528:DC%2BC3sXhs1ClsL7J
    • Hegde M, Corder A, Chow KK, Mukherjee M, Ashoori A, Kew Y, et al. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma. Mol Ther: J Am Soc Gene Ther. 2013;21(11):2087–101. doi:10.1038/mt.2013.185.
    • (2013) Mol Ther : J Am Soc Gene Ther , vol.21 , Issue.11 , pp. 2087-2101
    • Hegde, M.1    Corder, A.2    Chow, K.K.3    Mukherjee, M.4    Ashoori, A.5    Kew, Y.6
  • 84
    • 84899523433 scopus 로고    scopus 로고
    • EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma
    • PID: 24722266
    • Miao H, Choi BD, Suryadevara CM, Sanchez-Perez L, Yang S, De Leon G, et al. EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma. PLoS One. 2014;9(4), e94281. doi:10.1371/journal.pone.0094281.
    • (2014) PLoS One , vol.9 , Issue.4
    • Miao, H.1    Choi, B.D.2    Suryadevara, C.M.3    Sanchez-Perez, L.4    Yang, S.5    De Leon, G.6
  • 85
    • 84875198775 scopus 로고    scopus 로고
    • Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma
    • COI: 1:CAS:528:DC%2BC38XhsFCgsbrL, PID: 22780919
    • Morgan RA, Johnson LA, Davis JL, Zheng Z, Woolard KD, Reap EA, et al. Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. Hum Gene Ther. 2012;23(10):1043–53. doi:10.1089/hum.2012.041.
    • (2012) Hum Gene Ther , vol.23 , Issue.10 , pp. 1043-1053
    • Morgan, R.A.1    Johnson, L.A.2    Davis, J.L.3    Zheng, Z.4    Woolard, K.D.5    Reap, E.A.6
  • 86
    • 84942908170 scopus 로고    scopus 로고
    • Bioactivity and safety of IL13Ralpha2-redirected chimeric antigen receptor CD8+ T cells in patients with recurrent glioblastoma
    • Brown CE, Badie B, Barish ME, Weng L, Ostberg JR, Chang WC, et al. Bioactivity and safety of IL13Ralpha2-redirected chimeric antigen receptor CD8+ T cells in patients with recurrent glioblastoma. Clin Cancer Res: Off J Am Assoc Cancer Res. 2015. doi:10.1158/1078-0432.CCR-15-0428.
    • (2015) Clin Cancer Res : Off J Am Assoc Cancer Res
    • Brown, C.E.1    Badie, B.2    Barish, M.E.3    Weng, L.4    Ostberg, J.R.5    Chang, W.C.6
  • 87
  • 88
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria
    • COI: 1:CAS:528:DC%2BD1MXhsFSnu7vN
    • Wolchok JD, Hoos A, O’Day S, Weber JS, Hamid O, Lebbe C, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res: Off J Am Assoc Cancer Res. 2009;15(23):7412–20. doi:10.1158/1078-0432.CCR-09-1624.
    • (2009) Clin Cancer Res : Off J Am Assoc Cancer Res , vol.15 , Issue.23 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O’Day, S.3    Weber, J.S.4    Hamid, O.5    Lebbe, C.6
  • 90
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • COI: 1:CAS:528:DC%2BC3sXht1ektbrF, PID: 23724867, This work shows enhanced efficacy of combination CTLA-4 and PD-1 blockade in treatment of melanoma
    • Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013;369(2):122–33. doi:10.1056/NEJMoa1302369. This work shows enhanced efficacy of combination CTLA-4 and PD-1 blockade in treatment of melanoma.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3    Postow, M.A.4    Rizvi, N.A.5    Lesokhin, A.M.6
  • 91
    • 84937434464 scopus 로고    scopus 로고
    • Current challenges in designing GBM trials for immunotherapy
    • COI: 1:CAS:528:DC%2BC2MXhtVCru78%3D
    • Weathers SP, Gilbert MR. Current challenges in designing GBM trials for immunotherapy. J Neuro-Oncol. 2015;123(3):331–7. doi:10.1007/s11060-015-1716-2.
    • (2015) J Neuro-Oncol , vol.123 , Issue.3 , pp. 331-337
    • Weathers, S.P.1    Gilbert, M.R.2
  • 92
    • 84861233216 scopus 로고    scopus 로고
    • Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors
    • COI: 1:CAS:528:DC%2BC38Xnt1elt74%3D, PID: 22576343
    • Agarwalla P, Barnard Z, Fecci P, Dranoff G, Curry Jr WT. Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors. J Immunother. 2012;35(5):385–9. doi:10.1097/CJI.0b013e3182562d59.
    • (2012) J Immunother , vol.35 , Issue.5 , pp. 385-389
    • Agarwalla, P.1    Barnard, Z.2    Fecci, P.3    Dranoff, G.4    Curry, W.T.5
  • 93
    • 84892924268 scopus 로고    scopus 로고
    • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors—response
    • COI: 1:CAS:528:DC%2BC2cXptValsQ%3D%3D, PID: 24408920, discussion 5
    • Duraiswamy J, Freeman GJ, Coukos G. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors—response. Cancer Res. 2014;74(2):633–4. doi:10.1158/0008-5472.CAN-13-2752. discussion 5.
    • (2014) Cancer Res , vol.74 , Issue.2 , pp. 633-634
    • Duraiswamy, J.1    Freeman, G.J.2    Coukos, G.3
  • 94
    • 84937514581 scopus 로고    scopus 로고
    • Combining immunotherapy with radiation for the treatment of glioblastoma
    • COI: 1:CAS:528:DC%2BC2MXms1ahs7Y%3D
    • Chow KK, Hara W, Lim M, Li G. Combining immunotherapy with radiation for the treatment of glioblastoma. J Neuro-Oncol. 2015;123(3):459–64. doi:10.1007/s11060-015-1762-9.
    • (2015) J Neuro-Oncol , vol.123 , Issue.3 , pp. 459-464
    • Chow, K.K.1    Hara, W.2    Lim, M.3    Li, G.4
  • 95
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • COI: 1:CAS:528:DC%2BC38XktFOgurw%3D, PID: 22397654
    • Postow MA, Callahan MK, Barker CA, Yamada Y, Yuan J, Kitano S, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925–31. doi:10.1056/NEJMoa1112824.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3    Yamada, Y.4    Yuan, J.5    Kitano, S.6
  • 96
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
    • COI: 1:CAS:528:DC%2BD1MXpt1Wmsbc%3D, PID: 19349616
    • Lee Y, Auh SL, Wang Y, Burnette B, Wang Y, Meng Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood. 2009;114(3):589–95. doi:10.1182/blood-2009-02-206870.
    • (2009) Blood , vol.114 , Issue.3 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3    Burnette, B.4    Wang, Y.5    Meng, Y.6
  • 97
    • 45449090985 scopus 로고    scopus 로고
    • Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity
    • COI: 1:CAS:528:DC%2BD1cXit1Oks7g%3D, PID: 18292536
    • Lugade AA, Sorensen EW, Gerber SA, Moran JP, Frelinger JG, Lord EM. Radiation-induced IFN-gamma production within the tumor microenvironment influences antitumor immunity. J Immunol. 2008;180(5):3132–9.
    • (2008) J Immunol , vol.180 , Issue.5 , pp. 3132-3139
    • Lugade, A.A.1    Sorensen, E.W.2    Gerber, S.A.3    Moran, J.P.4    Frelinger, J.G.5    Lord, E.M.6
  • 98
    • 33646704729 scopus 로고    scopus 로고
    • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
    • COI: 1:CAS:528:DC%2BD28XkvFWiurc%3D, PID: 16636135
    • Reits EA, Hodge JW, Herberts CA, Groothuis TA, Chakraborty M, Wansley EK, et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med. 2006;203(5):1259–71. doi:10.1084/jem.20052494.
    • (2006) J Exp Med , vol.203 , Issue.5 , pp. 1259-1271
    • Reits, E.A.1    Hodge, J.W.2    Herberts, C.A.3    Groothuis, T.A.4    Chakraborty, M.5    Wansley, E.K.6
  • 99
    • 84937516687 scopus 로고    scopus 로고
    • Biomarkers for glioma immunotherapy: the next generation
    • COI: 1:CAS:528:DC%2BC2MXjvFWlurk%3D
    • Sims JS, Ung TH, Neira JA, Canoll P, Bruce JN. Biomarkers for glioma immunotherapy: the next generation. J Neuro-Oncol. 2015;123(3):359–72. doi:10.1007/s11060-015-1746-9.
    • (2015) J Neuro-Oncol , vol.123 , Issue.3 , pp. 359-372
    • Sims, J.S.1    Ung, T.H.2    Neira, J.A.3    Canoll, P.4    Bruce, J.N.5
  • 101
    • 84899490698 scopus 로고    scopus 로고
    • Validation of a prognostic multi-gene signature in high-risk neuroblastoma using the high throughput digital NanoString nCounter system
    • COI: 1:CAS:528:DC%2BC2cXislCkt7c%3D, PID: 24560446
    • Stricker TP, Morales La Madrid A, Chlenski A, Guerrero L, Salwen HR, Gosiengfiao Y, et al. Validation of a prognostic multi-gene signature in high-risk neuroblastoma using the high throughput digital NanoString nCounter system. Mol Oncol. 2014;8(3):669–78. doi:10.1016/j.molonc.2014.01.010.
    • (2014) Mol Oncol , vol.8 , Issue.3 , pp. 669-678
    • Stricker, T.P.1    Morales La Madrid, A.2    Chlenski, A.3    Guerrero, L.4    Salwen, H.R.5    Gosiengfiao, Y.6
  • 102
    • 84897400979 scopus 로고    scopus 로고
    • Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens
    • PID: 24625003
    • Nielsen T, Wallden B, Schaper C, Ferree S, Liu S, Gao D, et al. Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens. BMC Cancer. 2014;14:177. doi:10.1186/1471-2407-14-177.
    • (2014) BMC Cancer , vol.14 , pp. 177
    • Nielsen, T.1    Wallden, B.2    Schaper, C.3    Ferree, S.4    Liu, S.5    Gao, D.6
  • 103
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • COI: 1:CAS:528:DC%2BC2cXitFanu7jL, PID: 25428505
    • Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515(7528):568–71. doi:10.1038/nature13954.
    • (2014) Nature , vol.515 , Issue.7528 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3    Shintaku, I.P.4    Taylor, E.J.5    Robert, L.6
  • 104
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • COI: 1:CAS:528:DC%2BC3cXkvFKgsL4%3D, PID: 20129251
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17(1):98–110. doi:10.1016/j.ccr.2009.12.020.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.