Mucorpepsin

Handbook of Proteolytic Enzymes, Second Edition: Volume 1: Aspartic and Metallo Peptidases

Volumn 1, Issue , 2004, Pages 111-113

  Beppu, Teruhiko ^a   Nishiyama, Makoto ^b  

^a NIHON UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84944053200     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-079611-3.50034-3     Document Type: Chapter

References (31)

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2. J. Aikawa, Y.N. Park, M. Sugiyama, M. Nishiyama, S. Horinouchi and T. Beppu (2001) Replacements of amino acid residues at subsites and their effects on the catalytic properties of Rhizomucor pusillus pepsin, an aspartic proteinase from Rhizomucor pusillus. J. Biochem. 129 791-794.
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5. K. Arima, J. Yu and S. Iwasaki (1970) Milk-clotting enzyme from Mucor pusillus var. Lindt. Methods Enzymol. 19 446-459.
6. T. Beppu, Y.-N. Park, J. Aikawa, M. Nishiyama and S. Horinouchi (1995) Tyrosine 75 on the flap contributes to enhance catalytic efficiency of a fungal aspartic proteinase, Mucor pusillus pepsin. T. Takahashi (Ed.) Aspartic Proteinase: Structure, Function, Biology, and Biomedical Implications New York: Plenum Press 559-563.
7. E. Boel, A.M. Bech, K. Randrup, B. Draeger, N.P. Fiil and B. Foltmann (1986) Primary structure of a precursor to the aspartic proteinase from Rhizomucor miehei shows that the enzyme is synthesized as a zymogen. Proteins 1 363-369.
8. T. Christensen, H. Woeldike, E. Boel, S.B. Mortensen, K. Hjortshoej, L. Thim and M.T. Hansen (1988) High-level expression of recombinant genes in Aspergillus oryzae. Bio/Technology 6 1419-1422.
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10. G.L. Gray, K. Hayenga, D. Cullen, L.J. Wilson and S. Norton (1986) Primary structure of Mucor miehei aspartyl protease: evidence for a zymogen intermediate. Gene 48 41-53.
11. R. Hiramatsu, J. Aikawa, S. Horinouchi and T. Beppu (1989) Secretion by yeast of the zymogen form of Mucor rennin, an aspartic proteinase of Mucor pusillus, and its conversion to the mature form. J. Biol. Chem. 264 16862-16866.
12. S. Iwasaki, G. Tamura and K. Arima (1967) Milk clotting enzyme from microorganisms. Part II. The enzyme production and the properties of crude enzyme. Agric. Biol. Chem. 31 546-551.
13. P. Martin, M.-N. Raymond, E. Bricas and B. Ribadeau Ducas (1980) Kinetic studies on the action of Mucor pusillus, Mucor miehei acid proteases and chymosins A and B on a synthetic chromophoric hexapeptide. Biochim. Biophys. Acta 612 410-420.
14. K. Murakami, J. Aikawa, S. Horinouchi and T. Beppu (1993) Characterization of an aspartic proteinase of Mucor pusillus expressed in Aspergillus oryzae. Mol. Gen Genet. 241 312-318.
15. M. Newman, F. Watson, P. Roychowdhury, H. Jones, M. Badasso, A. Cleasby, S.P. Wood, I.J. Tickle and T.L. Blundell (1993) X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 Å resolution of the aspartic proteinase from Mucor pusillus. J. Mol. Biol. 230 260-283.
16. T. Oka, K. Ishino, H. Tsuzuki, K. Morihara and K. Arima (1973) On the specificity of a rennin-like enzyme from Mucor pusillus. Agric. Biol. Chem. 37 1177-1184.
17. M. Ottesen and W. Rickert (1970) The isolation and partial characterization of an acid protease produced by Mucor miehei. C. R. Trav. Lab. Carlsberg 37 301-325.
18. Y.-N. Park, J. Aikawa, M. Nishiyama, S. Horinouchi and T. Beppu (1996) Involvement of a residue at position 75 in the catalytic mechanism of a fungal aspartic proteinase, Rhizomucor pusillus pepsin. Replacement of tyrosine 75 on the flap by asparagine enhances catalytic efficiency. Protein Eng. 9 869-875.
19. Y.-N. Park, J. Aikawa, M. Nishiyama, S. Horinouchi and T. Beppu (1997) Site-directed mutagenesis of conserved Trp39 in Rhizomucor pusillus pepsin: possible role of Trp39 in maintaining Tyr75 in the correct orientation for maximizing catalytic activity. J. Biochem. 121 118-121.
20. G.H. Richardson, J.H. Nelson, R.E. Lubnow and R.L. Schwarberg (1967) Rennin-like enzyme from Mucor pusillus for cheese manufacture. J. Dairy Sci. 50 1066-1072.
21. W. Rickert (1970) The degradation of the B-chain of oxidized insulin by Mucor miehei protease. C. R. Trav. Lab. Carlsberg 38 1-17.
22. Schipper, M.A.A. (1978) On the genera Rhizomucor Parasitella. Studies in Mycology. No. 17. Inst. Roy. Netherlands Acad. Sci. Lett. 53–71.
23. M. Schlamowitz and L.U. Peterson (1959) Studies on the optimum pH for the action of pepsin on native and denatured bovine serum albumin and bovine haemoglobin. J. Biol. Chem. 234 3137-3145.
24. G.A. Somkuti and F.J. Babel (1968) Purification and properties of Mucor pusillus acid protease. J. Bacteriol. 95 1407-1414.
25. M.Z. Sternberg (1971) Crystalline milk-clotting protease from Mucor miehei and some of its properties. J. Dairy Sci. 54 150-167.
26. M. Sternberg (1972) Bond specificity, active site and milk clotting mechanism of the Mucor miehei protease. Biochim. Biophys. Acta 285 383-392.
27. K. Takahashi, W.J. Chang and K. Arima (1976) The structure and function of acid proteases. IV. Inactivation of the acid protease from Mucor pusillus by acid protease-specific inhibitors. J. Biochem. (Tokyo) 80 61-67.
28. N. Tonouchi, H. Shoun, T. Uozumi and T. Beppu (1986) Cloning and sequencing of a gene for Mucor rennin, an aspartate protease from Mucor pusillus. Nucleic Acids Res. 14 7557-7568.
29. T. Yamashita, N. Tonouchi, T. Uozumi and T. Beppu (1987) Secretion of Mucor rennin, a fungal aspartic protease of Mucor pusillus, by recombinant yeast cells. Mol. Gen. Genet. 210 462-467.
30. J. Yang and J.W. Quail (1999) Structure of the Rhizomucor miehei aspartic proteinase complexed with the inhibitor pepstatin A at 2.7 Å resolution. Acta Crystallogr. D Biol. Crystallogr. 55 625-630.
31. J. Yang, A. Teplyakov and J.W. Quail (1997) Crystal structure of the aspartic proteinase from Rhizomucor miehei at 2.15 Å resolution. J. Mol. Biol. 268 449-459.